TBC31_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBC31_HUMAN
• UniProt AC: Q96DN5
• Protein Name: TBC1 domain family member 31
• Gene Name: TBC1D31
• Organism: Homo sapiens (Human).
• Sequence Length: 1066
• Protein Sequence: MQSTDLGNKESGKIWHRKPSPATRDGIIVNIIHNTSDYHPKVLRFLNVAFDGTGDCLIAGDHQGNIYVFDLHGNRFNLVQRTAQACTALAFNLRRKSEFLVALADYSIKCFDTVTKELVSWMRGHESSVFSISVHASGKYAITTSSDTAQLWDLDTFQRKRKLNIRQSVGIQKVFFLPLSNTILSCFKDNSIFAWECDTLFCKYQLPAPPESSSILYKVFAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTKVRAIRHLEFLPDSFDAGSNQVLGVLSQDGIMRFINMQTCKLLFEIGSLDEGISSSAISPHGRYIASIMENGSLNIYSVQALTQEINKPPPPLVKVIEDLPKNKLSSSDLKMKVTSGRVQQPAKSRESKMQTRILKQDLTGDFESKKNELPDGLNKKRLQILLKGYGEYPTKYRMFIWRSLLQLPENHTAFSTLIDKGTHVAFLNLQKKYPIKSRKLLRVLQRTLSALAHWSVIFSDTPYLPLLAFPFVKLFQNNQLICFEVIATLIINWCQHWFEYFPNPPINILSMIENVLAFHDKELLQHFIDHDITSQLYAWPLLETVFSEVLTREEWLKLFDNIFSNHPSFLLMTVVAYNICSRTPLLSCNLKDDFEFFFHHRNNLDINVVIRQVYHLMETTPTDIHPDSMLNVFVALTKGQYPVFNQYPKFIVDYQTQERERIRNDELDYLRERQTVEDMQAKVDQQRVEDEAWYQKQELLRKAEETRREMLLQEEEKMIQQRQRLAAVKRELKVKEMHLQDAARRRFLKLQQDQQEMELRRLDDEIGRKVYMRDREIAATARDLEMRQLELESQKRLYEKNLTENQEALAKEMRADADAYRRKVDLEEHMFHKLIEAGETQSQKTQKVIKENLAKAEQACLNTDWQIQSLHKQKCDDLQRNKCYQEVAKLLRENRRKEIEIINAMVEEEAKKWKEAEGKEFRLRSAKKASALSDASRKWFLKQEINAAVEHAENPCHKEEPRFQNEQDSSCLPRTSQLNDSSEMDPSTQISLNRRAVEWDTTGQNLIKKVRNLRQRLTARARHRCQTPHLLAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	QSTDLGNKESGKIWH CCCCCCCCCCCCCCC		-
20	Phosphorylation	KIWHRKPSPATRDGI CCCCCCCCCCCCCCE		21964256
41	Ubiquitination	NTSDYHPKVLRFLNV CCCCCCHHHHHHHEE		21890473
41	Ubiquitination	NTSDYHPKVLRFLNV CCCCCCHHHHHHHEE		21890473
41 (in isoform 2)	Ubiquitination	-		21890473
41 (in isoform 1)	Ubiquitination	-		21890473
96	Sumoylation	LAFNLRRKSEFLVAL HHHHCHHCCHHHHHH		-
107	Phosphorylation	LVALADYSIKCFDTV HHHHHHHCCHHHHHH		24719451
180	Phosphorylation	KVFFLPLSNTILSCF EEEEEECCCHHHHHH		27732954
182	Phosphorylation	FFLPLSNTILSCFKD EEEECCCHHHHHHCC		27732954
185	Phosphorylation	PLSNTILSCFKDNSI ECCCHHHHHHCCCCE		27732954
257	Ubiquitination	RIIQMPTKVRAIRHL HHCCCCCHHHHHHCC		-
360	Acetylation	IEDLPKNKLSSSDLK HCCCCCCCCCHHHCC		19657427
360	Ubiquitination	IEDLPKNKLSSSDLK HCCCCCCCCCHHHCC		-
362	Phosphorylation	DLPKNKLSSSDLKMK CCCCCCCCHHHCCCC		30108239
363	Phosphorylation	LPKNKLSSSDLKMKV CCCCCCCHHHCCCCC		30108239
364	Phosphorylation	PKNKLSSSDLKMKVT CCCCCCHHHCCCCCC		27251275
380	Ubiquitination	GRVQQPAKSRESKMQ CCCCCCCCCCHHHHH		-
385	Ubiquitination	PAKSRESKMQTRILK CCCCCHHHHHHHHHH		-
392	Ubiquitination	KMQTRILKQDLTGDF HHHHHHHHHHCCCCH		21906983
392 (in isoform 1)	Ubiquitination	-		21890473
392 (in isoform 2)	Ubiquitination	-		21890473
396	Phosphorylation	RILKQDLTGDFESKK HHHHHHCCCCHHHHC		-
402	Ubiquitination	LTGDFESKKNELPDG CCCCHHHHCCCCCCC		-
403	Ubiquitination	TGDFESKKNELPDGL CCCHHHHCCCCCCCC		-
403	Acetylation	TGDFESKKNELPDGL CCCHHHHCCCCCCCC		90809
412	Acetylation	ELPDGLNKKRLQILL CCCCCCCHHHHHHHH		7303161
412	Ubiquitination	ELPDGLNKKRLQILL CCCCCCCHHHHHHHH		-
413	Acetylation	LPDGLNKKRLQILLK CCCCCCHHHHHHHHH		90813
428	Ubiquitination	GYGEYPTKYRMFIWR CCCCCCHHHHHHHHH		-
464	Ubiquitination	VAFLNLQKKYPIKSR EEEEECCCCCCCCHH		21890473
464 (in isoform 1)	Ubiquitination	-		21890473
464 (in isoform 2)	Ubiquitination	-		21890473
464	Ubiquitination	VAFLNLQKKYPIKSR EEEEECCCCCCCCHH		21890473
647	Phosphorylation	NVVIRQVYHLMETTP HHHHHHHHHHHHCCC		24043423
652	Phosphorylation	QVYHLMETTPTDIHP HHHHHHHCCCCCCCH		24043423
653	Phosphorylation	VYHLMETTPTDIHPD HHHHHHCCCCCCCHH		24043423
655	Phosphorylation	HLMETTPTDIHPDSM HHHHCCCCCCCHHHH		24043423
661	Phosphorylation	PTDIHPDSMLNVFVA CCCCCHHHHHHHHHH		24043423
670	Phosphorylation	LNVFVALTKGQYPVF HHHHHHHHCCCCCCH		24043423
682 (in isoform 1)	Ubiquitination	-		21890473
682 (in isoform 2)	Ubiquitination	-		21890473
682	Ubiquitination	PVFNQYPKFIVDYQT CCHHCCCCEEEEHHH		21890473
682	Ubiquitination	PVFNQYPKFIVDYQT CCHHCCCCEEEEHHH		21890473
689	Phosphorylation	KFIVDYQTQERERIR CEEEEHHHHHHHHHH		-
702	Phosphorylation	IRNDELDYLRERQTV HHHHHHHHHHHHHCH		-
715 (in isoform 1)	Ubiquitination	-		21890473
715	Ubiquitination	TVEDMQAKVDQQRVE CHHHHHHHHHHHHHH		21906983
715 (in isoform 2)	Ubiquitination	-		21890473
727	Phosphorylation	RVEDEAWYQKQELLR HHHHHHHHHHHHHHH		-
729	Ubiquitination	EDEAWYQKQELLRKA HHHHHHHHHHHHHHH		21890473
729 (in isoform 1)	Ubiquitination	-		21890473
729	Ubiquitination	EDEAWYQKQELLRKA HHHHHHHHHHHHHHH		21890473
729 (in isoform 2)	Ubiquitination	-		21890473
750	Ubiquitination	MLLQEEEKMIQQRQR HHHHHHHHHHHHHHH		-
768	Ubiquitination	VKRELKVKEMHLQDA HHHHHHHHHHHHHHH		-
782	Ubiquitination	AARRRFLKLQQDQQE HHHHHHHHHHHHHHH		-
813	Ubiquitination	RDREIAATARDLEMR HHHHHHHHHHHHHHH		21890473
828	Ubiquitination	QLELESQKRLYEKNL HHHHHHHHHHHHHCC		-
833	Ubiquitination	SQKRLYEKNLTENQE HHHHHHHHCCCHHHH		21890473
833 (in isoform 2)	Ubiquitination	-		21890473
833 (in isoform 1)	Ubiquitination	-		21890473
835	Ubiquitination	KRLYEKNLTENQEAL HHHHHHCCCHHHHHH		21890473
844	Ubiquitination	ENQEALAKEMRADAD HHHHHHHHHHHHCHH		21890473
844 (in isoform 1)	Ubiquitination	-		21890473
844 (in isoform 2)	Ubiquitination	-		21890473
856	Ubiquitination	DADAYRRKVDLEEHM CHHHHHHCCCHHHHH		-
866 (in isoform 1)	Ubiquitination	-		21890473
866 (in isoform 2)	Ubiquitination	-		21890473
866	Acetylation	LEEHMFHKLIEAGET HHHHHHHHHHHCCCC		11789955
866	Ubiquitination	LEEHMFHKLIEAGET HHHHHHHHHHHCCCC		21890473
873	Phosphorylation	KLIEAGETQSQKTQK HHHHCCCCCCHHHHH		29978859
875	Phosphorylation	IEAGETQSQKTQKVI HHCCCCCCHHHHHHH		29255136
877	Ubiquitination	AGETQSQKTQKVIKE CCCCCCHHHHHHHHH		-
883	Ubiquitination	QKTQKVIKENLAKAE HHHHHHHHHHHHHHH		-
888	Ubiquitination	VIKENLAKAEQACLN HHHHHHHHHHHHHHC		-
902	Phosphorylation	NTDWQIQSLHKQKCD CCHHHHHHHHHHCCH		25159151
905	Ubiquitination	WQIQSLHKQKCDDLQ HHHHHHHHHCCHHHH		-
907	Ubiquitination	IQSLHKQKCDDLQRN HHHHHHHCCHHHHHC		-
915	Ubiquitination	CDDLQRNKCYQEVAK CHHHHHCHHHHHHHH		-
917	Phosphorylation	DLQRNKCYQEVAKLL HHHHCHHHHHHHHHH		29496907
922	Ubiquitination	KCYQEVAKLLRENRR HHHHHHHHHHHHHHH		-
961	Ubiquitination	FRLRSAKKASALSDA HCCHHHHHHHHCCHH		-
963	Phosphorylation	LRSAKKASALSDASR CHHHHHHHHCCHHHH		-
969	Phosphorylation	ASALSDASRKWFLKQ HHHCCHHHHHHHHHH		22817900
1008	Phosphorylation	DSSCLPRTSQLNDSS CCCCCCCCCCCCCCC		29978859
1009	Phosphorylation	SSCLPRTSQLNDSSE CCCCCCCCCCCCCCC		29978859
1014	Phosphorylation	RTSQLNDSSEMDPST CCCCCCCCCCCCCCC		29978859
1015	Phosphorylation	TSQLNDSSEMDPSTQ CCCCCCCCCCCCCCC		29978859
1041	Ubiquitination	TTGQNLIKKVRNLRQ CHHHHHHHHHHHHHH		-
1042	Ubiquitination	TGQNLIKKVRNLRQR HHHHHHHHHHHHHHH		-
1060	Phosphorylation	RARHRCQTPHLLAA- HHHHHCCCCHHHCC-		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBC31_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBC31_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBC31_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TBC31_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.