AP4M1_HUMAN - dbPTM
AP4M1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP4M1_HUMAN
UniProt AC O00189
Protein Name AP-4 complex subunit mu-1 {ECO:0000305}
Gene Name AP4M1 {ECO:0000312|HGNC:HGNC:574}
Organism Homo sapiens (Human).
Sequence Length 453
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein . Early endosome . Found in soma and dendritic shafts of neuronal cells.
Protein Description Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. [PubMed: 10436028]
Protein Sequence MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationISQFFILSSKGDPLI
CCEEEEECCCCCCEE		25.7829083192
10PhosphorylationSQFFILSSKGDPLIY
CEEEEECCCCCCEEE		36.8929083192
11UbiquitinationQFFILSSKGDPLIYK
EEEEECCCCCCEEEE		65.05-
18UbiquitinationKGDPLIYKDFRGDSG
CCCCEEEECCCCCCC		43.3121890473
45PhosphorylationTGLPGDESPVVMHHH
HCCCCCCCCEEEEEC		27.9523312004
62PhosphorylationHFIHIRHSGLYLVVT
EEEEEECCEEEEEEE		22.2024719451
65PhosphorylationHIRHSGLYLVVTTSE
EEECCEEEEEEECCC		10.8526503514
75PhosphorylationVTTSENVSPFSLLEL
EECCCCCCHHHHHHH		31.6326503514
78PhosphorylationSENVSPFSLLELLSR
CCCCCHHHHHHHHHH		35.1124719451
84PhosphorylationFSLLELLSRLATLLG
HHHHHHHHHHHHHHH		37.5624719451
136PhosphorylationMLRNFIQTEAVVSKP
HHHHHHCHHHHHCCC		22.5426270265
141PhosphorylationIQTEAVVSKPFSLFD
HCHHHHHCCCCCCCC		28.1926270265
145PhosphorylationAVVSKPFSLFDLSSV
HHHCCCCCCCCHHHC		36.33-
150PhosphorylationPFSLFDLSSVGLFGA
CCCCCCHHHCCCCCC		25.48-
159PhosphorylationVGLFGAETQQSKVAP
CCCCCCCCCCCCCCC		31.23-
162PhosphorylationFGAETQQSKVAPSSA
CCCCCCCCCCCCCCH		21.19-
163UbiquitinationGAETQQSKVAPSSAA
CCCCCCCCCCCCCHH		37.77-
167PhosphorylationQQSKVAPSSAASRPV
CCCCCCCCCHHHCCC		23.9118691976
168PhosphorylationQSKVAPSSAASRPVL
CCCCCCCCHHHCCCC		27.1326434776
171PhosphorylationVAPSSAASRPVLSSR
CCCCCHHHCCCCCCC		36.5117192257
177PhosphorylationASRPVLSSRSDQSQK
HHCCCCCCCCCHHHC		31.4824719451
196PhosphorylationLDVVERLSVLIASNG
HHHHHHHHEEEECCC		22.5425404012
201PhosphorylationRLSVLIASNGSLLKV
HHHEEEECCCCEEEE		34.4325693802
204PhosphorylationVLIASNGSLLKVDVQ
EEEECCCCEEEEEEC		34.4824719451
238UbiquitinationTEEFCVGKSELRGYG
CCEEECCHHHHCCCC		21.9921906983
324UbiquitinationLRCDLLSKSQALNVR
EECHHCCCCCCCCEE		46.70-
342PhosphorylationPLPRGVVSLSQELSS
CCCCCEEEHHHHCCC		21.6417924679
349PhosphorylationSLSQELSSPEQKAEL
EHHHHCCCHHHHHHH		45.1121815630
353UbiquitinationELSSPEQKAELAEGA
HCCCHHHHHHHHHHH		42.0121890473
438UbiquitinationCGNANPHKWVRHLSH
CCCCCHHHHHHCCCC		48.95-
444PhosphorylationHKWVRHLSHSDAYVI
HHHHHCCCCCCCEEE		18.1523312004
446PhosphorylationWVRHLSHSDAYVIRI
HHHCCCCCCCEEEEC		22.1423312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP4M1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AP4M1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP4M1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP4E1_HUMANAP4E1physical
10436028
AP4B1_HUMANAP4B1physical
10436028
DDX52_HUMANDDX52physical
21988832
ZBT22_HUMANZBTB22physical
21988832
CTF8_HUMANCHTF8physical
21988832
UBP47_HUMANUSP47physical
25416956
ACY1_HUMANACY1physical
26496610
AKT2_HUMANAKT2physical
26496610
GALT2_HUMANGALNT2physical
26496610
H33_HUMANH3F3Aphysical
26496610
HMGA1_HUMANHMGA1physical
26496610
IMDH2_HUMANIMPDH2physical
26496610
NPAT_HUMANNPATphysical
26496610
RALA_HUMANRALAphysical
26496610
CBX4_HUMANCBX4physical
26496610
TYW4_HUMANLCMT2physical
26496610
SF3B2_HUMANSF3B2physical
26496610
AP4S1_HUMANAP4S1physical
26496610
AP4E1_HUMANAP4E1physical
26496610
ZN318_HUMANZNF318physical
26496610
MED31_HUMANMED31physical
26496610
TFB1M_HUMANTFB1Mphysical
26496610
RM48_HUMANMRPL48physical
26496610
RT23_HUMANMRPS23physical
26496610
WDR76_HUMANWDR76physical
26496610
TIM29_HUMANC19orf52physical
26496610
AP4AT_HUMANENTHD2physical
26496610
ARID2_HUMANARID2physical
26496610
ARPIN_HUMANARPINphysical
26496610
CD11A_HUMANCDK11Aphysical
26496610
Drug and Disease Associations
Kegg Disease
H01097 Cerebral palsy
OMIM Disease
612936Cerebral palsy, spastic quadriplegic 3 (CPSQ3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP4M1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342, AND MASSSPECTROMETRY.

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