VATD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATD_HUMAN
• UniProt AC: Q9Y5K8
• Protein Name: V-type proton ATPase subunit D
• Gene Name: ATP6V1D
• Organism: Homo sapiens (Human).
• Sequence Length: 247
• Subcellular Localization: Membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to centrosome and the base of the cilium.
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium..
• Protein Sequence: MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGKDRIEI ------CCCCCCEEC	55.33	27251275
4	Methylation	----MSGKDRIEIFP ----CCCCCCEECCH	36.20	-
6	Methylation	--MSGKDRIEIFPSR --CCCCCCEECCHHH	31.74	-
12	Phosphorylation	DRIEIFPSRMAQTIM CCEECCHHHHHHHHH	24.76	27251275
13	Methylation	RIEIFPSRMAQTIMK CEECCHHHHHHHHHH	25.37	-
20	Methylation	RMAQTIMKARLKGAQ HHHHHHHHHHHCCHH	26.89	-
20	Acetylation	RMAQTIMKARLKGAQ HHHHHHHHHHHCCHH	26.89	19819281
20	Ubiquitination	RMAQTIMKARLKGAQ HHHHHHHHHHHCCHH	26.89	-
24	Ubiquitination	TIMKARLKGAQTGRN HHHHHHHCCHHHHHH	46.80	-
89	Ubiquitination	TVIQNVNKAQVKIRA HHEECCCHHHHEEEE	35.59	-
98	Ubiquitination	QVKIRAKKDNVAGVT HHEEEECCCCCCCEE	54.25	-
105	Phosphorylation	KDNVAGVTLPVFEHY CCCCCCEEEEEECCC	25.15	26552605
112	Phosphorylation	TLPVFEHYHEGTDSY EEEEECCCCCCCCCC	8.38	29978859
116	Phosphorylation	FEHYHEGTDSYELTG ECCCCCCCCCCCCCC	20.84	28796482
118	Phosphorylation	HYHEGTDSYELTGLA CCCCCCCCCCCCCCH	21.98	28796482
119	Phosphorylation	YHEGTDSYELTGLAR CCCCCCCCCCCCCHH	20.12	25884760
122	Phosphorylation	GTDSYELTGLARGGE CCCCCCCCCCHHCHH	20.43	28796482
133	Ubiquitination	RGGEQLAKLKRNYAK HCHHHHHHHHHHHHH	64.23	-
186	Phosphorylation	RIERTLAYIITELDE HHHHHHHHHHHHCCH	8.93	27811184
189	Phosphorylation	RTLAYIITELDERER HHHHHHHHHCCHHHH	22.42	27811184
200	Phosphorylation	EREREEFYRLKKIQE HHHHHHHHHHHHHHH	20.51	27811184
216	Phosphorylation	KKILKEKSEKDLEQR HHHHHHHCHHHHHHH	51.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATE1_HUMAN	ATP6V1E1	physical	22939629
VATH_HUMAN	ATP6V1H	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
VPP3_HUMAN	TCIRG1	physical	22939629
VPP1_HUMAN	ATP6V0A1	physical	22939629
VPP2_HUMAN	ATP6V0A2	physical	22939629
XPP1_HUMAN	XPNPEP1	physical	22939629
CI016_HUMAN	C9orf16	physical	25416956
AIMP2_HUMAN	AIMP2	physical	26344197
VA0D1_HUMAN	ATP6V0D1	physical	26344197
VATA_HUMAN	ATP6V1A	physical	26344197
VATB2_HUMAN	ATP6V1B2	physical	26344197
VATF_HUMAN	ATP6V1F	physical	26344197
VATH_HUMAN	ATP6V1H	physical	26344197
COMD8_HUMAN	COMMD8	physical	26344197
CUL2_HUMAN	CUL2	physical	26344197
MCMBP_HUMAN	MCMBP	physical	26344197
SC31A_HUMAN	SEC31A	physical	26344197
XPP1_HUMAN	XPNPEP1	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.