ZNT5_HUMAN - dbPTM
ZNT5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZNT5_HUMAN
UniProt AC Q8TAD4
Protein Name Zinc transporter 5
Gene Name SLC30A5
Organism Homo sapiens (Human).
Sequence Length 765
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Multi-pass membrane protein . Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.
Protein Description Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP..
Protein Sequence MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEEKYGGD
-------CCCCCCCC		15.7522814378
5Phosphorylation---MEEKYGGDVLAG
---CCCCCCCCCCCC		29.6222210691
30PhosphorylationDVPSARLTKYIVLLC
CCCHHHHHHHHHHHH		19.0927251275
32PhosphorylationPSARLTKYIVLLCFT
CHHHHHHHHHHHHHH		7.3327251275
39PhosphorylationYIVLLCFTKFLKAVG
HHHHHHHHHHHHHHC		21.6427251275
47 (in isoform 4)Phosphorylation-3.28-
48UbiquitinationFLKAVGLFESYDLLK
HHHHHCCHHCHHHHH		4.8829967540
54 (in isoform 4)Phosphorylation-2.82-
88 (in isoform 3)Phosphorylation-27.92-
89UbiquitinationSSGKTITKHQWIKIF
CCCCEECHHHHHHHH		29.9229967540
95 (in isoform 3)Phosphorylation-4.02-
194UbiquitinationLTHMLYTAIAFLGVA
HHHHHHHHHHHHCCC		4.2327667366
200 (in isoform 2)Ubiquitination-6.5121906983
228PhosphorylationHTASRKLSVDVGGAK
CCCCCCEECCCCHHH		21.2123532336
235UbiquitinationSVDVGGAKRLQALSH
ECCCCHHHHHHHHHH		57.8427667366
326UbiquitinationFWTHPITDQLRAMNK
CCCCHHHHHHHHHHH		46.3522817900
330UbiquitinationPITDQLRAMNKAAHQ
HHHHHHHHHHHHHHH		17.9422817900
364PhosphorylationLSANILSSPSKRGQK
HHHHHHCCCCCCCCC		29.73-
367UbiquitinationNILSSPSKRGQKGTL
HHHCCCCCCCCCCCE		65.0222817900
371 (in isoform 1)Ubiquitination-57.6021906983
371UbiquitinationSPSKRGQKGTLIGYS
CCCCCCCCCCEEEEC		57.6022817900
373PhosphorylationSKRGQKGTLIGYSPE
CCCCCCCCEEEECCC		23.4129523821
377PhosphorylationQKGTLIGYSPEGTPL
CCCCEEEECCCCCCC		17.6618691976
378PhosphorylationKGTLIGYSPEGTPLY
CCCEEEECCCCCCCC		15.9725849741
382PhosphorylationIGYSPEGTPLYNFMG
EEECCCCCCCCCHHH		14.4129496963
385PhosphorylationSPEGTPLYNFMGDAF
CCCCCCCCCHHHHHH		13.9325850435
396PhosphorylationGDAFQHSSQSIPRFI
HHHHHCCCCHHHHHH		26.3130631047
398PhosphorylationAFQHSSQSIPRFIKE
HHHCCCCHHHHHHHH		36.1930631047
404UbiquitinationQSIPRFIKESLKQIL
CHHHHHHHHHHHHHH		38.2429967540
666UbiquitinationELHIALEKIQKIEGL
HHHHHHHHHHHHHCC		51.8129967540
675UbiquitinationQKIEGLISYRDPHFW
HHHHCCHHCCCCCHH		21.1122505724
716UbiquitinationQVTGILKDAGVNNLT
HHHHHHHHCCCCCEE		45.1422505724
718UbiquitinationTGILKDAGVNNLTIQ
HHHHHHCCCCCEEEE		32.5922505724
754PhosphorylationAMTKQMESMKYCKDG
HHHHHHHHHHCCCCC		18.4224505115
756UbiquitinationTKQMESMKYCKDGTY
HHHHHHHHCCCCCCC		57.69-
757PhosphorylationKQMESMKYCKDGTYI
HHHHHHHCCCCCCCC		8.9724505115
759UbiquitinationMESMKYCKDGTYIM-
HHHHHCCCCCCCCC-		56.9822505724
759AcetylationMESMKYCKDGTYIM-
HHHHHCCCCCCCCC-		56.987667053
762PhosphorylationMKYCKDGTYIM----
HHCCCCCCCCC----		21.73-
763PhosphorylationKYCKDGTYIM-----
HCCCCCCCCC-----		10.66-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZNT5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZNT5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZNT5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZNT6_HUMANSLC30A6physical
21402707
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZNT5_HUMAN

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Related Literatures of Post-Translational Modification

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