| UniProt ID | JIP2_HUMAN | |
|---|---|---|
| UniProt AC | Q13387 | |
| Protein Name | C-Jun-amino-terminal kinase-interacting protein 2 | |
| Gene Name | MAPK8IP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 824 | |
| Subcellular Localization | Cytoplasm. Accumulates in cell surface projections. | |
| Protein Description | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).. | |
| Protein Sequence | MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSLSLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPAPGPLIPSPSVEEPHKHRPTTLRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALRELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPAPGGTSPSSDPGIEADLRSRSSGGRGGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSSGRSSHLTNSIEEASSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPPAPAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEEDAEDSAGSPGGRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDSGGEASEEEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 (in isoform 2) | Phosphorylation | - | 2.42 | - | |
| 7 (in isoform 3) | Phosphorylation | - | 2.42 | - | |
| 61 | Phosphorylation | HCEKDSLSLGRSEQP CCCCCCCCCCCCCCC | 32.50 | 27499020 | |
| 173 | Phosphorylation | WQETALCSPAPEALR HHHHCEECCCHHHHH | 25.58 | 27732954 | |
| 189 | Phosphorylation | LPGPLPATDTGPGGA CCCCCCCCCCCCCCC | 31.96 | 28348404 | |
| 191 | Phosphorylation | GPLPATDTGPGGAQS CCCCCCCCCCCCCCC | 40.70 | 28348404 | |
| 194 (in isoform 4) | Ubiquitination | - | 45.47 | 21890473 | |
| 198 | Phosphorylation | TGPGGAQSPVRPGCD CCCCCCCCCCCCCCC | 25.48 | 28348404 | |
| 236 | Phosphorylation | EADLRSRSSGGRGGR CHHHHCCCCCCCCCC | 34.28 | 23532336 | |
| 237 | Phosphorylation | ADLRSRSSGGRGGRR HHHHCCCCCCCCCCC | 44.12 | 23532336 | |
| 240 | Methylation | RSRSSGGRGGRRSSQ HCCCCCCCCCCCCCC | 48.17 | 115386351 | |
| 245 | Phosphorylation | GGRGGRRSSQELSSP CCCCCCCCCCCCCCC | 34.70 | 27732954 | |
| 246 | Phosphorylation | GRGGRRSSQELSSPG CCCCCCCCCCCCCCC | 26.34 | 20363803 | |
| 250 | Phosphorylation | RRSSQELSSPGSDSE CCCCCCCCCCCCCCC | 33.46 | 27732954 | |
| 251 | Phosphorylation | RSSQELSSPGSDSED CCCCCCCCCCCCCCC | 46.00 | 28985074 | |
| 254 | Phosphorylation | QELSSPGSDSEDAGG CCCCCCCCCCCCCHH | 41.15 | 20363803 | |
| 256 | Phosphorylation | LSSPGSDSEDAGGAR CCCCCCCCCCCHHHH | 38.79 | 27251275 | |
| 269 | Phosphorylation | ARLGRMISSISETEL HHHHHHHHCCCEEEE | 16.57 | 27251275 | |
| 270 | Phosphorylation | RLGRMISSISETELE HHHHHHHCCCEEEEE | 21.14 | 27251275 | |
| 272 | Phosphorylation | GRMISSISETELELS HHHHHCCCEEEEEEC | 40.17 | 26471730 | |
| 274 | Phosphorylation | MISSISETELELSSD HHHCCCEEEEEECCC | 38.79 | 26471730 | |
| 279 | Phosphorylation | SETELELSSDGGSSS CEEEEEECCCCCCCC | 19.60 | - | |
| 280 (in isoform 3) | Ubiquitination | - | 53.55 | 21890473 | |
| 287 (in isoform 4) | Ubiquitination | - | 39.92 | 21890473 | |
| 302 | Phosphorylation | NSIEEASSPASEPEP CCHHHHCCCCCCCCC | 31.37 | - | |
| 305 | Phosphorylation | EEASSPASEPEPPRE HHHCCCCCCCCCCCC | 58.00 | - | |
| 360 | Phosphorylation | NLVSRMISEGSSPIR HHHHHHHHCCCCCCC | 26.93 | 27732954 | |
| 363 | Phosphorylation | SRMISEGSSPIRCPG HHHHHCCCCCCCCCC | 28.96 | 27732954 | |
| 364 | Phosphorylation | RMISEGSSPIRCPGQ HHHHCCCCCCCCCCC | 34.89 | 27732954 | |
| 373 (in isoform 3) | Ubiquitination | - | 5.44 | 21890473 | |
| 468 | Phosphorylation | RACSAACSEEEDEED CCCCCCCCCCCCCCC | 43.23 | 24719451 | |
| 525 | Phosphorylation | HTQLELVSLRRCAGL CCCEEEEEHHHHCCC | 28.87 | 24719451 | |
| 531 | Ubiquitination | VSLRRCAGLGHDSEE EEHHHHCCCCCCCCC | 35.50 | 21890473 | |
| 538 | Ubiquitination | GLGHDSEEDSGGEAS CCCCCCCCCCCCCCC | 62.52 | 21890473 | |
| 548 (in isoform 2) | Ubiquitination | - | 48.64 | 21890473 | |
| 575 (in isoform 1) | Ubiquitination | - | 54.61 | 21890473 | |
| 575 | Ubiquitination | PDLTFSKKFLNVFVN CCCCCCHHHHHEECC | 54.61 | 21890473 | |
| 576 | Ubiquitination | DLTFSKKFLNVFVNS CCCCCHHHHHEECCC | 7.44 | 21890473 | |
| 583 | Phosphorylation | FLNVFVNSTSRSSST HHHEECCCCCCCCCC | 23.58 | 24076635 | |
| 624 | Ubiquitination | PRHPDELELDVDDPV CCCCCCCCCCCCCCE | 40.66 | 21890473 | |
| 631 | Ubiquitination | ELDVDDPVLVEAEED CCCCCCCEEEEECCC | 13.88 | 21890473 | |
| 641 (in isoform 2) | Ubiquitination | - | 6.77 | 21890473 | |
| 668 (in isoform 1) | Ubiquitination | - | 52.63 | 21890473 | |
| 668 | Ubiquitination | HAVPGPAKDLLGSKR ECCCCCHHHHCCCCC | 52.63 | 21890473 | |
| 669 | Ubiquitination | AVPGPAKDLLGSKRS CCCCCHHHHCCCCCC | 49.59 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of JIP2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of JIP2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of JIP2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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