SYNJ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYNJ1_HUMAN
• UniProt AC: O43426
• Protein Name: Synaptojanin-1
• Gene Name: SYNJ1
• Organism: Homo sapiens (Human).
• Sequence Length: 1573
• Subcellular Localization: Cytoplasm, perinuclear region .
• Protein Description: Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. [PubMed: 27435091 Has a role in clathrin-mediated endocytosis (By similarity Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity]
• Protein Sequence: MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKAQLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSCMPTMPPIPARSQSQENMRSSPNPFITGLTRTNPFSDRTAAPGNPFRAKSEESEATSWFSKEEPVTISPFPSLQPLGHNKSRASSSLDGFKDSFDLQGQSTLKISNPKGWVTFEEEEDFGVKGKSKSACSDLLGNQPSSFSGSNLTLNDDWNKGTNVSFCVLPSRRPPPPPVPLLPPGTSPPVDPFTTLASKASPTLDFTER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAFSKGFRIYH ----CCCCCCEEEEE	38.64	-
5	Ubiquitination	---MAFSKGFRIYHK ---CCCCCCEEEEEC	56.46	-
43	O-linked_Glycosylation	GAVAVLSSAEKEAIK CCEEEECHHHHHHHH	35.96	30059200
60	Phosphorylation	YSKVLDAYGLLGVLR HHHHHHHHHHHHHEE	14.15	22817900
73	Phosphorylation	LRLNLGDTMLHYLVL EECCCCHHHHHHHHH	21.60	29759185
93	Phosphorylation	SVGKIQESEVFRVTS CCCCCCCCEEEEEEC	23.76	30576142
99	Phosphorylation	ESEVFRVTSTEFISL CCEEEEEECCEEEEE	26.19	25693802
100	Phosphorylation	SEVFRVTSTEFISLR CEEEEEECCEEEEEE	24.08	25693802
101	Phosphorylation	EVFRVTSTEFISLRI EEEEEECCEEEEEEE	26.08	25693802
105	Phosphorylation	VTSTEFISLRIDSSD EECCEEEEEEECCCC	19.54	30576142
242	Phosphorylation	QVVYLDDSVSSFIQI EEEEECCCHHHHEEE	24.46	18452278
244	Phosphorylation	VYLDDSVSSFIQIRG EEECCCHHHHEEECC	24.39	18452278
245	Phosphorylation	YLDDSVSSFIQIRGS EECCCHHHHEEECCC	24.98	18452278
281	Phosphorylation	GFEANAPAFDRHFRT CHHCCCCCHHHHHHH	19.30	18452278
283	Phosphorylation	EANAPAFDRHFRTLK HCCCCCHHHHHHHHH	45.30	18452278
284	Methylation	ANAPAFDRHFRTLKN CCCCCHHHHHHHHHH	25.13	115918081
284	Phosphorylation	ANAPAFDRHFRTLKN CCCCCHHHHHHHHHH	25.13	18452278
304	Phosphorylation	IIVNLLGSKEGEHML HHHHHHCCHHHHHHH	27.74	-
310	Sulfoxidation	GSKEGEHMLSKAFQS CCHHHHHHHHHHHHH	3.83	30846556
312	Phosphorylation	KEGEHMLSKAFQSHL HHHHHHHHHHHHHHH	17.86	29449344
323	Methylation	QSHLKASEHAADIQM HHHHHHHHHCCCCEE	42.26	-
391	Ubiquitination	LDCLDRTNSVQAFLG HHHHHCCCHHHHHHH	40.87	-
435	Phosphorylation	MWSVNGDSISKIYAG HHCCCCCCCCEEECC	30.11	22210691
440	Phosphorylation	GDSISKIYAGTGALE CCCCCEEECCCCCCC	11.60	22210691
443	Phosphorylation	ISKIYAGTGALEGKA CCEEECCCCCCCCCE	15.88	-
479	Phosphorylation	KQEAIDVLLLGNTLN HHHHHHHHHHCCCCC	2.64	27642862
488	Ubiquitination	LGNTLNSDLADKARA HCCCCCHHHHHHHHH	44.81	-
498	Phosphorylation	DKARALLTTGSLRVS HHHHHHHHHCCCCCC	29.93	20068231
499	Phosphorylation	KARALLTTGSLRVSE HHHHHHHHCCCCCCH	25.41	20068231
501	Phosphorylation	RALLTTGSLRVSEQT HHHHHHCCCCCCHHH	15.77	20068231
501 (in isoform 5)	Phosphorylation	-	15.77	20068231
502 (in isoform 5)	Phosphorylation	-	7.11	20068231
504 (in isoform 5)	Phosphorylation	-	10.03	20068231
505	Phosphorylation	TTGSLRVSEQTLQSA HHCCCCCCHHHHHHH	19.97	25002506
508	Phosphorylation	SLRVSEQTLQSASSK CCCCCHHHHHHHHHH	23.78	25002506
511	Phosphorylation	VSEQTLQSASSKVLK CCHHHHHHHHHHHHH	32.98	25002506
513	Phosphorylation	EQTLQSASSKVLKSM HHHHHHHHHHHHHHH	35.62	25002506
514	Phosphorylation	QTLQSASSKVLKSMC HHHHHHHHHHHHHHH	26.88	25002506
515	Acetylation	TLQSASSKVLKSMCE HHHHHHHHHHHHHHH	49.44	12653491
518	Acetylation	SASSKVLKSMCENFY HHHHHHHHHHHHHHH	38.85	12653507
519	Phosphorylation	ASSKVLKSMCENFYK HHHHHHHHHHHHHHH	25.22	25002506
526	Methylation	SMCENFYKYSKPKKI HHHHHHHHHCCCCCE	38.62	24129315
531	Ubiquitination	FYKYSKPKKIRVCVG HHHHCCCCCEEEEEE	65.65	-
537	Phosphorylation	PKKIRVCVGTWNVNG CCCEEEEEEEEEECC	7.57	20068231
538	Phosphorylation	KKIRVCVGTWNVNGG CCEEEEEEEEEECCC	21.64	20068231
540	Phosphorylation	IRVCVGTWNVNGGKQ EEEEEEEEEECCCCE	10.80	20068231
554	Methylation	QFRSIAFKNQTLTDW EEEEEEECCCCHHHH	38.84	115980265
593	Methylation	AIGFEEMVELNAGNI EECHHHHEEECCCCE	9.53	-
616	Ubiquitination	KLWAVELQKTISRDN EEEEEEEHHHHCCCC	27.60	-
680	Phosphorylation	AIRMLFHTTSLCFVC HHHHHHCHHHHHHHH	15.67	-
682	Phosphorylation	RMLFHTTSLCFVCSH HHHHCHHHHHHHHHH	25.05	22210691
695	Phosphorylation	SHFAAGQSQVKERNE HHHHCCHHHHHHHCH	35.70	22210691
786	Phosphorylation	TFAPTYKYDLFSDDY EEECCCCEECCCCCC	13.89	21082442
820	Phosphorylation	RKWPFDRSAEDLDLL CCCCCCCCHHHHHHH	37.54	-
824	Ubiquitination	FDRSAEDLDLLNASF CCCCHHHHHHHCCCC	3.63	-
830	Phosphorylation	DLDLLNASFQDESKI HHHHHCCCCCCCCCE	23.51	30266825
835	Phosphorylation	NASFQDESKILYTWT CCCCCCCCCEEEEEC	33.03	30266825
837	Ubiquitination	SFQDESKILYTWTPG CCCCCCCEEEEECCC	5.04	-
869	Phosphorylation	VVALIDIDIFEVEAE EEEEEEEEEEEECHH	35.46	24719451
987	O-linked_Glycosylation	EMSLEKISIALPSST HHCCCEEEEECCCCC	16.93	30059200
992	O-linked_Glycosylation	KISIALPSSTSSTLL EEEEECCCCCCCCCC	47.28	30059200
1033	Phosphorylation	LPQHLQPSSSSGLGT HHHHCCCCCCCCCCC	29.86	30257219
1040	Phosphorylation	SSSSGLGTSPSSSPR CCCCCCCCCCCCCCC	42.37	30257219
1041	Phosphorylation	SSSGLGTSPSSSPRT CCCCCCCCCCCCCCC	22.46	22468782
1043	Phosphorylation	SGLGTSPSSSPRTSP CCCCCCCCCCCCCCC	43.12	24275569
1044	Phosphorylation	GLGTSPSSSPRTSPC CCCCCCCCCCCCCCC	47.98	25137130
1045	Phosphorylation	LGTSPSSSPRTSPCQ CCCCCCCCCCCCCCC	23.80	22468782
1048	Phosphorylation	SPSSSPRTSPCQSPT CCCCCCCCCCCCCCC	40.17	23401153
1049	Phosphorylation	PSSSPRTSPCQSPTI CCCCCCCCCCCCCCC	25.59	23401153
1053	Phosphorylation	PRTSPCQSPTISEGP CCCCCCCCCCCCCCC	30.63	23401153
1055	Phosphorylation	TSPCQSPTISEGPVP CCCCCCCCCCCCCCC	42.24	30278072
1057	Phosphorylation	PCQSPTISEGPVPSL CCCCCCCCCCCCCCC	38.69	30278072
1063	Phosphorylation	ISEGPVPSLPIRPSR CCCCCCCCCCCCCCC	47.19	23927012
1069	Phosphorylation	PSLPIRPSRAPSRTP CCCCCCCCCCCCCCC	31.09	23927012
1073	Phosphorylation	IRPSRAPSRTPGPPS CCCCCCCCCCCCCCC	48.04	30576142
1075	Phosphorylation	PSRAPSRTPGPPSAQ CCCCCCCCCCCCCCC	36.61	30576142
1080	Phosphorylation	SRTPGPPSAQSSPID CCCCCCCCCCCCCCC	41.91	26055452
1083	Phosphorylation	PGPPSAQSSPIDAQP CCCCCCCCCCCCCCC	37.49	27134283
1084	Phosphorylation	GPPSAQSSPIDAQPA CCCCCCCCCCCCCCC	17.50	22199227
1087	Phosphorylation	SAQSSPIDAQPATPL CCCCCCCCCCCCCCC	42.40	24719451
1088	Phosphorylation	AQSSPIDAQPATPLP CCCCCCCCCCCCCCC	20.27	24719451
1092	Phosphorylation	PIDAQPATPLPQKDP CCCCCCCCCCCCCCC	31.85	26055452
1114	Phosphorylation	RPPPPRPVAPPTRPA CCCCCCCCCCCCCCC	15.31	27251275
1119	Phosphorylation	RPVAPPTRPAPPQRP CCCCCCCCCCCCCCC	31.02	18669648
1122	Phosphorylation	APPTRPAPPQRPPPP CCCCCCCCCCCCCCC	28.39	18669648
1123	Phosphorylation	PPTRPAPPQRPPPPS CCCCCCCCCCCCCCC	44.94	27251275
1131	Phosphorylation	QRPPPPSGARSPAPT CCCCCCCCCCCCCCC	30.68	27251275
1134	Phosphorylation	PPPSGARSPAPTRKE CCCCCCCCCCCCCHH	25.53	-
1134 (in isoform 4)	Phosphorylation	-	25.53	27251275
1138 (in isoform 4)	Phosphorylation	-	57.38	27251275
1147 (in isoform 4)	Phosphorylation	-	15.77	-
1150	Phosphorylation	GGIGAPPSPGVARRE CCCCCCCCCCCCCCC	32.97	-
1163	Phosphorylation	REMEAPKSPGTTRKD CCCCCCCCCCCCCCC	27.74	22817900
1166	Phosphorylation	EAPKSPGTTRKDNIG CCCCCCCCCCCCCCC	27.15	-
1175	Phosphorylation	RKDNIGRSQPSPQAG CCCCCCCCCCCCCCC	41.03	27732954
1178	Phosphorylation	NIGRSQPSPQAGLAG CCCCCCCCCCCCCCC	23.23	26657352
1191	Phosphorylation	AGPGPAGYSTARPTI CCCCCCCCCCCCCCC	12.64	22461510
1201	Methylation	ARPTIPPRAGVISAP CCCCCCCCCCCCCCC	38.32	-
1215	Phosphorylation	PQSHARASAGRLTPE CHHHHHHHCCCCCHH	26.21	30266825
1217	Phosphorylation	SHARASAGRLTPESQ HHHHHHCCCCCHHHH	23.72	27251275
1220	Phosphorylation	RASAGRLTPESQSKT HHHCCCCCHHHHCCC	24.53	29255136
1223	Phosphorylation	AGRLTPESQSKTSET CCCCCHHHHCCCCCC	40.74	30266825
1225	Phosphorylation	RLTPESQSKTSETSK CCCHHHHCCCCCCCC	47.37	30266825
1230	Phosphorylation	SQSKTSETSKGSTFL HHCCCCCCCCCCCCC	35.19	27642862
1259	Phosphorylation	SLPPPAQRLQEPLVP CCCCCHHHCCCCCCC	40.21	20166139
1262	Phosphorylation	PPAQRLQEPLVPVAA CCHHHCCCCCCCEEC	45.23	27251275
1274	Phosphorylation	VAAPMPQSGPQPNLE EECCCCCCCCCCCCC	46.71	22199227
1276 (in isoform 4)	Phosphorylation	-	52.26	27732954
1277 (in isoform 4)	Phosphorylation	-	42.93	27251275
1279 (in isoform 4)	Phosphorylation	-	45.31	25307156
1282	Phosphorylation	GPQPNLETPPQPPPR CCCCCCCCCCCCCCC	43.36	22199227
1282 (in isoform 4)	Phosphorylation	-	43.36	24076635
1285 (in isoform 4)	Phosphorylation	-	65.42	28985074
1290	Phosphorylation	PPQPPPRSRSSHSLP CCCCCCCCCCCCCCC	42.14	23401153
1292	Phosphorylation	QPPPRSRSSHSLPSE CCCCCCCCCCCCCCC	33.38	25159151
1292 (in isoform 2)	Phosphorylation	-	33.38	27732954
1293	Phosphorylation	PPPRSRSSHSLPSEA CCCCCCCCCCCCCCC	18.91	25159151
1293 (in isoform 2)	Phosphorylation	-	18.91	27251275
1294 (in isoform 4)	Phosphorylation	-	34.30	25307156
1295	Phosphorylation	PRSRSSHSLPSEASS CCCCCCCCCCCCCCC	43.88	25159151
1295 (in isoform 2)	Phosphorylation	-	43.88	25307156
1298	Phosphorylation	RSSHSLPSEASSQPQ CCCCCCCCCCCCCCC	51.60	28450419
1298 (in isoform 2)	Phosphorylation	-	51.60	24076635
1301	Phosphorylation	HSLPSEASSQPQVKT CCCCCCCCCCCCCCC	26.00	28450419
1301 (in isoform 2)	Phosphorylation	-	26.00	28985074
1302	Phosphorylation	SLPSEASSQPQVKTN CCCCCCCCCCCCCCC	53.58	25159151
1310 (in isoform 2)	Phosphorylation	-	26.47	25307156
1318	Phosphorylation	ISDGKRESPLKIDPF CCCCCCCCCCCCCCC	39.30	25159151
1321	Phosphorylation	GKRESPLKIDPFEDL CCCCCCCCCCCCCCC	48.74	-
1329	O-linked_Glycosylation	IDPFEDLSFNLLAVS CCCCCCCCHHHEEEE	25.14	30059200
1329	Phosphorylation	IDPFEDLSFNLLAVS CCCCCCCCHHHEEEE	25.14	27251275
1331	Phosphorylation	PFEDLSFNLLAVSKA CCCCCCHHHEEEEEE	30.67	27251275
1332	Phosphorylation	FEDLSFNLLAVSKAQ CCCCCHHHEEEEEEE	2.83	24719451
1334	Phosphorylation	DLSFNLLAVSKAQLS CCCHHHEEEEEEEEE	13.50	27251275
1336	O-linked_Glycosylation	SFNLLAVSKAQLSVQ CHHHEEEEEEEEEEE	19.37	30059200
1341	Phosphorylation	AVSKAQLSVQTSPVP EEEEEEEEEECCCCC	10.49	21712546
1344	Phosphorylation	KAQLSVQTSPVPTPD EEEEEEECCCCCCCC	32.61	29255136
1345	Phosphorylation	AQLSVQTSPVPTPDP EEEEEECCCCCCCCH	13.55	29255136
1349	Phosphorylation	VQTSPVPTPDPKRLI EECCCCCCCCHHHEE	40.32	29255136
1357	Phosphorylation	PDPKRLIQLPSATQS CCHHHEEECCCCCCC	52.49	20068231
1380	Phosphorylation	MPTMPPIPARSQSQE CCCCCCCCCCCCCCH	27.65	-
1383	Phosphorylation	MPPIPARSQSQENMR CCCCCCCCCCCHHHH	35.97	20363803
1384	Phosphorylation	PPIPARSQSQENMRS CCCCCCCCCCHHHHC	43.51	24719451
1385	Phosphorylation	PIPARSQSQENMRSS CCCCCCCCCHHHHCC	40.48	23927012
1388	Phosphorylation	ARSQSQENMRSSPNP CCCCCCHHHHCCCCC	24.43	20068231
1391	Phosphorylation	QSQENMRSSPNPFIT CCCHHHHCCCCCCCC	39.10	23401153
1392	Phosphorylation	SQENMRSSPNPFITG CCHHHHCCCCCCCCC	20.52	23927012
1398	Phosphorylation	SSPNPFITGLTRTNP CCCCCCCCCCCCCCC	26.90	23403867
1401	Phosphorylation	NPFITGLTRTNPFSD CCCCCCCCCCCCCCC	36.47	23403867
1409	Methylation	RTNPFSDRTAAPGNP CCCCCCCCCCCCCCC	25.68	115918077
1421	Phosphorylation	GNPFRAKSEESEATS CCCCCCCCCCCCCCC	45.68	28450419
1424	Phosphorylation	FRAKSEESEATSWFS CCCCCCCCCCCCCCC	28.60	23312004
1427	Phosphorylation	KSEESEATSWFSKEE CCCCCCCCCCCCCCC	23.57	28102081
1428	Phosphorylation	SEESEATSWFSKEEP CCCCCCCCCCCCCCC	32.92	28102081
1430	Phosphorylation	ESEATSWFSKEEPVT CCCCCCCCCCCCCCE	8.18	18669648
1431	Phosphorylation	SEATSWFSKEEPVTI CCCCCCCCCCCCCEE	32.66	24719451
1437	Phosphorylation	FSKEEPVTISPFPSL CCCCCCCEECCCCCC	26.84	25627689
1439	Phosphorylation	KEEPVTISPFPSLQP CCCCCEECCCCCCCC	15.89	27050516
1448	Methylation	FPSLQPLGHNKSRAS CCCCCCCCCCCCCCC	29.07	-
1455	Phosphorylation	GHNKSRASSSLDGFK CCCCCCCCCCCCCCC	21.25	21815630
1456	Phosphorylation	HNKSRASSSLDGFKD CCCCCCCCCCCCCCC	33.66	23312004
1457	Phosphorylation	NKSRASSSLDGFKDS CCCCCCCCCCCCCCC	28.16	21815630
1460	Phosphorylation	RASSSLDGFKDSFDL CCCCCCCCCCCCEEC	36.48	24719451
1464	Phosphorylation	SLDGFKDSFDLQGQS CCCCCCCCEECCCCE	22.66	28348404
1471	Phosphorylation	SFDLQGQSTLKISNP CEECCCCEEEEECCC	42.40	28555341
1472	Phosphorylation	FDLQGQSTLKISNPK EECCCCEEEEECCCC	24.96	28555341
1478	Phosphorylation	STLKISNPKGWVTFE EEEEECCCCCEEEEE	29.73	-
1496	Phosphorylation	DFGVKGKSKSACSDL CCCCCCCCHHHHHHH	40.28	27251275
1529	Phosphorylation	WNKGTNVSFCVLPSR CCCCCCEEEEECCCC	18.26	25159151
1550	Phosphorylation	VPLLPPGTSPPVDPF CCCCCCCCCCCCCCC	43.78	28450419
1551	Phosphorylation	PLLPPGTSPPVDPFT CCCCCCCCCCCCCCH	32.87	25159151
1558	Phosphorylation	SPPVDPFTTLASKAS CCCCCCCHHHHCCCC	26.70	28450419
1559	Phosphorylation	PPVDPFTTLASKASP CCCCCCHHHHCCCCC	22.24	28450419
1562	Phosphorylation	DPFTTLASKASPTLD CCCHHHHCCCCCCCC	31.69	28450419
1565	Phosphorylation	TTLASKASPTLDFTE HHHHCCCCCCCCCCC	23.35	23401153
1567	Phosphorylation	LASKASPTLDFTER- HHCCCCCCCCCCCC-	36.14	30266825
1568	Phosphorylation	ASKASPTLDFTER-- HCCCCCCCCCCCC--	6.06	-
1571	Phosphorylation	ASPTLDFTER----- CCCCCCCCCC-----	30.43	23403867
1589	Phosphorylation	----------------------- -----------------------		24719451
1590	Phosphorylation	------------------------ ------------------------		20068231
1601	Phosphorylation	----------------------------------- -----------------------------------		18669648
1604	Phosphorylation	-------------------------------------- --------------------------------------		18669648

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYNJ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYNJ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYNJ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMPH_HUMAN	AMPH	physical	9341169
SH3G2_HUMAN	SH3GL2	physical	9341169
AMPH_HUMAN	AMPH	physical	10542231
SH3G1_HUMAN	SH3GL1	physical	10542231
AP2A1_HUMAN	AP2A1	physical	12057195
AP2M1_HUMAN	AP2M1	physical	12057195
CLH1_HUMAN	CLTC	physical	12057195
CLCA_HUMAN	CLTA	physical	12057195

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615530: Parkinson disease 20, early-onset (PARK20)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-830, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1392, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-830; THR-1220; SER-1551AND SER-1565, AND MASS SPECTROMETRY.
PubMed: 18669648