| UniProt ID | CE104_HUMAN | |
|---|---|---|
| UniProt AC | O60308 | |
| Protein Name | Centrosomal protein of 104 kDa | |
| Gene Name | CEP104 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 925 | |
| Subcellular Localization | Cell projection, cilium . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole. In interphase non-ciliated cells, lo | |
| Protein Description | Required for ciliogenesis and for structural integrity at the ciliary tip.. | |
| Protein Sequence | MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQEIVLQMVERCRIRKLQLLAHQYMISSKIEFYISESLPEYFAPYQAERFRRLGYVSLCDNEKTGCKARELKSVYVDAVGQFLKLIFHQNHVNKYNIYNQVALVAINIIGDPADFSDESNTASREKLIDHYLGHNSEDPALEGTYARKSDYISPLDDLAFDMYQDPEVAQIIRKLDERKREAVQKERYDYAKKLKQAIADLQKVGERLGRYEVEKRCAVEKEDYDLAKEKKQQMEQYRAEVYEQLELHSLLDAELMRRPFDLPLQPLARSGSPCHQKPMPSLPQLEERGTENQFAEPFLQEKPSSYSLTISPQHSAVDPLLPATDPHPKINAESLPYDERPLPAIRKHYGEAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSYREDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPKHKLSKLETAHCVERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQIIPSYLVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHRVYEVRETAVRIILDMYRQHQASILEYLPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFCGERSESFTEEGLDLHYWKHCLMLTRCDHCKQVVEISSLTEHLLTECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKSSSRTYAKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | ELMIHAPTVSGWRSP HHEEECCCCCCCCCC | 28.25 | 23403867 | |
| 32 | Phosphorylation | MIHAPTVSGWRSPRF EEECCCCCCCCCCCC | 34.81 | 24719451 | |
| 36 | Phosphorylation | PTVSGWRSPRFCQFP CCCCCCCCCCCCCCC | 17.58 | 23403867 | |
| 105 | Ubiquitination | VSLCDNEKTGCKARE EECCCCCCCCCCHHH | 57.37 | - | |
| 109 | Ubiquitination | DNEKTGCKARELKSV CCCCCCCCHHHCCEE | 52.39 | - | |
| 168 | Ubiquitination | SNTASREKLIDHYLG CCCCHHHHHHHHHCC | 50.02 | - | |
| 187 | Phosphorylation | DPALEGTYARKSDYI CHHHCCCCCCCCCCC | 18.44 | 27642862 | |
| 190 | Ubiquitination | LEGTYARKSDYISPL HCCCCCCCCCCCCCH | 39.24 | - | |
| 237 | Ubiquitination | YDYAKKLKQAIADLQ HHHHHHHHHHHHHHH | 46.71 | - | |
| 266 | Phosphorylation | CAVEKEDYDLAKEKK HCCCHHHCHHHHHHH | 17.59 | 22817900 | |
| 312 | Phosphorylation | PLQPLARSGSPCHQK CCHHCCCCCCCCCCC | 37.71 | 28450419 | |
| 314 | Phosphorylation | QPLARSGSPCHQKPM HHCCCCCCCCCCCCC | 26.12 | 28450419 | |
| 346 | Phosphorylation | PFLQEKPSSYSLTIS HHHCCCCCCEEEEEC | 53.64 | 28348404 | |
| 347 | Phosphorylation | FLQEKPSSYSLTISP HHCCCCCCEEEEECC | 27.54 | 28348404 | |
| 348 | Phosphorylation | LQEKPSSYSLTISPQ HCCCCCCEEEEECCC | 16.43 | 28348404 | |
| 349 | Phosphorylation | QEKPSSYSLTISPQH CCCCCCEEEEECCCC | 22.45 | 23663014 | |
| 351 | Phosphorylation | KPSSYSLTISPQHSA CCCCEEEEECCCCCC | 17.30 | 25159151 | |
| 353 | Phosphorylation | SSYSLTISPQHSAVD CCEEEEECCCCCCCC | 17.17 | 25159151 | |
| 357 | Phosphorylation | LTISPQHSAVDPLLP EEECCCCCCCCCCCC | 25.41 | 25159151 | |
| 376 | Phosphorylation | HPKINAESLPYDERP CCCCCHHHCCCCCCC | 32.03 | 27251275 | |
| 379 | Phosphorylation | INAESLPYDERPLPA CCHHHCCCCCCCCHH | 35.41 | - | |
| 389 | Ubiquitination | RPLPAIRKHYGEAVV CCCHHHHHHHCEEEE | 34.76 | - | |
| 449 | Phosphorylation | EAYCKTWSYREDALL HHHHHHCCCCHHHHH | 21.39 | - | |
| 450 | Phosphorylation | AYCKTWSYREDALLA HHHHHCCCCHHHHHH | 15.02 | - | |
| 469 | Phosphorylation | LMEMPVGTPKEDLKN HHCCCCCCCHHHHHH | 31.27 | - | |
| 481 | Phosphorylation | LKNTLRASVFLVRRA HHHHHHHHHHHHHHH | 13.63 | - | |
| 529 | Phosphorylation | TAHCVERTIPVLLTR HHHHHHCCCCEEEEE | 19.00 | - | |
| 535 | Phosphorylation | RTIPVLLTRTGDSSA CCCCEEEEECCCCCH | 23.25 | - | |
| 540 | Phosphorylation | LLTRTGDSSARLRVT EEEECCCCCHHHHHH | 27.52 | - | |
| 563 | Phosphorylation | ALFKEVKSLQIIPSY HHHHHHHHCCCCCHH | 30.59 | - | |
| 600 | Phosphorylation | RLLKDLGTGSSGFTI HHHHHHCCCCCCEEC | 40.98 | - | |
| 602 | Phosphorylation | LKDLGTGSSGFTIDN HHHHCCCCCCEECCH | 27.42 | - | |
| 603 | Phosphorylation | KDLGTGSSGFTIDNV HHHCCCCCCEECCHH | 38.99 | - | |
| 606 | Phosphorylation | GTGSSGFTIDNVMKF CCCCCCEECCHHHEE | 30.83 | - | |
| 614 | Phosphorylation | IDNVMKFSVSALEHR CCHHHEEHHHHHHHH | 15.05 | 26074081 | |
| 616 | Phosphorylation | NVMKFSVSALEHRVY HHHEEHHHHHHHHHH | 26.41 | 26074081 | |
| 628 | Phosphorylation | RVYEVRETAVRIILD HHHHHHHHHHHHHHH | 21.64 | 26074081 | |
| 685 | Acetylation | AEMRARRKAATEEAE HHHHHHHHHHHHHHH | 36.50 | 19814677 | |
| 710 | Ubiquitination | QGQLAALKEIQAEVQ HHHHHHHHHHHHHHH | 48.31 | - | |
| 793 | Phosphorylation | CKQVVEISSLTEHLL HHHEEHHHHHHHHHH | 13.04 | - | |
| 794 | Phosphorylation | KQVVEISSLTEHLLT HHEEHHHHHHHHHHH | 45.00 | - | |
| 853 | Phosphorylation | PLCHENFSPGEEAWK CCCCCCCCCCHHHHH | 43.51 | 25159151 | |
| 905 | Phosphorylation | PLGSKAGSKIPTPKG CCCCCCCCCCCCCCC | 32.07 | 22817900 | |
| 915 | Phosphorylation | PTPKGGLSKSSSRTY CCCCCCCCCCCCCCC | 33.49 | - | |
| 917 | Phosphorylation | PKGGLSKSSSRTYAK CCCCCCCCCCCCCCC | 30.12 | 22817900 | |
| 918 | Phosphorylation | KGGLSKSSSRTYAKR CCCCCCCCCCCCCCC | 27.81 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CE104_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CE104_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CE104_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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