ADA19_HUMAN - dbPTM
ADA19_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADA19_HUMAN
UniProt AC Q9H013
Protein Name Disintegrin and metalloproteinase domain-containing protein 19
Gene Name ADAM19
Organism Homo sapiens (Human).
Sequence Length 955
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)..
Protein Sequence MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAPKVSPREALKVKAGTRGLQGGRCRVEKTKQFMLLVVWTELPEQKPRAKHSCFLVPA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
144N-linked_GlycosylationGLITVSSNLSYVIEP
EEEEEECCCEEEEEE		26.04UniProtKB CARBOHYD
155PhosphorylationVIEPLPDSKGQHLIY
EEEECCCCCCCEEEE		36.4226074081
162PhosphorylationSKGQHLIYRSEHLKP
CCCCEEEEECCCCCC		17.9126074081
183O-linked_GlycosylationFEHSKPTTRDWALQF
CCCCCCCCHHHHHHH		34.85OGP
191O-linked_GlycosylationRDWALQFTQQTKKRP
HHHHHHHHHHHHCCC		13.55OGP
194O-linked_GlycosylationALQFTQQTKKRPRRM
HHHHHHHHHCCCCCC		28.81OGP
208PhosphorylationMKREDLNSMKYVELY
CCHHHHHHCCHHHHH		24.7726074081
211PhosphorylationEDLNSMKYVELYLVA
HHHHHCCHHHHHHHH		7.1826074081
215PhosphorylationSMKYVELYLVADYLE
HCCHHHHHHHHHHHH		5.8926074081
220PhosphorylationELYLVADYLEFQKNR
HHHHHHHHHHHHHCC		9.8226074081
243PhosphorylationKLIEIANYVDKFYRS
HHHHHHHHHHHHHHH		10.8729978859
248PhosphorylationANYVDKFYRSLNIRI
HHHHHHHHHHHCCEE		12.6729978859
250PhosphorylationYVDKFYRSLNIRIAL
HHHHHHHHHCCEEEE		17.8746159035
272PhosphorylationHGNMCEVSENPYSTL
CCCCCEECCCHHHHH		14.9026552605
276PhosphorylationCEVSENPYSTLWSFL
CEECCCHHHHHHHHH		26.3526552605
277PhosphorylationEVSENPYSTLWSFLS
EECCCHHHHHHHHHH		20.4826552605
278PhosphorylationVSENPYSTLWSFLSW
ECCCHHHHHHHHHHH		26.8026552605
281PhosphorylationNPYSTLWSFLSWRRK
CHHHHHHHHHHHHHH		21.3026552605
284PhosphorylationSTLWSFLSWRRKLLA
HHHHHHHHHHHHHHH		19.2724719451
288UbiquitinationSFLSWRRKLLAQKYH
HHHHHHHHHHHHHHH		39.00-
444N-linked_GlycosylationECNNPCCNASNCTLR
CCCCCCCCCCCCEEC		53.79UniProtKB CARBOHYD
447N-linked_GlycosylationNPCCNASNCTLRPGA
CCCCCCCCCEECCCC		22.00UniProtKB CARBOHYD
645N-linked_GlycosylationCFEGQCRNTSFFETE
EEECCCCCCCCEEEC		47.93UniProtKB CARBOHYD
740PhosphorylationLKPSALPSKLRQQFS
CCCCCCCHHHHHHHC		45.2124719451
753PhosphorylationFSCPFRVSQNSGTGH
HCCCEEEECCCCCCC		21.2724961811
764PhosphorylationGTGHANPTFKLQTPQ
CCCCCCCEEEECCCC		32.9623312004
769PhosphorylationNPTFKLQTPQGKRKV
CCEEEECCCCCCCCC		28.1928985074
779PhosphorylationGKRKVINTPEILRKP
CCCCCCCCHHHHCCC		15.9219664994
797PhosphorylationPPRPPPDYLRGGSPP
CCCCCCCCCCCCCCC		12.2226356563
802PhosphorylationPDYLRGGSPPAPLPA
CCCCCCCCCCCCCCH		30.4530266825
818PhosphorylationLSRAARNSPGPGSQI
HHHHHHHCCCCCHHC		26.1928985074
823PhosphorylationRNSPGPGSQIERTES
HHCCCCCHHCCCCCC		30.9928985074
828PhosphorylationPGSQIERTESSRRPP
CCHHCCCCCCCCCCC		27.6826552605
830PhosphorylationSQIERTESSRRPPPS
HHCCCCCCCCCCCCC		28.6510539501
831PhosphorylationQIERTESSRRPPPSR
HCCCCCCCCCCCCCC		26.5226552605
872PhosphorylationNPVPGRRSLPRPGGA
CCCCCCCCCCCCCCC		41.1718330259
880PhosphorylationLPRPGGASPLRPPGA
CCCCCCCCCCCCCCC		27.9518330267
892PhosphorylationPGAGPQQSRPLAALA
CCCCCCCCCCHHHHC		30.5318330275
909UbiquitinationVSPREALKVKAGTRG
CCHHHHHHCCCCCCC		49.06-
921MethylationTRGLQGGRCRVEKTK
CCCCCCCCCCEECCC		16.34-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADA19_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADA19_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADA19_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
COPB_HUMANCOPB1physical
12463424
ABI2_HUMANABI2physical
12463424
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADA19_HUMAN

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Related Literatures of Post-Translational Modification

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