SH3G2_HUMAN - dbPTM
SH3G2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SH3G2_HUMAN
UniProt AC Q99962
Protein Name Endophilin-A1
Gene Name SH3GL2
Organism Homo sapiens (Human).
Sequence Length 352
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein . Early endosome . Concentrated in presynaptic nerve terminals in neurons.
Protein Description Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes..
Protein Sequence MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSVAGLKKQ
------CCHHHHHHH		22.2229514088
14PhosphorylationKKQFHKATQKVSEKV
HHHHHHHHHHHHHHH		33.4522817900
54PhosphorylationVMEIMTKTIEYLQPN
HHHHHHHHHHHHCCC		15.1828152594
57PhosphorylationIMTKTIEYLQPNPAS
HHHHHHHHHCCCHHH		13.5428152594
64PhosphorylationYLQPNPASRAKLSMI
HHCCCHHHHHHHHHH		33.7528152594
75PhosphorylationLSMINTMSKIRGQEK
HHHHHHHHHHCCCCC		23.9222817900
76AcetylationSMINTMSKIRGQEKG
HHHHHHHHHCCCCCC		26.1219812095
86PhosphorylationGQEKGPGYPQAEALL
CCCCCCCCHHHHHHH		8.7022817900
149UbiquitinationPLQNLHDKDLREIQH
HHHHCCHHHHHHHHH		48.17-
159UbiquitinationREIQHHLKKLEGRRL
HHHHHHHHHHCCCCC		51.46-
177UbiquitinationYKKKRQGKIPDEELR
HHHHHCCCCCHHHHH		42.60-
184MethylationKIPDEELRQALEKFD
CCCHHHHHHHHHHHH		24.01-
237PhosphorylationVQILQQVTVRLEERI
HHHHHHHHHHHHHHH		8.7924719451
249PhosphorylationERIRQASSQPRREYQ
HHHHHHHCCCCCCCC		47.4122617229
262PhosphorylationYQPKPRMSLEFPTGD
CCCCCCEEEECCCCC		26.4829449344
267PhosphorylationRMSLEFPTGDSTQPN
CEEEECCCCCCCCCC		59.9729449344
270PhosphorylationLEFPTGDSTQPNGGL
EECCCCCCCCCCCCC		30.2229449344
271PhosphorylationEFPTGDSTQPNGGLS
ECCCCCCCCCCCCCC		53.4324719451
278PhosphorylationTQPNGGLSHTGTPKP
CCCCCCCCCCCCCCC		23.4424719451
280PhosphorylationPNGGLSHTGTPKPSG
CCCCCCCCCCCCCCC		39.1025627689
282PhosphorylationGGLSHTGTPKPSGVQ
CCCCCCCCCCCCCCC		29.3325627689
299PhosphorylationQPCCRALYDFEPENE
CCCEEECCCCCCCCC		20.01-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
14TPhosphorylationKinaseROCK2O75116
PSP
-KUbiquitinationE3 ubiquitin ligasePRKNO60260
PMID:20064468
-KUbiquitinationE3 ubiquitin ligaseITCHQ96J02
PMID:14684745
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SH3G2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SH3G2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DYN1_HUMANDNM1physical
9341169
SYNJ1_HUMANSYNJ1physical
9341169
ADA19_HUMANADAM19physical
10531379
ADAM9_HUMANADAM9physical
10531379
ADA15_HUMANADAM15physical
10531379
SH3K1_HUMANSH3KBP1physical
11894095
CBL_HUMANCBLphysical
11894095
SH3K1_HUMANSH3KBP1physical
15456872
PDC6I_HUMANPDCD6IPphysical
15456872
ITCH_HUMANITCHphysical
14684745
ZXDC_HUMANZXDCphysical
21900206
SH3G3_HUMANSH3GL3physical
21900206
PPR21_HUMANPPP1R21physical
21900206
DLGP4_HUMANDLGAP4physical
21900206
F13A_HUMANF13A1physical
21900206
LCP2_HUMANLCP2physical
21900206
ZN219_HUMANZNF219physical
21900206
DPYL4_HUMANDPYSL4physical
21900206
TIAM2_HUMANTIAM2physical
21900206
SH3K1_HUMANSH3KBP1physical
21900206
SH3G1_HUMANSH3GL1physical
21900206
ZN580_HUMANZNF580physical
21900206
DACT1_HUMANDACT1physical
21900206
GCH1_HUMANGCH1physical
21900206
PRR14_HUMANPRR14physical
21900206
TM108_HUMANTMEM108physical
21900206
TYSY_HUMANTYMSphysical
21900206
GSTM3_HUMANGSTM3physical
21900206
MAST2_HUMANMAST2physical
21900206
DPPA4_HUMANDPPA4physical
21900206
PP6R1_HUMANPPP6R1physical
21900206
TETN_HUMANCLEC3Bphysical
21900206
EGFL6_HUMANEGFL6physical
21900206
ITSN1_HUMANITSN1physical
21900206
ATX2_HUMANATXN2physical
18602463
DYN3_HUMANDNM3physical
18602463
DYR1A_HUMANDYRK1Aphysical
19722700
ATX2_HUMANATXN2physical
16115810
SH3G3_HUMANSH3GL3physical
16115810
SH3G2_HUMANSH3GL2physical
16115810
SH3G1_HUMANSH3GL1physical
16115810
A4_HUMANAPPphysical
21832049
SH3G1_HUMANSH3GL1physical
26186194
SH3G3_HUMANSH3GL3physical
26186194
ITCH_HUMANITCHphysical
26613292
EGFR_HUMANEGFRphysical
24854121
SH3G3_HUMANSH3GL3physical
28514442
SH3G1_HUMANSH3GL1physical
28514442
FBX32_HUMANFBXO32physical
27720640
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SH3G2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, AND MASSSPECTROMETRY.

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