TFB1M_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFB1M_HUMAN
• UniProt AC: Q8WVM0
• Protein Name: Dimethyladenosine transferase 1, mitochondrial
• Gene Name: TFB1M
• Organism: Homo sapiens (Human).
• Sequence Length: 346
• Subcellular Localization: Mitochondrion .
• Protein Description: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity..
• Protein Sequence: MAASGKLSTCRLPPLPTIREIIKLLRLQAAKQLSQNFLLDLRLTDKIVRKAGNLTNAYVYEVGPGPGGITRSILNADVAELLVVEKDTRFIPGLQMLSDAAPGKLRIVHGDVLTFKVEKAFSESLKRPWEDDPPNVHIIGNLPFSVSTPLIIKWLENISCRDGPFVYGRTQMTLTFQKEVAERLAANTGSKQRSRLSVMAQYLCNVRHIFTIPGQAFVPKPEVDVGVVHFTPLIQPKIEQPFKLVEKVVQNVFQFRRKYCHRGLRMLFPEAQRLESTGRLLELADIDPTLRPRQLSISHFKSLCDVYRKMCDEDPQLFAYNFREELKRRKSKNEEKEEDDAENYRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MAASGKLSTCRLP --CCCCCCCCCCCCC	36.45	25953088
9	Phosphorylation	AASGKLSTCRLPPLP CCCCCCCCCCCCCCC	16.45	28188228
17	Phosphorylation	CRLPPLPTIREIIKL CCCCCCCCHHHHHHH	40.11	28188228
46	Malonylation	LDLRLTDKIVRKAGN HHHHCHHHHHHHHCC	37.55	26320211
50	Malonylation	LTDKIVRKAGNLTNA CHHHHHHHHCCCCCE	50.15	26320211
88	Phosphorylation	LLVVEKDTRFIPGLQ HEEEECCCCCCCCCH	38.25	-
98	Phosphorylation	IPGLQMLSDAAPGKL CCCCHHHCCCCCCCE	21.62	-
114	Phosphorylation	IVHGDVLTFKVEKAF EEECCEEEEEEEEHH	22.66	20068231
159	Phosphorylation	IKWLENISCRDGPFV HHHHHHCCCCCCCEE	18.06	-
167	Phosphorylation	CRDGPFVYGRTQMTL CCCCCEEECCEEEEE	10.98	-
173	Phosphorylation	VYGRTQMTLTFQKEV EECCEEEEEEEHHHH	16.90	-
175	Phosphorylation	GRTQMTLTFQKEVAE CCEEEEEEEHHHHHH	18.17	-
211	Phosphorylation	CNVRHIFTIPGQAFV HCCCEEEEECCCCCC	26.17	21406692
296	Phosphorylation	TLRPRQLSISHFKSL CCCHHHHCHHHHHHH	17.44	28355574
298	Phosphorylation	RPRQLSISHFKSLCD CHHHHCHHHHHHHHH	21.35	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFB1M_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFB1M_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFB1M_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFAM_HUMAN	TFAM	physical	12897151
RPOM_HUMAN	POLRMT	physical	12897151
CH60_HUMAN	HSPD1	physical	28514442
DCAF8_HUMAN	DCAF8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.