dbPTM

CC138_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CC138_HUMAN
UniProt AC	Q96M89
Protein Name	Coiled-coil domain-containing protein 138
Gene Name	CCDC138
Organism	Homo sapiens (Human).
Sequence Length	665
Subcellular Localization
Protein Description
Protein Sequence	MEPRVVKPPGQDLVVESLKSRYGLGGSCPDEYDFSNFYQSKYKRRTLTSPGDLDIYSGDKVGSSLKYSDESKHCRTPLGSLFKHVNVNCLDDELDSFHDLKKQETEEELIENDYRVSTSKITKQSFKEIEKVALPTNTTSSRPRTECCSDAGDSPLKPVSCPKSKASDKRSLLPHQISQIYDELFQIHLKLQCETAAQQKFAEELQKRERFLLEREQLLFRHENALSKIKGVEEEVLTRFQIIKEQHDAEVEHLTEVLKEKNKETKRLRSSFDALKELNDTLKKQLNEASEENRKIDIQAKRVQARLDNLQRKYEFMTIQRLKGSSHAVHEMKSLKQEKAPVSKTYKVPLNGQVYELLTVFMDWISDHHLSKVKHEESGMDGKKPQLKFASQRNDIQEKCVKLLPLMTEQLQWMPFVNIKLHEPFVKFIYWSLRQLDAGAQHSTMTSTLRRLGEDIFKGVVTKGIQDNSPQHSVENKPKTAAFFKSSNLPLRFLSTLIVLKTVTQADYLAQAFDSLCLDLKTEEGKTLFLEYQAVPVILSHLRISSKGLLSNVIDSLLQMTVESKSLQPFLEACSNSLFFRTCSVLLRAPKLDLQILEKLSIILQKLSKIKSNKKLFELFTIHLMLQEIQRTTNPEHAFLCINLNSTLFNLGLTKCNSLVSSASP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Ubiquitination	GQDLVVESLKSRYGL CCCCCHHCHHHHHCC	29.50	29967540
19	Ubiquitination	DLVVESLKSRYGLGG CCCHHCHHHHHCCCC	42.01	27667366
19 (in isoform 1)	Ubiquitination	-	42.01	21890473
19 (in isoform 2)	Ubiquitination	-	42.01	21890473
20	Phosphorylation	LVVESLKSRYGLGGS CCHHCHHHHHCCCCC	35.71	-
23	Ubiquitination	ESLKSRYGLGGSCPD HCHHHHHCCCCCCCC	19.41	27667366
24	Ubiquitination	SLKSRYGLGGSCPDE CHHHHHCCCCCCCCC	5.35	33845483
27	Phosphorylation	SRYGLGGSCPDEYDF HHHCCCCCCCCCCCC	22.22	-
28	Ubiquitination	RYGLGGSCPDEYDFS HHCCCCCCCCCCCCC	5.79	29967540
32	Phosphorylation	GGSCPDEYDFSNFYQ CCCCCCCCCCCHHHH	29.66	-
41	Ubiquitination	FSNFYQSKYKRRTLT CCHHHHHHHCCCCCC	38.99	32015554
46	Phosphorylation	QSKYKRRTLTSPGDL HHHHCCCCCCCCCCE	38.12	30108239
48	Phosphorylation	KYKRRTLTSPGDLDI HHCCCCCCCCCCEEE	32.06	25159151
49	Phosphorylation	YKRRTLTSPGDLDIY HCCCCCCCCCCEEEC	29.96	19664994
56	Phosphorylation	SPGDLDIYSGDKVGS CCCCEEECCCCCCCC	13.28	29978859
57	Phosphorylation	PGDLDIYSGDKVGSS CCCEEECCCCCCCCC	40.63	29978859
59	Ubiquitination	DLDIYSGDKVGSSLK CEEECCCCCCCCCCC	36.20	33845483
60	Ubiquitination	LDIYSGDKVGSSLKY EEECCCCCCCCCCCC	52.61	33845483
61	Ubiquitination	DIYSGDKVGSSLKYS EECCCCCCCCCCCCC	12.22	33845483
63	Phosphorylation	YSGDKVGSSLKYSDE CCCCCCCCCCCCCCC	35.17	29978859
64	Phosphorylation	SGDKVGSSLKYSDES CCCCCCCCCCCCCCC	23.97	29978859
66	Methylation	DKVGSSLKYSDESKH CCCCCCCCCCCCCCC	44.66	-
66	Ubiquitination	DKVGSSLKYSDESKH CCCCCCCCCCCCCCC	44.66	21906983
66 (in isoform 1)	Ubiquitination	-	44.66	21890473
66 (in isoform 2)	Ubiquitination	-	44.66	21890473
67	Phosphorylation	KVGSSLKYSDESKHC CCCCCCCCCCCCCCC	27.01	29083192
67	Ubiquitination	KVGSSLKYSDESKHC CCCCCCCCCCCCCCC	27.01	29967540
68	Phosphorylation	VGSSLKYSDESKHCR CCCCCCCCCCCCCCC	33.06	29083192
71	Phosphorylation	SLKYSDESKHCRTPL CCCCCCCCCCCCCCH	32.46	29083192
72	Ubiquitination	LKYSDESKHCRTPLG CCCCCCCCCCCCCHH	44.68	27667366
76	Phosphorylation	DESKHCRTPLGSLFK CCCCCCCCCHHHHHH	28.41	23312004
78	Ubiquitination	SKHCRTPLGSLFKHV CCCCCCCHHHHHHCC	7.81	21963094
80	Phosphorylation	HCRTPLGSLFKHVNV CCCCCHHHHHHCCCC	38.01	24719451
83	Ubiquitination	TPLGSLFKHVNVNCL CCHHHHHHCCCCCCC	52.52	21963094
89	Ubiquitination	FKHVNVNCLDDELDS HHCCCCCCCCCCHHH	3.72	21963094
96	Phosphorylation	CLDDELDSFHDLKKQ CCCCCHHHHHHHCHH	36.79	30576142
96	Ubiquitination	CLDDELDSFHDLKKQ CCCCCHHHHHHHCHH	36.79	33845483
97	Ubiquitination	LDDELDSFHDLKKQE CCCCHHHHHHHCHHH	5.33	33845483
101	Ubiquitination	LDSFHDLKKQETEEE HHHHHHHCHHHHHHH	59.47	32015554
102	Ubiquitination	DSFHDLKKQETEEEL HHHHHHCHHHHHHHH	61.74	21906983
102 (in isoform 1)	Ubiquitination	-	61.74	21890473
102 (in isoform 2)	Ubiquitination	-	61.74	21890473
105	Phosphorylation	HDLKKQETEEELIEN HHHCHHHHHHHHHHC	46.32	28985074
107	Ubiquitination	LKKQETEEELIENDY HCHHHHHHHHHHCCC	66.57	33845483
108	Ubiquitination	KKQETEEELIENDYR CHHHHHHHHHHCCCC	49.14	33845483
114	Phosphorylation	EELIENDYRVSTSKI HHHHHCCCCCCCHHH	25.21	30576142
115	Ubiquitination	ELIENDYRVSTSKIT HHHHCCCCCCCHHHC	20.83	33845483
120	Ubiquitination	DYRVSTSKITKQSFK CCCCCCHHHCHHHHH	55.25	27667366
123	Ubiquitination	VSTSKITKQSFKEIE CCCHHHCHHHHHHHH	47.63	-
125	Phosphorylation	TSKITKQSFKEIEKV CHHHCHHHHHHHHEE	39.58	-
126	Ubiquitination	SKITKQSFKEIEKVA HHHCHHHHHHHHEEE	8.35	27667366
127	Ubiquitination	KITKQSFKEIEKVAL HHCHHHHHHHHEEEC	64.13	29967540
131	Ubiquitination	QSFKEIEKVALPTNT HHHHHHHEEECCCCC	38.17	27667366
137	Ubiquitination	EKVALPTNTTSSRPR HEEECCCCCCCCCCC	39.14	27667366
142	Ubiquitination	PTNTTSSRPRTECCS CCCCCCCCCCCCCCC	25.20	22817900
145	Phosphorylation	TTSSRPRTECCSDAG CCCCCCCCCCCCCCC	35.74	26074081
147	Ubiquitination	SSRPRTECCSDAGDS CCCCCCCCCCCCCCC	2.38	21963094
149	Phosphorylation	RPRTECCSDAGDSPL CCCCCCCCCCCCCCC	42.00	25159151
152	Ubiquitination	TECCSDAGDSPLKPV CCCCCCCCCCCCCCC	40.70	27667366
154	Phosphorylation	CCSDAGDSPLKPVSC CCCCCCCCCCCCCCC	31.08	25159151
157	Ubiquitination	DAGDSPLKPVSCPKS CCCCCCCCCCCCCCC	46.92	27667366
160	Phosphorylation	DSPLKPVSCPKSKAS CCCCCCCCCCCCCCC	32.98	26074081
161	Ubiquitination	SPLKPVSCPKSKASD CCCCCCCCCCCCCCC	5.11	22817900
163	Ubiquitination	LKPVSCPKSKASDKR CCCCCCCCCCCCCCH	69.76	27667366
165	Ubiquitination	PVSCPKSKASDKRSL CCCCCCCCCCCCHHC	59.02	-
171	Phosphorylation	SKASDKRSLLPHQIS CCCCCCHHCCHHHHH	39.74	-
178	Phosphorylation	SLLPHQISQIYDELF HCCHHHHHHHHHHHH	12.17	-
188	Ubiquitination	YDELFQIHLKLQCET HHHHHHHHHHHHHHH	13.21	33845483
195	Ubiquitination	HLKLQCETAAQQKFA HHHHHHHHHHHHHHH	34.61	21963094
200	Ubiquitination	CETAAQQKFAEELQK HHHHHHHHHHHHHHH	34.17	21963094
205	Ubiquitination	QQKFAEELQKRERFL HHHHHHHHHHHHHHH	5.68	22817900
206	Ubiquitination	QKFAEELQKRERFLL HHHHHHHHHHHHHHH	46.14	21963094
207	Ubiquitination	KFAEELQKRERFLLE HHHHHHHHHHHHHHH	69.70	29967540
210	Ubiquitination	EELQKRERFLLEREQ HHHHHHHHHHHHHHH	31.39	21963094
223	Ubiquitination	EQLLFRHENALSKIK HHHHHHCHHHHHHCC	39.69	22817900
225	Ubiquitination	LLFRHENALSKIKGV HHHHCHHHHHHCCCC	15.38	33845483
228	Ubiquitination	RHENALSKIKGVEEE HCHHHHHHCCCCHHH	49.65	22817900
230	Ubiquitination	ENALSKIKGVEEEVL HHHHHHCCCCHHHHH	61.72	21906983
230 (in isoform 1)	Ubiquitination	-	61.72	21890473
230 (in isoform 2)	Ubiquitination	-	61.72	21890473
234	Ubiquitination	SKIKGVEEEVLTRFQ HHCCCCHHHHHHHHH	51.50	22817900
236	Ubiquitination	IKGVEEEVLTRFQII CCCCHHHHHHHHHHH	8.17	33845483
244	Ubiquitination	LTRFQIIKEQHDAEV HHHHHHHHHHHHHHH	53.61	29967540
259	Ubiquitination	EHLTEVLKEKNKETK HHHHHHHHHHCHHHH	72.34	29967540
276	Ubiquitination	RSSFDALKELNDTLK HHHHHHHHHHHHHHH	62.97	29967540
278	Ubiquitination	SFDALKELNDTLKKQ HHHHHHHHHHHHHHH	7.22	27667366
281	Phosphorylation	ALKELNDTLKKQLNE HHHHHHHHHHHHHHH	39.13	-
282	Ubiquitination	LKELNDTLKKQLNEA HHHHHHHHHHHHHHH	7.91	27667366
283	Ubiquitination	KELNDTLKKQLNEAS HHHHHHHHHHHHHHH	40.33	27667366
284	Ubiquitination	ELNDTLKKQLNEASE HHHHHHHHHHHHHHH	64.23	29967540
288	Ubiquitination	TLKKQLNEASEENRK HHHHHHHHHHHHHHH	63.26	27667366
289	Ubiquitination	LKKQLNEASEENRKI HHHHHHHHHHHHHHH	22.59	27667366
290	Ubiquitination	KKQLNEASEENRKID HHHHHHHHHHHHHHH	38.98	17203973
294	Ubiquitination	NEASEENRKIDIQAK HHHHHHHHHHHHHHH	40.35	17203973
295	Ubiquitination	EASEENRKIDIQAKR HHHHHHHHHHHHHHH	57.20	17203973
300	Ubiquitination	NRKIDIQAKRVQARL HHHHHHHHHHHHHHH	11.27	17203973
301	Ubiquitination	RKIDIQAKRVQARLD HHHHHHHHHHHHHHH	36.40	17203973
313	Ubiquitination	RLDNLQRKYEFMTIQ HHHHHHHHHHHHHHH	35.85	-
314	Phosphorylation	LDNLQRKYEFMTIQR HHHHHHHHHHHHHHH	19.31	23663014
318	Phosphorylation	QRKYEFMTIQRLKGS HHHHHHHHHHHHCCC	21.19	23663014
323	Ubiquitination	FMTIQRLKGSSHAVH HHHHHHHCCCCHHHH	59.96	29967540
333	Ubiquitination	SHAVHEMKSLKQEKA CHHHHHHHHHCCCCC	50.04	29967540
334	Ubiquitination	HAVHEMKSLKQEKAP HHHHHHHHHCCCCCC	39.22	27667366
338	Ubiquitination	EMKSLKQEKAPVSKT HHHHHCCCCCCCCCC	49.99	27667366
339	Ubiquitination	MKSLKQEKAPVSKTY HHHHCCCCCCCCCCE	56.34	27667366
344	Ubiquitination	QEKAPVSKTYKVPLN CCCCCCCCCEEECCC	56.99	27667366
345	Ubiquitination	EKAPVSKTYKVPLNG CCCCCCCCEEECCCC	22.52	27667366
346	Ubiquitination	KAPVSKTYKVPLNGQ CCCCCCCEEECCCCC	17.45	32015554
359	Phosphorylation	GQVYELLTVFMDWIS CCHHHHHHHHHHHHH	25.07	27732954
366	Phosphorylation	TVFMDWISDHHLSKV HHHHHHHHHHHHHHH	27.00	27732954
371	Phosphorylation	WISDHHLSKVKHEES HHHHHHHHHHCCCCC	30.92	27732954
383	Ubiquitination	EESGMDGKKPQLKFA CCCCCCCCCCHHHHH	57.95	32015554
387	Ubiquitination	MDGKKPQLKFASQRN CCCCCCHHHHHHHCC	7.17	32015554
388	Ubiquitination	DGKKPQLKFASQRND CCCCCHHHHHHHCCH	33.37	32015554
393	Ubiquitination	QLKFASQRNDIQEKC HHHHHHHCCHHHHHH	40.05	32015554
394	Ubiquitination	LKFASQRNDIQEKCV HHHHHHCCHHHHHHH	43.00	32015554
399	Ubiquitination	QRNDIQEKCVKLLPL HCCHHHHHHHHHHHH	28.14	29967540
414	Ubiquitination	MTEQLQWMPFVNIKL CHHHHHCCCCCCCEE	0.88	22817900
419	Ubiquitination	QWMPFVNIKLHEPFV HCCCCCCCEECCCHH	4.17	21963094
425	Ubiquitination	NIKLHEPFVKFIYWS CCEECCCHHHHHHHH	9.45	22817900
430	Phosphorylation	EPFVKFIYWSLRQLD CCHHHHHHHHHHHCC	7.65	25002506
430	Ubiquitination	EPFVKFIYWSLRQLD CCHHHHHHHHHHHCC	7.65	21963094
432	Phosphorylation	FVKFIYWSLRQLDAG HHHHHHHHHHHCCCC	9.19	24719451
433	Ubiquitination	VKFIYWSLRQLDAGA HHHHHHHHHHCCCCC	2.21	22817900
435	Ubiquitination	FIYWSLRQLDAGAQH HHHHHHHHCCCCCCH	49.33	22817900
443	Phosphorylation	LDAGAQHSTMTSTLR CCCCCCHHHHHHHHH	14.06	25002506
444	Phosphorylation	DAGAQHSTMTSTLRR CCCCCHHHHHHHHHH	23.50	25002506
444	Ubiquitination	DAGAQHSTMTSTLRR CCCCCHHHHHHHHHH	23.50	22817900
446	Phosphorylation	GAQHSTMTSTLRRLG CCCHHHHHHHHHHHC	20.74	25002506
446	Ubiquitination	GAQHSTMTSTLRRLG CCCHHHHHHHHHHHC	20.74	22817900
447	Phosphorylation	AQHSTMTSTLRRLGE CCHHHHHHHHHHHCC	18.02	25002506
448	Phosphorylation	QHSTMTSTLRRLGED CHHHHHHHHHHHCCC	18.34	25002506
453	Ubiquitination	TSTLRRLGEDIFKGV HHHHHHHCCCHHHHH	28.81	22817900
457	Ubiquitination	RRLGEDIFKGVVTKG HHHCCCHHHHHHCCC	9.72	22817900
458	Ubiquitination	RLGEDIFKGVVTKGI HHCCCHHHHHHCCCC	51.64	21963094
462	Ubiquitination	DIFKGVVTKGIQDNS CHHHHHHCCCCCCCC	22.58	21963094
463	Ubiquitination	IFKGVVTKGIQDNSP HHHHHHCCCCCCCCC	42.27	21963094
464	Ubiquitination	FKGVVTKGIQDNSPQ HHHHHCCCCCCCCCC	17.27	22817900
468	Ubiquitination	VTKGIQDNSPQHSVE HCCCCCCCCCCCCCC	38.93	21963094
469	Phosphorylation	TKGIQDNSPQHSVEN CCCCCCCCCCCCCCC	33.94	25159151
469	Ubiquitination	TKGIQDNSPQHSVEN CCCCCCCCCCCCCCC	33.94	21963094
472	Ubiquitination	IQDNSPQHSVENKPK CCCCCCCCCCCCCCC	36.88	22817900
473	Phosphorylation	QDNSPQHSVENKPKT CCCCCCCCCCCCCCC	26.36	22496350
474	Ubiquitination	DNSPQHSVENKPKTA CCCCCCCCCCCCCCH	9.85	22817900
476	Ubiquitination	SPQHSVENKPKTAAF CCCCCCCCCCCCHHH	64.87	22817900
477	Ubiquitination	PQHSVENKPKTAAFF CCCCCCCCCCCHHHH	34.09	22817900
477 (in isoform 1)	Ubiquitination	-	34.09	21890473
477 (in isoform 2)	Ubiquitination	-	34.09	21890473
478	Ubiquitination	QHSVENKPKTAAFFK CCCCCCCCCCHHHHH	51.30	22817900
479	Ubiquitination	HSVENKPKTAAFFKS CCCCCCCCCHHHHHC	53.02	22817900
482	Ubiquitination	ENKPKTAAFFKSSNL CCCCCCHHHHHCCCC	18.68	21963094
483	Ubiquitination	NKPKTAAFFKSSNLP CCCCCHHHHHCCCCC	8.00	22817900
484	Ubiquitination	KPKTAAFFKSSNLPL CCCCHHHHHCCCCCH	6.86	22817900
485	Ubiquitination	PKTAAFFKSSNLPLR CCCHHHHHCCCCCHH	46.66	22817900
488	Ubiquitination	AAFFKSSNLPLRFLS HHHHHCCCCCHHHHH	53.41	22817900
493	Ubiquitination	SSNLPLRFLSTLIVL CCCCCHHHHHHHHHH	9.23	21963094
516	Ubiquitination	LAQAFDSLCLDLKTE HHHHHHHHHEEEECC	3.46	22817900
520	Ubiquitination	FDSLCLDLKTEEGKT HHHHHEEEECCCCCE	4.82	22817900
521	Ubiquitination	DSLCLDLKTEEGKTL HHHHEEEECCCCCEE	54.26	21963094
525	Ubiquitination	LDLKTEEGKTLFLEY EEEECCCCCEEEEEE	23.24	21963094
526	Ubiquitination	DLKTEEGKTLFLEYQ EEECCCCCEEEEEEC	45.38	21963094
527	Phosphorylation	LKTEEGKTLFLEYQA EECCCCCEEEEEECH	33.33	22210691
527	Ubiquitination	LKTEEGKTLFLEYQA EECCCCCEEEEEECH	33.33	22817900
531	Ubiquitination	EGKTLFLEYQAVPVI CCCEEEEEECHHHHH	28.41	21963094
532	Phosphorylation	GKTLFLEYQAVPVIL CCEEEEEECHHHHHH	12.15	22210691
532	Ubiquitination	GKTLFLEYQAVPVIL CCEEEEEECHHHHHH	12.15	21963094
556	Phosphorylation	LLSNVIDSLLQMTVE HHHHHHHHHHHHHHH	21.61	22210691
561	Phosphorylation	IDSLLQMTVESKSLQ HHHHHHHHHHCCCHH	14.25	28258704
564	Phosphorylation	LLQMTVESKSLQPFL HHHHHHHCCCHHHHH	24.17	28258704
582	Phosphorylation	SNSLFFRTCSVLLRA CCCHHHHHHHHHHHC	12.18	26074081
584	Phosphorylation	SLFFRTCSVLLRAPK CHHHHHHHHHHHCCC	18.39	26074081
606	Ubiquitination	KLSIILQKLSKIKSN HHHHHHHHHHHHCCC	51.81	-
661	Phosphorylation	TKCNSLVSSASP--- HHHHHHHHCCCC---	26.02	30108239
662	Phosphorylation	KCNSLVSSASP---- HHHHHHHCCCC----	25.86	30108239
664	Phosphorylation	NSLVSSASP------ HHHHHCCCC------	32.84	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CC138_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CC138_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CC138_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CC138_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CC138_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.	19690332 [Abstract]
Ubiquitylation
Reference	PubMed
"The proteomic reactor facilitates the analysis of affinity-purifiedproteins by mass spectrometry: application for identifyingubiquitinated proteins in human cells."; Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,Haines D.S., Figeys D.; J. Proteome Res. 6:298-305(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-295, AND MASSSPECTROMETRY.	17203973 [Abstract]