AASD1_HUMAN - dbPTM
AASD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AASD1_HUMAN
UniProt AC Q9BTE6
Protein Name Alanyl-tRNA editing protein Aarsd1
Gene Name AARSD1
Organism Homo sapiens (Human).
Sequence Length 412
Subcellular Localization Cytoplasm.
Protein Description Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala)..
Protein Sequence MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSGFQVVLEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPGSQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWELGRFRSAIELDTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEVEQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLSDLQVIKILGTEKGKKNRTNLIFLSGNRVLKWMERSHGTEKALTALLKCGAEDHVEAVKKLQNSTKILQKNNLNLLRDLAVHIAHSLRNSPDWGGVVILHRKEGDSEFMNIIANEIGSEETLLFLTVGDEKGGGLFLLAGPPASVETLGPRVAEVLEGKGAGKKGRFQGKATKMSRRMEAQALLQDYISTQSAKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationCCPAELQTEGSNGKK
ECCHHHHCCCCCCCE		55.74-
31PhosphorylationAELQTEGSNGKKEVL
HHHHCCCCCCCEEEE		35.86-
34AcetylationQTEGSNGKKEVLSGF
HCCCCCCCEEEECEE		50.4326051181
34UbiquitinationQTEGSNGKKEVLSGF
HCCCCCCCEEEECEE		50.4321963094
35UbiquitinationTEGSNGKKEVLSGFQ
CCCCCCCEEEECEEE		55.22-
68PhosphorylationRGTINDISVLRVTRR
CCCCCCEEEEEEEEC		20.2625693802
83PhosphorylationGEQADHFTQTPLDPG
CCCCCCCCCCCCCCC		28.2825693802
83 (in isoform 2)Phosphorylation-28.2822673903
85PhosphorylationQADHFTQTPLDPGSQ
CCCCCCCCCCCCCCE		23.8225693802
91PhosphorylationQTPLDPGSQVLVRVD
CCCCCCCCEEEEEEE		23.6225693802
124UbiquitinationAVADHLFKLKTTSWE
HHHHHHHHCCCCCHH		56.2722817900
126UbiquitinationADHLFKLKTTSWELG
HHHHHHCCCCCHHHC		50.8022817900
128 (in isoform 2)Phosphorylation-30.20-
137PhosphorylationWELGRFRSAIELDTP
HHHCHHHCEEECCCC		30.7730622161
143PhosphorylationRSAIELDTPSMTAEQ
HCEEECCCCCCCHHH		29.8630622161
144 (in isoform 3)Phosphorylation-23.0522673903
145PhosphorylationAIELDTPSMTAEQVA
EEECCCCCCCHHHHH		30.7530622161
147UbiquitinationELDTPSMTAEQVAAI
ECCCCCCCHHHHHHH		31.2329967540
147PhosphorylationELDTPSMTAEQVAAI
ECCCCCCCHHHHHHH		31.2330622161
161UbiquitinationIEQSVNEKIRDRLPV
HHHHHHHHHHHHCCC		37.5321963094
174PhosphorylationPVNVRELSLDDPEVE
CCCCEEECCCCCHHH		25.6225159151
184PhosphorylationDPEVEQVSGRGLPDD
CCHHHHCCCCCCCCC		23.5920068231
189 (in isoform 3)Phosphorylation-48.05-
206PhosphorylationVNIEGVDSNMCCGTH
EEEECCCCCCCCCCC		24.8525693802
208UbiquitinationIEGVDSNMCCGTHVS
EECCCCCCCCCCCCC		2.0129967540
209 (in isoform 1)Ubiquitination-1.9621890473
212PhosphorylationDSNMCCGTHVSNLSD
CCCCCCCCCCCCCHH		12.7525693802
215PhosphorylationMCCGTHVSNLSDLQV
CCCCCCCCCCHHCEE		25.1725693802
218PhosphorylationGTHVSNLSDLQVIKI
CCCCCCCHHCEEEEH		40.2925693802
224UbiquitinationLSDLQVIKILGTEKG
CHHCEEEEHHCCCCC		32.7829967540
230UbiquitinationIKILGTEKGKKNRTN
EEHHCCCCCCCCCCE		75.7127667366
236PhosphorylationEKGKKNRTNLIFLSG
CCCCCCCCEEEEEEC		43.7118452278
237UbiquitinationKGKKNRTNLIFLSGN
CCCCCCCEEEEEECH		28.0922817900
239 (in isoform 2)Ubiquitination-3.3721890473
239UbiquitinationKKNRTNLIFLSGNRV
CCCCCEEEEEECHHH		3.3722817900
242PhosphorylationRTNLIFLSGNRVLKW
CCEEEEEECHHHHHH		24.2321712546
244 (in isoform 1)Ubiquitination-27.7521890473
248UbiquitinationLSGNRVLKWMERSHG
EECHHHHHHHHHCCC		41.45-
258UbiquitinationERSHGTEKALTALLK
HHCCCHHHHHHHHHH		48.8329967540
258AcetylationERSHGTEKALTALLK
HHCCCHHHHHHHHHH		48.8325953088
265UbiquitinationKALTALLKCGAEDHV
HHHHHHHHCCCHHHH		31.3229967540
265AcetylationKALTALLKCGAEDHV
HHHHHHHHCCCHHHH		31.3225953088
274UbiquitinationGAEDHVEAVKKLQNS
CCHHHHHHHHHHHHH		19.8321963094
274 (in isoform 2)Ubiquitination-19.8321890473
276UbiquitinationEDHVEAVKKLQNSTK
HHHHHHHHHHHHHHH		55.61-
276AcetylationEDHVEAVKKLQNSTK
HHHHHHHHHHHHHHH		55.6125953088
277UbiquitinationDHVEAVKKLQNSTKI
HHHHHHHHHHHHHHH		49.0229967540
283MalonylationKKLQNSTKILQKNNL
HHHHHHHHHHHHCCH		41.0426320211
283UbiquitinationKKLQNSTKILQKNNL
HHHHHHHHHHHHCCH		41.0422817900
287AcetylationNSTKILQKNNLNLLR
HHHHHHHHCCHHHHH		44.3425953088
287MalonylationNSTKILQKNNLNLLR
HHHHHHHHCCHHHHH		44.3426320211
287UbiquitinationNSTKILQKNNLNLLR
HHHHHHHHCCHHHHH		44.3421890473
298UbiquitinationNLLRDLAVHIAHSLR
HHHHHHHHHHHHHHH		4.3322817900
300UbiquitinationLRDLAVHIAHSLRNS
HHHHHHHHHHHHHCC		2.7222817900
335UbiquitinationIIANEIGSEETLLFL
HHHHHCCCCCEEEEE		37.6121963094
337UbiquitinationANEIGSEETLLFLTV
HHHCCCCCEEEEEEE		46.5929967540
343UbiquitinationEETLLFLTVGDEKGG
CCEEEEEEECCCCCC		18.3327667366
361PhosphorylationLLAGPPASVETLGPR
EEECCCCCHHHHCHH		26.6820886841
364PhosphorylationGPPASVETLGPRVAE
CCCCCHHHHCHHHHH		34.5520886841
370 (in isoform 1)Ubiquitination-11.4921890473
371UbiquitinationTLGPRVAEVLEGKGA
HHCHHHHHHHCCCCC		44.7929967540
376UbiquitinationVAEVLEGKGAGKKGR
HHHHHCCCCCCCCCC		35.8933845483
378UbiquitinationEVLEGKGAGKKGRFQ
HHHCCCCCCCCCCCC		30.0729967540
380UbiquitinationLEGKGAGKKGRFQGK
HCCCCCCCCCCCCCH		52.0722817900
381UbiquitinationEGKGAGKKGRFQGKA
CCCCCCCCCCCCCHH		55.1722817900
387UbiquitinationKKGRFQGKATKMSRR
CCCCCCCHHHHHHHH		41.9427667366
390UbiquitinationRFQGKATKMSRRMEA
CCCCHHHHHHHHHHH		39.4724816145
396UbiquitinationTKMSRRMEAQALLQD
HHHHHHHHHHHHHHH		35.5022817900
398UbiquitinationMSRRMEAQALLQDYI
HHHHHHHHHHHHHHH		21.1629967540
400UbiquitinationRRMEAQALLQDYIST
HHHHHHHHHHHHHHH		2.6821890473
400 (in isoform 2)Ubiquitination-2.6821890473
404UbiquitinationAQALLQDYISTQSAK
HHHHHHHHHHHHCCC		5.4727667366
406PhosphorylationALLQDYISTQSAKE-
HHHHHHHHHHCCCC-		17.7329214152
407PhosphorylationLLQDYISTQSAKE--
HHHHHHHHHCCCC--		19.5826074081
409PhosphorylationQDYISTQSAKE----
HHHHHHHCCCC----		41.2026074081
432Ubiquitination---------------------------
---------------------------		29967540
439Ubiquitination----------------------------------
----------------------------------		29967540
451Ubiquitination----------------------------------------------
----------------------------------------------		29967540
457Ubiquitination----------------------------------------------------
----------------------------------------------------		22817900
459 (in isoform 1)Ubiquitination-21890473
461Ubiquitination--------------------------------------------------------
--------------------------------------------------------		21890473
461Ubiquitination--------------------------------------------------------
--------------------------------------------------------		21890473
461 (in isoform 3)Ubiquitination--
489Ubiquitination------------------------------------------------------------------------------------
------------------------------------------------------------------------------------		33845483
489 (in isoform 2)Ubiquitination-21890473
493Ubiquitination----------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------		22817900
494Ubiquitination-----------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------		22817900
500Ubiquitination-----------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------		27667366
503Ubiquitination--------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------		24816145
550Ubiquitination-------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------		33845483
554Ubiquitination-----------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------------------------		22817900
555Ubiquitination------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------		22817900
561Ubiquitination------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------		27667366
564Ubiquitination---------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------------------------------------------------		24816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AASD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AASD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AASD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FUBP1_HUMANFUBP1physical
22863883
NIF3L_HUMANNIF3L1physical
22863883
TPD54_HUMANTPD52L2physical
22863883
IRS4_HUMANIRS4physical
25036637
DYLT1_HUMANDYNLT1physical
25036637
HECD1_HUMANHECTD1physical
25036637
TBA1A_HUMANTUBA1Aphysical
25036637
HSPB1_HUMANHSPB1physical
25036637
SERPH_HUMANSERPINH1physical
25036637
PP14B_HUMANPPP1R14Bphysical
26344197
SBDS_HUMANSBDSphysical
26344197
SEPT2_HUMANSEPT2physical
26344197
SEPT8_HUMANSEPT8physical
26344197
SPEE_HUMANSRMphysical
26344197
TBCB_HUMANTBCBphysical
26344197
TRI45_HUMANTRIM45physical
28514442
M3K7_HUMANMAP3K7physical
28514442
DDHD2_HUMANDDHD2physical
28514442
NPHP3_HUMANNPHP3physical
28514442
ALKB2_HUMANALKBH2physical
28514442
TAB1_HUMANTAB1physical
28514442
ALMS1_HUMANALMS1physical
28514442
LUZP1_HUMANLUZP1physical
28514442
SAS6_HUMANSASS6physical
28514442
FIGL1_HUMANFIGNL1physical
28514442
ERC6L_HUMANERCC6Lphysical
28514442
SSFA2_HUMANSSFA2physical
28514442
FBX7_HUMANFBXO7physical
28514442
HPS5_HUMANHPS5physical
28514442
POC5_HUMANPOC5physical
28514442
WNK1_HUMANWNK1physical
28514442
HOOK1_HUMANHOOK1physical
28514442
RL23_HUMANRPL23physical
28514442
UBXN1_HUMANUBXN1physical
28514442
APAF_HUMANAPAF1physical
28514442
STIL_HUMANSTILphysical
28514442
MLF1_HUMANMLF1physical
28514442
BORA_HUMANBORAphysical
28514442
FA83H_HUMANFAM83Hphysical
28514442
KIF1A_HUMANKIF1Aphysical
28514442
RAD21_HUMANRAD21physical
28514442
ARRB2_HUMANARRB2physical
28514442
HECD1_HUMANHECTD1physical
28514442
RICTR_HUMANRICTORphysical
28514442
RIC8B_HUMANRIC8Bphysical
28514442
TPPC4_HUMANTRAPPC4physical
28514442
BRCA2_HUMANBRCA2physical
28514442
PEAK1_HUMANPEAK1physical
28514442
CND3_HUMANNCAPGphysical
28514442
PCH2_HUMANTRIP13physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AASD1_HUMAN

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