NDUA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUA5_HUMAN
• UniProt AC: Q16718
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
• Gene Name: NDUFA5
• Organism: Homo sapiens (Human).
• Sequence Length: 116
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAGVLKKTTGLVGLAVCNTPHERLRILYTKILDVLEEIPKNAAYRKYTEQITNEKLAMVKAEPDVKKLEDQLQGGQLEEVILQAEHELNLARKMREWKLWEPLVEEPPADQWKWPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGVLKKTT ------CCCCCCCCC	19.46	-
27	Acetylation	PHERLRILYTKILDV HHHHHHHHHHHHHHH	3.43	19608861
28	Phosphorylation	HERLRILYTKILDVL HHHHHHHHHHHHHHH	12.01	-
30	Acetylation	RLRILYTKILDVLEE HHHHHHHHHHHHHHH	27.93	19608861
40	Succinylation	DVLEEIPKNAAYRKY HHHHHCCCCHHHHHH	65.95	23954790
40	Acetylation	DVLEEIPKNAAYRKY HHHHHCCCCHHHHHH	65.95	26822725
46	Acetylation	PKNAAYRKYTEQITN CCCHHHHHHHHHHCH	43.79	27452117
46	2-Hydroxyisobutyrylation	PKNAAYRKYTEQITN CCCHHHHHHHHHHCH	43.79	-
55	2-Hydroxyisobutyrylation	TEQITNEKLAMVKAE HHHHCHHHHHHHCCC	43.55	-
55	Acetylation	TEQITNEKLAMVKAE HHHHCHHHHHHHCCC	43.55	27452117
57	Acetylation	QITNEKLAMVKAEPD HHCHHHHHHHCCCCC	16.28	19608861
60	Sumoylation	NEKLAMVKAEPDVKK HHHHHHHCCCCCHHH	33.67	19608861
60	Malonylation	NEKLAMVKAEPDVKK HHHHHHHCCCCCHHH	33.67	26320211
60	Sumoylation	NEKLAMVKAEPDVKK HHHHHHHCCCCCHHH	33.67	-
60	Acetylation	NEKLAMVKAEPDVKK HHHHHHHCCCCCHHH	33.67	19608861
60	Succinylation	NEKLAMVKAEPDVKK HHHHHHHCCCCCHHH	33.67	27452117
66	Acetylation	VKAEPDVKKLEDQLQ HCCCCCHHHHHHHHC	60.05	25038526
67	Acetylation	KAEPDVKKLEDQLQG CCCCCHHHHHHHHCC	57.89	25038526
98	Succinylation	ARKMREWKLWEPLVE HHHHHHHCCCCCCCC	38.68	-
98	Succinylation	ARKMREWKLWEPLVE HHHHHHHCCCCCCCC	38.68	-
98	Acetylation	ARKMREWKLWEPLVE HHHHHHHCCCCCCCC	38.68	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUA5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUA5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DAZP2_HUMAN	DAZAP2	physical	16189514
NDUB1_HUMAN	NDUFB1	physical	16189514
CC85B_HUMAN	CCDC85B	physical	16189514
A4_HUMAN	APP	physical	21832049
NDUS3_HUMAN	NDUFS3	physical	22939629
NDUB9_HUMAN	NDUFB9	physical	22939629
NDUBA_HUMAN	NDUFB10	physical	22939629
RAB8A_HUMAN	RAB8A	physical	27173435
WDR26_HUMAN	WDR26	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-30 AND LYS-60, AND MASSSPECTROMETRY.
PubMed: 19608861