ARID2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARID2_HUMAN
• UniProt AC: Q68CP9
• Protein Name: AT-rich interactive domain-containing protein 2 {ECO:0000305}
• Gene Name: ARID2 {ECO:0000312|HGNC:HGNC:18037}
• Organism: Homo sapiens (Human).
• Sequence Length: 1835
• Subcellular Localization: Nucleus.
• Protein Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes..
• Protein Sequence: MANSTGKAPPDERRKGLAFLDELRQFHHSRGSPFKKIPAVGGKELDLHGLYTRVTTLGGFAKVSEKNQWGEIVEEFNFPRSCSNAAFALKQYYLRYLEKYEKVHHFGEDDDEVPPGNPKPQLPIGAIPSSYNYQQHSVSDYLRQSYGLSMDFNSPNDYNKLVLSLLSGLPNEVDFAINVCTLLSNESKHVMQLEKDPKIITLLLANAGVFDDTLGSFSTVFGEEWKEKTDRDFVKFWKDIVDDNEVRDLISDRNKSHEGTSGEWIWESLFHPPRKLGINDIEGQRVLQIAVILRNLSFEEGNVKLLAANRTCLRFLLLSAHSHFISLRQLGLDTLGNIAAELLLDPVDFKTTHLMFHTVTKCLMSRDRFLKMRGMEILGNLCKAEDNGVLICEYVDQDSYREIICHLTLPDVLLVISTLEVLYMLTEMGDVACTKIAKVEKSIDMLVCLVSMDIQMFGPDALAAVKLIEHPSSSHQMLSEIRPQAIEQVQTQTHVASAPASRAVVAQHVAPPPGIVEIDSEKFACQWLNAHFEVNPDCSVSRAEMYSEYLSTCSKLARGGILTSTGFYKCLRTVFPNHTVKRVEDSSSNGQAHIHVVGVKRRAIPLPIQMYYQQQPVSTSVVRVDSVPDVSPAPSPAGIPHGSQTIGNHFQRTPVANQSSNLTATQMSFPVQGVHTVAQTVSRIPQNPSPHTHQQQNAPVTVIQSKAPIPCEVVKATVIQNSIPQTGVPVSIAVGGGPPQSSVVQNHSTGPQPVTVVNSQTLLHHPSVIPQQSPLHTVVPGQIPSGTPVTVIQQAVPQSHMFGRVQNIPACTSTVSQGQQLITTSPQPVQTSSQQTSAGSQSQDTVIIAPPQYVTTSASNIVSATSVQNFQVATGQMVTIAGVPSPQASRVGFQNIAPKPLPSQQVSSTVVQQPIQQPQQPTQQSVVIVSQPAQQGQTYAPAIHQIVLANPAALPAGQTVQLTGQPNITPSSSPSPVPATNNQVPTAMSSSSTPQSQGPPPTVSQMLSVKRQQQQQHSPAPPPQQVQVQVQQPQQVQMQVQPQQSNAGVGQPASGESSLIKQLLLPKRGPSTPGGKLILPAPQIPPPNNARAPSPQVVYQVASNQAAGFGVQGQTPAQQLLVGQQNVQLVPSAMPPSGGVQTVPISNLQILPGPLISNSPATIFQGTSGNQVTITVVPNTSFAPATVSQGNATQLIAPAGITMSGTQTGVGLPVQTLPATQASPAGQSSCTTATPPFKGDKIICQKEEEAKEATGLHVHERKIEVMENPSCRRGATNTSNGDTKENEMHVGSLLNGRKYSDSSLPPSNSGKIQSETNQCSLISNGPSLELGENGASGKQNSEQIDMQDIKSDLRKPLVNGICDFDKGDGSHLSKNIPNHKTSNHVGNGEISPMEPQGTLDITQQDTAKGDQLERISNGPVLTLGGSSVSSIQEASNAATQQFSGTDLLNGPLASSLNSDVPQQRPSVVVSPHSTTSVIQGHQIIAVPDSGSKVSHSPALSSDVRSTNGTAECKTVKRPAEDTDRETVAGIPNKVGVRIVTISDPNNAGCSATMVAVPAGADPSTVAKVAIESAVQQKQQHPPTYVQNVVPQNTPMPPSPAVQVQGQPNSSQPSPFSGSSQPGDPMRKPGQNFMCLWQSCKKWFQTPSQVFYHAATEHGGKDVYPGQCLWEGCEPFQRQRFSFITHLQDKHCSKDALLAGLKQDEPGQAGSQKSSTKQPTVGGTSSTPRAQKAIVNHPSAALMALRRGSRNLVFRDFTDEKEGPITKHIRLTAALILKNIGKYSECGRRLLKRHENNLSVLAISNMEASSTLAKCLYELNFTVQSKEQEKDSEMLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANSTGKAP ------CCCCCCCCC	29.95	22814378
4	Phosphorylation	----MANSTGKAPPD ----CCCCCCCCCHH	45.67	29083192
5	Phosphorylation	---MANSTGKAPPDE ---CCCCCCCCCHHH	42.37	23186163
7	Acetylation	-MANSTGKAPPDERR -CCCCCCCCCHHHHH	58.78	25953088
7	Sumoylation	-MANSTGKAPPDERR -CCCCCCCCCHHHHH	58.78	28112733
7	Ubiquitination	-MANSTGKAPPDERR -CCCCCCCCCHHHHH	58.78	33845483
15	Sumoylation	APPDERRKGLAFLDE CCHHHHHHHHHHHHH	65.58	28112733
15	Ubiquitination	APPDERRKGLAFLDE CCHHHHHHHHHHHHH	65.58	22817900
15 (in isoform 1)	Ubiquitination	-	65.58	21890473
15 (in isoform 3)	Ubiquitination	-	65.58	21890473
29	Phosphorylation	ELRQFHHSRGSPFKK HHHHHHHHCCCCCCC	29.75	20068231
32	Phosphorylation	QFHHSRGSPFKKIPA HHHHHCCCCCCCCCC	26.50	20068231
43	Ubiquitination	KIPAVGGKELDLHGL CCCCCCCCEEECCCC	49.53	-
56	Phosphorylation	GLYTRVTTLGGFAKV CCEEEEEEECCCEEC	22.13	20068231
62	Ubiquitination	TTLGGFAKVSEKNQW EEECCCEECCCCCCH	43.99	22817900
62 (in isoform 1)	Ubiquitination	-	43.99	21890473
62 (in isoform 3)	Ubiquitination	-	43.99	21890473
66	Ubiquitination	GFAKVSEKNQWGEIV CCEECCCCCCHHHHC	47.10	22817900
90	Acetylation	SNAAFALKQYYLRYL CCHHHHHHHHHHHHH	32.59	26051181
92	Phosphorylation	AAFALKQYYLRYLEK HHHHHHHHHHHHHHH	11.68	26074081
93	Phosphorylation	AFALKQYYLRYLEKY HHHHHHHHHHHHHHH	5.13	26074081
96	Phosphorylation	LKQYYLRYLEKYEKV HHHHHHHHHHHHHHC	19.33	26074081
119	Sumoylation	EVPPGNPKPQLPIGA CCCCCCCCCCCCCCC	49.77	28112733
119	Ubiquitination	EVPPGNPKPQLPIGA CCCCCCCCCCCCCCC	49.77	29967540
195	Ubiquitination	KHVMQLEKDPKIITL HHHHHHCCCHHHHHH	84.01	29967540
235	Ubiquitination	KTDRDFVKFWKDIVD HCCHHHHHHHHHHCC	45.56	29967540
238	Ubiquitination	RDFVKFWKDIVDDNE HHHHHHHHHHCCHHH	40.48	29967540
255	Ubiquitination	DLISDRNKSHEGTSG HHHHCCCCCCCCCCC	54.83	29967540
275	Ubiquitination	SLFHPPRKLGINDIE HHCCCCCCCCCCCCC	57.76	29967540
297	Phosphorylation	AVILRNLSFEEGNVK HHHHHHCCCCCCCEE	33.87	22468782
358	Phosphorylation	TTHLMFHTVTKCLMS HHHHHHHHHHHHHHC	20.71	22985185
371	Ubiquitination	MSRDRFLKMRGMEIL HCCHHHHHHHHHHHH	24.68	-
479	Phosphorylation	SSSHQMLSEIRPQAI CCHHHHHHHHCHHHH	26.15	24719451
546	Phosphorylation	SVSRAEMYSEYLSTC CCCHHHHHHHHHHHH	7.00	23401153
547	Phosphorylation	VSRAEMYSEYLSTCS CCHHHHHHHHHHHHH	20.60	23401153
549	Phosphorylation	RAEMYSEYLSTCSKL HHHHHHHHHHHHHHH	10.46	24043423
551	Phosphorylation	EMYSEYLSTCSKLAR HHHHHHHHHHHHHHH	26.85	23401153
552	Phosphorylation	MYSEYLSTCSKLARG HHHHHHHHHHHHHHC	20.43	23401153
554	Phosphorylation	SEYLSTCSKLARGGI HHHHHHHHHHHHCCC	30.69	23401153
555	Acetylation	EYLSTCSKLARGGIL HHHHHHHHHHHCCCC	48.60	26051181
555	Sumoylation	EYLSTCSKLARGGIL HHHHHHHHHHHCCCC	48.60	28112733
569	Acetylation	LTSTGFYKCLRTVFP CHHHCHHHHHHHHCC	25.24	26051181
581	Ubiquitination	VFPNHTVKRVEDSSS HCCCCEEEEEECCCC	52.46	29967540
587	Phosphorylation	VKRVEDSSSNGQAHI EEEEECCCCCCCEEE	39.89	28555341
600	Acetylation	HIHVVGVKRRAIPLP EEEEEEECCCCCCCC	30.18	26051181
618	O-linked_Glycosylation	YYQQQPVSTSVVRVD EECCCCCCEEEEEEC	22.96	30059200
620	Phosphorylation	QQQPVSTSVVRVDSV CCCCCCEEEEEECCC	15.88	28555341
626	Phosphorylation	TSVVRVDSVPDVSPA EEEEEECCCCCCCCC	32.46	21712546
631	Phosphorylation	VDSVPDVSPAPSPAG ECCCCCCCCCCCCCC	23.79	25159151
635	Phosphorylation	PDVSPAPSPAGIPHG CCCCCCCCCCCCCCC	29.50	25159151
643	Phosphorylation	PAGIPHGSQTIGNHF CCCCCCCCCCCCCCC	22.55	28450419
645	Phosphorylation	GIPHGSQTIGNHFQR CCCCCCCCCCCCCCC	32.33	28450419
653	Phosphorylation	IGNHFQRTPVANQSS CCCCCCCCCCCCCCC	16.01	18669648
659	Phosphorylation	RTPVANQSSNLTATQ CCCCCCCCCCCEEEE	22.47	27251275
660	Phosphorylation	TPVANQSSNLTATQM CCCCCCCCCCEEEEE	26.54	27251275
676	Phosphorylation	FPVQGVHTVAQTVSR CCCCCCEEHHHHHHC	18.35	-
680	Phosphorylation	GVHTVAQTVSRIPQN CCEEHHHHHHCCCCC	15.65	-
689	Phosphorylation	SRIPQNPSPHTHQQQ HCCCCCCCCCCCCCC	36.54	30266825
692	Phosphorylation	PQNPSPHTHQQQNAP CCCCCCCCCCCCCCC	25.43	30266825
701	Phosphorylation	QQQNAPVTVIQSKAP CCCCCCEEEEECCCC	15.72	24732914
705	Phosphorylation	APVTVIQSKAPIPCE CCEEEEECCCCCCCE	21.47	24732914
1008	Phosphorylation	PTVSQMLSVKRQQQQ CCHHHHHHHHHHHHH	21.90	24719451
1058	Phosphorylation	QPASGESSLIKQLLL CCCCCCCHHHHHHHC	29.79	24719451
1067	Acetylation	IKQLLLPKRGPSTPG HHHHHCCCCCCCCCC	70.70	7219291
1072	Phosphorylation	LPKRGPSTPGGKLIL CCCCCCCCCCCEEEE	29.14	-
1076	Acetylation	GPSTPGGKLILPAPQ CCCCCCCEEEEECCC	37.96	25953088
1094	Phosphorylation	PNNARAPSPQVVYQV CCCCCCCCCCEEEEE	27.29	26074081
1099	Phosphorylation	APSPQVVYQVASNQA CCCCCEEEEEECCCC	9.83	26074081
1187	Ubiquitination	TSFAPATVSQGNATQ CCCCCCEECCCCCCE	4.34	21890473
1233	Ubiquitination	GQSSCTTATPPFKGD CCCCCCCCCCCCCCC	10.43	21890473
1237	Ubiquitination	CTTATPPFKGDKIIC CCCCCCCCCCCEEEE	16.97	22817900
1241	Acetylation	TPPFKGDKIICQKEE CCCCCCCEEEECCHH	42.51	25953088
1241	Ubiquitination	TPPFKGDKIICQKEE CCCCCCCEEEECCHH	42.51	-
1246	Acetylation	GDKIICQKEEEAKEA CCEEEECCHHHHHHH	63.78	26051181
1262	Ubiquitination	GLHVHERKIEVMENP CCCEEEEEEEECCCC	39.99	29967540
1266	Sulfoxidation	HERKIEVMENPSCRR EEEEEEECCCCCCCC	2.40	21406390
1276	Phosphorylation	PSCRRGATNTSNGDT CCCCCCCCCCCCCCC	41.68	23401153
1278	Phosphorylation	CRRGATNTSNGDTKE CCCCCCCCCCCCCCC	21.15	23401153
1279	Phosphorylation	RRGATNTSNGDTKEN CCCCCCCCCCCCCCC	40.67	23401153
1292	Phosphorylation	ENEMHVGSLLNGRKY CCCEEHHHHHCCCCC	28.70	20068231
1299	Phosphorylation	SLLNGRKYSDSSLPP HHHCCCCCCCCCCCC	19.15	26657352
1300	Phosphorylation	LLNGRKYSDSSLPPS HHCCCCCCCCCCCCC	33.77	30266825
1302	Phosphorylation	NGRKYSDSSLPPSNS CCCCCCCCCCCCCCC	28.03	30266825
1303	Phosphorylation	GRKYSDSSLPPSNSG CCCCCCCCCCCCCCC	50.30	25262027
1316	Phosphorylation	SGKIQSETNQCSLIS CCCCCCCCCCCEEEC	35.52	-
1323	Phosphorylation	TNQCSLISNGPSLEL CCCCEEECCCCCCCC	40.81	-
1346	Sulfoxidation	QNSEQIDMQDIKSDL CCCHHCCHHHHHHHH	4.05	21406390
1350	Ubiquitination	QIDMQDIKSDLRKPL HCCHHHHHHHHHCHH	46.32	29967540
1351	Phosphorylation	IDMQDIKSDLRKPLV CCHHHHHHHHHCHHH	42.06	30576142
1366	Acetylation	NGICDFDKGDGSHLS CCCCCCCCCCCCCCC	59.92	26051181
1370	Phosphorylation	DFDKGDGSHLSKNIP CCCCCCCCCCCCCCC	26.45	30576142
1373	Phosphorylation	KGDGSHLSKNIPNHK CCCCCCCCCCCCCCC	20.45	30576142
1381	Phosphorylation	KNIPNHKTSNHVGNG CCCCCCCCCCCCCCC	27.49	30108239
1382	Phosphorylation	NIPNHKTSNHVGNGE CCCCCCCCCCCCCCC	29.73	30108239
1391	Phosphorylation	HVGNGEISPMEPQGT CCCCCCCCCCCCCCC	17.56	23401153
1398	Phosphorylation	SPMEPQGTLDITQQD CCCCCCCCEECCCCC	18.93	30108239
1402	Phosphorylation	PQGTLDITQQDTAKG CCCCEECCCCCCCCC	21.61	28555341
1466	Phosphorylation	DVPQQRPSVVVSPHS CCCCCCCCEEECCCC	29.72	25850435
1470	Phosphorylation	QRPSVVVSPHSTTSV CCCCEEECCCCCCCE	12.80	25849741
1473	Phosphorylation	SVVVSPHSTTSVIQG CEEECCCCCCCEECC	36.44	25850435
1474	Phosphorylation	VVVSPHSTTSVIQGH EEECCCCCCCEECCE	21.76	25850435
1475	Phosphorylation	VVSPHSTTSVIQGHQ EECCCCCCCEECCEE	24.82	25850435
1476	Phosphorylation	VSPHSTTSVIQGHQI ECCCCCCCEECCEEE	19.81	25850435
1489	Phosphorylation	QIIAVPDSGSKVSHS EEEECCCCCCCCCCC	38.61	26074081
1491	Phosphorylation	IAVPDSGSKVSHSPA EECCCCCCCCCCCCC	33.56	26074081
1494	O-linked_Glycosylation	PDSGSKVSHSPALSS CCCCCCCCCCCCCCC	23.22	30059200
1494	Phosphorylation	PDSGSKVSHSPALSS CCCCCCCCCCCCCCC	23.22	30266825
1496	Phosphorylation	SGSKVSHSPALSSDV CCCCCCCCCCCCCCC	12.36	30266825
1500	Phosphorylation	VSHSPALSSDVRSTN CCCCCCCCCCCCCCC	26.97	24732914
1501	O-linked_Glycosylation	SHSPALSSDVRSTNG CCCCCCCCCCCCCCC	40.76	30059200
1501	Phosphorylation	SHSPALSSDVRSTNG CCCCCCCCCCCCCCC	40.76	24732914
1505	O-linked_Glycosylation	ALSSDVRSTNGTAEC CCCCCCCCCCCCCEE	26.52	30059200
1513	Acetylation	TNGTAECKTVKRPAE CCCCCEEEEECCCCC	48.10	25953088
1533	Ubiquitination	TVAGIPNKVGVRIVT HHCCCCCCCCEEEEE	34.70	29901268
1540	Phosphorylation	KVGVRIVTISDPNNA CCCEEEEEECCCCCC	16.64	-
1550	Phosphorylation	DPNNAGCSATMVAVP CCCCCCCCEEEEEEC	26.34	-
1572	Phosphorylation	VAKVAIESAVQQKQQ HHHHHHHHHHHHHHH	27.85	-
1681	Phosphorylation	PFQRQRFSFITHLQD HHHHHHHHHHHHHCC	20.23	28555341
1693	Ubiquitination	LQDKHCSKDALLAGL HCCCCCCHHHHHHCC	53.03	29967540
1701	Sumoylation	DALLAGLKQDEPGQA HHHHHCCCCCCCCCC	55.58	28112733
1701	Ubiquitination	DALLAGLKQDEPGQA HHHHHCCCCCCCCCC	55.58	29967540
1713	Phosphorylation	GQAGSQKSSTKQPTV CCCCCCCCCCCCCCC	35.29	-
1715	Phosphorylation	AGSQKSSTKQPTVGG CCCCCCCCCCCCCCC	40.57	26074081
1716	Sumoylation	GSQKSSTKQPTVGGT CCCCCCCCCCCCCCC	57.11	28112733
1716	Ubiquitination	GSQKSSTKQPTVGGT CCCCCCCCCCCCCCC	57.11	29967540
1719	Phosphorylation	KSSTKQPTVGGTSST CCCCCCCCCCCCCCC	29.32	26074081
1723	Phosphorylation	KQPTVGGTSSTPRAQ CCCCCCCCCCCHHHH	17.36	19664995
1724	Phosphorylation	QPTVGGTSSTPRAQK CCCCCCCCCCHHHHH	35.17	21815630
1725	Phosphorylation	PTVGGTSSTPRAQKA CCCCCCCCCHHHHHH	42.12	30576142
1726	Phosphorylation	TVGGTSSTPRAQKAI CCCCCCCCHHHHHHH	19.30	25159151
1731	Sumoylation	SSTPRAQKAIVNHPS CCCHHHHHHHHCCHH	38.81	28112733
1731	Ubiquitination	SSTPRAQKAIVNHPS CCCHHHHHHHHCCHH	38.81	21890473
1731 (in isoform 1)	Ubiquitination	-	38.81	21890473
1731 (in isoform 3)	Ubiquitination	-	38.81	21890473
1760	Acetylation	FRDFTDEKEGPITKH EECCCCCCCCCCCHH	71.44	26051181
1760	Ubiquitination	FRDFTDEKEGPITKH EECCCCCCCCCCCHH	71.44	29967540
1766	Ubiquitination	EKEGPITKHIRLTAA CCCCCCCHHHHHHHH	37.44	-
1777	Ubiquitination	LTAALILKNIGKYSE HHHHHHHHHHHCCCH	39.25	22817900
1777 (in isoform 1)	Ubiquitination	-	39.25	21890473
1777 (in isoform 3)	Ubiquitination	-	39.25	21890473
1781	Acetylation	LILKNIGKYSECGRR HHHHHHHCCCHHHHH	41.63	25953088
1781	Ubiquitination	LILKNIGKYSECGRR HHHHHHHCCCHHHHH	41.63	22817900
1798	Phosphorylation	KRHENNLSVLAISNM HHHCCCCEEEEEECC	19.74	20068231
1803	Phosphorylation	NLSVLAISNMEASST CCEEEEEECCCHHHH	25.23	20068231
1808	Phosphorylation	AISNMEASSTLAKCL EEECCCHHHHHHHHH	15.56	20068231
1809	Phosphorylation	ISNMEASSTLAKCLY EECCCHHHHHHHHHH	34.19	20068231
1810	Phosphorylation	SNMEASSTLAKCLYE ECCCHHHHHHHHHHH	28.39	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARID2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARID2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARID2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PB1_HUMAN	PBRM1	physical	15985610
SMRC2_HUMAN	SMARCC2	physical	15985610
SMRC1_HUMAN	SMARCC1	physical	15985610
SMRD1_HUMAN	SMARCD1	physical	15985610
SMCE1_HUMAN	SMARCE1	physical	15985610
SNF5_HUMAN	SMARCB1	physical	15985610
SMCA4_HUMAN	SMARCA4	physical	15985610
RIR2_HUMAN	RRM2	genetic	28319113
VHL_HUMAN	VHL	genetic	28319113

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631; SER-635; THR-653;SER-689; THR-692 AND SER-1496, AND MASS SPECTROMETRY.
PubMed: 18669648