dbPTM

MY18A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MY18A_HUMAN
UniProt AC	Q92614
Protein Name	Unconventional myosin-XVIIIa
Gene Name	MYO18A
Organism	Homo sapiens (Human).
Sequence Length	2054
Subcellular Localization	Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasm, cytoskeleton. Colocalizes with actin. Isoform 2: Cytoplasm. Lacks the PDZ domain. Diffusely localized in the cytoplasm. Golgi apparatus. Golgi apparatus, trans-Golgi n
Protein Description	May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. [PubMed: 19837035]
Protein Sequence	MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSLRRGFFNLNRSSKRESKTRLEISNPIPIKVASGSDLHLTDIDSDSNRGSVILDSGHLSTASSSDDLKGEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLVQHPGPGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRVVHFAEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAGATKEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYLSDSDTEAKLTETNA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	KEKKERMSAAELRSL HHHHHHHCHHHHHHH	30.46	24670416
35	Phosphorylation	MSAAELRSLEEMSLR HCHHHHHHHHHHHHH	53.40	29255136
40	Phosphorylation	LRSLEEMSLRRGFFN HHHHHHHHHHHCCCC	23.23	23312004
51	Phosphorylation	GFFNLNRSSKRESKT CCCCCCCCCCCCCCC	38.85	23403867
52	Phosphorylation	FFNLNRSSKRESKTR CCCCCCCCCCCCCCC	32.28	29507054
56	Phosphorylation	NRSSKRESKTRLEIS CCCCCCCCCCCEEEC	43.28	24719451
58	Phosphorylation	SSKRESKTRLEISNP CCCCCCCCCEEECCC	50.17	23312004
63	Phosphorylation	SKTRLEISNPIPIKV CCCCEEECCCEEEEE	27.46	25159151
72	Phosphorylation	PIPIKVASGSDLHLT CEEEEECCCCCCEEE	41.64	30266825
74	Phosphorylation	PIKVASGSDLHLTDI EEEECCCCCCEEEEC	34.21	30266825
79	Phosphorylation	SGSDLHLTDIDSDSN CCCCCEEEECCCCCC	21.84	30266825
83	Phosphorylation	LHLTDIDSDSNRGSV CEEEECCCCCCCCCE	43.18	30266825
83 (in isoform 4)	Phosphorylation	-	43.18	18669648
85	Phosphorylation	LTDIDSDSNRGSVIL EEECCCCCCCCCEEE	32.17	30266825
89	Phosphorylation	DSDSNRGSVILDSGH CCCCCCCCEEEECCC	11.62	23663014
94	Phosphorylation	RGSVILDSGHLSTAS CCCEEEECCCCCCCC	25.35	30266825
98	Phosphorylation	ILDSGHLSTASSSDD EEECCCCCCCCCCCC	19.09	30266825
99	Phosphorylation	LDSGHLSTASSSDDL EECCCCCCCCCCCCC	36.60	30266825
101	Phosphorylation	SGHLSTASSSDDLKG CCCCCCCCCCCCCCC	30.39	30266825
101 (in isoform 4)	Phosphorylation	-	30.39	18669648
102	Phosphorylation	GHLSTASSSDDLKGE CCCCCCCCCCCCCCC	35.01	30266825
102 (in isoform 4)	Phosphorylation	-	35.01	18669648
103	Phosphorylation	HLSTASSSDDLKGEE CCCCCCCCCCCCCCC	32.42	30266825
112	Phosphorylation	DLKGEEGSFRGSVLQ CCCCCCCCCHHHHHH	18.30	30266825
116	Phosphorylation	EEGSFRGSVLQRAAK CCCCCHHHHHHHHHH	18.52	25159151
126	Phosphorylation	QRAAKFGSLAKQNSQ HHHHHHHHHHHHHHH	28.43	28355574
132	Phosphorylation	GSLAKQNSQMIVKRF HHHHHHHHHHHHHHC	20.73	25159151
137	Acetylation	QNSQMIVKRFSFSQR HHHHHHHHHCCCCHH	36.48	30590615
140	Phosphorylation	QMIVKRFSFSQRSRD HHHHHHCCCCHHCCC	28.20	29255136
140 (in isoform 4)	Phosphorylation	-	28.20	18220336
142	Phosphorylation	IVKRFSFSQRSRDES HHHHCCCCHHCCCCC	24.40	26846344
145	Phosphorylation	RFSFSQRSRDESASE HCCCCHHCCCCCCCC	36.12	23401153
149	Phosphorylation	SQRSRDESASETSTP CHHCCCCCCCCCCCC	41.19	23927012
151	Phosphorylation	RSRDESASETSTPSE HCCCCCCCCCCCCCC	51.16	23927012
153	Phosphorylation	RDESASETSTPSEHS CCCCCCCCCCCCCCC	35.09	23927012
154	Phosphorylation	DESASETSTPSEHSA CCCCCCCCCCCCCCC	33.98	23927012
155	Phosphorylation	ESASETSTPSEHSAA CCCCCCCCCCCCCCC	37.95	23927012
157	Phosphorylation	ASETSTPSEHSAAPS CCCCCCCCCCCCCCC	48.29	23927012
160	Phosphorylation	TSTPSEHSAAPSPQV CCCCCCCCCCCCCCE	23.29	29255136
164	Phosphorylation	SEHSAAPSPQVEVRT CCCCCCCCCCEEEEE	24.20	29255136
191	Phosphorylation	IPRPGHRSRAPELVT CCCCCCCCCCCCHHC	27.41	27251275
217	Phosphorylation	VVPLPPPTLRELELQ CCCCCCCCHHHHHHH	44.19	-
228	Phosphorylation	LELQRRPTGDFGFSL HHHHCCCCCCCCCCC	47.79	30266825
234	Phosphorylation	PTGDFGFSLRRTTML CCCCCCCCCEEECCC	22.73	30266825
239	Phosphorylation	GFSLRRTTMLDRGPE CCCCEEECCCCCCCC	17.58	23403867
286	Phosphorylation	INGHNVESKSRDEIV ECCCCCCCCCHHHHH	31.48	27174698
288	Phosphorylation	GHNVESKSRDEIVEM CCCCCCCCHHHHHHH	55.00	27174698
332	Phosphorylation	EGPRREPSDAKTEEQ CCCCCCCCCCCCHHH	45.51	28985074
335	Ubiquitination	RREPSDAKTEEQIAA CCCCCCCCCHHHHHH	62.55	-
336	Phosphorylation	REPSDAKTEEQIAAE CCCCCCCCHHHHHHH	46.61	24719451
351	Ubiquitination	EAWNETEKVWLVHRD HHHHHCCCEEEEECC	46.24	-
364	Phosphorylation	RDGFSLASQLKSEEL CCCCCHHHHHCCCCC	41.14	28857561
367	Ubiquitination	FSLASQLKSEELNLP CCHHHHHCCCCCCCC	48.46	-
377	Ubiquitination	ELNLPEGKVRVKLDH CCCCCCCCEEEEECC	25.80	-
381	Ubiquitination	PEGKVRVKLDHDGAI CCCCEEEEECCCCCE	37.32	-
398	Ubiquitination	VDEDDVEKANAPSCD CCHHHHHHCCCCCCC	46.95	-
403	Phosphorylation	VEKANAPSCDRLEDL HHHCCCCCCCCHHHH	26.66	24247654
415	Phosphorylation	EDLASLVYLNESSVL HHHHHHHHCCHHHHH	14.76	22817900
454	Phosphorylation	PRGAPAVYSEKVMHM CCCCCCCCCHHHHHH	17.14	21214269
455	Phosphorylation	RGAPAVYSEKVMHMF CCCCCCCCHHHHHHH	25.09	21214269
457	Acetylation	APAVYSEKVMHMFKG CCCCCCHHHHHHHCC	38.63	23749302
457	Ubiquitination	APAVYSEKVMHMFKG CCCCCCHHHHHHHCC	38.63	-
463	Methylation	EKVMHMFKGCRREDM HHHHHHHCCCCHHHC	49.91	115973513
463	Ubiquitination	EKVMHMFKGCRREDM HHHHHHHCCCCHHHC	49.91	-
493	Phosphorylation	LMSRQDQSIILLGSS HCCCCCCEEEEECCC	21.64	26074081
499	Phosphorylation	QSIILLGSSGSGKTT CEEEEECCCCCCCHH	31.34	26074081
500	Phosphorylation	SIILLGSSGSGKTTS EEEEECCCCCCCHHH	34.87	26074081
502	Phosphorylation	ILLGSSGSGKTTSCQ EEECCCCCCCHHHHH	38.78	26074081
505	Phosphorylation	GSSGSGKTTSCQHLV CCCCCCCHHHHHHHH	27.71	26074081
506	Phosphorylation	SSGSGKTTSCQHLVQ CCCCCCHHHHHHHHH	30.87	26074081
507	Phosphorylation	SGSGKTTSCQHLVQY CCCCCHHHHHHHHHH	19.60	26074081
514	Phosphorylation	SCQHLVQYLATIAGI HHHHHHHHHHHHHCC	7.27	26074081
517	Phosphorylation	HLVQYLATIAGISGN HHHHHHHHHHCCCCC	14.57	26074081
522	Phosphorylation	LATIAGISGNKVFSV HHHHHCCCCCCCCCH	35.08	26074081
528	Phosphorylation	ISGNKVFSVEKWQAL CCCCCCCCHHHHHHH	32.14	26074081
637	Ubiquitination	AKPEEKQKAAQQFSK CCHHHHHHHHHHHHH	57.67	-
643	Phosphorylation	QKAAQQFSKLQAAMK HHHHHHHHHHHHHHH	28.28	20068231
644	Ubiquitination	KAAQQFSKLQAAMKV HHHHHHHHHHHHHHH	46.00	-
650	Ubiquitination	SKLQAAMKVLGISPD HHHHHHHHHHCCCHH	29.58	-
715	Acetylation	ELSSAIFKHQHKGGT HHHHHHHHCCCCCCC	35.92	25953088
719	Ubiquitination	AIFKHQHKGGTLQRS HHHHCCCCCCCCCCC	53.09	-
722	Phosphorylation	KHQHKGGTLQRSTSF HCCCCCCCCCCCCCC	28.52	29514088
726	Phosphorylation	KGGTLQRSTSFRQGP CCCCCCCCCCCCCCC	18.55	23927012
726 (in isoform 4)	Phosphorylation	-	18.55	18669648
727	Phosphorylation	GGTLQRSTSFRQGPE CCCCCCCCCCCCCCC	33.79	20201521
728	Phosphorylation	GTLQRSTSFRQGPEE CCCCCCCCCCCCCCC	21.48	20201521
728 (in isoform 4)	Phosphorylation	-	21.48	18669648
736	Phosphorylation	FRQGPEESGLGDGTG CCCCCCCCCCCCCCC	37.34	23927012
742	Phosphorylation	ESGLGDGTGPKLSAL CCCCCCCCCCCHHHH	55.86	23403867
806	Phosphorylation	GGSARGASFEELCHN CCCCCCCCHHHHHHC	35.69	24247654
835	Phosphorylation	FVQELERYKEENIEL HHHHHHHHHHHCCEE	17.24	-
865	Phosphorylation	VDQASHQSLVRSLAR HHHHHHHHHHHHHHC	24.33	24719451
903	Phosphorylation	TLLERLFSYYGPQEG HHHHHHHHHHCCCCC	23.26	28857561
904	Phosphorylation	LLERLFSYYGPQEGD HHHHHHHHHCCCCCC	12.71	-
905	Phosphorylation	LERLFSYYGPQEGDK HHHHHHHHCCCCCCC	22.56	-
913	Ubiquitination	GPQEGDKKGQSPLLH CCCCCCCCCCCCCCC	67.91	-
916	Phosphorylation	EGDKKGQSPLLHSSK CCCCCCCCCCCCCCC	26.61	23312004
965	Phosphorylation	APRLLQDSQKKIISN CCHHCHHHHHHHHHH	30.82	23403867
967	2-Hydroxyisobutyrylation	RLLQDSQKKIISNLF HHCHHHHHHHHHHHH	50.30	-
967	Sumoylation	RLLQDSQKKIISNLF HHCHHHHHHHHHHHH	50.30	-
968	Sumoylation	LLQDSQKKIISNLFL HCHHHHHHHHHHHHC	37.32	-
971	Phosphorylation	DSQKKIISNLFLGRA HHHHHHHHHHHCCCC	30.84	26074081
980	Phosphorylation	LFLGRAGSATVLSGS HHCCCCCCEEEECCC	21.56	29255136
982	Phosphorylation	LGRAGSATVLSGSIA CCCCCCEEEECCCCC	24.55	26657352
985	Phosphorylation	AGSATVLSGSIAGLE CCCEEEECCCCCCCC	26.59	30266825
987	Phosphorylation	SATVLSGSIAGLEGG CEEEECCCCCCCCCH	13.09	23401153
995	Phosphorylation	IAGLEGGSQLALRRA CCCCCCHHHHHHHHH	32.64	22199227
1003	Phosphorylation	QLALRRATSMRKTFT HHHHHHHHHCCCCCH	22.65	27282143
1004	Phosphorylation	LALRRATSMRKTFTT HHHHHHHHCCCCCHH	18.66	27282143
1008	Phosphorylation	RATSMRKTFTTGMAA HHHHCCCCCHHCCHH	18.82	23403867
1010	Phosphorylation	TSMRKTFTTGMAAVK HHCCCCCHHCCHHHH	27.89	23186163
1011	Phosphorylation	SMRKTFTTGMAAVKK HCCCCCHHCCHHHHC	22.29	23186163
1017	Acetylation	TTGMAAVKKKSLCIQ HHCCHHHHCHHHEEE	50.16	25953088
1017	Ubiquitination	TTGMAAVKKKSLCIQ HHCCHHHHCHHHEEE	50.16	-
1037	2-Hydroxyisobutyrylation	DALIDTIKKSKLHFV HHHHHHHHHHCCEEE	53.76	-
1037	Ubiquitination	DALIDTIKKSKLHFV HHHHHHHHHHCCEEE	53.76	-
1038	Ubiquitination	ALIDTIKKSKLHFVH HHHHHHHHHCCEEEE	49.31	-
1039	Phosphorylation	LIDTIKKSKLHFVHC HHHHHHHHCCEEEEE	35.13	22817900
1060	Phosphorylation	GWAGEPRSASSRRVS CCCCCCCCCCCCCCC	43.12	26074081
1062	Phosphorylation	AGEPRSASSRRVSSS CCCCCCCCCCCCCCC	26.14	26074081
1063	Phosphorylation	GEPRSASSRRVSSSS CCCCCCCCCCCCCCC	24.67	26074081
1067	Phosphorylation	SASSRRVSSSSELDL CCCCCCCCCCCCCCC	23.77	25159151
1067 (in isoform 4)	Phosphorylation	-	23.77	18669648
1068	Phosphorylation	ASSRRVSSSSELDLP CCCCCCCCCCCCCCC	34.72	30266825
1069	Phosphorylation	SSRRVSSSSELDLPS CCCCCCCCCCCCCCC	21.96	30183078
1069 (in isoform 4)	Phosphorylation	-	21.96	18220336
1070	Phosphorylation	SRRVSSSSELDLPSG CCCCCCCCCCCCCCC	44.09	22617229
1070 (in isoform 4)	Phosphorylation	-	44.09	18669648
1076	Phosphorylation	SSELDLPSGDHCEAG CCCCCCCCCCCCCCC	65.24	30266825
1099	Phosphorylation	LRTQLRGSRLLDAMR HHHHHCCHHHHHHHH	17.20	-
1108	Phosphorylation	LLDAMRMYRQGYPDH HHHHHHHHHCCCCCC	6.87	22817900
1140	Phosphorylation	TKKHGRNYIVVDERR HCCCCCCEEEECCHH	8.17	28796482
1161	Phosphorylation	ECLDLEKSSCCMGLS HHHCHHHCCCCHHHH	21.16	22210691
1162	Phosphorylation	CLDLEKSSCCMGLSR HHCHHHCCCCHHHHH	23.54	22210691
1168	Phosphorylation	SSCCMGLSRVFFRAG CCCCHHHHHHHHHHH	22.22	22210691
1284	Phosphorylation	RNELRLNSDRLESRI HHHHHCCHHHHHHHH	28.79	-
1292	Phosphorylation	DRLESRISELTSELT HHHHHHHHHHHHHHC	25.99	20068231
1295	Phosphorylation	ESRISELTSELTDER HHHHHHHHHHHCCCC	18.99	20068231
1296	Phosphorylation	SRISELTSELTDERN HHHHHHHHHHCCCCC	43.14	20068231
1299	Phosphorylation	SELTSELTDERNTGE HHHHHHHCCCCCCCC	31.59	20068231
1304	Phosphorylation	ELTDERNTGESASQL HHCCCCCCCCCHHHH	48.85	29396449
1307	Phosphorylation	DERNTGESASQLLDA CCCCCCCCHHHHHCH	34.27	29396449
1309	Phosphorylation	RNTGESASQLLDAET CCCCCCHHHHHCHHH	30.55	21815630
1386	2-Hydroxyisobutyrylation	VREVDFTKKRLQQEF HHHCCCCHHHHHHHH	35.57	-
1386	Ubiquitination	VREVDFTKKRLQQEF HHHCCCCHHHHHHHH	35.57	-
1429	Acetylation	QRALQQLKKKCQRLT HHHHHHHHHHHHHHH	45.94	25953088
1436	Phosphorylation	KKKCQRLTAELQDTK HHHHHHHHHHHHHCH	21.92	21815630
1442	Phosphorylation	LTAELQDTKLHLEGQ HHHHHHHCHHHHCCH	23.65	-
1465	Phosphorylation	KKQRRFDSELSQAHE HHHHHHHHHHHHHHH	37.41	-
1484 (in isoform 5)	Phosphorylation	-	5.07	18669648
1490	Sulfoxidation	KLQREKDMLLAEAFS HHHHHHHHHHHHHHH	4.97	21406390
1493 (in isoform 5)	Phosphorylation	-	11.34	18669648
1497	Phosphorylation	MLLAEAFSLKQQLEE HHHHHHHHHHHHHHH	41.53	24719451
1497 (in isoform 5)	Phosphorylation	-	41.53	18669648
1501 (in isoform 5)	Phosphorylation	-	49.61	18669648
1518	Phosphorylation	GFTQKVVSLEAELQD HHHHHHHHHHHHHHH	24.39	28450419
1527	Phosphorylation	EAELQDISSQESKDE HHHHHHCCCCCCCCH	33.97	29632367
1528	Phosphorylation	AELQDISSQESKDEA HHHHHCCCCCCCCHH	38.00	29632367
1531	Phosphorylation	QDISSQESKDEASLA HHCCCCCCCCHHHHH	37.46	29632367
1536	Phosphorylation	QESKDEASLAKVKKQ CCCCCHHHHHHHHHH	27.15	29632367
1567	Sulfoxidation	EQAGTIQMLEQAKLR HHHHHHHHHHHHHHH	3.83	21406390
1583	Methylation	EMEMERMRQTHSKEM HHHHHHHHHHHHHHH	44.46	24383655
1585	Phosphorylation	EMERMRQTHSKEMES HHHHHHHHHHHHHHH	20.11	28509920
1635	Ubiquitination	EKRELEGKLATLSDQ HHHHHHHHHHHHHHH	26.10	-
1638	Phosphorylation	ELEGKLATLSDQVNR HHHHHHHHHHHHHHH	36.91	30266825
1640	Phosphorylation	EGKLATLSDQVNRRD HHHHHHHHHHHHHHH	22.95	30266825
1650	Phosphorylation	VNRRDFESEKRLRKD HHHHHHHHHHHHHHH	48.70	28102081
1728	Phosphorylation	DDIAKAKTALEEQLS HHHHHHHHHHHHHHH	41.14	-
1843	Phosphorylation	TQVKRLESLASRLKE HHHHHHHHHHHHHHH	33.55	28450419
1846	Phosphorylation	KRLESLASRLKENME HHHHHHHHHHHHHHH	43.36	23186163
1884	2-Hydroxyisobutyrylation	QRQLRDTKEEMGELA HHHHHHHHHHHHHHH	56.84	-
1887	Sulfoxidation	LRDTKEEMGELARKE HHHHHHHHHHHHHHH	5.47	21406390
1905 (in isoform 3)	Phosphorylation	-	27.89	18669648
1910	Phosphorylation	ELEMDLESLEAANQS HHHHHHHHHHHHHHH	38.51	21955146
1914 (in isoform 3)	Phosphorylation	-	12.76	18669648
1917	Phosphorylation	SLEAANQSLQADLKL HHHHHHHHHHHHHHH	23.43	21955146
1918 (in isoform 3)	Phosphorylation	-	3.33	18669648
1922 (in isoform 3)	Phosphorylation	-	5.70	18669648
1942	Phosphorylation	AIEDEMESDENEDLI HHHHHHCCCCCHHHH	49.25	25159151
1942 (in isoform 4)	Phosphorylation	-	49.25	18669648
1951	Phosphorylation	ENEDLINSLQDMVTK CCHHHHHHHHHHHHH	22.03	18669648
1951 (in isoform 4)	Phosphorylation	-	22.03	18669648
1955 (in isoform 4)	Phosphorylation	-	2.38	18669648
1957	Phosphorylation	NSLQDMVTKYQKRKN HHHHHHHHHHHHHHH	19.86	20873877
1959 (in isoform 4)	Phosphorylation	-	15.20	18669648
1970	Phosphorylation	KNKLEGDSDVDSELE HHHCCCCCCCCHHHH	50.84	29255136
1974	Phosphorylation	EGDSDVDSELEDRVD CCCCCCCHHHHHHHH	43.88	29255136
1985	Phosphorylation	DRVDGVKSWLSKNKG HHHHHHHHHHHCCCC	30.73	28122231
1988	Phosphorylation	DGVKSWLSKNKGPSK HHHHHHHHCCCCCCC	28.11	28122231
1990 (in isoform 4)	Phosphorylation	-	51.66	18669648
1994	Phosphorylation	LSKNKGPSKAASDDG HHCCCCCCCCCCCCC	43.53	28111955
1998	Phosphorylation	KGPSKAASDDGSLKS CCCCCCCCCCCCCCC	40.88	23927012
2002	Phosphorylation	KAASDDGSLKSSSPT CCCCCCCCCCCCCCC	39.35	29255136
2005	Phosphorylation	SDDGSLKSSSPTSYW CCCCCCCCCCCCCHH	41.14	25159151
2006	Phosphorylation	DDGSLKSSSPTSYWK CCCCCCCCCCCCHHH	38.46	23927012
2007	Phosphorylation	DGSLKSSSPTSYWKS CCCCCCCCCCCHHHH	39.01	23927012
2009	Phosphorylation	SLKSSSPTSYWKSLA CCCCCCCCCHHHHCC	36.07	23927012
2010	Phosphorylation	LKSSSPTSYWKSLAP CCCCCCCCHHHHCCC	32.17	23927012
2011	Phosphorylation	KSSSPTSYWKSLAPD CCCCCCCHHHHCCCC	21.23	23927012
2014	Phosphorylation	SPTSYWKSLAPDRSD CCCCHHHHCCCCCCC	18.67	29255136
2015 (in isoform 4)	Phosphorylation	-	7.72	18669648
2020	Phosphorylation	KSLAPDRSDDEHDPL HHCCCCCCCCCCCCC	57.71	29255136
2030	Phosphorylation	EHDPLDNTSRPRYSH CCCCCCCCCCCCCCC	26.27	23927012
2031	Phosphorylation	HDPLDNTSRPRYSHS CCCCCCCCCCCCCCC	46.68	23927012
2035	Phosphorylation	DNTSRPRYSHSYLSD CCCCCCCCCCCCCCC	17.26	23927012
2036	Phosphorylation	NTSRPRYSHSYLSDS CCCCCCCCCCCCCCC	13.77	22167270
2038	Phosphorylation	SRPRYSHSYLSDSDT CCCCCCCCCCCCCCC	23.10	22167270
2039	Phosphorylation	RPRYSHSYLSDSDTE CCCCCCCCCCCCCCC	12.56	29255136
2041	Phosphorylation	RYSHSYLSDSDTEAK CCCCCCCCCCCCCHH	27.17	29255136
2043	Phosphorylation	SHSYLSDSDTEAKLT CCCCCCCCCCCHHHH	42.95	29255136
2045	Phosphorylation	SYLSDSDTEAKLTET CCCCCCCCCHHHHCC	41.62	29255136
2050	Phosphorylation	SDTEAKLTETNA--- CCCCHHHHCCCC---	39.80	23927012
2052	Phosphorylation	TEAKLTETNA----- CCHHHHCCCC-----	31.07	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MY18A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MY18A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MY18A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX46_HUMAN	DDX46	physical	26344197
ACTS_HUMAN	ACTA1	physical	26496610
ACTB_HUMAN	ACTB	physical	26496610
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
AP2A1_HUMAN	AP2A1	physical	26496610
ANXA2_HUMAN	ANXA2	physical	26496610
DYST_HUMAN	DST	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
COF1_HUMAN	CFL1	physical	26496610
COF2_HUMAN	CFL2	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
KC1A_HUMAN	CSNK1A1	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DAPK3_HUMAN	DAPK3	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DSG2_HUMAN	DSG2	physical	26496610
SRC8_HUMAN	CTTN	physical	26496610
FLII_HUMAN	FLII	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FLNB_HUMAN	FLNB	physical	26496610
FYN_HUMAN	FYN	physical	26496610
GELS_HUMAN	GSN	physical	26496610
HMGB2_HUMAN	HMGB2	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
LMO7_HUMAN	LMO7	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYH9_HUMAN	MYH9	physical	26496610
MYL6_HUMAN	MYL6	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO1E_HUMAN	MYO1E	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYO5B_HUMAN	MYO5B	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
MYPT2_HUMAN	PPP1R12B	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
PP1B_HUMAN	PPP1CB	physical	26496610
TWF1_HUMAN	TWF1	physical	26496610
RAGP1_HUMAN	RANGAP1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SPTN2_HUMAN	SPTBN2	physical	26496610
SSFA2_HUMAN	SSFA2	physical	26496610
ST5_HUMAN	ST5	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
BACD2_HUMAN	TNFAIP1	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
TPM2_HUMAN	TPM2	physical	26496610
TPM3_HUMAN	TPM3	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
PICAL_HUMAN	PICALM	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
LRRF2_HUMAN	LRRFIP2	physical	26496610
ZO2_HUMAN	TJP2	physical	26496610
MRCKB_HUMAN	CDC42BPB	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
RHGBA_HUMAN	ARHGAP11A	physical	26496610
ARHGH_HUMAN	ARHGEF17	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
ARPC4_HUMAN	ARPC4	physical	26496610
ARPC3_HUMAN	ARPC3	physical	26496610
ARC1B_HUMAN	ARPC1B	physical	26496610
ARP3_HUMAN	ACTR3	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
DCTN2_HUMAN	DCTN2	physical	26496610
ML12A_HUMAN	MYL12A	physical	26496610
DEST_HUMAN	DSTN	physical	26496610
TARA_HUMAN	TRIOBP	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
LIMC1_HUMAN	LIMCH1	physical	26496610
SI1L3_HUMAN	SIPA1L3	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
COBL_HUMAN	COBL	physical	26496610
CYTSA_HUMAN	SPECC1L	physical	26496610
FBX46_HUMAN	FBXO46	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
NOCT_HUMAN	CCRN4L	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
TES_HUMAN	TES	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
MYO5C_HUMAN	MYO5C	physical	26496610
COR1B_HUMAN	CORO1B	physical	26496610
K1211_HUMAN	KIAA1211	physical	26496610
CING_HUMAN	CGN	physical	26496610
MICA3_HUMAN	MICAL3	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
EFHD2_HUMAN	EFHD2	physical	26496610
CYBR1_HUMAN	CYBRD1	physical	26496610
MYO19_HUMAN	MYO19	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
BACD3_HUMAN	KCTD10	physical	26496610
LZTS2_HUMAN	LZTS2	physical	26496610
STON2_HUMAN	STON2	physical	26496610
SSH2_HUMAN	SSH2	physical	26496610
PHLB2_HUMAN	PHLDB2	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
MISP_HUMAN	MISP	physical	26496610
MYL6B_HUMAN	MYL6B	physical	26496610
PPR18_HUMAN	PPP1R18	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
DDX51_HUMAN	DDX51	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MY18A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974, ANDMASS SPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067; SER-1070;SER-1942; SER-1951; SER-1970; SER-1974; SER-1998; SER-2002; SER-2007;SER-2020; SER-2041; SER-2043 AND THR-2045, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1067, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, ANDMASS SPECTROMETRY.	18088087 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1039 AND SER-1063, ANDMASS SPECTROMETRY.	18187866 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-234; SER-1942;SER-1970; SER-1974 AND SER-2020, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043, ANDMASS SPECTROMETRY.	16083285 [Abstract]