dbPTM

SSFA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SSFA2_HUMAN
UniProt AC	P28290
Protein Name	Sperm-specific antigen 2
Gene Name	SSFA2
Organism	Homo sapiens (Human).
Sequence Length	1259
Subcellular Localization	Cytoplasm . Located near the plasma membrane. Associated with actin filaments. May also exist as a membrane-bound form with extracellular regions.
Protein Description
Protein Sequence	MDRPLSSSAEAEEELEWQVASRRRKAWAKCRSSWQASETEDLSTEATTQDEEEDEEEDLPGAQLPAAGGRGNVPNEKIAIWLKDCRTPLGASLDEQSSSTLKGVLVRNGGSFEDDLSLGAEANHLHESDAQIENCNNILAKERRLQFHQKGRSMNSTGSGKSSGTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRMEVENPNYALTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTSNKETDPPPPLTRSNTANRLMKTLSKLNLCVDKTEKGESSSPSPSAEKGKILNVSVIEESGNKNDQKSQKIMKKKESSSMLATVKEEVSGSSAAVTENADSDRISDEANSNFNQGTENEQSKETQSHESKLGEESGIVESKLDSDFNISSHSELENSSELKSVHISTPEKEPCAPLTIPSIRNIMTQQKDSFEMEEVQSTEGEAPHVPATYQLGLTKSKRDHLLRTASQHSDSSGFAEDSTDCLSLNHLQVQESLQAMGSSADSCDSETTVTSLGEDLATPTAQDQPYFNESEEESLVPLQKGLEKAAAVADKRKSGSQDFPQCNTIENTGTKQSTCSPGDHIIEITEVEEDLFPAETVELLREASAESDVGKSSESEFTQYTTHHILKSLASIEAKCSDMSSENTTGPPSSMDRVNTALQRAQMKVCSLSNQRMGRSLLKSKDLLKQRYLFAKAGYPLRRSQSLPTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEEQELEKRVMEHDGQSLVKSTIFISPSSVKKEEAPQSEAPRVEECHHGRTPTCSRLAPPPMSQSTCSLHSIHSEWQERPLCEHTRTLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQYPMMRGPDPAAAPYSTQKSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELAMLRQQTMVYHHMTEEERFEVDQLQGLRNSVRMELQDLELQLEERLLGLEEQLRAVRMPSPFRSSALMGMCGSRSADNLSCPSPLNVMEPVTELMQEQSYLKSELGLGLGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSTASVGKSKTPLVARKKVFRASVALTPTAPSRTGSVQTPPDLESSEEVDAAEGAPEVVGPKSEVEEGHGKLPSMPAAEEMHKNVEQDELQQVIREIKESIVGEIRREIVSGLLAAVSSSKASNSKQDYH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46 (in isoform 2)	Ubiquitination	-	18.94	21890473
59 (in isoform 2)	Ubiquitination	-	4.82	21890473
77 (in isoform 3)	Ubiquitination	-	44.04	21890473
77 (in isoform 1)	Ubiquitination	-	44.04	21890473
102 (in isoform 3)	Ubiquitination	-	47.24	21890473
102 (in isoform 1)	Ubiquitination	-	47.24	21890473
125 (in isoform 2)	Ubiquitination	-	4.87	21890473
148 (in isoform 2)	Ubiquitination	-	18.58	21890473
158 (in isoform 2)	Ubiquitination	-	33.93	21890473
172 (in isoform 2)	Ubiquitination	-	3.33	21890473
199 (in isoform 1)	Ubiquitination	-	50.00	21890473
199 (in isoform 3)	Ubiquitination	-	50.00	21890473
212 (in isoform 3)	Ubiquitination	-	55.15	21890473
212 (in isoform 1)	Ubiquitination	-	55.15	21890473
244 (in isoform 2)	Ubiquitination	-	24.12	21890473
252 (in isoform 2)	Ubiquitination	-	8.92	21890473
263 (in isoform 2)	Ubiquitination	-	17.20	21890473
278 (in isoform 1)	Ubiquitination	-	62.85	21890473
278 (in isoform 3)	Ubiquitination	-	62.85	21890473
301 (in isoform 1)	Ubiquitination	-	44.50	21890473
301 (in isoform 3)	Ubiquitination	-	44.50	21890473
308	Acetylation	KLNLCVDKTEKGESS HHCEEEECCCCCCCC	37.88	26051181
311 (in isoform 3)	Ubiquitination	-	73.53	21890473
311 (in isoform 1)	Ubiquitination	-	73.53	21890473
325 (in isoform 3)	Ubiquitination	-	55.90	21890473
325 (in isoform 1)	Ubiquitination	-	55.90	21890473
360	Sumoylation	SSMLATVKEEVSGSS HHHHHHHHHHHCCCC	43.75	28112733
397 (in isoform 3)	Ubiquitination	-	65.56	21890473
397 (in isoform 1)	Ubiquitination	-	65.56	21890473
405 (in isoform 3)	Ubiquitination	-	58.49	21890473
405 (in isoform 1)	Ubiquitination	-	58.49	21890473
416 (in isoform 3)	Ubiquitination	-	42.69	21890473
416 (in isoform 1)	Ubiquitination	-	42.69	21890473
445	Acetylation	VHISTPEKEPCAPLT CEECCCCCCCCCCCC	69.06	26051181
511 (in isoform 2)	Ubiquitination	-	7.90	21890473
632 (in isoform 2)	Ubiquitination	-	54.33	21890473
644 (in isoform 2)	Ubiquitination	-	36.99	21890473
655 (in isoform 2)	Ubiquitination	-	19.33	21890473
664 (in isoform 3)	Ubiquitination	-	42.70	21890473
664 (in isoform 1)	Ubiquitination	-	42.70	21890473
785 (in isoform 3)	Ubiquitination	-	64.02	21890473
785 (in isoform 1)	Ubiquitination	-	64.02	21890473
794 (in isoform 2)	Ubiquitination	-	40.43	21890473
797 (in isoform 3)	Ubiquitination	-	47.37	21890473
797 (in isoform 1)	Ubiquitination	-	47.37	21890473
808 (in isoform 3)	Ubiquitination	-	57.31	21890473
808 (in isoform 1)	Ubiquitination	-	57.31	21890473
947 (in isoform 3)	Ubiquitination	-	44.80	21890473
947 (in isoform 1)	Ubiquitination	-	44.80	21890473
1047 (in isoform 2)	Ubiquitination	-	3.09	21890473
1059 (in isoform 2)	Ubiquitination	-	6.00	21890473
1097 (in isoform 2)	Ubiquitination	-	24.52	21890473
1102 (in isoform 2)	Ubiquitination	-	29.59	21890473
1200 (in isoform 3)	Ubiquitination	-	52.10	21890473
1200 (in isoform 1)	Ubiquitination	-	52.10	21890473
1212 (in isoform 1)	Ubiquitination	-	62.47	21890473
1212 (in isoform 3)	Ubiquitination	-	62.47	21890473
1250 (in isoform 1)	Ubiquitination	-	58.75	21890473
1255 (in isoform 1)	Ubiquitination	-	51.98	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SSFA2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SSFA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SSFA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LC7L2_HUMAN	LUC7L2	physical	16169070
1433Z_HUMAN	YWHAZ	physical	21988832
1433T_HUMAN	YWHAQ	physical	21988832
CBL_HUMAN	CBL	physical	26186194
FKB15_HUMAN	FKBP15	physical	26186194
SGF29_HUMAN	CCDC101	physical	26186194
PIGR_HUMAN	PIGR	physical	26186194
PCM1_HUMAN	PCM1	physical	26186194
VP33B_HUMAN	VPS33B	physical	26186194
FKB15_HUMAN	FKBP15	physical	28514442
SGF29_HUMAN	CCDC101	physical	28514442
VP33B_HUMAN	VPS33B	physical	28514442
CBL_HUMAN	CBL	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SSFA2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92 AND SER-739, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-330; SER-737 ANDSER-739, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-87; SER-92; SER-668;SER-737; SER-739; SER-746; SER-1131 AND SER-1134, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300; TYR-725 ANDTYR-732, AND MASS SPECTROMETRY.	18187866 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163; THR-165; SER-167;SER-168; SER-610; SER-1055; SER-1060 AND SER-1063, AND MASSSPECTROMETRY.	17081983 [Abstract]