ISK2_HUMAN - dbPTM
ISK2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ISK2_HUMAN
UniProt AC P20155
Protein Name Serine protease inhibitor Kazal-type 2
Gene Name SPINK2
Organism Homo sapiens (Human).
Sequence Length 84
Subcellular Localization Secreted.
Protein Description Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin..
Protein Sequence MALSVLRLALLLLAVTFAASLIPQFGLFSKYRTPNCSQYRLPGCPRHFNPVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MALSVLRLALL
----CHHHHHHHHHH		15.0124719451
24Pyrrolidone_carboxylic_acidFAASLIPQFGLFSKY
HHHHHHHHHCCCCCC		37.74-
24Pyrrolidone_carboxylic_acidFAASLIPQFGLFSKY
HHHHHHHHHCCCCCC		37.742226783
24Pyrrolidone_carboxylic_acidFAASLIPQFGLFSKY
HHHHHHHHHCCCCCC		37.742226783
29PhosphorylationIPQFGLFSKYRTPNC
HHHHCCCCCCCCCCC		33.5424719451
30UbiquitinationPQFGLFSKYRTPNCS
HHHCCCCCCCCCCCH		31.27-
33PhosphorylationGLFSKYRTPNCSQYR
CCCCCCCCCCCHHCC		18.7622210691
54PhosphorylationHFNPVCGSDMSTYAN
CCCCCCCCCHHHCCC		25.6430576142
58PhosphorylationVCGSDMSTYANECTL
CCCCCHHHCCCCCEE		21.7322210691
77UbiquitinationREGGHNIKIIRNGPC
CCCCCCEEEEECCCC		37.08-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ISK2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ISK2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ISK2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATL4_HUMANADAMTSL4physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
GFRP_HUMANGCHFRphysical
28514442
ATP5S_HUMANATP5Sphysical
28514442
NUDT8_HUMANNUDT8physical
28514442
MIPEP_HUMANMIPEPphysical
28514442
DCA15_HUMANDCAF15physical
28514442
CT2NL_HUMANCTTNBP2NLphysical
28514442
PRDC1_HUMANPRTFDC1physical
28514442
UBR2_HUMANUBR2physical
28514442
PDP2_HUMANPDP2physical
28514442
IDE_HUMANIDEphysical
28514442
MPPB_HUMANPMPCBphysical
28514442
RSPRY_HUMANRSPRY1physical
28514442
MPPA_HUMANPMPCAphysical
28514442
PHOCN_HUMANMOB4physical
28514442
STRP1_HUMANSTRIP1physical
28514442
IKIP_HUMANIKBIPphysical
28514442
STRN_HUMANSTRNphysical
28514442
UBR1_HUMANUBR1physical
28514442
STRN3_HUMANSTRN3physical
28514442
STRN4_HUMANSTRN4physical
28514442
VATD_HUMANATP6V1Dphysical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ISK2_HUMAN

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Related Literatures of Post-Translational Modification
Pyrrolidone carboxylic acid
ReferencePubMed
"Amino acid sequence elucidation of human acrosin-trypsin inhibitor(HUSI-II) reveals that Kazal-type proteinase inhibitors arestructurally related to beta-subunits of glycoprotein hormones.";
Fink E., Hehlein-Fink C., Eulitz M.;
FEBS Lett. 270:222-224(1990).
Cited for: PROTEIN SEQUENCE OF 24-84.

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