KBTB6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KBTB6_HUMAN
• UniProt AC: Q86V97
• Protein Name: Kelch repeat and BTB domain-containing protein 6
• Gene Name: KBTBD6
• Organism: Homo sapiens (Human).
• Sequence Length: 674
• Protein Sequence: MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSKRMFCYDPSHNMWLKCVSLKRNDFQEACVFNEEIYCICDIPVMKVYNPVRAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGTTLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSSSLSDDDFWVRVAPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PRSRRLASPRGGKRP CHHHHCCCCCCCCCC	21.52	30576142
54	Ubiquitination	AALLAQLKSFYDARL HHHHHHHHHHHHHHH	26.83	22817900
135	Phosphorylation	YCYTGRVSLSEANVE EEECCCCCCCHHHHH	25.47	-
137	Phosphorylation	YTGRVSLSEANVERL ECCCCCCCHHHHHHH	27.44	-
162	Phosphorylation	YVREACASFLARRLD HHHHHHHHHHHHHCC	22.22	24719451
178	Ubiquitination	TNCTAILKFADAFGH CCHHHHHHHHHHHCC	32.18	21963094
201	Ubiquitination	SYIAQNFKQLSHMGS HHHHHHHHHHHCCCC	58.86	21963094
204	Phosphorylation	AQNFKQLSHMGSIRE HHHHHHHHCCCCCCH	14.66	29978859
208	Phosphorylation	KQLSHMGSIREETLA HHHHCCCCCCHHHHH	15.76	29978859
263	Ubiquitination	PSAAEVFKCVRWMHF CCHHHHHHHHHHHCC	36.68	21963094
284	Ubiquitination	YLEGLLTKPIVKKYC HHHHHCCHHHHHHHH	32.49	21906983
288	Ubiquitination	LLTKPIVKKYCLDVI HCCHHHHHHHHHHHH	38.45	22817900
289	Ubiquitination	LTKPIVKKYCLDVIE CCHHHHHHHHHHHHH	30.24	22817900
290	Phosphorylation	TKPIVKKYCLDVIEG CHHHHHHHHHHHHHH	7.79	-
308	Phosphorylation	MRYGDLLYKSLVPVP HHHHCCEEEEEEECC	13.06	-
309	Ubiquitination	RYGDLLYKSLVPVPN HHHCCEEEEEEECCC	36.96	21906983
317	Phosphorylation	SLVPVPNSSSSSSSS EEEECCCCCCCCCCC	26.06	28555341
343	Ubiquitination	QRLGMCAKEMVIFFG HHHCCCCCEEEHHCC	41.22	21963094
368	Ubiquitination	PYSGDLYKVPSPLTC CCCCCCCCCCCCCHH	55.77	21963094
408	Phosphorylation	PRTDLWVYKPAQNSW CCCEEEEEECCCCHH	10.32	20090780
409	Ubiquitination	RTDLWVYKPAQNSWQ CCEEEEEECCCCHHH	25.02	21906983
450	Ubiquitination	RDPITGVKLKEVECY CCCCCCCEECEEEEE	56.01	22817900
452	Ubiquitination	PITGVKLKEVECYNV CCCCCEECEEEEEEC	54.73	22817900
460	Ubiquitination	EVECYNVKRNQWALV EEEEEECCCCEEEEE	41.83	21963094
492	Ubiquitination	YLYALNSKRMFCYDP HHHHHHCCCCEEEEC	46.97	-
535	Ubiquitination	ICDIPVMKVYNPVRA EECCCEEEECCHHHH	41.63	21963094
563	Ubiquitination	TNNYRIIKHGQKLLL CCCEEEEECCEEEEE	39.03	29967540
572	Phosphorylation	GQKLLLITSRTPQWK CEEEEEEECCCCCHH	16.48	24719451
573	Phosphorylation	QKLLLITSRTPQWKK EEEEEEECCCCCHHH	27.45	28348404
575	Phosphorylation	LLLITSRTPQWKKNR EEEEECCCCCHHHCC	21.43	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KBTB6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KBTB6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KBTB6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KBTB7_HUMAN	KBTBD7	physical	25684205
CUL3_HUMAN	CUL3	physical	25684205
RBX1_HUMAN	RBX1	physical	25684205
TIAM1_HUMAN	TIAM1	physical	25684205
MLP3B_HUMAN	MAP1LC3B	physical	25684205
GBRAP_HUMAN	GABARAP	physical	25684205
GBRL1_HUMAN	GABARAPL1	physical	25684205
GBRL2_HUMAN	GABARAPL2	physical	25684205

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.