ALKB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALKB2_HUMAN
• UniProt AC: Q6NS38
• Protein Name: DNA oxidative demethylase ALKBH2
• Gene Name: ALKBH2
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Nucleus . Detected in replication foci during S-phase.
• Protein Description: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron..
• Protein Sequence: MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MDRFLVKGAQGGLL -CCCHHCCCCCCCCC	51.15	23749302
7	Ubiquitination	-MDRFLVKGAQGGLL -CCCHHCCCCCCCCC	51.15	23000965
7	Sumoylation	-MDRFLVKGAQGGLL -CCCHHCCCCCCCCC	51.15	-
7	Sumoylation	-MDRFLVKGAQGGLL -CCCHHCCCCCCCCC	51.15	-
16	Sumoylation	AQGGLLRKQEEQEPT CCCCCCCCCCCCCCC	63.13	-
16	Sumoylation	AQGGLLRKQEEQEPT CCCCCCCCCCCCCCC	63.13	-
16	Ubiquitination	AQGGLLRKQEEQEPT CCCCCCCCCCCCCCC	63.13	29967540
34	Acetylation	PAVLGGDKESTRKRP CCCCCCCHHHCCCCC	57.76	26051181
34	Ubiquitination	PAVLGGDKESTRKRP CCCCCCCHHHCCCCC	57.76	24816145
52	Phosphorylation	APGNGGHSAGPSWRH CCCCCCCCCCCCCHH	37.89	20068231
56	Phosphorylation	GGHSAGPSWRHIRAE CCCCCCCCCHHHHCC	35.51	26091039
91	Phosphorylation	ELEKEVEYFTGALAR HHHHHHHHHHHHHHE	16.18	46162407
93	Phosphorylation	EKEVEYFTGALARVQ HHHHHHHHHHHHEEE	22.20	46162401
104	Acetylation	ARVQVFGKWHSVPRK HEEEECCEEECCCCH	30.21	25953088
104	Ubiquitination	ARVQVFGKWHSVPRK HEEEECCEEECCCCH	30.21	21890473
115	Phosphorylation	VPRKQATYGDAGLTY CCCHHCCCCCCCEEE	18.94	23401153
128	Phosphorylation	TYTFSGLTLSPKPWI EEEECCEECCCCCCH	28.81	23401153
130	Phosphorylation	TFSGLTLSPKPWIPV EECCEECCCCCCHHH	26.16	23401153
139 (in isoform 2)	Ubiquitination	-	46.42	-
162	Ubiquitination	FVLINRYKDGCDHIG EEEEEECCCCCCCCC	44.39	-
182	Phosphorylation	ERELAPGSPIASVSF CCCCCCCCCCEEEEE	16.45	28122231
252	Phosphorylation	LAPRVNLTFRKILLT CCCCCCEEEEHHHEE	19.05	46162395
259	Phosphorylation	TFRKILLTKK----- EEEHHHEECC-----	33.08	23532336
260	Ubiquitination	FRKILLTKK------ EEHHHEECC------	57.36	27667366
261	Ubiquitination	RKILLTKK------- EHHHEECC-------	61.41	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALKB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALKB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALKB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHX16_HUMAN	DHX16	physical	26344197
OTUD4_HUMAN	OTUD4	physical	25944111
SYNJ1_HUMAN	SYNJ1	physical	28514442
CC151_HUMAN	CCDC151	physical	28514442
ARL3_HUMAN	ARL3	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00126: Vitamin C