NUDT8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUDT8_HUMAN
• UniProt AC: Q8WV74
• Protein Name: Nucleoside diphosphate-linked moiety X motif 8
• Gene Name: NUDT8
• Organism: Homo sapiens (Human).
• Sequence Length: 236
• Protein Description: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives..
• Protein Sequence: MLPDCLSAEGELRCRRLLAGATARLRARPASAAVLVPLCSVRGVPALLYTLRSSRLTGRHKGDVSFPGGKCDPADQDVVHTALRETREELGLAVPEEHVWGLLRPVYDPQKATVVPVLAGVGPLDPQSLRPNSEEVDEVFALPLAHLLQTQNQGYTHFCRGGHFRYTLPVFLHGPHRVWGLTAVITEFALQLLAPGTYQPRLAGLTCSGAEGLARPKQPLASPCQASSTPGLNKGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	RRLLAGATARLRARP HHHHCHHHHHHHCCC	16.05	24719451
40	Phosphorylation	AVLVPLCSVRGVPAL EEHHCCCCCCCCCHH	23.64	-
50	Phosphorylation	GVPALLYTLRSSRLT CCCHHHHHHHHCCCC	18.70	24719451
61	Ubiquitination	SRLTGRHKGDVSFPG CCCCCCCCCCCCCCC	56.28	-
61	Malonylation	SRLTGRHKGDVSFPG CCCCCCCCCCCCCCC	56.28	26320211
70	Succinylation	DVSFPGGKCDPADQD CCCCCCCCCCHHHCH	41.18	-
70	Ubiquitination	DVSFPGGKCDPADQD CCCCCCCCCCHHHCH	41.18	29967540
70	Succinylation	DVSFPGGKCDPADQD CCCCCCCCCCHHHCH	41.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUDT8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUDT8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUDT8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NUDT8_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.