PPR21_HUMAN - dbPTM
PPR21_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPR21_HUMAN
UniProt AC Q6ZMI0
Protein Name Protein phosphatase 1 regulatory subunit 21
Gene Name PPP1R21
Organism Homo sapiens (Human).
Sequence Length 780
Subcellular Localization
Protein Description
Protein Sequence MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9MethylationASAELQGKYQKLAQE
CHHHHHHHHHHHHHH		31.3915821833
10PhosphorylationSAELQGKYQKLAQEY
HHHHHHHHHHHHHHH		20.08-
12UbiquitinationELQGKYQKLAQEYSK
HHHHHHHHHHHHHHH		42.5829967540
17PhosphorylationYQKLAQEYSKLRAQN
HHHHHHHHHHHHHHH		10.0625884760
18PhosphorylationQKLAQEYSKLRAQNQ
HHHHHHHHHHHHHHH		25.1826552605
83PhosphorylationLQDELALSEPRGKKN
HHHHHHHCCCCCCCC		39.6924719451
93PhosphorylationRGKKNKKSGESSSQL
CCCCCCCCCCCHHHH		49.7721815630
97PhosphorylationNKKSGESSSQLSQEQ
CCCCCCCHHHHCHHH		20.1526074081
98PhosphorylationKKSGESSSQLSQEQK
CCCCCCHHHHCHHHH		44.4126074081
101PhosphorylationGESSSQLSQEQKSVF
CCCHHHHCHHHHHHC		24.8426074081
188SumoylationVKSQTLEKEAKECRL
HHHHHHHHHHHHHHH		67.11-
188SumoylationVKSQTLEKEAKECRL
HHHHHHHHHHHHHHH		67.11-
362AcetylationKILPYQLKSLEEECE
HHHCHHHHCHHHHHH		37.1525953088
457PhosphorylationAIEHELPTATQKLIT
HHCCCCCCHHCHHHH		55.7723403867
459PhosphorylationEHELPTATQKLITTN
CCCCCCHHCHHHHCC		28.8123403867
510PhosphorylationKAASGFISPLSAECM
CHHCCCCCCCCHHHH		19.9624719451
527 (in isoform 5)Phosphorylation-10.5927174698
530 (in isoform 5)Phosphorylation-19.5127174698
537 (in isoform 5)Phosphorylation-58.3227174698
555PhosphorylationRRILLSSTESREGLA
CEEEECCCCCHHHHH		34.3128857561
557PhosphorylationILLSSTESREGLAQQ
EEECCCCCHHHHHHH		35.4028857561
573PhosphorylationQQSLEKISKLEQEKE
HHHHHHHHHHHHHHH		42.1122817900
642PhosphorylationAVLEPIQSTSLIGTL
HHHHHHHCCCCEEEE		22.2329978859
643PhosphorylationVLEPIQSTSLIGTLT
HHHHHHCCCCEEEEE		15.9229978859
644PhosphorylationLEPIQSTSLIGTLTR
HHHHHCCCCEEEEEC		24.2029978859
648PhosphorylationQSTSLIGTLTRTSDS
HCCCCEEEEECCCCC		20.2629978859
650PhosphorylationTSLIGTLTRTSDSEV
CCCEEEEECCCCCCC		31.5729978859
652PhosphorylationLIGTLTRTSDSEVPD
CEEEEECCCCCCCCC		31.4830108239
653PhosphorylationIGTLTRTSDSEVPDV
EEEEECCCCCCCCCC		35.5325159151
655PhosphorylationTLTRTSDSEVPDVES
EEECCCCCCCCCCCC		40.0230108239
662PhosphorylationSEVPDVESREDLIKN
CCCCCCCCHHHHHHH		40.6029978859
668AcetylationESREDLIKNHYMARI
CCHHHHHHHHHHHHH		44.9923236377
714PhosphorylationEKSKEALTEEMKLAS
HHHHHHHHHHHHHHH		36.63-
721PhosphorylationTEEMKLASQNISRLQ
HHHHHHHHHHHHHHH		33.91-
725PhosphorylationKLASQNISRLQDELT
HHHHHHHHHHHHHHH		34.19-
770PhosphorylationIDTLKMSSKGNSKKN
HHHHHHCCCCCCCCC		40.87-
774PhosphorylationKMSSKGNSKKNKSR-
HHCCCCCCCCCCCC-		54.39-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPR21_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPR21_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPR21_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TXND5_HUMANTXNDC5physical
22939629
QORL1_HUMANCRYZL1physical
26186194
PIBF1_HUMANPIBF1physical
26186194
FEN1_HUMANFEN1physical
26496610
MYBPH_HUMANMYBPHphysical
26496610
TAF6_HUMANTAF6physical
26496610
TOX4_HUMANTOX4physical
26496610
QORL1_HUMANCRYZL1physical
26496610
CE162_HUMANCEP162physical
26496610
RB6I2_HUMANERC1physical
26496610
RM18_HUMANMRPL18physical
26496610
CIA30_HUMANNDUFAF1physical
26496610
CL004_HUMANC12orf4physical
26496610
TBCK_HUMANTBCKphysical
26496610
GALD1_HUMANPDDC1physical
26496610
KMT2D_HUMANKMT2Dphysical
26496610
KBTB7_HUMANKBTBD7physical
28514442
BTBD9_HUMANBTBD9physical
28514442
KLH26_HUMANKLHL26physical
28514442
KLH24_HUMANKLHL24physical
28514442
KBTB6_HUMANKBTBD6physical
28514442
TXLNA_HUMANTXLNAphysical
28514442
BACD3_HUMANKCTD10physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPR21_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, AND MASSSPECTROMETRY.

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