DEDD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEDD_HUMAN
• UniProt AC: O75618
• Protein Name: Death effector domain-containing protein
• Gene Name: DEDD
• Organism: Homo sapiens (Human).
• Sequence Length: 318
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous stru
• Protein Description: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity)..
• Protein Sequence: MAGLKRRASQVWPEEHGEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKRRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGPQMCSKRPARGRATLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AGLKRRASQVWPEEH CCCCCHHHHCCCHHH	24.37	29449344
25	Phosphorylation	EQEHGLYSLHRMFDI CCCCCCHHHHHHHHH	23.81	24719451
46	Phosphorylation	HRDVRVLSFLFVDVI CCHHHHHHEEEEEEC	19.62	-
116	Ubiquitination	VCPDLVDKYLEETSI CCHHHHHHHHHHCCC	44.23	-
181	Acetylation	GSQRKRRKSVTPDPK CCHHHHHCCCCCCHH	54.00	30588105
182	Phosphorylation	SQRKRRKSVTPDPKE CHHHHHCCCCCCHHH	29.43	28102081
184	Phosphorylation	RKRRKSVTPDPKEKQ HHHHCCCCCCHHHCC	29.12	28348404
237	Ubiquitination	NQANTILKSRDLGSI HHHHHHHHHCCCCCE	39.33	2189047
237 (in isoform 1)	Ubiquitination	-	39.33	21890473
267 (in isoform 2)	Ubiquitination	-	25.87	21890473
282	Ubiquitination	VFITDSLKQAVGHEA CCCCHHHHHHHCHHH	39.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEDD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEDD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEDD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RANB3_HUMAN	RANBP3	physical	17353931
KHK_HUMAN	KHK	physical	17353931
TAP26_HUMAN	CCDC59	physical	17353931
CASP8_HUMAN	CASP8	physical	11965497
CFLAR_HUMAN	CFLAR	physical	11965497
DEDD_HUMAN	DEDD	physical	12527898
DEDD2_HUMAN	DEDD2	physical	12527898
DEDD_HUMAN	DEDD	physical	11965497
DEDD2_HUMAN	DEDD2	physical	11965497
TF3C3_HUMAN	GTF3C3	physical	11965497
A4_HUMAN	APP	physical	21832049
GLYC_HUMAN	SHMT1	physical	21988832
APLP2_HUMAN	APLP2	physical	20195357

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.