GLYC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLYC_HUMAN
• UniProt AC: P34896
• Protein Name: Serine hydroxymethyltransferase, cytosolic
• Gene Name: SHMT1
• Organism: Homo sapiens (Human).
• Sequence Length: 483
• Subcellular Localization: Cytoplasm.
• Protein Description: Interconversion of serine and glycine. [PubMed: 8505317]
• Protein Sequence: MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTMPVNGAH ------CCCCCCCCC	30.13	19413330
2	Phosphorylation	------MTMPVNGAH ------CCCCCCCCC	30.13	20068231
10	Acetylation	MPVNGAHKDADLWSS CCCCCCCCCCCCCCC	54.82	23954790
10	Ubiquitination	MPVNGAHKDADLWSS CCCCCCCCCCCCCCC	54.82	-
16	Phosphorylation	HKDADLWSSHDKMLA CCCCCCCCCCHHHHC	25.70	28857561
17	Phosphorylation	KDADLWSSHDKMLAQ CCCCCCCCCHHHHCC	24.91	28857561
19	Ubiquitination	ADLWSSHDKMLAQPL CCCCCCCHHHHCCCC	39.75	29967540
20	Ubiquitination	DLWSSHDKMLAQPLK CCCCCCHHHHCCCCC	30.32	29967540
21	Ubiquitination	LWSSHDKMLAQPLKD CCCCCHHHHCCCCCC	4.70	-
27	Ubiquitination	KMLAQPLKDSDVEVY HHHCCCCCCCCCHHH	62.97	21906983
27 (in isoform 1)	Ubiquitination	-	62.97	21890473
27 (in isoform 3)	Ubiquitination	-	62.97	21890473
29	Phosphorylation	LAQPLKDSDVEVYNI HCCCCCCCCCHHHEE	41.80	20068231
34	Phosphorylation	KDSDVEVYNIIKKES CCCCCHHHEEEECCC	6.27	27155012
35	Ubiquitination	DSDVEVYNIIKKESN CCCCHHHEEEECCCC	34.38	-
35	Ubiquitination	DSDVEVYNIIKKESN CCCCHHHEEEECCCC	34.38	21963094
38	Sumoylation	VEVYNIIKKESNRQR CHHHEEEECCCCCCC	46.84	-
38	Sumoylation	VEVYNIIKKESNRQR CHHHEEEECCCCCCC	46.84	-
38	Ubiquitination	VEVYNIIKKESNRQR CHHHEEEECCCCCCC	46.84	21906983
38 (in isoform 1)	Ubiquitination	-	46.84	21890473
38 (in isoform 3)	Ubiquitination	-	46.84	21890473
39	Sumoylation	EVYNIIKKESNRQRV HHHEEEECCCCCCCE	56.84	-
39	Sumoylation	EVYNIIKKESNRQRV HHHEEEECCCCCCCE	56.84	-
39	Ubiquitination	EVYNIIKKESNRQRV HHHEEEECCCCCCCE	56.84	22817900
53	Phosphorylation	VGLELIASENFASRA EEEEEHHCCCHHHHH	26.53	28857561
58	Ubiquitination	IASENFASRAVLEAL HHCCCHHHHHHHHHH	19.35	-
58	O-linked_Glycosylation	IASENFASRAVLEAL HHCCCHHHHHHHHHH	19.35	OGP
67	Phosphorylation	AVLEALGSCLNNKYS HHHHHHHHHHHCCCC	19.11	28857561
72	Ubiquitination	LGSCLNNKYSEGYPG HHHHHHCCCCCCCCC	49.43	21890473
72	Acetylation	LGSCLNNKYSEGYPG HHHHHHCCCCCCCCC	49.43	25953088
72	Ubiquitination	LGSCLNNKYSEGYPG HHHHHHCCCCCCCCC	49.43	21963094
72 (in isoform 1)	Ubiquitination	-	49.43	21890473
72 (in isoform 3)	Ubiquitination	-	49.43	21890473
73	Phosphorylation	GSCLNNKYSEGYPGQ HHHHHCCCCCCCCCC	17.68	21253578
74	Phosphorylation	SCLNNKYSEGYPGQR HHHHCCCCCCCCCCC	26.59	28857561
77	Phosphorylation	NNKYSEGYPGQRYYG HCCCCCCCCCCCCCC	10.51	28152594
86	Phosphorylation	GQRYYGGTEFIDELE CCCCCCCHHHHHHHH	24.29	28857561
98	Ubiquitination	ELETLCQKRALQAYK HHHHHHHHHHHHHHC	38.35	21963094
105	Ubiquitination	KRALQAYKLDPQCWG HHHHHHHCCCCCCEE	49.80	21963094
118	Phosphorylation	WGVNVQPYSGSPANF EEEECCCCCCCCCCE	14.47	20090780
119	Phosphorylation	GVNVQPYSGSPANFA EEECCCCCCCCCCEE	39.20	28857561
121	Phosphorylation	NVQPYSGSPANFAVY ECCCCCCCCCCEEEE	18.20	28857561
150	Phosphorylation	LPDGGHLTHGFMTDK CCCCCCCCCCEECCC	17.80	28857561
155	Phosphorylation	HLTHGFMTDKKKISA CCCCCEECCCCCEEE	42.26	28857561
157	Acetylation	THGFMTDKKKISATS CCCEECCCCCEEEEE	46.96	24886807
157	Ubiquitination	THGFMTDKKKISATS CCCEECCCCCEEEEE	46.96	29967540
158	Acetylation	HGFMTDKKKISATSI CCEECCCCCEEEEEE	59.14	25953088
158	Ubiquitination	HGFMTDKKKISATSI CCEECCCCCEEEEEE	59.14	-
159	Ubiquitination	GFMTDKKKISATSIF CEECCCCCEEEEEEE	47.86	-
161	Phosphorylation	MTDKKKISATSIFFE ECCCCCEEEEEEEEE	34.08	28857561
163	Phosphorylation	DKKKISATSIFFESM CCCCEEEEEEEEECC	18.63	22210691
164	Phosphorylation	KKKISATSIFFESMP CCCEEEEEEEEECCC	19.67	28857561
168	Ubiquitination	SATSIFFESMPYKVN EEEEEEEECCCCEEC	35.06	21963094
169	Phosphorylation	ATSIFFESMPYKVNP EEEEEEECCCCEECC	21.65	28857561
173	Ubiquitination	FFESMPYKVNPDTGY EEECCCCEECCCCCC	29.66	21906983
173 (in isoform 1)	Ubiquitination	-	29.66	21890473
173 (in isoform 2)	Ubiquitination	-	29.66	-
173 (in isoform 3)	Ubiquitination	-	29.66	21890473
180	Phosphorylation	KVNPDTGYINYDQLE EECCCCCCCCHHHHH	6.51	27642862
183	Phosphorylation	PDTGYINYDQLEENA CCCCCCCHHHHHHHH	8.77	27642862
196	Acetylation	NARLFHPKLIIAGTS HHHHHCCCEEEECCC	43.69	26051181
196	Ubiquitination	NARLFHPKLIIAGTS HHHHHCCCEEEECCC	43.69	-
198	Ubiquitination	RLFHPKLIIAGTSCY HHHCCCEEEECCCHH	2.24	27667366
202	Phosphorylation	PKLIIAGTSCYSRNL CCEEEECCCHHHCCC	13.45	26074081
202	Ubiquitination	PKLIIAGTSCYSRNL CCEEEECCCHHHCCC	13.45	21890473
203	Phosphorylation	KLIIAGTSCYSRNLE CEEEECCCHHHCCCH	15.33	26074081
205	Phosphorylation	IIAGTSCYSRNLEYA EEECCCHHHCCCHHH	15.50	26074081
206	Phosphorylation	IAGTSCYSRNLEYAR EECCCHHHCCCHHHH	21.01	26074081
209	Ubiquitination	TSCYSRNLEYARLRK CCHHHCCCHHHHHHH	5.31	21963094
228	Ubiquitination	NGAYLMADMAHISGL CCCEEEEEHHHHHHH	22.34	24816145
237	Acetylation	AHISGLVAAGVVPSP HHHHHHHHCCCCCCC	11.98	-
237	Ubiquitination	AHISGLVAAGVVPSP HHHHHHHHCCCCCCC	11.98	-
237	Ubiquitination	AHISGLVAAGVVPSP HHHHHHHHCCCCCCC	11.98	29901268
238	Ubiquitination	HISGLVAAGVVPSPF HHHHHHHCCCCCCCC	12.11	21890473
239	Ubiquitination	ISGLVAAGVVPSPFE HHHHHHCCCCCCCCC	15.95	27667366
243	Ubiquitination	VAAGVVPSPFEHCHV HHCCCCCCCCCCCEE	30.52	21890473
248	Ubiquitination	VPSPFEHCHVVTTTT CCCCCCCCEEEEEEC	1.73	-
248	Ubiquitination	VPSPFEHCHVVTTTT CCCCCCCCEEEEEEC	1.73	21963094
257	N6-(pyridoxal phosphate)lysine	VVTTTTHKTLRGCRA EEEEECCHHHCCCCE	47.35	-
257	Other	VVTTTTHKTLRGCRA EEEEECCHHHCCCCE	47.35	9753690
269	Ubiquitination	CRAGMIFYRKGVKSV CCEEEEEEECCCCCC	10.65	24816145
271	Acetylation	AGMIFYRKGVKSVDP EEEEEEECCCCCCCC	57.59	7962587
271 (in isoform 2)	Acetylation	-	57.59	19608861
274	Acetylation	IFYRKGVKSVDPKTG EEEECCCCCCCCCCC	54.13	7962599
278	Ubiquitination	KGVKSVDPKTGKEIL CCCCCCCCCCCHHHH	33.67	-
278	Ubiquitination	KGVKSVDPKTGKEIL CCCCCCCCCCCHHHH	33.67	27667366
279	Acetylation	GVKSVDPKTGKEILY CCCCCCCCCCHHHHH	66.50	7962611
279	Ubiquitination	GVKSVDPKTGKEILY CCCCCCCCCCHHHHH	66.50	21890473
282	Ubiquitination	SVDPKTGKEILYNLE CCCCCCCHHHHHCHH	46.98	-
282	Ubiquitination	SVDPKTGKEILYNLE CCCCCCCHHHHHCHH	46.98	21890473
306	Ubiquitination	GLQGGPHNHAIAGVA CCCCCCCHHHHHHHH	29.44	21963094
308	Ubiquitination	QGGPHNHAIAGVAVA CCCCCHHHHHHHHHH	9.92	-
308	Ubiquitination	QGGPHNHAIAGVAVA CCCCCHHHHHHHHHH	9.92	24816145
311	Ubiquitination	PHNHAIAGVAVALKQ CCHHHHHHHHHHHHH	11.21	-
318	Ubiquitination	GVAVALKQAMTLEFK HHHHHHHHHCCCEEE	36.90	-
318	Ubiquitination	GVAVALKQAMTLEFK HHHHHHHHHCCCEEE	36.90	21963094
321	Phosphorylation	VALKQAMTLEFKVYQ HHHHHHCCCEEEEEE	26.59	28857561
336	Ubiquitination	HQVVANCRALSEALT HHHHHHHHHHHHHHH	38.07	21890473
336	Ubiquitination	HQVVANCRALSEALT HHHHHHHHHHHHHHH	38.07	27667366
336 (in isoform 3)	Ubiquitination	-	38.07	21890473
339	Phosphorylation	VANCRALSEALTELG HHHHHHHHHHHHHCC	21.60	21406692
340	Ubiquitination	ANCRALSEALTELGY HHHHHHHHHHHHCCC	48.85	21890473
340	Ubiquitination	ANCRALSEALTELGY HHHHHHHHHHHHCCC	48.85	21890473
340 (in isoform 3)	Ubiquitination	-	48.85	21890473
343	Phosphorylation	RALSEALTELGYKIV HHHHHHHHHCCCEEE	35.89	21406692
347	Phosphorylation	EALTELGYKIVTGGS HHHHHCCCEEECCCC	15.34	21406692
347	Ubiquitination	EALTELGYKIVTGGS HHHHHCCCEEECCCC	15.34	21963094
351	Phosphorylation	ELGYKIVTGGSDNHL HCCCEEECCCCCCEE	39.02	30622161
354	Phosphorylation	YKIVTGGSDNHLILV CEEECCCCCCEEEEE	36.26	28857561
366	Ubiquitination	ILVDLRSKGTDGGRA EEEECHHCCCCCCHH	60.44	24816145
375	Acetylation	TDGGRAEKVLEACSI CCCCHHHHHHHHHHH	51.65	23749302
375	Ubiquitination	TDGGRAEKVLEACSI CCCCHHHHHHHHHHH	51.65	29901268
376	Ubiquitination	DGGRAEKVLEACSIA CCCHHHHHHHHHHHH	4.37	21890473
376	Ubiquitination	DGGRAEKVLEACSIA CCCHHHHHHHHHHHH	4.37	21890473
376 (in isoform 3)	Ubiquitination	-	4.37	21890473
377	Ubiquitination	GGRAEKVLEACSIAC CCHHHHHHHHHHHHC	5.24	27667366
377 (in isoform 2)	Ubiquitination	-	5.24	-
381	Phosphorylation	EKVLEACSIACNKNT HHHHHHHHHHCCCCC	21.92	28857561
381	Ubiquitination	EKVLEACSIACNKNT HHHHHHHHHHCCCCC	21.92	21890473
386	Acetylation	ACSIACNKNTCPGDR HHHHHCCCCCCCCCH	54.22	25953088
386	Ubiquitination	ACSIACNKNTCPGDR HHHHHCCCCCCCCCH	54.22	21963094
388	Phosphorylation	SIACNKNTCPGDRSA HHHCCCCCCCCCHHH	22.99	28857561
405	Phosphorylation	PSGLRLGTPALTSRG CCCCCCCCHHHCCCC	15.24	28857561
407	Ubiquitination	GLRLGTPALTSRGLL CCCCCCHHHCCCCHH	24.26	24816145
409	Phosphorylation	RLGTPALTSRGLLEK CCCCHHHCCCCHHHH	20.63	28857561
410	Phosphorylation	LGTPALTSRGLLEKD CCCHHHCCCCHHHHH	25.79	28857561
416	Acetylation	TSRGLLEKDFQKVAH CCCCHHHHHHHHHHH	64.91	25953088
416	Ubiquitination	TSRGLLEKDFQKVAH CCCCHHHHHHHHHHH	64.91	27667366
416 (in isoform 1)	Ubiquitination	-	64.91	21890473
417	Ubiquitination	SRGLLEKDFQKVAHF CCCHHHHHHHHHHHH	41.66	21963094
420	Ubiquitination	LLEKDFQKVAHFIHR HHHHHHHHHHHHHHH	41.19	22817900
420 (in isoform 1)	Ubiquitination	-	41.19	21890473
444	Phosphorylation	SDTGVRATLKEFKER CCCCHHHHHHHHHHH	28.00	30576142
446	Acetylation	TGVRATLKEFKERLA CCHHHHHHHHHHHHC	57.67	25953088
446	Ubiquitination	TGVRATLKEFKERLA CCHHHHHHHHHHHHC	57.67	24816145
449	Ubiquitination	RATLKEFKERLAGDK HHHHHHHHHHHCCHH	42.91	-
456	Ubiquitination	KERLAGDKYQAAVQA HHHHCCHHHHHHHHH	38.04	21963094
456 (in isoform 1)	Ubiquitination	-	38.04	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLYC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLYC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLYC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIM1_HUMAN	PIM1	physical	16169070
ZC3H4_HUMAN	ZC3H4	physical	22939629
HS71L_HUMAN	HSPA1L	physical	22939629
ACPH_HUMAN	APEH	physical	22863883
SRC8_HUMAN	CTTN	physical	22863883
SYCC_HUMAN	CARS	physical	22863883
NIBL1_HUMAN	FAM129B	physical	22863883
GARS_HUMAN	GARS	physical	22863883
ERF3B_HUMAN	GSPT2	physical	22863883
SYHC_HUMAN	HARS	physical	22863883
IDE_HUMAN	IDE	physical	22863883
PAWR_HUMAN	PAWR	physical	22863883
GLYM_HUMAN	SHMT2	physical	22863883
SNX2_HUMAN	SNX2	physical	22863883
SNX6_HUMAN	SNX6	physical	22863883
STAT1_HUMAN	STAT1	physical	22863883
VPS29_HUMAN	VPS29	physical	22863883
GLYC_HUMAN	SHMT1	physical	25416956
ST1A3_HUMAN	SULT1A3	physical	25416956
ST1A4_HUMAN	SULT1A3	physical	25416956
ARFP1_HUMAN	ARFIP1	physical	26344197
PUR9_HUMAN	ATIC	physical	26344197
CH10_HUMAN	HSPE1	physical	26344197
ITPA_HUMAN	ITPA	physical	26344197
PGK2_HUMAN	PGK2	physical	26344197
GLYM_HUMAN	SHMT2	physical	28514442
DPYL5_HUMAN	DPYSL5	physical	28514442
ARNT_HUMAN	ARNT	physical	28514442
ABRX2_HUMAN	FAM175B	physical	24075985

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00145: Glycine
• DB01055: Mimosine
• DB00116: Tetrahydrofolic acid

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-271, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-34, AND MASSSPECTROMETRY.
PubMed: 19690332