SYHC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYHC_HUMAN
• UniProt AC: P12081
• Protein Name: Histidine--tRNA ligase, cytoplasmic
• Gene Name: HARS
• Organism: Homo sapiens (Human).
• Sequence Length: 509
• Subcellular Localization: Cytoplasm.
• Protein Description: Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance..
• Protein Sequence: MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Acetylation	SKQKFVLKTPKGTRD HHCCEEEECCCCCCC	58.44	25953088
106	Acetylation	LKETLMGKYGEDSKL HHHHHCCCCCCCCEE	35.80	27452117
143	Acetylation	ARYLAMNKLTNIKRY HHHHHHHHCCCCCHH	43.53	25953088
224	Glutathionylation	LDGMFAICGVSDSKF EEECEEEECCCHHHH	3.85	22555962
235	Glutathionylation	DSKFRTICSSVDKLD HHHHHHHHHCCCCCC	2.16	22555962
240	Acetylation	TICSSVDKLDKVSWE HHHHCCCCCCCCCHH	57.33	25953088
253	Ubiquitination	WEEVKNEMVGEKGLA HHHHHHHHCCCCCCC	7.02	21890473
253	Ubiquitination	WEEVKNEMVGEKGLA HHHHHHHHCCCCCCC	7.02	21890473
383	Acetylation	KVPCVGLSIGVERIF CCCEEEEECCHHHHH	16.03	19608861
403	Acetylation	RLEALEEKIRTTETQ HHHHHHHHHCCCHHH	28.28	19608861
418	Acetylation	VLVASAQKKLLEERL HHHHHHHHHHHHHHH	45.14	25953088
423	Acetylation	AQKKLLEERLKLVSE HHHHHHHHHHHHHHH	64.38	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYHC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYHC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYHC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AASD1_HUMAN	AARSD1	physical	22863883
CALU_HUMAN	CALU	physical	22863883
U5S1_HUMAN	EFTUD2	physical	22863883
FEN1_HUMAN	FEN1	physical	22863883
IPO7_HUMAN	IPO7	physical	22863883
PFD1_HUMAN	PFDN1	physical	22863883
RUSD2_HUMAN	RPUSD2	physical	22863883
SNF8_HUMAN	SNF8	physical	22863883
THG1_HUMAN	THG1L	physical	22863883
CKAP5_HUMAN	CKAP5	physical	26344197
DTD1_HUMAN	DTD1	physical	26344197
GCN1_HUMAN	GCN1L1	physical	26344197
HNRPF_HUMAN	HNRNPF	physical	26344197
PLST_HUMAN	PLS3	physical	26344197
PRRC1_HUMAN	PRRC1	physical	26344197
SYWC_HUMAN	WARS	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614504: Usher syndrome 3B (USH3B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00117: L-Histidine

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-443, AND MASS SPECTROMETRY.
PubMed: 19608861