| UniProt ID | CE162_HUMAN | |
|---|---|---|
| UniProt AC | Q5TB80 | |
| Protein Name | Centrosomal protein of 162 kDa | |
| Gene Name | CEP162 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1403 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Nucleus. Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to | |
| Protein Description | Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.. | |
| Protein Sequence | MANCSQEELDEEFEQFMKELSDDSFENSDKTARQSKKEMKKKDTVPWWITEDDFKDDGLLGTNVSYLKTKKTSQPVMEIEEESAEKIQFLKSSGTSLLSTDSLETNELVVSELNHSSLGVGLDTLEEQEEKEQFFARLEKGLTSSIDYSRLNKELDSNDSTHFKALHSNQANAELTDDEHENESKHEELAENYSDDFEDEYVGAPLTTKDEEMPSKENSKSEKISVPKQEEEKTGMLANVVLLDSLDSVAEVNLDEQDKITPKPRCLPEMTENEMTGTGVSYGQSSSDVEALHQAYCHIAHSLGDEDKQKIESNTVEDIKSSVKGHPQENEENSKNISTMESDLPTVEELMKPIRIDSFGISGFDLQPVSSEKVAERKETEFFSSLPLKMNPNILSQDSQHVNLFFDKNDENVILQKTTNESMENSCPQVTEVTATEEHVDKMYLNILRKKITVNSSSLSQDDKINKTYRSQLSSEEEGAVMGKQVPYKKARSAPPLLKRKPQSGLYASVRSSGYGKPSSPLKMFSTLEKKTSEDIIKSKNLRSISTSNQPRKKEILSGTKLIKPAALDKPAHKTESCLSTRKKSENPTETDSCIQFQTDSLGYCGENKEKKLLMFKRVQEAEDKWRGAQALIEQIKATFSEKEKELENKLEELKKQQEKELFKLNQDNYILQAKLSSFEETNKKQRWLHFGEAADPVTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQSLFSEVASLKEQMHKSRFLSQVVEDSEPTRNQNFTDLLAELRMAQKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHRQGVVVPVAFADEMNAPEY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MANCSQEELDEE ---CCCCCHHHHHHH | 24850871 | ||
| 21 | Phosphorylation | EQFMKELSDDSFENS HHHHHHHCCCCCCCC | 25159151 | ||
| 24 | Phosphorylation | MKELSDDSFENSDKT HHHHCCCCCCCCHHH | 25159151 | ||
| 28 | Phosphorylation | SDDSFENSDKTARQS CCCCCCCCHHHHHHH | 26471730 | ||
| 62 | Phosphorylation | KDDGLLGTNVSYLKT CCCCCCCCCHHHHCC | - | ||
| 65 | Phosphorylation | GLLGTNVSYLKTKKT CCCCCCHHHHCCCCC | - | ||
| 66 | Phosphorylation | LLGTNVSYLKTKKTS CCCCCHHHHCCCCCC | - | ||
| 68 | Ubiquitination | GTNVSYLKTKKTSQP CCCHHHHCCCCCCCC | 29967540 | ||
| 95 | Phosphorylation | QFLKSSGTSLLSTDS HHHHHCCCCCCCCCC | - | ||
| 143 | Phosphorylation | ARLEKGLTSSIDYSR HHHHHHCCCCCCHHH | 27251275 | ||
| 144 | Phosphorylation | RLEKGLTSSIDYSRL HHHHHCCCCCCHHHH | 30108239 | ||
| 145 | Phosphorylation | LEKGLTSSIDYSRLN HHHHCCCCCCHHHHH | 30108239 | ||
| 149 | Phosphorylation | LTSSIDYSRLNKELD CCCCCCHHHHHHHCC | 30108239 | ||
| 157 | Phosphorylation | RLNKELDSNDSTHFK HHHHHCCCCCCHHHH | 25159151 | ||
| 160 | Phosphorylation | KELDSNDSTHFKALH HHCCCCCCHHHHHHH | 25627689 | ||
| 161 | Phosphorylation | ELDSNDSTHFKALHS HCCCCCCHHHHHHHH | 27251275 | ||
| 168 | Phosphorylation | THFKALHSNQANAEL HHHHHHHHCCCCCCC | 20363803 | ||
| 176 | Phosphorylation | NQANAELTDDEHENE CCCCCCCCCCCCCCH | 29255136 | ||
| 184 | Phosphorylation | DDEHENESKHEELAE CCCCCCHHHHHHHHH | 20363803 | ||
| 193 | Phosphorylation | HEELAENYSDDFEDE HHHHHHHCCCCCCCC | 26471730 | ||
| 194 | Phosphorylation | EELAENYSDDFEDEY HHHHHHCCCCCCCCC | 26471730 | ||
| 225 | Phosphorylation | NSKSEKISVPKQEEE CCCCCCCCCCHHHHH | 24719451 | ||
| 313 | Phosphorylation | EDKQKIESNTVEDIK HHHHHHHHCCHHHHH | 23312004 | ||
| 315 | Phosphorylation | KQKIESNTVEDIKSS HHHHHHCCHHHHHHH | 23312004 | ||
| 321 | Phosphorylation | NTVEDIKSSVKGHPQ CCHHHHHHHHCCCCC | 23312004 | ||
| 322 | Phosphorylation | TVEDIKSSVKGHPQE CHHHHHHHHCCCCCC | 23312004 | ||
| 358 | Phosphorylation | MKPIRIDSFGISGFD HCCCCCCCCCCCCCC | 24260401 | ||
| 362 | Phosphorylation | RIDSFGISGFDLQPV CCCCCCCCCCCCCCC | 24260401 | ||
| 370 | Phosphorylation | GFDLQPVSSEKVAER CCCCCCCCHHHHHHH | 24260401 | ||
| 371 | Phosphorylation | FDLQPVSSEKVAERK CCCCCCCHHHHHHHH | 24260401 | ||
| 384 | Phosphorylation | RKETEFFSSLPLKMN HHCCCCHHCCCCCCC | 25850435 | ||
| 385 | Phosphorylation | KETEFFSSLPLKMNP HCCCCHHCCCCCCCC | 25850435 | ||
| 399 | Phosphorylation | PNILSQDSQHVNLFF CCCCCCCCCCEEEEE | 33259812 | ||
| 418 | Phosphorylation | ENVILQKTTNESMEN CCEEEEECCCHHHHC | 23401153 | ||
| 419 | Phosphorylation | NVILQKTTNESMENS CEEEEECCCHHHHCC | 23401153 | ||
| 426 | Phosphorylation | TNESMENSCPQVTEV CCHHHHCCCCCCEEE | 23401153 | ||
| 431 | Phosphorylation | ENSCPQVTEVTATEE HCCCCCCEEEECCHH | 23401153 | ||
| 434 | Phosphorylation | CPQVTEVTATEEHVD CCCCEEEECCHHHHH | 23401153 | ||
| 444 | Phosphorylation | EEHVDKMYLNILRKK HHHHHHHHHHHHHHC | - | ||
| 457 | Phosphorylation | KKITVNSSSLSQDDK HCCEECCCCCCCCHH | - | ||
| 458 | Phosphorylation | KITVNSSSLSQDDKI CCEECCCCCCCCHHC | - | ||
| 471 | Phosphorylation | KINKTYRSQLSSEEE HCCHHHHHHCCCHHC | 28450419 | ||
| 474 | Phosphorylation | KTYRSQLSSEEEGAV HHHHHHCCCHHCCCC | 25159151 | ||
| 475 | Phosphorylation | TYRSQLSSEEEGAVM HHHHHCCCHHCCCCC | 25159151 | ||
| 493 | Phosphorylation | VPYKKARSAPPLLKR CCCHHHCCCCCCHHC | 28555341 | ||
| 507 | Phosphorylation | RKPQSGLYASVRSSG CCCCCCCEEEHHHCC | 29978859 | ||
| 509 | Phosphorylation | PQSGLYASVRSSGYG CCCCCEEEHHHCCCC | 29978859 | ||
| 512 | Phosphorylation | GLYASVRSSGYGKPS CCEEEHHHCCCCCCC | 23186163 | ||
| 513 | Phosphorylation | LYASVRSSGYGKPSS CEEEHHHCCCCCCCC | 23186163 | ||
| 515 | Phosphorylation | ASVRSSGYGKPSSPL EEHHHCCCCCCCCCC | 23312004 | ||
| 519 | Phosphorylation | SSGYGKPSSPLKMFS HCCCCCCCCCCHHHH | 23312004 | ||
| 519 | Ubiquitination | SSGYGKPSSPLKMFS HCCCCCCCCCCHHHH | 22817900 | ||
| 520 | Phosphorylation | SGYGKPSSPLKMFST CCCCCCCCCCHHHHH | 23312004 | ||
| 523 | Ubiquitination | GKPSSPLKMFSTLEK CCCCCCCHHHHHCCC | 22817900 | ||
| 527 | Phosphorylation | SPLKMFSTLEKKTSE CCCHHHHHCCCCCHH | - | ||
| 549 | Ubiquitination | LRSISTSNQPRKKEI CCCCCCCCCCCCCHH | 29967540 | ||
| 574 | Ubiquitination | ALDKPAHKTESCLST HCCCCCCCCHHHHCC | 29967540 | ||
| 577 | Phosphorylation | KPAHKTESCLSTRKK CCCCCCHHHHCCCCC | 25367160 | ||
| 580 | Phosphorylation | HKTESCLSTRKKSEN CCCHHHHCCCCCCCC | 25367160 | ||
| 599 | Ubiquitination | DSCIQFQTDSLGYCG CCCEEHHCCCCCCCC | 29967540 | ||
| 625 | Ubiquitination | RVQEAEDKWRGAQAL CHHHHHHHHHHHHHH | 29967540 | ||
| 632 | Ubiquitination | KWRGAQALIEQIKAT HHHHHHHHHHHHHHH | 29967540 | ||
| 650 | Ubiquitination | KEKELENKLEELKKQ HHHHHHHHHHHHHHH | 29967540 | ||
| 670 | Phosphorylation | FKLNQDNYILQAKLS HHHCCCCHHHEEHHH | - | ||
| 675 | Ubiquitination | DNYILQAKLSSFEET CCHHHEEHHHHHHHH | 29967540 | ||
| 684 | Ubiquitination | SSFEETNKKQRWLHF HHHHHHCCCCCEEEC | 29967540 | ||
| 708 | Ubiquitination | EKLKQIQKEIQEQET HHHHHHHHHHHHHHH | 29967540 | ||
| 730 | Ubiquitination | ENERLYNQVKDLQEQ HHHHHHHHHHHHHHH | 29967540 | ||
| 751 | Phosphorylation | RMFKENQSLFSEVAS HHHHHHHHHHHHHHH | 29052541 | ||
| 754 | Phosphorylation | KENQSLFSEVASLKE HHHHHHHHHHHHHHH | 29052541 | ||
| 758 | Phosphorylation | SLFSEVASLKEQMHK HHHHHHHHHHHHHHH | 29052541 | ||
| 760 | Ubiquitination | FSEVASLKEQMHKSR HHHHHHHHHHHHHHH | 29967540 | ||
| 770 | Phosphorylation | MHKSRFLSQVVEDSE HHHHHHHHHHHCCCC | 29496963 | ||
| 776 | Phosphorylation | LSQVVEDSEPTRNQN HHHHHCCCCCCCCCC | 17924679 | ||
| 806 | Ubiquitination | DSLLEDIKRLKQDKQ HHHHHHHHHHHHHHH | 29967540 | ||
| 832 | Ubiquitination | ERDQAKDQIAYVTGE HHHHHHHHEEEEHHH | 22817900 | ||
| 836 | Ubiquitination | AKDQIAYVTGEKLYE HHHHEEEEHHHHHEE | 22817900 | ||
| 850 | Phosphorylation | EIKILEETHKQEISR EEEECHHHHHHHHHH | 30576142 | ||
| 856 | Phosphorylation | ETHKQEISRLQKRLQ HHHHHHHHHHHHHHH | 29255136 | ||
| 870 | Ubiquitination | QWYAENQELLDKDAL HHHHHCHHHCCHHHH | 22817900 | ||
| 874 | Ubiquitination | ENQELLDKDALRLRE HCHHHCCHHHHHHHH | 22817900 | ||
| 900 | Phosphorylation | IEKLKAESGNPSIRQ HHHHHHHHCCHHHHH | 23403867 | ||
| 904 | Phosphorylation | KAESGNPSIRQKIRL HHHHCCHHHHHHHHH | 28060719 | ||
| 908 | Ubiquitination | GNPSIRQKIRLKDKA CCHHHHHHHHHHCHH | 22817900 | ||
| 912 | Ubiquitination | IRQKIRLKDKAADAK HHHHHHHHCHHHCHH | 22817900 | ||
| 939 | Phosphorylation | EGILKRRYPNSLPAL HHHHHHHCCCCHHHH | - | ||
| 939 | Ubiquitination | EGILKRRYPNSLPAL HHHHHHHCCCCHHHH | 29967540 | ||
| 942 | Phosphorylation | LKRRYPNSLPALILA HHHHCCCCHHHHHHH | - | ||
| 951 | Phosphorylation | PALILAASAAGDTVD HHHHHHHHHCCCCCC | - | ||
| 956 | Phosphorylation | AASAAGDTVDKNTVE HHHHCCCCCCHHHHH | - | ||
| 996 | Ubiquitination | TMEQQFQKMKIQYEQ HHHHHHHHHHHHHHH | - | ||
| 1015 | Ubiquitination | QEQLLACKLNQHDSP HHHHHHHHCCCCCCH | 29967540 | ||
| 1021 | Phosphorylation | CKLNQHDSPRIKALE HHCCCCCCHHHHHHH | 26471730 | ||
| 1041 | Phosphorylation | IKEAHQITVRNLEAE HHHHHHHHHHHHHHH | 23312004 | ||
| 1073 | Phosphorylation | KDDEDFQSIEFQVEQ CCCHHHHHHHHHHHH | 24247654 | ||
| 1104 | Ubiquitination | KKREIQDLSKTVERL HHHHHHHHHHHHHHH | 29967540 | ||
| 1147 | Ubiquitination | LHSSKGNANSFPGTL HHCCCCCCCCCCCCC | 29967540 | ||
| 1156 | Ubiquitination | SFPGTLDSKLYQPHT CCCCCCCCCCCCCCC | 29967540 | ||
| 1180 | Ubiquitination | LQENYRLKNELEGLI HHHHHHHHHHHHHHH | 29967540 | ||
| 1188 | Phosphorylation | NELEGLISEKNELKM HHHHHHHCCCHHHHH | 24719451 | ||
| 1197 | Phosphorylation | KNELKMKSEAVMNQF CHHHHHHHHHHHHHH | 24719451 | ||
| 1207 | Phosphorylation | VMNQFENSMRRVKED HHHHHHHHHHHHHHH | 24719451 | ||
| 1223 | Ubiquitination | AAHIASLKASHQREI HHHHHHHHHHHHHHH | 29967540 | ||
| 1225 | Phosphorylation | HIASLKASHQREIEK HHHHHHHHHHHHHHH | - | ||
| 1232 | Ubiquitination | SHQREIEKLLCQNAV HHHHHHHHHHHHHHH | 29967540 | ||
| 1255 | Phosphorylation | ELNRKIATQEVLIRH HHHHHHHHHHHHHHH | - | ||
| 1371 | Phosphorylation | RELEKFRTELDSILD HHHHHHHHHHHHHHH | 23403867 | ||
| 1375 | Phosphorylation | KFRTELDSILDVLRE HHHHHHHHHHHHHHH | 23403867 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CE162_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CE162_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CE162_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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