GCN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCN1_HUMAN
• UniProt AC: Q92616
• Protein Name: eIF-2-alpha kinase activator GCN1 {ECO:0000250|UniProtKB:E9PVA8}
• Gene Name: GCN1 {ECO:0000312|HGNC:HGNC:4199}
• Organism: Homo sapiens (Human).
• Sequence Length: 2671
• Subcellular Localization: Cytoplasm . Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation.
• Protein Description: Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion..
• Protein Sequence: MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALTWTCLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDGAVKKLTKLWKENPGLVEQYLSAILSLEPNQNYAGMLGLLVQFCTSHKEMDVVSQHKSALLDFYMKNILMSKVKPPKYLLDSCAPLLRYLSHSEFKDLILPTIQKSLLRSPENVIETISSLLASVTLDLSQYAMDIVKGLAGHLKSNSPRLMDEAVLALRNLARQCSDSSAMESLTKHLFAILGGSEGKLTVVAQKMSVLSGIGSVSHHVVSGPSSQVLNGIVAELFIPFLQQEVHEGTLVHAVSVLALWCNRFTMEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLASYRGDTLLQALDLLPLLIQTVEKAASQSTQVPTITEGVAAALLLLKLSVADSQAEAKLSSFWQLIVDEKKQVFTSEKFLVMASEDALCTVLHLTERLFLDHPHRLTGNKVQQYHRALVAVLLSRTWHVRRQAQQTVRKLLSSLGGFKLAHGLLEELKTVLSSHKVLPLEALVTDAGEVTEAGKAYVPPRVLQEALCVISGVPGLKGDVTDTEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFITRHLDQIIPRMTTQSPLNQSSMNAMGSLSVLSPDRVLPQLISTITASVQNPALRLVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDREAQVRRRLQELDGELEAALGLLDIILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKNPFLSLAACVMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVKRAVMLLHTHTITSRVGKGEPGAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEEWMAQILQILTVQAQLRASPNTPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLTTLCASSSGDDGCAFAEQEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSMMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQYLDSSQVKPLFQFFVPDALNDRHPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVERRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEYLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRLIGNESKGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFTELLNGIRAMEDPGVRDTMLQALRFVIQGAGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSAVLQQCLLADVSGIDWMVRHGRSLALSVAVNVAPGRLCAGRYSSDVQEMILSSATADRIPIAVSGVRGMGFLMRHHIETGGGQLPAKLSSLFVKCLQNPSSDIRLVAEKMIWWANKDPLPPLDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLSKILDVASLEVLNEVNRRSLKKLASQADSTEQVDDTILT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAADTQVSE ------CCCHHHHHH		22223895
5	Phosphorylation	---MAADTQVSETLK ---CCCHHHHHHHHH		21406692
8	Phosphorylation	MAADTQVSETLKRFA CCCHHHHHHHHHHHC		21406692
10	Phosphorylation	ADTQVSETLKRFAGK CHHHHHHHHHHHCCC		25159151
12	2-Hydroxyisobutyrylation	TQVSETLKRFAGKVT HHHHHHHHHHCCCCC		-
12	Malonylation	TQVSETLKRFAGKVT HHHHHHHHHHCCCCC		26320211
12	Ubiquitination	TQVSETLKRFAGKVT HHHHHHHHHHCCCCC		33845483
17	Ubiquitination	TLKRFAGKVTTASVK HHHHHCCCCCCCCHH		29967540
19	Phosphorylation	KRFAGKVTTASVKER HHHCCCCCCCCHHHH		27251275
20	Phosphorylation	RFAGKVTTASVKERR HHCCCCCCCCHHHHH		27251275
22	Phosphorylation	AGKVTTASVKERREI CCCCCCCCHHHHHHH		29514088
24	Ubiquitination	KVTTASVKERREILS CCCCCCHHHHHHHHH		-
35	Acetylation	EILSELGKCVAGKDL HHHHHHCCHHCCCCC		20167786
35	Ubiquitination	EILSELGKCVAGKDL HHHHHHCCHHCCCCC		32015554
40	Acetylation	LGKCVAGKDLPEGAV HCCHHCCCCCCCCHH		26051181
40	Ubiquitination	LGKCVAGKDLPEGAV HCCHHCCCCCCCCHH		29967540
48	Malonylation	DLPEGAVKGLCKLFC CCCCCHHHHHHHHHH		26320211
48	Ubiquitination	DLPEGAVKGLCKLFC CCCCCHHHHHHHHHH		29967540
52	Acetylation	GAVKGLCKLFCLTLH CHHHHHHHHHHHHHH		26051181
57	Phosphorylation	LCKLFCLTLHRYRDA HHHHHHHHHHHHHHH		20393185
87	Ubiquitination	AQPEATAKNLLHSLQ HCCHHHHHHHHHHHH		-
92	Phosphorylation	TAKNLLHSLQSSGIG HHHHHHHHHHHCCCC		20873877
95	Phosphorylation	NLLHSLQSSGIGSKA HHHHHHHHCCCCCCC		20873877
96	Phosphorylation	LLHSLQSSGIGSKAG HHHHHHHCCCCCCCC		20873877
100	Phosphorylation	LQSSGIGSKAGVPSK HHHCCCCCCCCCCCC		20873877
101	Ubiquitination	QSSGIGSKAGVPSKS HHCCCCCCCCCCCCC		21906983
157	Phosphorylation	LLEVLGGSHKHAVDG HHHHHCCCCHHHHHH		-
159	Ubiquitination	EVLGGSHKHAVDGAV HHHCCCCHHHHHHHH		33845483
167	2-Hydroxyisobutyrylation	HAVDGAVKKLTKLWK HHHHHHHHHHHHHHH		-
167	Ubiquitination	HAVDGAVKKLTKLWK HHHHHHHHHHHHHHH		32015554
235	Ubiquitination	MKNILMSKVKPPKYL HHHHHHHCCCCCHHH		29967540
241	Phosphorylation	SKVKPPKYLLDSCAP HCCCCCHHHHHHHHH		28152594
252	Phosphorylation	SCAPLLRYLSHSEFK HHHHHHHHHCCHHHH		28152594
254	Phosphorylation	APLLRYLSHSEFKDL HHHHHHHCCHHHHHH		28152594
256	Phosphorylation	LLRYLSHSEFKDLIL HHHHHCCHHHHHHHH		28152594
268	Acetylation	LILPTIQKSLLRSPE HHHHHHHHHHCCCHH		23236377
268	Ubiquitination	LILPTIQKSLLRSPE HHHHHHHHHHCCCHH		23000965
269	Phosphorylation	ILPTIQKSLLRSPEN HHHHHHHHHCCCHHH		24719451
308	2-Hydroxyisobutyrylation	KGLAGHLKSNSPRLM HHHHHHHHCCCHHHH		-
308	Ubiquitination	KGLAGHLKSNSPRLM HHHHHHHHCCCHHHH		21906983
315	Sulfoxidation	KSNSPRLMDEAVLAL HCCCHHHHHHHHHHH		21406390
330	Phosphorylation	RNLARQCSDSSAMES HHHHHHCCCCHHHHH		20068231
332	Phosphorylation	LARQCSDSSAMESLT HHHHCCCCHHHHHHH		20068231
333	Phosphorylation	ARQCSDSSAMESLTK HHHCCCCHHHHHHHH		20068231
337	Phosphorylation	SDSSAMESLTKHLFA CCCHHHHHHHHHHHH		20068231
339	Phosphorylation	SSAMESLTKHLFAIL CHHHHHHHHHHHHHH		20068231
349	Phosphorylation	LFAILGGSEGKLTVV HHHHHCCCCCCCHHH		-
354	Phosphorylation	GGSEGKLTVVAQKMS CCCCCCCHHHHHHHH		-
434	Phosphorylation	EWFKKAFSLKTSTSA HHHHHHHCCCCCHHH		24719451
436	2-Hydroxyisobutyrylation	FKKAFSLKTSTSAVR HHHHHCCCCCHHHHH		-
436	Malonylation	FKKAFSLKTSTSAVR HHHHHCCCCCHHHHH		26320211
436	Ubiquitination	FKKAFSLKTSTSAVR HHHHHCCCCCHHHHH		27667366
437	Phosphorylation	KKAFSLKTSTSAVRH HHHHCCCCCHHHHHH		-
504	Phosphorylation	LKLSVADSQAEAKLS HHHHHCCHHHHHHHH		23401153
511	Phosphorylation	SQAEAKLSSFWQLIV HHHHHHHHHHHHHHH		23401153
521	2-Hydroxyisobutyrylation	WQLIVDEKKQVFTSE HHHHHCCHHHCCCCC		-
521	Ubiquitination	WQLIVDEKKQVFTSE HHHHHCCHHHCCCCC		21906983
522	2-Hydroxyisobutyrylation	QLIVDEKKQVFTSEK HHHHCCHHHCCCCCC		-
522	Ubiquitination	QLIVDEKKQVFTSEK HHHHCCHHHCCCCCC		22817900
526	Phosphorylation	DEKKQVFTSEKFLVM CCHHHCCCCCCEEEE		-
546	Phosphorylation	LCTVLHLTERLFLDH HHHHHHHHHHHHCCC		-
561	Ubiquitination	PHRLTGNKVQQYHRA CCCCCCCHHHHHHHH		-
577	Phosphorylation	VAVLLSRTWHVRRQA HHHHHHCCHHHHHHH		20068231
587	Phosphorylation	VRRQAQQTVRKLLSS HHHHHHHHHHHHHHH		20068231
590	Ubiquitination	QAQQTVRKLLSSLGG HHHHHHHHHHHHCCC		21906983
593	Phosphorylation	QTVRKLLSSLGGFKL HHHHHHHHHCCCHHH		20873877
594	Phosphorylation	TVRKLLSSLGGFKLA HHHHHHHHCCCHHHH		20873877
599	Acetylation	LSSLGGFKLAHGLLE HHHCCCHHHHHHHHH		26051181
599	Ubiquitination	LSSLGGFKLAHGLLE HHHCCCHHHHHHHHH		32015554
609	Acetylation	HGLLEELKTVLSSHK HHHHHHHHHHHHHCC		26051181
609	Ubiquitination	HGLLEELKTVLSSHK HHHHHHHHHHHHHCC		21963094
616	2-Hydroxyisobutyrylation	KTVLSSHKVLPLEAL HHHHHHCCEEEHHHE		-
616	Acetylation	KTVLSSHKVLPLEAL HHHHHHCCEEEHHHE		26051181
616	Ubiquitination	KTVLSSHKVLPLEAL HHHHHHCCEEEHHHE		21906983
625	Phosphorylation	LPLEALVTDAGEVTE EEHHHEECCCCCCCC		20068231
631	Phosphorylation	VTDAGEVTEAGKAYV ECCCCCCCCCCCCCC		20068231
635	Ubiquitination	GEVTEAGKAYVPPRV CCCCCCCCCCCCHHH		23503661
651	Phosphorylation	QEALCVISGVPGLKG HHHHHHHCCCCCCCC		21406692
695	2-Hydroxyisobutyrylation	PALLARMKIDPEAFI HHHHHHCCCCHHHHH		-
695	Ubiquitination	PALLARMKIDPEAFI HHHHHHCCCCHHHHH		21906983
714	Phosphorylation	DQIIPRMTTQSPLNQ HHHHHHCCCCCCCCH		18691976
715	Phosphorylation	QIIPRMTTQSPLNQS HHHHHCCCCCCCCHH		20068231
717	Phosphorylation	IPRMTTQSPLNQSSM HHHCCCCCCCCHHHC		17192257
722	Phosphorylation	TQSPLNQSSMNAMGS CCCCCCHHHCHHCCC		20068231
723	Phosphorylation	QSPLNQSSMNAMGSL CCCCCHHHCHHCCCH		20068231
729	Phosphorylation	SSMNAMGSLSVLSPD HHCHHCCCHHCCCCC		27050516
734	Phosphorylation	MGSLSVLSPDRVLPQ CCCHHCCCCCCHHHH		21815630
766	Sulfoxidation	TREEFAIMQTPAGEL CHHHHHCEECCCCHH		30846556
774	Phosphorylation	QTPAGELYDKSIIQS ECCCCHHCCHHHHHH		27642862
776	Ubiquitination	PAGELYDKSIIQSAQ CCCHHCCHHHHHHHH		21906983
777	Phosphorylation	AGELYDKSIIQSAQQ CCHHCCHHHHHHHHH		28555341
781	Phosphorylation	YDKSIIQSAQQDSIK CCHHHHHHHHHHHHH		21712546
786	Phosphorylation	IQSAQQDSIKKANMK HHHHHHHHHHHHHHC		23401153
788	Acetylation	SAQQDSIKKANMKRE HHHHHHHHHHHHCCC		26051181
788	Ubiquitination	SAQQDSIKKANMKRE HHHHHHHHHHHHCCC		27667366
789	Ubiquitination	AQQDSIKKANMKREN HHHHHHHHHHHCCCC		23503661
793	Ubiquitination	SIKKANMKRENKAYS HHHHHHHCCCCCCCC		23503661
797	Ubiquitination	ANMKRENKAYSFKEQ HHHCCCCCCCCHHHH		22817900
799	Phosphorylation	MKRENKAYSFKEQII HCCCCCCCCHHHHHH		-
800	Phosphorylation	KRENKAYSFKEQIIE CCCCCCCCHHHHHHH		24719451
802	Ubiquitination	ENKAYSFKEQIIELE CCCCCCHHHHHHHHH		21906983
818	Ubiquitination	KEEIKKKKGIKEEVQ HHHHHHHCCCHHHHH		29967540
821	Acetylation	IKKKKGIKEEVQLTS HHHHCCCHHHHHCCH		26051181
821	Ubiquitination	IKKKKGIKEEVQLTS HHHHCCCHHHHHCCH		29967540
829	2-Hydroxyisobutyrylation	EEVQLTSKQKEMLQA HHHHCCHHHHHHHHH		-
829	Ubiquitination	EEVQLTSKQKEMLQA HHHHCCHHHHHHHHH		27667366
831	Ubiquitination	VQLTSKQKEMLQAQL HHCCHHHHHHHHHHH		-
889	Methylation	DSFLPLLKSPLAAPR HHHHHHHCCCCCCCC		-
898	Ubiquitination	PLAAPRIKNPFLSLA CCCCCCCCCHHHHHH		21963094
914	Ubiquitination	CVMPSRLKALGTLVS HHCHHHHHHHHHHHH		-
918	Phosphorylation	SRLKALGTLVSHVTL HHHHHHHHHHHHHHH		21406692
921	Phosphorylation	KALGTLVSHVTLRLL HHHHHHHHHHHHHHH		21406692
924	Phosphorylation	GTLVSHVTLRLLKPE HHHHHHHHHHHHCCH		21406692
929	Acetylation	HVTLRLLKPECVLDK HHHHHHHCCHHEECC		26051181
937	Phosphorylation	PECVLDKSWCQEELS CHHEECCHHCHHHHH		25159151
948	Ubiquitination	EELSVAVKRAVMLLH HHHHHHHHHHHHHHH		21906983
952	Sulfoxidation	VAVKRAVMLLHTHTI HHHHHHHHHHHHHHC		28183972
956	Phosphorylation	RAVMLLHTHTITSRV HHHHHHHHHHCCCCC		22617229
958	Phosphorylation	VMLLHTHTITSRVGK HHHHHHHHCCCCCCC		22617229
960	Phosphorylation	LLHTHTITSRVGKGE HHHHHHCCCCCCCCC		22617229
961	Phosphorylation	LHTHTITSRVGKGEP HHHHHCCCCCCCCCC		23403867
965	Ubiquitination	TITSRVGKGEPGAAP HCCCCCCCCCCCCCC		23000965
974	Phosphorylation	EPGAAPLSAPAFSLV CCCCCCCCCHHHHHH		-
1022	Phosphorylation	QLRASPNTPPGRVDE HHHCCCCCCCCCCCC		17192257
1101	Phosphorylation	PCASVRETVLRGLME CCHHHHHHHHHHHHH		17081983
1118	Phosphorylation	MVLPAPDTDEKNGLN EEECCCCCCCCCCHH		20860994
1121	Ubiquitination	PAPDTDEKNGLNLLR CCCCCCCCCCHHHHH		-
1134	Ubiquitination	LRRLWVVKFDKEEEI HHHHHEEECCCHHHH		21890473
1137	Acetylation	LWVVKFDKEEEIRKL HHEEECCCHHHHHHH		26051181
1205	Phosphorylation	MGRLMEIYQEKLYRP HHHHHHHHHHHHCCC		22817900
1208	Acetylation	LMEIYQEKLYRPPPV HHHHHHHHHCCCCCH		26051181
1208	Ubiquitination	LMEIYQEKLYRPPPV HHHHHHHHHCCCCCH		21906983
1210	Phosphorylation	EIYQEKLYRPPPVLD HHHHHHHCCCCCHHH		28152594
1254	Ubiquitination	YLDSSQVKPLFQFFV HCCHHCCCCHHHHHC		-
1294	Phosphorylation	HGKENVNSLLPVFEE CCCCCHHHHHHHHHH		28348404
1304	Ubiquitination	PVFEEFLKNAPNDAS HHHHHHHHCCCCCCC		32015554
1318	Phosphorylation	SYDAVRQSVVVLMGS CHHHHHHHHHHHHHH		20068231
1325	Phosphorylation	SVVVLMGSLAKHLDK HHHHHHHHHHHHCCC		20068231
1328	Acetylation	VLMGSLAKHLDKSDP HHHHHHHHHCCCCCC		26051181
1332	2-Hydroxyisobutyrylation	SLAKHLDKSDPKVKP HHHHHCCCCCCCHHH		-
1336	Ubiquitination	HLDKSDPKVKPIVAK HCCCCCCCHHHHHHH		29967540
1338	Ubiquitination	DKSDPKVKPIVAKLI CCCCCCHHHHHHHHH		-
1388	Phosphorylation	LMQQLLESDKYAERK HHHHHHHCCHHHHHH		29116813
1390	Acetylation	QQLLESDKYAERKGA HHHHHCCHHHHHHHH		26051181
1390	Ubiquitination	QQLLESDKYAERKGA HHHHHCCHHHHHHHH		21906983
1395	Ubiquitination	SDKYAERKGAAYGLA CCHHHHHHHHHHHHH		22817900
1399	Phosphorylation	AERKGAAYGLAGLVK HHHHHHHHHHHHHHH		28152594
1406	Ubiquitination	YGLAGLVKGLGILSL HHHHHHHHHHCCCCH		21906983
1412	Phosphorylation	VKGLGILSLKQQEMM HHHHCCCCHHHHHHH		20071362
1414	Ubiquitination	GLGILSLKQQEMMAA HHCCCCHHHHHHHHH		23503661
1429	Ubiquitination	LTDAIQDKKNFRRRE HHHHHHHHHHHHHHH		29967540
1433	Methylation	IQDKKNFRRREGALF HHHHHHHHHHHHHHH		-
1484	Ubiquitination	EAADDCAKAVMSNLS HHHHHHHHHHHHCCH		32015554
1491	Phosphorylation	KAVMSNLSAHGVKLV HHHHHCCHHHCHHHH		25159151
1501	Phosphorylation	GVKLVLPSLLAALEE CHHHHHHHHHHHHHH		21406692
1510	Phosphorylation	LAALEEESWRTKAGS HHHHHHHHHCCCCCC		21406692
1513	Phosphorylation	LEEESWRTKAGSVEL HHHHHHCCCCCCHHH		24719451
1514	Ubiquitination	EEESWRTKAGSVELL HHHHHCCCCCCHHHH		-
1533	Phosphorylation	YCAPKQLSSCLPNIV HHCHHHHHHHCCCHH		23879269
1534	Phosphorylation	CAPKQLSSCLPNIVP HCHHHHHHHCCCHHH		23879269
1535	S-nitrosocysteine	APKQLSSCLPNIVPK CHHHHHHHCCCHHHH		-
1544	Phosphorylation	PNIVPKLTEVLTDSH CCHHHHHHHHHCCCC		23879269
1553	2-Hydroxyisobutyrylation	VLTDSHVKVQKAGQQ HHCCCCHHHHHHHHH		-
1553	Acetylation	VLTDSHVKVQKAGQQ HHCCCCHHHHHHHHH		25953088
1553	Malonylation	VLTDSHVKVQKAGQQ HHCCCCHHHHHHHHH		26320211
1553	Ubiquitination	VLTDSHVKVQKAGQQ HHCCCCHHHHHHHHH		22817900
1556	Ubiquitination	DSHVKVQKAGQQALR CCCHHHHHHHHHHHH		21906983
1591	Ubiquitination	ALTDPSRKTQKCLQT HCCCCCHHHHHHHHH		22817900
1594	Ubiquitination	DPSRKTQKCLQTLLD CCCHHHHHHHHHHHC		21906983
1603	Ubiquitination	LQTLLDTKFVHFIDA HHHHHCCCCCHHCCC		-
1628	Phosphorylation	QRAFQDRSTDTRKMA HHHHCCCCCCHHHHH		26699800
1629	Phosphorylation	RAFQDRSTDTRKMAA HHHCCCCCCHHHHHH		23401153
1631	Phosphorylation	FQDRSTDTRKMAAQI HCCCCCCHHHHHHHH		26699800
1633	Ubiquitination	DRSTDTRKMAAQIIG CCCCCHHHHHHHHHH		-
1643	Phosphorylation	AQIIGNMYSLTDQKD HHHHHHHHHCCCCHH		-
1644	Phosphorylation	QIIGNMYSLTDQKDL HHHHHHHHCCCCHHH		-
1663	Methylation	PSVTPGLKASLLDPV CCCCCCCCHHHCCCC		-
1663	Ubiquitination	PSVTPGLKASLLDPV CCCCCCCCHHHCCCC		21906983
1665	Phosphorylation	VTPGLKASLLDPVPE CCCCCCHHHCCCCCC		-
1677	Phosphorylation	VPEVRTVSAKALGAM CCCHHHCCHHHHHHH		-
1679	Ubiquitination	EVRTVSAKALGAMVK CHHHCCHHHHHHHHH		32015554
1731	Acetylation	MAGLGVEKLEKLMPE HHCCCHHHHHHHHHH		26051181
1731	Ubiquitination	MAGLGVEKLEKLMPE HHCCCHHHHHHHHHH		21906983
1734	Ubiquitination	LGVEKLEKLMPEIVA CCHHHHHHHHHHHHH		22817900
1742	Phosphorylation	LMPEIVATASKVDIA HHHHHHHHHCCCCCC		30622161
1744	Phosphorylation	PEIVATASKVDIAPH HHHHHHHCCCCCCCC		30622161
1745	Ubiquitination	EIVATASKVDIAPHV HHHHHHCCCCCCCCC		33845483
1835	Phosphorylation	LWRIRFSSVQLLGDL HHHHHHHHHHHHHHH		19690332
1847	Phosphorylation	GDLLFHISGVTGKMT HHHHHHHHCCCCCCC		19690332
1854	Phosphorylation	SGVTGKMTTETASED HCCCCCCCCCCCCCC		20873877
1855	Phosphorylation	GVTGKMTTETASEDD CCCCCCCCCCCCCCC		20873877
1857	Phosphorylation	TGKMTTETASEDDNF CCCCCCCCCCCCCCC		20873877
1859	Phosphorylation	KMTTETASEDDNFGT CCCCCCCCCCCCCCC		25159151
1866	Phosphorylation	SEDDNFGTAQSNKAI CCCCCCCCHHCCHHH		20873877
1869	Phosphorylation	DNFGTAQSNKAIITA CCCCCHHCCHHHHHH		-
1871	Ubiquitination	FGTAQSNKAIITALG CCCHHCCHHHHHHHC		21906983
1875	Phosphorylation	QSNKAIITALGVERR HCCHHHHHHHCHHHH		21406692
1948	Phosphorylation	KRTIAARTLGDLVRK HHHHHHHHHHHHHHH		24961811
1955	Ubiquitination	TLGDLVRKLGEKILP HHHHHHHHHHHHHHH		23503661
1959	Ubiquitination	LVRKLGEKILPEIIP HHHHHHHHHHHHHHH		23503661
1992	Ubiquitination	IGLSEIMKSTSRDAV EEHHHHHHHCCCCHH		32015554
2001	Phosphorylation	TSRDAVLYFSESLVP CCCCHHHHCHHCCCH		21406692
2003	Phosphorylation	RDAVLYFSESLVPTA CCHHHHCHHCCCHHH		21406692
2005	Phosphorylation	AVLYFSESLVPTARK HHHHCHHCCCHHHHH		21406692
2009	Phosphorylation	FSESLVPTARKALCD CHHCCCHHHHHHHCC		21406692
2012	Ubiquitination	SLVPTARKALCDPLE CCCHHHHHHHCCCHH		24816145
2058	Phosphorylation	QLDDEEVSEFALDGL CCCHHHHHHHHHHHH		-
2066	Sumoylation	EFALDGLKQVMAIKS HHHHHHHHHHHHHHH		-
2066	Ubiquitination	EFALDGLKQVMAIKS HHHHHHHHHHHHHHH		21906983
2072	Acetylation	LKQVMAIKSRVVLPY HHHHHHHHHHEEHHH		25953088
2072	Ubiquitination	LKQVMAIKSRVVLPY HHHHHHHHHHEEHHH		29967540
2079	Phosphorylation	KSRVVLPYLVPKLTT HHHEEHHHHCCCCCC		25599653
2083	Acetylation	VLPYLVPKLTTPPVN EHHHHCCCCCCCCCC		26051181
2083	Ubiquitination	VLPYLVPKLTTPPVN EHHHHCCCCCCCCCC		21906983
2121	Ubiquitination	PAVMLALKEKLGTPD HHHHHHHHHHHCCCH		-
2183	Ubiquitination	NIYCSRSKADYTSHL HHHCCCCCCHHHHHH		23000965
2220	Phosphorylation	WDALNAITKKLDAGN HHHHHHHHHHCCCCC		-
2221	Ubiquitination	DALNAITKKLDAGNQ HHHHHHHHHCCCCCH		21906983
2222	2-Hydroxyisobutyrylation	ALNAITKKLDAGNQL HHHHHHHHCCCCCHH		-
2222	Ubiquitination	ALNAITKKLDAGNQL HHHHHHHHCCCCCHH		22817900
2237	Acetylation	ALIEELHKEIRLIGN HHHHHHHHHHHHHCC		26051181
2237	Ubiquitination	ALIEELHKEIRLIGN HHHHHHHHHHHHHCC		21906983
2246	Phosphorylation	IRLIGNESKGEHVPG HHHHCCCCCCCCCCC		28258704
2247	Ubiquitination	RLIGNESKGEHVPGF HHHCCCCCCCCCCCC		32015554
2258	2-Hydroxyisobutyrylation	VPGFCLPKKGVTSIL CCCCCCCCCCCCCHH		-
2258	Acetylation	VPGFCLPKKGVTSIL CCCCCCCCCCCCCHH		26051181
2258	Ubiquitination	VPGFCLPKKGVTSIL CCCCCCCCCCCCCHH		29967540
2259	Ubiquitination	PGFCLPKKGVTSILP CCCCCCCCCCCCHHH		27667366
2262	Phosphorylation	CLPKKGVTSILPVLR CCCCCCCCCHHHHHH		20068231
2263	Phosphorylation	LPKKGVTSILPVLRE CCCCCCCCHHHHHHC		20068231
2274	Phosphorylation	VLREGVLTGSPEQKE HHHCCCCCCCHHHHH		18691976
2276	Phosphorylation	REGVLTGSPEQKEEA HCCCCCCCHHHHHHH		21815630
2280	Acetylation	LTGSPEQKEEAAKAL CCCCHHHHHHHHHHH		26051181
2280	Ubiquitination	LTGSPEQKEEAAKAL CCCCHHHHHHHHHHH		21906983
2285	Acetylation	EQKEEAAKALGLVIR HHHHHHHHHHCCHHH		26051181
2285	Ubiquitination	EQKEEAAKALGLVIR HHHHHHHHHHCCHHH		21906983
2294	Phosphorylation	LGLVIRLTSADALRP HCCHHHHHCHHHHCC		-
2295	Phosphorylation	GLVIRLTSADALRPS CCHHHHHCHHHHCCH		-
2342	Ubiquitination	AKVGIALKPFLPQLQ HHHCHHHHCCHHHHH		29967540
2359	Phosphorylation	FTKALQDSNRGVRLK HHHHHHCCCCCHHHH		27067055
2366	2-Hydroxyisobutyrylation	SNRGVRLKAADALGK CCCCHHHHHHHHHHH		-
2366	Ubiquitination	SNRGVRLKAADALGK CCCCHHHHHHHHHHH		21906983
2376	Phosphorylation	DALGKLISIHIKVDP HHHHHHHHEEEECCH		28857561
2380	Ubiquitination	KLISIHIKVDPLFTE HHHHEEEECCHHHHH		21906983
2418	2-Hydroxyisobutyrylation	VIQGAGAKVDAVIRK HHHCCCCCHHHHHHH		-
2418	Ubiquitination	VIQGAGAKVDAVIRK HHHCCCCCHHHHHHH		21906983
2505	Phosphorylation	GRLCAGRYSSDVQEM CCCCCCCCCHHHHHH		20873877
2521	Methylation	LSSATADRIPIAVSG HHHCCCCCCCEEEEC		-
2550	Acetylation	GGGQLPAKLSSLFVK CCCCCCHHHHHHHHH		26051181
2550	Ubiquitination	GGGQLPAKLSSLFVK CCCCCCHHHHHHHHH		21906983
2557	Acetylation	KLSSLFVKCLQNPSS HHHHHHHHHHCCCCH		26051181
2557	Malonylation	KLSSLFVKCLQNPSS HHHHHHHHHHCCCCH		26320211
2557	Ubiquitination	KLSSLFVKCLQNPSS HHHHHHHHHHCCCCH		21906983
2567	Methylation	QNPSSDIRLVAEKMI CCCCHHHHHHHHHHH		-
2572	Ubiquitination	DIRLVAEKMIWWANK HHHHHHHHHHHHHCC		23000965
2591	Succinylation	PLDPQAIKPILKALL CCCHHHHHHHHHHHH		23954790
2591	Ubiquitination	PLDPQAIKPILKALL CCCHHHHHHHHHHHH		22817900
2595	Ubiquitination	QAIKPILKALLDNTK HHHHHHHHHHHHCCC		22817900
2602	Ubiquitination	KALLDNTKDKNTVVR HHHHHCCCCCCCHHH		29967540
2604	2-Hydroxyisobutyrylation	LLDNTKDKNTVVRAY HHHCCCCCCCHHHHC		-
2611	Phosphorylation	KNTVVRAYSDQAIVN CCCHHHHCCCHHHHH		29888752
2612	Phosphorylation	NTVVRAYSDQAIVNL CCHHHHCCCHHHHHH		28152594
2621	Ubiquitination	QAIVNLLKMRQGEEV HHHHHHHHHHCCHHH		22505724
2631	Phosphorylation	QGEEVFQSLSKILDV CCHHHHHHHHHHHCH		30622161
2633	Phosphorylation	EEVFQSLSKILDVAS HHHHHHHHHHHCHHC		30622161
2634	Ubiquitination	EVFQSLSKILDVASL HHHHHHHHHHCHHCH		29967540
2651	Phosphorylation	LNEVNRRSLKKLASQ HHHHCHHHHHHHHHC		-
2654	Ubiquitination	VNRRSLKKLASQADS HCHHHHHHHHHCCCC		29967540
2657	Phosphorylation	RSLKKLASQADSTEQ HHHHHHHHCCCCHHC		28857561
2661	Phosphorylation	KLASQADSTEQVDDT HHHHCCCCHHCCCCC		20873877
2662	Phosphorylation	LASQADSTEQVDDTI HHHCCCCHHCCCCCC		25627689
2668	Phosphorylation	STEQVDDTILT---- CHHCCCCCCCC----		20873877
2671	Phosphorylation	QVDDTILT------- CCCCCCCC-------		20873877

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRSF1_HUMAN	SRSF1	physical	22939629
ROA3_HUMAN	HNRNPA3	physical	22939629
RU17_HUMAN	SNRNP70	physical	22939629
SRSF3_HUMAN	SRSF3	physical	22939629
TRA2B_HUMAN	TRA2B	physical	22939629
PGRC1_HUMAN	PGRMC1	physical	22939629
THIL_HUMAN	ACAT1	physical	22939629
NDUA5_HUMAN	NDUFA5	physical	22939629
PDCD6_HUMAN	PDCD6	physical	22939629
SAFB1_HUMAN	SAFB	physical	22939629
INF2_HUMAN	INF2	physical	22939629
HNRPL_HUMAN	HNRNPL	physical	22939629
IF2B_HUMAN	EIF2S2	physical	22863883
E41L1_HUMAN	EPB41L1	physical	22863883
COPA_HUMAN	COPA	physical	26344197
DNMT1_HUMAN	DNMT1	physical	26344197
EIF2D_HUMAN	EIF2D	physical	26344197
HELLS_HUMAN	HELLS	physical	26344197
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.