ZNT6_HUMAN - dbPTM
ZNT6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZNT6_HUMAN
UniProt AC Q6NXT4
Protein Name Zinc transporter 6
Gene Name SLC30A6
Organism Homo sapiens (Human).
Sequence Length 461
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Multi-pass membrane protein. Found in vesicles..
Protein Description Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment..
Protein Sequence MGTIHLFRKPQRSFFGKLLREFRLVAADRRSWKILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFSLMTCLISYWVTLRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALCFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGIIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIPMPLLKGTDDLNPVTSTPAKPSSPPPEFSFNTPGKNVNPVILLNTQTRPYGFGLNHGHTPYSSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17UbiquitinationPQRSFFGKLLREFRL
CCHHHHHHHHHHHHH		38.9121906983
17 (in isoform 3)Ubiquitination-38.9121906983
17 (in isoform 2)Ubiquitination-38.9121890473
17 (in isoform 1)Ubiquitination-38.9121890473
76PhosphorylationFDLFSLMTCLISYWV
HHHHHHHHHHHHHHH		14.9525690035
81PhosphorylationLMTCLISYWVTLRKP
HHHHHHHHHHHCCCC		9.2625690035
84PhosphorylationCLISYWVTLRKPSPV
HHHHHHHHCCCCCCC		13.4924719451
122PhosphorylationALFILKESAERFLEQ
HHHHHHHHHHHHHHC		33.57-
184S-palmitoylationADLSRSLCGIIPGLS
HHHHHHHHCCCCCCH		3.7629575903
268UbiquitinationHVIGQLDKLIREVST
HHHHHHHHHHHHHHC		55.1721890473
268 (in isoform 3)Ubiquitination-55.1721906983
268 (in isoform 1)Ubiquitination-55.1721890473
268UbiquitinationHVIGQLDKLIREVST
HHHHHHHHHHHHHHC		55.1721890473
308 (in isoform 2)Ubiquitination-44.3021890473
356 (in isoform 3)Ubiquitination-18.8621906983
367PhosphorylationPMPLLKGTDDLNPVT
CCCCCCCCCCCCCCC		25.4226552605
374PhosphorylationTDDLNPVTSTPAKPS
CCCCCCCCCCCCCCC		28.3030108239
375PhosphorylationDDLNPVTSTPAKPSS
CCCCCCCCCCCCCCC		32.4026657352
376PhosphorylationDLNPVTSTPAKPSSP
CCCCCCCCCCCCCCC		20.2125159151
379UbiquitinationPVTSTPAKPSSPPPE
CCCCCCCCCCCCCCC		46.782190698
379 (in isoform 1)Ubiquitination-46.7821890473
381PhosphorylationTSTPAKPSSPPPEFS
CCCCCCCCCCCCCCC		55.5623401153
382PhosphorylationSTPAKPSSPPPEFSF
CCCCCCCCCCCCCCC		50.3729255136
388PhosphorylationSSPPPEFSFNTPGKN
CCCCCCCCCCCCCCC		18.8730278072
391PhosphorylationPPEFSFNTPGKNVNP
CCCCCCCCCCCCCCC		31.2625159151
419 (in isoform 2)Ubiquitination-22.7221890473
421PhosphorylationNHGHTPYSSMLNQGL
CCCCCCHHHHHCCCC		15.5218691976
421 (in isoform 2)Phosphorylation-15.5227251275
422 (in isoform 2)Phosphorylation-22.8024719451
422PhosphorylationHGHTPYSSMLNQGLG
CCCCCHHHHHCCCCC		22.8018691976
440MethylationIGATQGLRTGFTNIP
CCCCCCCCCCCCCCC		39.3630763175
440DimethylationIGATQGLRTGFTNIP
CCCCCCCCCCCCCCC		39.36-
444PhosphorylationQGLRTGFTNIPSRYG
CCCCCCCCCCCCCCC		33.3228555341
449MethylationGFTNIPSRYGTNNRI
CCCCCCCCCCCCCCC		28.6630763169
449DimethylationGFTNIPSRYGTNNRI
CCCCCCCCCCCCCCC		28.66-
455MethylationSRYGTNNRIGQPRP-
CCCCCCCCCCCCCC-		36.1630763181
455DimethylationSRYGTNNRIGQPRP-
CCCCCCCCCCCCCC-		36.16-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZNT6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZNT6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZNT6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CYTSA_HUMANSPECC1Lphysical
26186194
HDGR3_HUMANHDGFRP3physical
26186194
ACTB_HUMANACTBphysical
26186194
ACTBL_HUMANACTBL2physical
26186194
MY18A_HUMANMYO18Aphysical
26186194
CL043_HUMANC12orf43physical
26186194
MY18A_HUMANMYO18Aphysical
28514442
HDGR3_HUMANHDGFRP3physical
28514442
CL043_HUMANC12orf43physical
28514442
ACTBL_HUMANACTBL2physical
28514442
CYTSA_HUMANSPECC1Lphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZNT6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382, AND MASSSPECTROMETRY.

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