AP4E1_HUMAN - dbPTM
AP4E1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP4E1_HUMAN
UniProt AC Q9UPM8
Protein Name AP-4 complex subunit epsilon-1 {ECO:0000305}
Gene Name AP4E1 {ECO:0000312|HGNC:HGNC:573}
Organism Homo sapiens (Human).
Sequence Length 1137
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein .
Protein Description Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. [PubMed: 10066790]
Protein Sequence MSDIVEKTLTALPGLFLQNQPGGGPAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENVFYPQRFLQVMSWVLGEYSYLLDKETPEEVIAKLYKLLMNDSVSSETKAWLIAAVTKLTSQAHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENVELMKSLLPVDRSCEDLVVDASLSFLDGFVAEGLSQGAAPYKPPHQRQEEKLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSLKLEGIKKLWGKEGYLPKKESKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTINLLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGDKELKKFSLTSELLDSESLTELPLVEKFSYCSLSTPSLFANNNMEIFHPPQSTAASVAKESSLASSFLEETTEYIHSNAMEVCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLEIFPAENFKVTEQPGCCLPVMEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLEFSVNLSLLDFIRPLKISSDDFGKLWLSFANDVKQNVKMSESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQLLPSIPCLLHCRVHADVLALWFRSSCSTLPDYLLYQCQKVMEGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDIVEKTL
------CCHHHHHHH		47.5522210691
8PhosphorylationMSDIVEKTLTALPGL
CCHHHHHHHHHCCCH		18.81-
31PhosphorylationGPAAAKASFSSRLGS
CHHHHHHHHHHHHHH		25.59-
34PhosphorylationAAKASFSSRLGSLVR
HHHHHHHHHHHHHHH		29.5228787133
38PhosphorylationSFSSRLGSLVRGITA
HHHHHHHHHHHHHHH		28.4324719451
54AcetylationTSKHEEEKLIQQELS
CCHHHHHHHHHHHHH		54.9225953088
54MalonylationTSKHEEEKLIQQELS
CCHHHHHHHHHHHHH		54.9226320211
54UbiquitinationTSKHEEEKLIQQELS
CCHHHHHHHHHHHHH		54.92-
61PhosphorylationKLIQQELSSLKATVS
HHHHHHHHHCCCCCC		32.6424719451
64UbiquitinationQQELSSLKATVSAPT
HHHHHHCCCCCCCCH		43.91-
66PhosphorylationELSSLKATVSAPTTT
HHHHCCCCCCCCHHH		17.2629759185
72PhosphorylationATVSAPTTTLKMMKE
CCCCCCHHHHHHHHH		29.13-
181UbiquitinationEDKLQHSKEIVRRKA
HHHHHHCHHHHHHHH		49.70-
225PhosphorylationDVGVMAASLHIYLRM
CHHHHHHHHHHHHHH		15.7924719451
229PhosphorylationMAASLHIYLRMIKEN
HHHHHHHHHHHHHHC		4.2224719451
240PhosphorylationIKENSSGYKDLTGSF
HHHCCCCCCCCCCCH		11.8624719451
244PhosphorylationSSGYKDLTGSFVTIL
CCCCCCCCCCHHHHH		40.70-
2862-HydroxyisobutyrylationRILGLLGKDDQRTSE
HHHCCCCCCCHHHHH		59.09-
292PhosphorylationGKDDQRTSELMYDVL
CCCCHHHHHHHHHHH		30.8124719451
336UbiquitinationPKSELLEKAAKCIGK
CHHHHHHHHHHHHHH		54.32-
393PhosphorylationDPIIKRETLELLYRI
CCCCCHHHHHHHHHH		29.5720068231
398PhosphorylationRETLELLYRITNAQN
HHHHHHHHHHHCCCC		16.7620068231
401PhosphorylationLELLYRITNAQNITV
HHHHHHHHCCCCHHH		18.5920068231
407PhosphorylationITNAQNITVIVQKML
HHCCCCHHHHHHHHH		16.2420068231
605PhosphorylationENVELMKSLLPVDRS
HHHHHHHHHCCCCCC		22.60-
612PhosphorylationSLLPVDRSCEDLVVD
HHCCCCCCHHHHHHC		19.86-
655UbiquitinationEEKLSQEKVLNFEPY
HHHCCHHHCCCCCCC		44.37-
662PhosphorylationKVLNFEPYGLSFSSS
HCCCCCCCCEEECCC		24.4128450419
665PhosphorylationNFEPYGLSFSSSGFT
CCCCCCEEECCCCCC		20.7928450419
667PhosphorylationEPYGLSFSSSGFTGR
CCCCEEECCCCCCCC		21.8828450419
668PhosphorylationPYGLSFSSSGFTGRQ
CCCEEECCCCCCCCC		32.2528450419
669PhosphorylationYGLSFSSSGFTGRQS
CCEEECCCCCCCCCC		36.4128450419
672PhosphorylationSFSSSGFTGRQSPAG
EECCCCCCCCCCCCE		34.6728450419
676PhosphorylationSGFTGRQSPAGISLG
CCCCCCCCCCEEECC		18.5029255136
681PhosphorylationRQSPAGISLGSDVSG
CCCCCEEECCCCCCC		26.2628450419
684PhosphorylationPAGISLGSDVSGNSA
CCEEECCCCCCCCCC		39.8828450419
690PhosphorylationGSDVSGNSAETGLKE
CCCCCCCCCCCCCHH		30.8927135362
696MethylationNSAETGLKETNSLKL
CCCCCCCHHCCCCCC		64.93-
698PhosphorylationAETGLKETNSLKLEG
CCCCCHHCCCCCCHH		28.6427282143
700PhosphorylationTGLKETNSLKLEGIK
CCCHHCCCCCCHHHH		34.0126657352
723PhosphorylationLPKKESKTGDESGAL
CCCCCCCCCCCCCCC		60.1821712546
727PhosphorylationESKTGDESGALPVPQ
CCCCCCCCCCCCCCH		33.8221712546
736PhosphorylationALPVPQESIMENVDQ
CCCCCHHHHHHCHHH		23.2221712546
748UbiquitinationVDQAITKKDQSQVLT
HHHHHHHHHHHHHHH		52.96-
751PhosphorylationAITKKDQSQVLTQSK
HHHHHHHHHHHHCCH		32.1821815630
757PhosphorylationQSQVLTQSKEEKEKQ
HHHHHHCCHHHHHHH		36.4825627689
768PhosphorylationKEKQLLASSLFVGLG
HHHHHHHHHHHHCCC		27.7822210691
778PhosphorylationFVGLGSESTINLLGK
HHCCCCHHHHHHHCC		35.9622210691
790PhosphorylationLGKADTVSHKFRRKS
HCCHHHCCHHHHCHH		24.0522210691
792UbiquitinationKADTVSHKFRRKSKV
CHHHCCHHHHCHHHC		32.81-
797PhosphorylationSHKFRRKSKVKEAKS
CHHHHCHHHCCCCCC		40.65-
830PhosphorylationNVAYEDDYYSNTLHD
CCCCCCCCCCCCCCC		22.5522817900
831PhosphorylationVAYEDDYYSNTLHDT
CCCCCCCCCCCCCCC		11.4822817900
832PhosphorylationAYEDDYYSNTLHDTG
CCCCCCCCCCCCCCC		19.67-
845UbiquitinationTGDKELKKFSLTSEL
CCCHHHHHHCCCHHH		53.46-
847PhosphorylationDKELKKFSLTSELLD
CHHHHHHCCCHHHCC		39.3528450419
849PhosphorylationELKKFSLTSELLDSE
HHHHHCCCHHHCCCC		20.9626657352
850PhosphorylationLKKFSLTSELLDSES
HHHHCCCHHHCCCCC		31.3821082442
855PhosphorylationLTSELLDSESLTELP
CCHHHCCCCCCCCCC		29.1126657352
857PhosphorylationSELLDSESLTELPLV
HHHCCCCCCCCCCCE		44.5421712546
859PhosphorylationLLDSESLTELPLVEK
HCCCCCCCCCCCEEC		44.7628450419
868PhosphorylationLPLVEKFSYCSLSTP
CCCEECCCCCCCCCC		35.9821810154
871PhosphorylationVEKFSYCSLSTPSLF
EECCCCCCCCCCCHH		19.6821810154
955UbiquitinationNKSGLELKSADLEIF
CCCCCEEECCCEEEE		33.93-
1070UbiquitinationAALPSALKTLQQKLR
HHHHHHHHHHHHHHH		47.08-
1137PhosphorylationCQKVMEGS-------
HHHHHCCC-------		24.60-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP4E1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AP4E1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP4E1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP4B1_HUMANAP4B1physical
11409905
AP4B1_HUMANAP4B1physical
10436028
AP4S1_HUMANAP4S1physical
10436028
M3K4_HUMANMAP3K4physical
26496610
AP2A_HUMANTFAP2Aphysical
26496610
AP4M1_HUMANAP4M1physical
26496610
AP4B1_HUMANAP4B1physical
26496610
YMEL1_HUMANYME1L1physical
26496610
AP4S1_HUMANAP4S1physical
26496610
GOLI4_HUMANGOLIM4physical
26496610
AP4AT_HUMANENTHD2physical
26496610
LAMA1_HUMANLAMA1physical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613744Cerebral palsy, spastic quadriplegic 4 (CPSQ4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP4E1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-850 AND SER-857, ANDMASS SPECTROMETRY.

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