VPP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPP3_HUMAN
• UniProt AC: Q13488
• Protein Name: V-type proton ATPase 116 kDa subunit a isoform 3
• Gene Name: TCIRG1
• Organism: Homo sapiens (Human).
• Sequence Length: 830
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation..
• Protein Sequence: MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTFTFLQEEVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKITDCFHCHVFPFLQQEEARLGALQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMKAVYLALNQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSSMEEGVSAVAHRIPCRDMPPTLIRTNRFTASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFSRATSIFPSGWSVAAMANQSGWSDAFLAQHTMLTLDPNVTGVFLGPYPFGIDPIWSLAANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQRHRLLLETLPELTFLLGLFGYLVFLVIYKWLCVWAARAASAPSILIHFINMFLFSHSPSNRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEENKAGLLDLPDASVNGWSSDEEKAGGLDDEEEAELVPSEVLMHQAIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREVGVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFAATDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSMFRSEEV -----CCCCCCCHHH	17.28	24043423
7	Phosphorylation	-MGSMFRSEEVALVQ -CCCCCCCHHHHHHH	27.18	24043423
19	Phosphorylation	LVQLFLPTAAAYTCV HHHHHHHHHHHHHHH	30.95	24043423
23	Phosphorylation	FLPTAAAYTCVSRLG HHHHHHHHHHHHHHH	8.92	24043423
24	Phosphorylation	LPTAAAYTCVSRLGE HHHHHHHHHHHHHHH	11.16	24043423
27	Phosphorylation	AAAYTCVSRLGELGL HHHHHHHHHHHHCCC	24.76	24043423
45	Phosphorylation	RDLNASVSAFQRRFV ECCCCCCHHHHHHHE	22.37	21964256
152	Phosphorylation	TDGASERTPLLQAPG CCCCCCCCCCCCCCC	17.78	28674419
178	Ubiquitination	AGAVEPHKAPALERL EECCCCCCCHHHHHH	67.77	21906983
178 (in isoform 1)	Ubiquitination	-	67.77	21906983
218	Phosphorylation	GEPATWMTFLISYWG CCCCHHHHHHHHHHH	13.57	24043423
222	Phosphorylation	TWMTFLISYWGEQIG HHHHHHHHHHHHHHH	19.58	24043423
223	Phosphorylation	WMTFLISYWGEQIGQ HHHHHHHHHHHHHHH	15.50	24043423
303	Phosphorylation	VHKMKAVYLALNQCS HHHHHHHHHHHHCCC	7.36	-
368	Phosphorylation	LIRTNRFTASFQGIV EEECCCCEECCCCCH	20.39	24043423
370	Phosphorylation	RTNRFTASFQGIVDA ECCCCEECCCCCHHH	18.29	24043423
378	Phosphorylation	FQGIVDAYGVGRYQE CCCCHHHHCCCCCCC	14.10	24043423
459 (in isoform 2)	Ubiquitination	-	4.06	21906983
675	Ubiquitination	ADRQEENKAGLLDLP CCHHHHHCCCCCCCC	47.30	2190698
675 (in isoform 1)	Ubiquitination	-	47.30	21906983
685	Phosphorylation	LLDLPDASVNGWSSD CCCCCCCCCCCCCCH	24.40	25627689
690	Phosphorylation	DASVNGWSSDEEKAG CCCCCCCCCHHHHCC	29.34	30108239
691	Phosphorylation	ASVNGWSSDEEKAGG CCCCCCCCHHHHCCC	42.40	29507054
819	Ubiquitination	FYSGTGYKLSPFTFA CCCCCCCCCCCEEEE	43.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZNT5_HUMAN	SLC30A5	physical	22939629
TERF1_HUMAN	TERF1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• H00436: Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermed
• OMIM Disease
• 259700: Osteopetrosis, autosomal recessive 1 (OPTB1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.