dbPTM

TIAM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TIAM1_HUMAN
UniProt AC	Q13009
Protein Name	T-lymphoma invasion and metastasis-inducing protein 1
Gene Name	TIAM1
Organism	Homo sapiens (Human).
Sequence Length	1591
Subcellular Localization	Cell junction. Cell membrane Peripheral membrane protein Cytoplasmic side. Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction..
Protein Description	Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration..
Protein Sequence	MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTDSSVTPSVDSSIVLTAASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETRASPRQLSTCQRANSLGDLYAQKNSGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEGATNPQISHSNSMQGRRAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPTTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDSKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLAFASRPTKVAMGRLGIFSVSSFHALVAARTGETGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPSINQVFGEGTEAVKKSLEGIFDDIVPDGKREKEVVLPNVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKTHQLDHSAHYLRLKFLIENKMQLYVPQPEEDIYELLYKEIEICPKVTQSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPELEEGVELLESPPHRVDGPADLGESPLAFLTSNPGHSLCSEQGSSAETAPEETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNPSDQSPSPQDSTGPQLATMRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKAVHSILRDKHRRQLLKTESLPSSQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFTIDSDAVSASSPEKESQQPPGGGDTDRWVEEQFDLAQYEEQDDIKETDILSDDDEFCESVKGASVDRDLQERLQATSISQRERGRKTLDSHASRMAQLKKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGNAESQHV ------CCCCCHHCC	54.05	-
2	Myristoylation	------MGNAESQHV ------CCCCCHHCC	54.05	-
20	Phosphorylation	FYGEKHASLGRKHTS CCCHHHHHCCCCCCH	30.95	24719451
26	Phosphorylation	ASLGRKHTSRSLRLS HHCCCCCCHHHHHHC	28.95	-
29	Phosphorylation	GRKHTSRSLRLSHKT CCCCCHHHHHHCCCC	20.01	23898821
33	Phosphorylation	TSRSLRLSHKTRRTR CHHHHHHCCCCCCCC	19.26	23898821
43	Phosphorylation	TRRTRHASSGKVIHR CCCCCCCCCCCEEEC	33.23	24719451
52	Phosphorylation	GKVIHRNSEVSTRSS CCEEECCCCCCCCCC	39.05	27251275
55	Phosphorylation	IHRNSEVSTRSSSTP EECCCCCCCCCCCCC	17.66	29449344
56	Phosphorylation	HRNSEVSTRSSSTPS ECCCCCCCCCCCCCC	39.48	29449344
58	Phosphorylation	NSEVSTRSSSTPSIP CCCCCCCCCCCCCCC	28.82	28348404
59	Phosphorylation	SEVSTRSSSTPSIPQ CCCCCCCCCCCCCCH	34.63	28348404
60	Phosphorylation	EVSTRSSSTPSIPQS CCCCCCCCCCCCCHH	45.65	27251275
61	Phosphorylation	VSTRSSSTPSIPQSL CCCCCCCCCCCCHHH	24.01	28348404
63	Phosphorylation	TRSSSTPSIPQSLAE CCCCCCCCCCHHHHH	47.17	28348404
102	Phosphorylation	DMGLRPVSYTDSSVT ECCCEECCCCCCCCC	25.62	28348404
104	Phosphorylation	GLRPVSYTDSSVTPS CCEECCCCCCCCCCC	23.15	28348404
106	Phosphorylation	RPVSYTDSSVTPSVD EECCCCCCCCCCCCC	20.93	28348404
107	Phosphorylation	PVSYTDSSVTPSVDS ECCCCCCCCCCCCCC	32.59	28348404
135	Phosphorylation	DTEESRLYGDDATYL CCCHHHHHCCCCCCE	19.87	29978859
140	Phosphorylation	RLYGDDATYLAEGGR HHHCCCCCCEECCCC	26.51	29978859
141	Phosphorylation	LYGDDATYLAEGGRR HHCCCCCCEECCCCC	12.97	29978859
152	Phosphorylation	GGRRQHSYTSNGPTF CCCCCCCCCCCCCCH	16.44	-
158	Phosphorylation	SYTSNGPTFMETASF CCCCCCCCHHHHHCC	36.69	28348404
162	Phosphorylation	NGPTFMETASFKKKR CCCCHHHHHCCCCCC	18.80	28348404
164	Phosphorylation	PTFMETASFKKKRSK CCHHHHHCCCCCCCC	45.05	24719451
170	Phosphorylation	ASFKKKRSKSADIWR HCCCCCCCCCCCCCC	39.58	27732954
172	Phosphorylation	FKKKRSKSADIWRED CCCCCCCCCCCCCCC	32.21	28188228
216	Phosphorylation	EEARGMETRASPRQL HHHCCCCCCCCHHHH	23.73	29083192
219	Phosphorylation	RGMETRASPRQLSTC CCCCCCCCHHHHHHH	19.82	28348404
224	Phosphorylation	RASPRQLSTCQRANS CCCHHHHHHHHHHHH	20.85	23312004
225	Phosphorylation	ASPRQLSTCQRANSL CCHHHHHHHHHHHHH	22.65	23312004
231	Phosphorylation	STCQRANSLGDLYAQ HHHHHHHHHHHHHHH	32.51	19664994
236	Phosphorylation	ANSLGDLYAQKNSGV HHHHHHHHHHHCCCC	16.24	30266825
241	Phosphorylation	DLYAQKNSGVTANGG HHHHHHCCCCCCCCC	41.49	28111955
244	Phosphorylation	AQKNSGVTANGGPGS HHHCCCCCCCCCCCH	20.24	28111955
251	Phosphorylation	TANGGPGSKFAGYCR CCCCCCCHHHHHHHH	27.94	28111955
283	Phosphorylation	AAEETPPYSNYNTLP HCCCCCCCCCCCCCC	15.68	27642862
286	Phosphorylation	ETPPYSNYNTLPCRK CCCCCCCCCCCCCCH	12.00	27642862
288	Phosphorylation	PPYSNYNTLPCRKSH CCCCCCCCCCCCHHH	23.01	27050516
294	Phosphorylation	NTLPCRKSHCLSEGA CCCCCCHHHHCCCCC	10.48	29978859
298	Phosphorylation	CRKSHCLSEGATNPQ CCHHHHCCCCCCCCC	39.10	29978859
302	Phosphorylation	HCLSEGATNPQISHS HHCCCCCCCCCCCCC	59.28	29978859
307	Phosphorylation	GATNPQISHSNSMQG CCCCCCCCCCCCCCC	18.67	29507054
309	Phosphorylation	TNPQISHSNSMQGRR CCCCCCCCCCCCCCC	24.65	29978859
311	Phosphorylation	PQISHSNSMQGRRAK CCCCCCCCCCCCCCC	18.59	29978859
319	Phosphorylation	MQGRRAKTTQDVNAG CCCCCCCCCCCCCCC	28.80	27273156
320	Phosphorylation	QGRRAKTTQDVNAGE CCCCCCCCCCCCCCC	23.28	25850435
329	Phosphorylation	DVNAGEGSEFADSGI CCCCCCCCCCCCCCC	25.82	30624053
334	Phosphorylation	EGSEFADSGIEGATT CCCCCCCCCCCCCCC	37.94	30624053
340	Phosphorylation	DSGIEGATTDTDLLS CCCCCCCCCCHHHHH	35.74	-
350	Phosphorylation	TDLLSRRSNATNSSY HHHHHHHCCCCCCCC	29.70	23312004
353	Phosphorylation	LSRRSNATNSSYSPT HHHHCCCCCCCCCCC	39.62	23312004
355	Phosphorylation	RRSNATNSSYSPTTG HHCCCCCCCCCCCCC	26.71	28450419
356	Phosphorylation	RSNATNSSYSPTTGR HCCCCCCCCCCCCCC	31.53	22617229
357	Phosphorylation	SNATNSSYSPTTGRA CCCCCCCCCCCCCCC	20.63	20363803
358	Phosphorylation	NATNSSYSPTTGRAF CCCCCCCCCCCCCCE	20.09	19664994
360	Phosphorylation	TNSSYSPTTGRAFVG CCCCCCCCCCCCEEC	35.62	28450419
361	Phosphorylation	NSSYSPTTGRAFVGS CCCCCCCCCCCEECC	28.23	28450419
368	Phosphorylation	TGRAFVGSDSGSSST CCCCEECCCCCCCCH	24.25	27732954
370	Phosphorylation	RAFVGSDSGSSSTGD CCEECCCCCCCCHHH	42.12	27732954
372	Phosphorylation	FVGSDSGSSSTGDAA EECCCCCCCCHHHHH	25.68	27732954
373	Phosphorylation	VGSDSGSSSTGDAAR ECCCCCCCCHHHHHH	35.13	27732954
374	Phosphorylation	GSDSGSSSTGDAARQ CCCCCCCCHHHHHHH	37.80	27732954
375	Phosphorylation	SDSGSSSTGDAARQG CCCCCCCHHHHHHHH	40.82	27732954
384	Phosphorylation	DAARQGVYENFRREL HHHHHHHHHHHHHHH	16.39	25884760
456	Phosphorylation	KKNKKVESATRRKWK ECCCCCCHHHHHCCC	37.62	-
458	Phosphorylation	NKKVESATRRKWKHY CCCCCHHHHHCCCEE	40.04	-
483	Phosphorylation	FYESDGRSGIDHNSI EEECCCCCCCCCCCC	45.70	26270265
489	Phosphorylation	RSGIDHNSIPKHAVW CCCCCCCCCCCCEEE	36.53	26270265
592	Phosphorylation	EMQLSSVTDSKKKKT CCCHHCCCCCHHHHH	36.18	30576142
594	Phosphorylation	QLSSVTDSKKKKTIL CHHCCCCCHHHHHHH	36.69	30576142
596	Acetylation	SSVTDSKKKKTILDQ HCCCCCHHHHHHHHH	64.55	7679253
599	Phosphorylation	TDSKKKKTILDQIFV CCCHHHHHHHHHHHH	35.33	-
679	Phosphorylation	ETGVRRRTQAMSRSA CCHHHHHHHHHHHHH	20.90	22210691
687	Phosphorylation	QAMSRSASKRRSRFS HHHHHHHHHHHHHHH	28.13	22210691
694	Phosphorylation	SKRRSRFSSLWGLDT HHHHHHHHHHHCCCC	24.34	30576142
695	Phosphorylation	KRRSRFSSLWGLDTT HHHHHHHHHHCCCCC	25.98	28348404
701	Phosphorylation	SSLWGLDTTSKKKQG HHHHCCCCCCCCCCC	37.70	30576142
702	Phosphorylation	SLWGLDTTSKKKQGR HHHCCCCCCCCCCCC	37.91	29083192
703	Phosphorylation	LWGLDTTSKKKQGRP HHCCCCCCCCCCCCC	44.57	29083192
726	Phosphorylation	GTEAVKKSLEGIFDD CHHHHHHHHCHHHCC	26.40	29507054
820	Phosphorylation	IENKMQLYVPQPEED HHCCCEEECCCCHHH	8.00	-
829	Phosphorylation	PQPEEDIYELLYKEI CCCHHHHHHHHHHHH	16.91	-
887	Methylation	ETGLASKKGLKAGDE HHCCCCCCCCCCCHH	67.96	-
989	Phosphorylation	EGPDLESSDETDHSS CCCCCCCCCCCCCCC	30.05	-
992	Phosphorylation	DLESSDETDHSSKST CCCCCCCCCCCCCCH	43.96	-
998	Phosphorylation	ETDHSSKSTEQVAAF CCCCCCCCHHHHHHH	38.84	-
1008	Phosphorylation	QVAAFCRSLHEMNPS HHHHHHHHHHHCCCC	34.95	27732954
1015	Phosphorylation	SLHEMNPSDQSPSPQ HHHHCCCCCCCCCCC	43.19	29978859
1018	Phosphorylation	EMNPSDQSPSPQDST HCCCCCCCCCCCCCC	32.13	22199227
1020	Phosphorylation	NPSDQSPSPQDSTGP CCCCCCCCCCCCCCH	40.20	22199227
1024	Phosphorylation	QSPSPQDSTGPQLAT CCCCCCCCCCHHHHH	29.98	27732954
1025	Phosphorylation	SPSPQDSTGPQLATM CCCCCCCCCHHHHHH	62.26	27732954
1031	Phosphorylation	STGPQLATMRQLSDA CCCHHHHHHHHHCCH	22.83	28122231
1036	Phosphorylation	LATMRQLSDADKLRK HHHHHHHCCHHHHHH	23.55	29496963
1040	Acetylation	RQLSDADKLRKVICE HHHCCHHHHHHHHHH	52.49	25953088
1142	Phosphorylation	YADRFKLYSAFCASH HHHHHHHHHHHHHHC	9.88	20166139
1143	Phosphorylation	ADRFKLYSAFCASHT HHHHHHHHHHHHHCC	25.88	20166139
1317	Phosphorylation	QKKKLVGSHRLSIYE HHEEEECCEEEECCC	9.65	-
1321	Phosphorylation	LVGSHRLSIYEDWDP EECCEEEECCCCCCC	24.07	29978859
1323	Phosphorylation	GSHRLSIYEDWDPFR CCEEEECCCCCCCHH	12.40	25884760
1337	Phosphorylation	RFRHMIPTEALQVRA HCCCCCCCHHHHHHH	23.98	-
1397	Trimethylation	VHSILRDKHRRQLLK HHHHHCHHHHHHHHH	32.36	-
1397	Methylation	VHSILRDKHRRQLLK HHHHHCHHHHHHHHH	32.36	-
1405	Phosphorylation	HRRQLLKTESLPSSQ HHHHHHHCCCCCCCC	30.67	29978859
1407	Phosphorylation	RQLLKTESLPSSQQY HHHHHCCCCCCCCCC	51.30	23401153
1410	Phosphorylation	LKTESLPSSQQYVPF HHCCCCCCCCCCCCC	46.18	29978859
1411	Phosphorylation	KTESLPSSQQYVPFG HCCCCCCCCCCCCCC	21.26	23684312
1414	Phosphorylation	SLPSSQQYVPFGGKR CCCCCCCCCCCCCEE	11.49	21406692
1420	Acetylation	QYVPFGGKRLCALKG CCCCCCCEEHHHHCC	42.44	24468117
1433	Phosphorylation	KGARPAMSRAVSAPS CCCHHHHHHHHCCCC	21.13	29449344
1437	Phosphorylation	PAMSRAVSAPSKSLG HHHHHHHCCCCCHHH	33.21	26657352
1440	Phosphorylation	SRAVSAPSKSLGRRR HHHHCCCCCHHHHHH	34.29	29449344
1442	Phosphorylation	AVSAPSKSLGRRRRR HHCCCCCHHHHHHHH	40.15	24719451
1456	Phosphorylation	RLARNRFTIDSDAVS HHHHCCEECCCCCCC	22.19	23401153
1459	Phosphorylation	RNRFTIDSDAVSASS HCCEECCCCCCCCCC	24.50	23401153
1463	Phosphorylation	TIDSDAVSASSPEKE ECCCCCCCCCCCCCH	24.93	30266825
1465	Phosphorylation	DSDAVSASSPEKESQ CCCCCCCCCCCCHHC	38.63	25849741
1466	Phosphorylation	SDAVSASSPEKESQQ CCCCCCCCCCCHHCC	36.47	19664994
1471	Phosphorylation	ASSPEKESQQPPGGG CCCCCCHHCCCCCCC	45.22	30624053
1502	Phosphorylation	EQDDIKETDILSDDD CCCCCCCCCCCCCCH	24.28	29514088
1506	Phosphorylation	IKETDILSDDDEFCE CCCCCCCCCCHHHHH	39.05	19664994
1519	Phosphorylation	CESVKGASVDRDLQE HHHCCCCCCCHHHHH	32.97	23401153
1531	Phosphorylation	LQERLQATSISQRER HHHHHHHHCHHHHHH	17.40	23312004
1532	Phosphorylation	QERLQATSISQRERG HHHHHHHCHHHHHHH	24.21	23312004
1534	Phosphorylation	RLQATSISQRERGRK HHHHHCHHHHHHHHH	23.97	29978859
1542	Phosphorylation	QRERGRKTLDSHASR HHHHHHHHHHHHHHH	34.14	17322306
1560	Phosphorylation	LKKQAALSGINGGLE HHHHHHHCCCCCCCC	32.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
231	S	Phosphorylation	Kinase	AKT1	P31749	PSP
329	S	Phosphorylation	Kinase	CK1A	P48729	PSP
384	Y	Phosphorylation	Kinase	SRC	P12931	GPS
829	Y	Phosphorylation	Kinase	NTRK2	Q16620	Uniprot
1466	S	Phosphorylation	Kinase	CDK1	P06493	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:25124033

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TIAM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TIAM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEB2_HUMAN	PPP1R9B	physical	12531897
JIP2_HUMAN	MAPK8IP2	physical	12024021
JIP1_HUMAN	MAPK8IP1	physical	12024021
RAC1_HUMAN	RAC1	physical	11130063
RAC1_HUMAN	RAC1	physical	11595749
ANK1_HUMAN	ANK1	physical	10893266
ANK3_HUMAN	ANK3	physical	10893266
FBW1A_HUMAN	BTRC	physical	25124033
KC1A_HUMAN	CSNK1A1	physical	25124033
KC1E_HUMAN	CSNK1E	physical	25124033
KCTD3_HUMAN	KCTD3	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
CING_HUMAN	CGN	physical	27173435
MAST3_HUMAN	MAST3	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
NF1_HUMAN	NF1	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
UBP21_HUMAN	USP21	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
AN34A_HUMAN	ANKRD34A	physical	27173435
FA53C_HUMAN	FAM53C	physical	27173435
NADK_HUMAN	NADK	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
PKHA7_HUMAN	PLEKHA7	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TIAM1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356 AND SER-358, ANDMASS SPECTROMETRY.	19413330 [Abstract]