KIFC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIFC2_HUMAN
• UniProt AC: Q96AC6
• Protein Name: Kinesin-like protein KIFC2
• Gene Name: KIFC2
• Organism: Homo sapiens (Human).
• Sequence Length: 838
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity)..
• Protein Sequence: MYAFYSLLIYIFYSLFRRDGGAAAAAEPGDPAQRARKPRGRRRPDLPAPELWTELTGLAASSEPEDGSEGAAEGRAAAVSLEEALLRLAEFLSVQLGAEESCGGPADLGQSGEVPSLLTVTSQLLALLAWLRSPRGRQALLQGTQPAPRVRPPSPDGSTSQEESPSHFTAVPGEPLGDETQGQQPLQLEEDQRAWQRLEQLILGQLEELKQQLEQQEEELGRLRLGVGATDSEKRVQHLTLENEALKQSLSLMRDLLLHWGPGPPIRAPQEEAEALLELQGRLQEAQDTTEALRAQLGVQEVQLQGLQGALQQLQQETEQNCRRELQQMHGQLAGLRARMASLRQGCGDLRGLVSTFTQSCQGSLSEARGQVSWALGALSSGGPGTQLPEGQQGPPAGCPGRLPELKGNIRVLCRLRPGTSSSLVSVEPGPGGTVTTCYRGRHRRFRLDWVFPPDASQEEVFRELEPAVLSCLRGYSVCIFTYGQTGTGKTYSMEGPPEDPGIVPRALQSLFREMGAGRQHRVTLSMVEIYNEAVRDLLAPGPPERLAVRQGPEGQGGIQVAGLTHWDVPNLETLHQMLKLGRSNRATAATAMNQRSSRSHALVTLTLRAASPPRAPGTAGTLHLVDLAGSERARKAGAAGPPRGDPDGARRLREAQTINRSLLALGGVMAALRAHRPHVPFRDSQLTRLLQPALGPGTTAVLLLQVGAGAGQVCACRSPPTRARPPAPLARRSPRGRRISGRQSAPSSSPTEWVKWSWGQPGAAGSRAPPGRLLPSAPTLRSPGPPAPLRRPLAVLHAPVPTTARARLSRPQRACPSSPGSRPCPWGLRPGLCWQRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYAFYSLLI ------CHHHHHHHH	12.86	26552605
5	Phosphorylation	---MYAFYSLLIYIF ---CHHHHHHHHHHH	7.10	27251275
6	Phosphorylation	--MYAFYSLLIYIFY --CHHHHHHHHHHHH	15.39	26552605
10	Phosphorylation	AFYSLLIYIFYSLFR HHHHHHHHHHHHHHC	5.73	26552605
13	Phosphorylation	SLLIYIFYSLFRRDG HHHHHHHHHHHCCCC	8.56	26552605
14	Phosphorylation	LLIYIFYSLFRRDGG HHHHHHHHHHCCCCC	15.41	24043423
133	Phosphorylation	ALLAWLRSPRGRQAL HHHHHHHCHHHHHHH	19.44	17081983
154	Phosphorylation	APRVRPPSPDGSTSQ CCCCCCCCCCCCCCC	38.00	28348404
230	Phosphorylation	LRLGVGATDSEKRVQ HCCCCCCCCHHHHHH	33.84	23403867
232	Phosphorylation	LGVGATDSEKRVQHL CCCCCCCHHHHHHHH	40.43	23403867
249	Phosphorylation	ENEALKQSLSLMRDL CHHHHHHHHHHHHHH	20.52	23898821
342	Phosphorylation	GLRARMASLRQGCGD HHHHHHHHHHCCCHH	18.10	26552605
420	Phosphorylation	LCRLRPGTSSSLVSV EEEECCCCCCCEEEE	28.28	-
421	Phosphorylation	CRLRPGTSSSLVSVE EEECCCCCCCEEEEE	24.68	-
422	Phosphorylation	RLRPGTSSSLVSVEP EECCCCCCCEEEEEC	27.77	-
471	Phosphorylation	ELEPAVLSCLRGYSV HHHHHHHHHHCCCEE	12.42	24719451
491	Phosphorylation	GQTGTGKTYSMEGPP CCCCCCCEEECCCCC	23.36	22210691
493	Phosphorylation	TGTGKTYSMEGPPED CCCCCEEECCCCCCC	18.65	22210691
591	Phosphorylation	SNRATAATAMNQRSS CCHHHHHHHHHHHHC	24.79	-
612	Phosphorylation	TLTLRAASPPRAPGT EEEEECCCCCCCCCC	34.16	24076635
619	Phosphorylation	SPPRAPGTAGTLHLV CCCCCCCCCEEEEEE	22.36	27080861
622	Phosphorylation	RAPGTAGTLHLVDLA CCCCCCEEEEEEECC	14.45	24719451
631	Phosphorylation	HLVDLAGSERARKAG EEEECCCCHHHHHCC	20.50	24719451
658	Phosphorylation	RRLREAQTINRSLLA HHHHHHHHHCHHHHH	27.54	-
662	Phosphorylation	EAQTINRSLLALGGV HHHHHCHHHHHHHHH	24.21	-
734	Phosphorylation	PAPLARRSPRGRRIS CCCCCCCCCCCCCCC	17.25	17081983
741	Phosphorylation	SPRGRRISGRQSAPS CCCCCCCCCCCCCCC	26.55	-
777	Phosphorylation	PPGRLLPSAPTLRSP CCCCCCCCCCCCCCC	47.02	23312004
780	Phosphorylation	RLLPSAPTLRSPGPP CCCCCCCCCCCCCCC	34.22	23312004
783	Phosphorylation	PSAPTLRSPGPPAPL CCCCCCCCCCCCCCC	37.00	24043423
803	Phosphorylation	VLHAPVPTTARARLS EEECCCCCCHHHHHC	33.06	24043423
804	Phosphorylation	LHAPVPTTARARLSR EECCCCCCHHHHHCC	14.21	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIFC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIFC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIFC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TEAD3_HUMAN	TEAD3	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.