FGF13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGF13_HUMAN
• UniProt AC: Q92913
• Protein Name: Fibroblast growth factor 13
• Gene Name: FGF13
• Organism: Homo sapiens (Human).
• Sequence Length: 245
• Subcellular Localization: Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus . Cytoplasm . Not secreted..; Isoform 1: Nucleus, nucleolus.; Isoform 2: Cytoplasm. Nucleus.
• Protein Description: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.; May regulate voltage-gated sodium channels transport and function.; May also play a role in MAPK signaling..
• Protein Sequence: MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 4)	Phosphorylation	-	12.95	22468782
2 (in isoform 3)	Phosphorylation	-	12.95	22468782
6	Phosphorylation	--MAAAIASSLIRQK --CHHHHHHHHHHHH	6.58	-
6 (in isoform 5)	Phosphorylation	-	6.58	26471730
6 (in isoform 4)	Phosphorylation	-	6.58	22468782
6 (in isoform 3)	Phosphorylation	-	6.58	22468782
7 (in isoform 2)	Phosphorylation	-	21.40	24719451
8	Phosphorylation	MAAAIASSLIRQKRQ CHHHHHHHHHHHHHH	20.85	24719451
9	Phosphorylation	AAAIASSLIRQKRQA HHHHHHHHHHHHHHH	3.29	-
9 (in isoform 5)	Phosphorylation	-	3.29	26471730
22 (in isoform 2)	Phosphorylation	-	25.55	24719451
28 (in isoform 3)	Phosphorylation	-	3.77	27642862
35 (in isoform 3)	Phosphorylation	-	40.79	26471730
38 (in isoform 3)	Phosphorylation	-	11.91	26471730
40 (in isoform 5)	Phosphorylation	-	61.38	25332170
69 (in isoform 3)	Phosphorylation	-	3.21	25332170
75	Phosphorylation	GIVTKLYSRQGYHLQ HHHHHHHHCCCCEEE	28.67	24719451
155 (in isoform 2)	Phosphorylation	-	6.68	24719451
204	Phosphorylation	KPLKVAMYKEPSLHD CCEEEEEECCCCHHH	11.49	22617229
208	Phosphorylation	VAMYKEPSLHDLTEF EEEECCCCHHHHCCC	39.15	30266825
213	Phosphorylation	EPSLHDLTEFSRSGS CCCHHHHCCCCCCCC	40.83	23186163
216	Phosphorylation	LHDLTEFSRSGSGTP HHHHCCCCCCCCCCC	21.21	27135362
218 (in isoform 3)	Phosphorylation	-	35.79	27251275
228	Phosphorylation	GTPTKSRSVSGVLNG CCCCCCCCEEEEECC	27.94	26437602
230	Phosphorylation	PTKSRSVSGVLNGGK CCCCCCEEEEECCCC	25.16	23911959

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGF13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGF13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGF13_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FGF13_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.