PB1_HUMAN - dbPTM
PB1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PB1_HUMAN
UniProt AC Q86U86
Protein Name Protein polybromo-1
Gene Name PBRM1
Organism Homo sapiens (Human).
Sequence Length 1689
Subcellular Localization Nucleus .
Protein Description Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation..
Protein Sequence MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPAYLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLENV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationGSKRRRATSPSSSVS
CCCCCCCCCCCCCCC
39.0829255136
9 (in isoform 3)Phosphorylation-39.08-
9 (in isoform 4)Phosphorylation-39.08-
9 (in isoform 5)Phosphorylation-39.0824719451
9 (in isoform 6)Phosphorylation-39.08-
10PhosphorylationSKRRRATSPSSSVSG
CCCCCCCCCCCCCCC
23.0729255136
10 (in isoform 3)Phosphorylation-23.07-
10 (in isoform 4)Phosphorylation-23.0727251275
10 (in isoform 5)Phosphorylation-23.07-
10 (in isoform 6)Phosphorylation-23.07-
12PhosphorylationRRRATSPSSSVSGDF
CCCCCCCCCCCCCCC
34.7029255136
12 (in isoform 3)Phosphorylation-34.70-
12 (in isoform 4)Phosphorylation-34.70-
12 (in isoform 5)Phosphorylation-34.7024719451
12 (in isoform 6)Phosphorylation-34.70-
13PhosphorylationRRATSPSSSVSGDFD
CCCCCCCCCCCCCCC
37.8429255136
13 (in isoform 4)Phosphorylation-37.8427251275
13 (in isoform 5)Phosphorylation-37.8424719451
14PhosphorylationRATSPSSSVSGDFDD
CCCCCCCCCCCCCCC
25.3329255136
14 (in isoform 3)Phosphorylation-25.33-
14 (in isoform 4)Phosphorylation-25.3327251275
14 (in isoform 5)Phosphorylation-25.3324719451
14 (in isoform 6)Phosphorylation-25.33-
16PhosphorylationTSPSSSVSGDFDDGH
CCCCCCCCCCCCCCC
34.2929255136
16 (in isoform 3)Phosphorylation-34.29-
16 (in isoform 4)Phosphorylation-34.2927251275
16 (in isoform 5)Phosphorylation-34.29-
16 (in isoform 6)Phosphorylation-34.29-
25PhosphorylationDFDDGHHSVSTPGPS
CCCCCCCCCCCCCCC
16.4622167270
25 (in isoform 3)Phosphorylation-16.46-
25 (in isoform 4)Phosphorylation-16.4627251275
25 (in isoform 5)Phosphorylation-16.46-
25 (in isoform 6)Phosphorylation-16.46-
26PhosphorylationFDDGHHSVSTPGPSR
CCCCCCCCCCCCCCH
6.8432142685
27PhosphorylationDDGHHSVSTPGPSRK
CCCCCCCCCCCCCHH
31.7222167270
28PhosphorylationDGHHSVSTPGPSRKR
CCCCCCCCCCCCHHC
30.0622167270
28 (in isoform 3)Phosphorylation-30.06-
28 (in isoform 4)Phosphorylation-30.06-
28 (in isoform 5)Phosphorylation-30.06-
28 (in isoform 6)Phosphorylation-30.06-
30PhosphorylationHHSVSTPGPSRKRRR
CCCCCCCCCCHHCHH
32.6732142685
31PhosphorylationHSVSTPGPSRKRRRL
CCCCCCCCCHHCHHH
31.9733259812
32PhosphorylationSVSTPGPSRKRRRLS
CCCCCCCCHHCHHHH
57.2422167270
33PhosphorylationVSTPGPSRKRRRLSN
CCCCCCCHHCHHHHC
39.3732142685
34PhosphorylationSTPGPSRKRRRLSNL
CCCCCCHHCHHHHCC
55.3732142685
35PhosphorylationTPGPSRKRRRLSNLP
CCCCCHHCHHHHCCC
28.0433259812
37PhosphorylationGPSRKRRRLSNLPTV
CCCHHCHHHHCCCCC
46.6432142685
39PhosphorylationSRKRRRLSNLPTVDP
CHHCHHHHCCCCCCH
34.2125159151
39 (in isoform 3)Phosphorylation-34.21-
39 (in isoform 4)Phosphorylation-34.2127251275
39 (in isoform 5)Phosphorylation-34.2124719451
39 (in isoform 6)Phosphorylation-34.21-
43PhosphorylationRRLSNLPTVDPIAVC
HHHHCCCCCCHHHHH
40.4822617229
54PhosphorylationIAVCHELYNTIRDYK
HHHHHHHHHHHHHCC
13.7921082442
54 (in isoform 3)Phosphorylation-13.79-
54 (in isoform 4)Phosphorylation-13.79-
54 (in isoform 5)Phosphorylation-13.79-
56PhosphorylationVCHELYNTIRDYKDE
HHHHHHHHHHHCCCH
12.1124732914
57PhosphorylationCHELYNTIRDYKDEQ
HHHHHHHHHHCCCHH
2.5532645325
60PhosphorylationLYNTIRDYKDEQGRL
HHHHHHHCCCHHHCH
15.5332645325
84PhosphorylationKRRNQPDYYEVVSQP
CCCCCCCHHHHHCCC
14.2827642862
85PhosphorylationRRNQPDYYEVVSQPI
CCCCCCHHHHHCCCC
15.0427642862
89PhosphorylationPDYYEVVSQPIDLMK
CCHHHHHCCCCCHHH
35.1027050516
96SumoylationSQPIDLMKIQQKLKM
CCCCCHHHHHHHHCC
44.6628112733
96UbiquitinationSQPIDLMKIQQKLKM
CCCCCHHHHHHHHCC
44.6629967540
125PhosphorylationLLFNNAKSYYKPDSP
HHHCCCHHHCCCCCH
31.1429396449
125 (in isoform 5)Phosphorylation-31.1424719451
127PhosphorylationFNNAKSYYKPDSPEY
HCCCHHHCCCCCHHH
24.1229396449
127 (in isoform 5)Phosphorylation-24.1224719451
128UbiquitinationNNAKSYYKPDSPEYK
CCCHHHCCCCCHHHH
33.8329967540
131PhosphorylationKSYYKPDSPEYKAAC
HHHCCCCCHHHHHHH
28.3225159151
131 (in isoform 3)Phosphorylation-28.32-
131 (in isoform 4)Phosphorylation-28.3227251275
131 (in isoform 5)Phosphorylation-28.3224719451
131 (in isoform 6)Phosphorylation-28.32-
134PhosphorylationYKPDSPEYKAACKLW
CCCCCHHHHHHHHHH
14.8729396449
135AcetylationKPDSPEYKAACKLWD
CCCCHHHHHHHHHHH
28.0425953088
139AcetylationPEYKAACKLWDLYLR
HHHHHHHHHHHHHHH
48.1326051181
154SumoylationTRNEFVQKGEADDED
HHHHHHHCCCCCCCC
54.1128112733
154UbiquitinationTRNEFVQKGEADDED
HHHHHHHCCCCCCCC
54.1129967540
172PhosphorylationDGQDNQGTVTEGSSP
CCCCCCCCCCCCCCH
17.9428450419
174PhosphorylationQDNQGTVTEGSSPAY
CCCCCCCCCCCCHHH
34.1730278072
177PhosphorylationQGTVTEGSSPAYLKE
CCCCCCCCCHHHHHH
27.2430278072
178PhosphorylationGTVTEGSSPAYLKEI
CCCCCCCCHHHHHHH
25.1430278072
178 (in isoform 3)Phosphorylation-25.14-
178 (in isoform 4)Phosphorylation-25.1427251275
178 (in isoform 5)Phosphorylation-25.1424719451
178 (in isoform 6)Phosphorylation-25.14-
181PhosphorylationTEGSSPAYLKEILEQ
CCCCCHHHHHHHHHH
22.9921955146
210SumoylationLISELFQKLPSKVQY
HHHHHHHHCCCCCCC
55.8428112733
213PhosphorylationELFQKLPSKVQYPDY
HHHHHCCCCCCCCCC
56.7624719451
214UbiquitinationLFQKLPSKVQYPDYY
HHHHCCCCCCCCCCE
31.2729967540
225UbiquitinationPDYYAIIKEPIDLKT
CCCEEEECCCCCHHH
51.8529967540
231UbiquitinationIKEPIDLKTIAQRIQ
ECCCCCHHHHHHHHH
33.8529967540
232PhosphorylationKEPIDLKTIAQRIQN
CCCCCHHHHHHHHHC
28.92-
241PhosphorylationAQRIQNGSYKSIHAM
HHHHHCCCHHHHHHH
36.6228450419
242PhosphorylationQRIQNGSYKSIHAMA
HHHHCCCHHHHHHHH
15.3428450419
244PhosphorylationIQNGSYKSIHAMAKD
HHCCCHHHHHHHHHH
16.0428450419
250AcetylationKSIHAMAKDIDLLAK
HHHHHHHHHHHHHHH
41.9726051181
250UbiquitinationKSIHAMAKDIDLLAK
HHHHHHHHHHHHHHH
41.9729967540
257UbiquitinationKDIDLLAKNAKTYNE
HHHHHHHHHCCCCCC
58.3629967540
260UbiquitinationDLLAKNAKTYNEPGS
HHHHHHCCCCCCCCC
62.0229967540
294UbiquitinationIEHHEMAKSSLRMRT
HCCHHHHHHHHHCCC
38.9929967540
295PhosphorylationEHHEMAKSSLRMRTP
CCHHHHHHHHHCCCH
25.6829214152
301PhosphorylationKSSLRMRTPSNLAAA
HHHHHCCCHHHHHHH
23.0230266825
301 (in isoform 4)Phosphorylation-23.0227251275
301 (in isoform 5)Phosphorylation-23.0224719451
301 (in isoform 6)Phosphorylation-23.02-
303PhosphorylationSLRMRTPSNLAAARL
HHHCCCHHHHHHHHH
43.8130266825
303 (in isoform 4)Phosphorylation-43.81-
303 (in isoform 5)Phosphorylation-43.81-
303 (in isoform 6)Phosphorylation-43.81-
311PhosphorylationNLAAARLTGPSHSKG
HHHHHHHHCCCCCCC
41.3024732914
311 (in isoform 3)Phosphorylation-41.30-
314PhosphorylationAARLTGPSHSKGSLG
HHHHHCCCCCCCCCC
41.5626055452
314 (in isoform 3)Phosphorylation-41.56-
314 (in isoform 4)Phosphorylation-41.56-
314 (in isoform 5)Phosphorylation-41.56-
314 (in isoform 6)Phosphorylation-41.56-
316PhosphorylationRLTGPSHSKGSLGEE
HHHCCCCCCCCCCCC
42.9526055452
316 (in isoform 4)Phosphorylation-42.9527251275
316 (in isoform 5)Phosphorylation-42.95-
316 (in isoform 6)Phosphorylation-42.95-
317UbiquitinationLTGPSHSKGSLGEER
HHCCCCCCCCCCCCC
47.2824816145
319PhosphorylationGPSHSKGSLGEERNP
CCCCCCCCCCCCCCC
36.6225159151
319 (in isoform 3)Phosphorylation-36.62-
319 (in isoform 4)Phosphorylation-36.6227251275
319 (in isoform 5)Phosphorylation-36.62-
319 (in isoform 6)Phosphorylation-36.62-
321 (in isoform 3)Phosphorylation-36.09-
323 (in isoform 3)Phosphorylation-56.83-
326UbiquitinationSLGEERNPTSKYYRN
CCCCCCCCCCHHHHC
44.2524816145
327PhosphorylationLGEERNPTSKYYRNK
CCCCCCCCCHHHHCH
41.2124732914
328PhosphorylationGEERNPTSKYYRNKR
CCCCCCCCHHHHCHH
21.6624732914
329"N6,N6-dimethyllysine"EERNPTSKYYRNKRA
CCCCCCCHHHHCHHH
49.10-
329MethylationEERNPTSKYYRNKRA
CCCCCCCHHHHCHHH
49.10-
329UbiquitinationEERNPTSKYYRNKRA
CCCCCCCHHHHCHHH
49.1029967540
334UbiquitinationTSKYYRNKRAVQGGR
CCHHHHCHHHHHCCH
32.5124816145
334 (in isoform 3)Phosphorylation-32.51-
335UbiquitinationSKYYRNKRAVQGGRL
CHHHHCHHHHHCCHH
43.4724816145
338UbiquitinationYRNKRAVQGGRLSAI
HHCHHHHHCCHHHHH
47.8724816145
339PhosphorylationRNKRAVQGGRLSAIT
HCHHHHHCCHHHHHH
19.3132142685
339 (in isoform 3)Phosphorylation-19.31-
341PhosphorylationKRAVQGGRLSAITMA
HHHHHCCHHHHHHHH
32.0932142685
343PhosphorylationAVQGGRLSAITMALQ
HHHCCHHHHHHHHHH
19.1028176443
343 (in isoform 3)Phosphorylation-19.10-
343 (in isoform 4)Phosphorylation-19.10-
343 (in isoform 5)Phosphorylation-19.10-
343 (in isoform 6)Phosphorylation-19.10-
344UbiquitinationVQGGRLSAITMALQY
HHCCHHHHHHHHHHH
13.0824816145
345 (in isoform 3)Phosphorylation-2.13-
346PhosphorylationGGRLSAITMALQYGS
CCHHHHHHHHHHHCC
8.9828176443
346 (in isoform 4)Phosphorylation-8.98-
346 (in isoform 5)Phosphorylation-8.98-
346 (in isoform 6)Phosphorylation-8.98-
347UbiquitinationGRLSAITMALQYGSE
CHHHHHHHHHHHCCC
2.6124816145
351PhosphorylationAITMALQYGSESEED
HHHHHHHHCCCCHHH
24.3828176443
351 (in isoform 4)Phosphorylation-24.38-
351 (in isoform 5)Phosphorylation-24.38-
351 (in isoform 6)Phosphorylation-24.38-
353PhosphorylationTMALQYGSESEEDAA
HHHHHHCCCCHHHHH
32.7728176443
353 (in isoform 4)Phosphorylation-32.7727251275
353 (in isoform 5)Phosphorylation-32.77-
353 (in isoform 6)Phosphorylation-32.77-
355PhosphorylationALQYGSESEEDAALA
HHHHCCCCHHHHHHH
48.2428176443
355 (in isoform 4)Phosphorylation-48.2427251275
355 (in isoform 5)Phosphorylation-48.24-
355 (in isoform 6)Phosphorylation-48.24-
366PhosphorylationAALAAARYEEGESEA
HHHHHHHHHCCCCHH
17.3822115753
366 (in isoform 4)Phosphorylation-17.38-
366 (in isoform 5)Phosphorylation-17.38-
366 (in isoform 6)Phosphorylation-17.38-
370PhosphorylationAARYEEGESEAESIT
HHHHHCCCCHHHHHH
49.0032142685
371PhosphorylationARYEEGESEAESITS
HHHHCCCCHHHHHHH
53.6227362937
371 (in isoform 4)Phosphorylation-53.6227251275
371 (in isoform 5)Phosphorylation-53.6224719451
371 (in isoform 6)Phosphorylation-53.62-
372PhosphorylationRYEEGESEAESITSF
HHHCCCCHHHHHHHH
52.7532142685
373PhosphorylationYEEGESEAESITSFM
HHCCCCHHHHHHHHH
25.7232142685
374PhosphorylationEEGESEAESITSFMD
HCCCCHHHHHHHHHC
38.3332142685
375PhosphorylationEGESEAESITSFMDV
CCCCHHHHHHHHHCC
37.9127362937
375 (in isoform 4)Phosphorylation-37.9127251275
375 (in isoform 5)Phosphorylation-37.91-
375 (in isoform 6)Phosphorylation-37.91-
376PhosphorylationGESEAESITSFMDVS
CCCHHHHHHHHHCCC
2.5532142685
377PhosphorylationESEAESITSFMDVSN
CCHHHHHHHHHCCCC
25.7822115753
377 (in isoform 4)Phosphorylation-25.78-
377 (in isoform 5)Phosphorylation-25.7824719451
377 (in isoform 6)Phosphorylation-25.78-
378PhosphorylationSEAESITSFMDVSNP
CHHHHHHHHHCCCCH
19.5328464451
383PhosphorylationITSFMDVSNPFYQLY
HHHHHCCCCHHHHHH
34.2228464451
387PhosphorylationMDVSNPFYQLYDTVR
HCCCCHHHHHHHHHH
10.0021406692
390PhosphorylationSNPFYQLYDTVRSCR
CCHHHHHHHHHHHHH
8.2721406692
392PhosphorylationPFYQLYDTVRSCRNN
HHHHHHHHHHHHHCC
12.3121406692
413PhosphorylationEPFYHLPSKKKYPDY
ECEECCCCCCCCCCH
64.5624719451
414AcetylationPFYHLPSKKKYPDYY
CEECCCCCCCCCCHH
51.8823749302
415AcetylationFYHLPSKKKYPDYYQ
EECCCCCCCCCCHHH
62.9724848071
425SumoylationPDYYQQIKMPISLQQ
CCHHHHCCCCCCHHH
34.0028112733
425UbiquitinationPDYYQQIKMPISLQQ
CCHHHHCCCCCCHHH
34.0029967540
462PhosphorylationMFENAKRYNVPNSAI
HHCCHHHCCCCCHHH
21.5821406692
466 (in isoform 3)Phosphorylation-39.53-
467PhosphorylationKRYNVPNSAIYKRVL
HHCCCCCHHHHHHHH
15.2421406692
470PhosphorylationNVPNSAIYKRVLKLQ
CCCCHHHHHHHHHHH
7.7721406692
471SumoylationVPNSAIYKRVLKLQQ
CCCHHHHHHHHHHHH
29.8928112733
475AcetylationAIYKRVLKLQQVMQA
HHHHHHHHHHHHHHH
41.2025953088
475 (in isoform 3)Phosphorylation-41.20-
477 (in isoform 3)Phosphorylation-32.03-
498PhosphorylationDDIEDGDSMISSATS
CCCCCCCCHHHHHCC
24.4423401153
498 (in isoform 4)Phosphorylation-24.4427251275
498 (in isoform 5)Phosphorylation-24.44-
498 (in isoform 6)Phosphorylation-24.44-
499SulfoxidationDIEDGDSMISSATSD
CCCCCCCHHHHHCCC
4.0221406390
501PhosphorylationEDGDSMISSATSDTG
CCCCCHHHHHCCCCC
12.7930266825
501 (in isoform 7)Phosphorylation-12.7925159151
501 (in isoform 8)Phosphorylation-12.7925159151
502PhosphorylationDGDSMISSATSDTGS
CCCCHHHHHCCCCCC
25.3330266825
502 (in isoform 4)Phosphorylation-25.3327251275
502 (in isoform 7)Phosphorylation-25.3325159151
502 (in isoform 8)Phosphorylation-25.3325159151
504PhosphorylationDSMISSATSDTGSAK
CCHHHHHCCCCCCCC
29.1430266825
504 (in isoform 7)Phosphorylation-29.1425627689
504 (in isoform 8)Phosphorylation-29.1425627689
505PhosphorylationSMISSATSDTGSAKR
CHHHHHCCCCCCCCH
32.6523401153
505 (in isoform 5)Phosphorylation-32.6524719451
505 (in isoform 7)Phosphorylation-32.6525849741
505 (in isoform 8)Phosphorylation-32.6525849741
507PhosphorylationISSATSDTGSAKRKS
HHHHCCCCCCCCHHC
32.5730266825
507 (in isoform 4)Phosphorylation-32.5727251275
507 (in isoform 5)Phosphorylation-32.57-
507 (in isoform 6)Phosphorylation-32.57-
507 (in isoform 7)Phosphorylation-32.5725159151
507 (in isoform 8)Phosphorylation-32.5725159151
509PhosphorylationSATSDTGSAKRKSKK
HHCCCCCCCCHHCHH
32.4830266825
509 (in isoform 4)Phosphorylation-32.48-
509 (in isoform 5)Phosphorylation-32.48-
509 (in isoform 6)Phosphorylation-32.48-
509 (in isoform 7)Phosphorylation-32.4825849741
509 (in isoform 8)Phosphorylation-32.4825849741
511AcetylationTSDTGSAKRKSKKNI
CCCCCCCCHHCHHHH
63.1525953088
511SumoylationTSDTGSAKRKSKKNI
CCCCCCCCHHCHHHH
63.1528112733
516 (in isoform 7)Phosphorylation-65.7725159151
516 (in isoform 8)Phosphorylation-65.7725159151
519 (in isoform 7)Phosphorylation-38.1525159151
519 (in isoform 8)Phosphorylation-38.1525159151
549AcetylationLCDLFMVKPSKKDYP
CEEEEEECCCCCCCC
31.6126051181
569AcetylationILEPMDLKIIEHNIR
EECCCCHHHHHHCCC
37.067964249
569UbiquitinationILEPMDLKIIEHNIR
EECCCCHHHHHHCCC
37.0632015554
570UbiquitinationLEPMDLKIIEHNIRN
ECCCCHHHHHHCCCC
6.0932015554
579AcetylationEHNIRNDKYAGEEGM
HHCCCCCCCCCCCCC
40.3227452117
579UbiquitinationEHNIRNDKYAGEEGM
HHCCCCCCCCCCCCC
40.32-
586UbiquitinationKYAGEEGMIEDMKLM
CCCCCCCCHHHHHHH
3.2532015554
587UbiquitinationYAGEEGMIEDMKLMF
CCCCCCCHHHHHHHH
6.2932015554
590UbiquitinationEEGMIEDMKLMFRNA
CCCCHHHHHHHHHCC
2.0232015554
591SumoylationEGMIEDMKLMFRNAR
CCCHHHHHHHHHCCC
49.4728112733
591UbiquitinationEGMIEDMKLMFRNAR
CCCHHHHHHHHHCCC
49.4732015554
592UbiquitinationGMIEDMKLMFRNARH
CCHHHHHHHHHCCCC
2.9232015554
602UbiquitinationRNARHYNEEGSQVYN
HCCCCCCCCCCHHHC
57.4832015554
604 (in isoform 3)Phosphorylation-19.73-
605PhosphorylationRHYNEEGSQVYNDAH
CCCCCCCCHHHCHHH
21.5424247654
605UbiquitinationRHYNEEGSQVYNDAH
CCCCCCCCHHHCHHH
21.5432015554
608UbiquitinationNEEGSQVYNDAHILE
CCCCCHHHCHHHHHH
10.3332015554
609UbiquitinationEEGSQVYNDAHILEK
CCCCHHHCHHHHHHH
40.9332015554
612UbiquitinationSQVYNDAHILEKLLK
CHHHCHHHHHHHHHH
28.2032015554
613 (in isoform 3)Phosphorylation-5.95-
616AcetylationNDAHILEKLLKEKRK
CHHHHHHHHHHHHHH
56.5325953088
616UbiquitinationNDAHILEKLLKEKRK
CHHHHHHHHHHHHHH
56.5329967540
616 (in isoform 3)Phosphorylation-56.53-
623UbiquitinationKLLKEKRKELGPLPD
HHHHHHHHHHCCCCC
69.2529967540
624UbiquitinationLLKEKRKELGPLPDD
HHHHHHHHHCCCCCC
64.0932015554
627UbiquitinationEKRKELGPLPDDDDM
HHHHHHCCCCCCCCC
54.0332015554
634SulfoxidationPLPDDDDMASPKLKL
CCCCCCCCCCCCHHH
5.2421406390
636PhosphorylationPDDDDMASPKLKLSR
CCCCCCCCCCHHHHH
18.8725159151
636 (in isoform 4)Phosphorylation-18.8727251275
636 (in isoform 5)Phosphorylation-18.8724719451
636 (in isoform 6)Phosphorylation-18.87-
638SumoylationDDDMASPKLKLSRKS
CCCCCCCCHHHHHCC
56.6228112733
642PhosphorylationASPKLKLSRKSGISP
CCCCHHHHHCCCCCC
35.7530001349
645PhosphorylationKLKLSRKSGISPKKS
CHHHHHCCCCCCCCC
40.0030266825
645 (in isoform 4)Phosphorylation-40.00-
645 (in isoform 5)Phosphorylation-40.00-
645 (in isoform 6)Phosphorylation-40.00-
648PhosphorylationLSRKSGISPKKSKYM
HHHCCCCCCCCCCCC
33.9030266825
648 (in isoform 4)Phosphorylation-33.9027251275
648 (in isoform 5)Phosphorylation-33.9024719451
648 (in isoform 6)Phosphorylation-33.90-
653SumoylationGISPKKSKYMTPMQQ
CCCCCCCCCCCHHHH
48.1728112733
654PhosphorylationISPKKSKYMTPMQQK
CCCCCCCCCCHHHHH
17.2026552605
656PhosphorylationPKKSKYMTPMQQKLN
CCCCCCCCHHHHHHH
16.7226552605
657 (in isoform 3)Phosphorylation-11.31-
666PhosphorylationQQKLNEVYEAVKNYT
HHHHHHHHHHHHCCC
7.6226552605
669 (in isoform 3)Ubiquitination-2.4921890473
670UbiquitinationNEVYEAVKNYTDKRG
HHHHHHHHCCCCCCC
51.8132015554
671UbiquitinationEVYEAVKNYTDKRGR
HHHHHHHCCCCCCCC
38.0332015554
672PhosphorylationVYEAVKNYTDKRGRR
HHHHHHCCCCCCCCE
15.5926552605
673PhosphorylationYEAVKNYTDKRGRRL
HHHHHCCCCCCCCEE
44.4226552605
681O-linked_GlycosylationDKRGRRLSAIFLRLP
CCCCCEEEEEEECCC
19.9430379171
681PhosphorylationDKRGRRLSAIFLRLP
CCCCCEEEEEEECCC
19.9428450419
681 (in isoform 4)Phosphorylation-19.9427251275
681 (in isoform 5)Phosphorylation-19.9424719451
687UbiquitinationLSAIFLRLPSRSELP
EEEEEECCCCCCCCC
4.9932015554
688UbiquitinationSAIFLRLPSRSELPD
EEEEECCCCCCCCCC
22.6632015554
689PhosphorylationAIFLRLPSRSELPDY
EEEECCCCCCCCCCE
53.7028450419
689 (in isoform 4)Phosphorylation-53.7027251275
689 (in isoform 5)Phosphorylation-53.70-
689 (in isoform 6)Phosphorylation-53.70-
691PhosphorylationFLRLPSRSELPDYYL
EECCCCCCCCCCEEE
48.0728450419
691UbiquitinationFLRLPSRSELPDYYL
EECCCCCCCCCCEEE
48.0732015554
696PhosphorylationSRSELPDYYLTIKKP
CCCCCCCEEEEECCC
9.8329759185
697PhosphorylationRSELPDYYLTIKKPM
CCCCCCEEEEECCCC
12.5429759185
699PhosphorylationELPDYYLTIKKPMDM
CCCCEEEEECCCCCH
18.0329449344
701UbiquitinationPDYYLTIKKPMDMEK
CCEEEEECCCCCHHH
45.6621890473
701 (in isoform 1)Ubiquitination-45.6621890473
701 (in isoform 2)Ubiquitination-45.6621890473
701 (in isoform 4)Ubiquitination-45.6621890473
701 (in isoform 5)Ubiquitination-45.6621890473
701 (in isoform 6)Ubiquitination-45.6621890473
701 (in isoform 9)Ubiquitination-45.6621890473
703UbiquitinationYYLTIKKPMDMEKIR
EEEEECCCCCHHHHH
21.0032015554
706UbiquitinationTIKKPMDMEKIRSHM
EECCCCCHHHHHHHH
4.6132015554
708UbiquitinationKKPMDMEKIRSHMMA
CCCCCHHHHHHHHHH
36.4629967540
714UbiquitinationEKIRSHMMANKYQDI
HHHHHHHHHHCCCCH
2.8821890473
716UbiquitinationIRSHMMANKYQDIDS
HHHHHHHHCCCCHHH
26.1821890473
716 (in isoform 7)Ubiquitination-26.1821890473
716 (in isoform 8)Ubiquitination-26.1821890473
719UbiquitinationHMMANKYQDIDSMVE
HHHHHCCCCHHHHHH
42.6721890473
722UbiquitinationANKYQDIDSMVEDFV
HHCCCCHHHHHHHHH
38.6821890473
722 (in isoform 3)Ubiquitination-38.6821890473
725UbiquitinationYQDIDSMVEDFVMMF
CCCHHHHHHHHHHHH
8.0621890473
731UbiquitinationMVEDFVMMFNNACTY
HHHHHHHHHHCCCCC
2.4621890473
733UbiquitinationEDFVMMFNNACTYNE
HHHHHHHHCCCCCCC
19.7921890473
734UbiquitinationDFVMMFNNACTYNEP
HHHHHHHCCCCCCCC
25.7321890473
737UbiquitinationMMFNNACTYNEPESL
HHHHCCCCCCCCHHH
27.2921890473
743UbiquitinationCTYNEPESLIYKDAL
CCCCCCHHHHHHHHH
30.6821890473
746UbiquitinationNEPESLIYKDALVLH
CCCHHHHHHHHHHHH
14.2221890473
754UbiquitinationKDALVLHKVLLETRR
HHHHHHHHHHHHHHH
30.3421890473
754 (in isoform 1)Ubiquitination-30.3421890473
754 (in isoform 2)Ubiquitination-30.3421890473
754 (in isoform 4)Ubiquitination-30.3421890473
754 (in isoform 5)Ubiquitination-30.3421890473
754 (in isoform 6)Ubiquitination-30.3421890473
754 (in isoform 9)Ubiquitination-30.3421890473
767UbiquitinationRRDLEGDEDSHVPNV
HHHHCCCCCCCCCCH
72.7321890473
769UbiquitinationDLEGDEDSHVPNVTL
HHCCCCCCCCCCHHH
25.0821890473
769 (in isoform 7)Ubiquitination-25.0821890473
769 (in isoform 8)Ubiquitination-25.0821890473
772UbiquitinationGDEDSHVPNVTLLIQ
CCCCCCCCCHHHHHH
24.9321890473
775UbiquitinationDSHVPNVTLLIQELI
CCCCCCHHHHHHHHH
23.6121890473
778UbiquitinationVPNVTLLIQELIHNL
CCCHHHHHHHHHHHH
3.1721890473
784UbiquitinationLIQELIHNLFVSVMS
HHHHHHHHHHHHHHC
28.3421890473
786UbiquitinationQELIHNLFVSVMSHQ
HHHHHHHHHHHHCCC
4.7121890473
787UbiquitinationELIHNLFVSVMSHQD
HHHHHHHHHHHCCCC
4.8021890473
790UbiquitinationHNLFVSVMSHQDDEG
HHHHHHHHCCCCCCC
2.0021890473
796UbiquitinationVMSHQDDEGRCYSDS
HHCCCCCCCCCCCCC
57.7521890473
799UbiquitinationHQDDEGRCYSDSLAE
CCCCCCCCCCCCCCC
5.8421890473
881UbiquitinationKIRDELCKNGEILLS
HHHHHHHHCCCEEEC
79.2929967540
916 (in isoform 3)Phosphorylation-67.13-
930UbiquitinationEEKREAEKSEDSSGA
HHHHHHHHCCCCCCC
67.2224816145
931PhosphorylationEKREAEKSEDSSGAA
HHHHHHHCCCCCCCC
37.8330108239
934PhosphorylationEAEKSEDSSGAAGLS
HHHHCCCCCCCCCCC
26.9825159151
934 (in isoform 4)Phosphorylation-26.9827251275
935PhosphorylationAEKSEDSSGAAGLSG
HHHCCCCCCCCCCCC
44.7828450419
941PhosphorylationSSGAAGLSGLHRTYS
CCCCCCCCCCCCCCC
38.0928450419
943UbiquitinationGAAGLSGLHRTYSQD
CCCCCCCCCCCCCCC
1.9124816145
945UbiquitinationAGLSGLHRTYSQDCS
CCCCCCCCCCCCCCC
40.1624816145
946PhosphorylationGLSGLHRTYSQDCSF
CCCCCCCCCCCCCCC
19.4429691806
947PhosphorylationLSGLHRTYSQDCSFK
CCCCCCCCCCCCCCC
12.3226552605
948PhosphorylationSGLHRTYSQDCSFKN
CCCCCCCCCCCCCCC
20.9423401153
948UbiquitinationSGLHRTYSQDCSFKN
CCCCCCCCCCCCCCC
20.9424816145
948 (in isoform 4)Phosphorylation-20.9427251275
948 (in isoform 5)Phosphorylation-20.9424719451
951UbiquitinationHRTYSQDCSFKNSMY
CCCCCCCCCCCCCCE
3.9024816145
952PhosphorylationRTYSQDCSFKNSMYH
CCCCCCCCCCCCCEE
47.7729691806
954AcetylationYSQDCSFKNSMYHVG
CCCCCCCCCCCEEEC
31.6426051181
954UbiquitinationYSQDCSFKNSMYHVG
CCCCCCCCCCCEEEC
31.6424816145
960UbiquitinationFKNSMYHVGDYVYVE
CCCCCEEECCEEEEC
3.2624816145
962UbiquitinationNSMYHVGDYVYVEPA
CCCEEECCEEEECCH
28.7424816145
963UbiquitinationSMYHVGDYVYVEPAE
CCEEECCEEEECCHH
6.4324816145
966UbiquitinationHVGDYVYVEPAEANL
EECCEEEECCHHHCC
5.1824816145
972UbiquitinationYVEPAEANLQPHIVC
EECCHHHCCCCEEEE
30.6224816145
975UbiquitinationPAEANLQPHIVCIER
CHHHCCCCEEEEEEE
23.4924816145
987PhosphorylationIERLWEDSAGEKWLY
EEECCCCCCCCEEEE
27.0228355574
990UbiquitinationLWEDSAGEKWLYGCW
CCCCCCCCEEEEEEE
40.5529967540
994UbiquitinationSAGEKWLYGCWFYRP
CCCCEEEEEEEEECC
14.7729967540
1005UbiquitinationFYRPNETFHLATRKF
EECCCCCEEHHHHHH
3.4727667366
1019AcetylationFLEKEVFKSDYYNKV
HHHHHHHCCCCCCCC
47.8225953088
1019UbiquitinationFLEKEVFKSDYYNKV
HHHHHHHCCCCCCCC
47.8229967540
1025AcetylationFKSDYYNKVPVSKIL
HCCCCCCCCCHHHHH
31.6226051181
1025UbiquitinationFKSDYYNKVPVSKIL
HCCCCCCCCCHHHHH
31.62-
1026UbiquitinationKSDYYNKVPVSKILG
CCCCCCCCCHHHHHH
5.1527667366
1030UbiquitinationYNKVPVSKILGKCVV
CCCCCHHHHHHHHHH
42.0327667366
1043UbiquitinationVVMFVKEYFKLCPEN
HHHHHHHHHHHCCCC
10.5727667366
1045UbiquitinationMFVKEYFKLCPENFR
HHHHHHHHHCCCCCC
48.5627667366
1048UbiquitinationKEYFKLCPENFRDED
HHHHHHCCCCCCCCC
50.4227667366
1050UbiquitinationYFKLCPENFRDEDVF
HHHHCCCCCCCCCEE
23.5427667366
1051UbiquitinationFKLCPENFRDEDVFV
HHHCCCCCCCCCEEE
11.2527667366
1054UbiquitinationCPENFRDEDVFVCES
CCCCCCCCCEEEECC
52.3927667366
1059UbiquitinationRDEDVFVCESRYSAK
CCCCEEEECCCCCCC
2.3927667366
1060UbiquitinationDEDVFVCESRYSAKT
CCCEEEECCCCCCCC
32.7127667366
1062UbiquitinationDVFVCESRYSAKTKS
CEEEECCCCCCCCCC
13.7127667366
1063UbiquitinationVFVCESRYSAKTKSF
EEEECCCCCCCCCCC
23.4327667366
1065UbiquitinationVCESRYSAKTKSFKK
EECCCCCCCCCCCCE
18.0127667366
1066UbiquitinationCESRYSAKTKSFKKI
ECCCCCCCCCCCCEE
51.0127667366
1069PhosphorylationRYSAKTKSFKKIKLW
CCCCCCCCCCEEEEE
47.75-
1072UbiquitinationAKTKSFKKIKLWTMP
CCCCCCCEEEEEEEE
42.9627667366
1074UbiquitinationTKSFKKIKLWTMPIS
CCCCCEEEEEEEECC
47.0227667366
1074 (in isoform 4)Phosphorylation-47.0227251275
1075UbiquitinationKSFKKIKLWTMPISS
CCCCEEEEEEEECCC
5.3927667366
1081PhosphorylationKLWTMPISSVRFVPR
EEEEEECCCEEEECC
19.5324719451
1091 (in isoform 4)Phosphorylation-34.9227251275
1094 (in isoform 4)Phosphorylation-5.9027251275
1099PhosphorylationLPVVRVASVFANADK
CCEEEEEEECCCCCC
18.2127251275
1106SumoylationSVFANADKGDDEKNT
EECCCCCCCCCCCCC
62.9328112733
1111SumoylationADKGDDEKNTDNSED
CCCCCCCCCCCCCCC
72.6228112733
1113PhosphorylationKGDDEKNTDNSEDSR
CCCCCCCCCCCCCHH
47.8530108239
1116PhosphorylationDEKNTDNSEDSRAED
CCCCCCCCCCHHHHH
45.6625159151
1119PhosphorylationNTDNSEDSRAEDNFN
CCCCCCCHHHHHHCC
29.3723401153
1136 (in isoform 3)Phosphorylation-10.95-
1142UbiquitinationPVEMSNGEPGCHYFE
CCCCCCCCCCCCCHH
42.6529967540
1143 (in isoform 4)Phosphorylation-52.70-
1156UbiquitinationEQLHYNDMWLKVGDC
HHCCCCCEEEEECCE
3.9329967540
1167AcetylationVGDCVFIKSHGLVRP
ECCEEEEECCCCCCC
25.5725953088
1167SumoylationVGDCVFIKSHGLVRP
ECCEEEEECCCCCCC
25.5728112733
1167UbiquitinationVGDCVFIKSHGLVRP
ECCEEEEECCCCCCC
25.5729967540
1168PhosphorylationGDCVFIKSHGLVRPR
CCEEEEECCCCCCCC
20.2620068231
1168 (in isoform 5)Phosphorylation-20.26-
1181UbiquitinationPRVGRIEKVWVRDGA
CCCCCEEEEEEECCC
38.7429967540
1188UbiquitinationKVWVRDGAAYFYGPI
EEEEECCCEEEECCE
11.8629967540
1213UbiquitinationPTKMFYKKEVFLSNL
CCCCCCCHHHHHHCH
47.9729967540
1237PhosphorylationLGKCAVLSFKDFLSC
HCCEEEEEHHHHHCC
24.5324719451
1253 (in isoform 4)Phosphorylation-31.1127251275
1261PhosphorylationILLCESRYNESDKQM
EEEECCCCCCCHHHH
32.3425367160
1268NeddylationYNESDKQMKKFKGLK
CCCCHHHHHHCCCCC
6.6732015554
1268UbiquitinationYNESDKQMKKFKGLK
CCCCHHHHHHCCCCC
6.6729967540
1274UbiquitinationQMKKFKGLKRFSLSA
HHHHCCCCCCEECEE
3.5729967540
1278PhosphorylationFKGLKRFSLSAKVVD
CCCCCCEECEEEEEC
26.0030108239
1278 (in isoform 5)Phosphorylation-26.0024719451
1280PhosphorylationGLKRFSLSAKVVDDE
CCCCEECEEEEECCE
25.5030108239
1282UbiquitinationKRFSLSAKVVDDEIY
CCEECEEEEECCEEE
39.1429967540
1283UbiquitinationRFSLSAKVVDDEIYY
CEECEEEEECCEEEE
5.9629967540
1289NeddylationKVVDDEIYYFRKPIV
EEECCEEEEECCCCC
8.4332015554
1289PhosphorylationKVVDDEIYYFRKPIV
EEECCEEEEECCCCC
8.4322817900
1293SumoylationDEIYYFRKPIVPQKE
CEEEEECCCCCCCCC
29.24-
1293AcetylationDEIYYFRKPIVPQKE
CEEEEECCCCCCCCC
29.2426051181
1293NeddylationDEIYYFRKPIVPQKE
CEEEEECCCCCCCCC
29.2432015554
1293SumoylationDEIYYFRKPIVPQKE
CEEEEECCCCCCCCC
29.2425114211
1293UbiquitinationDEIYYFRKPIVPQKE
CEEEEECCCCCCCCC
29.2429967540
1294NeddylationEIYYFRKPIVPQKEP
EEEEECCCCCCCCCC
28.6632015554
1299UbiquitinationRKPIVPQKEPSPLLE
CCCCCCCCCCCCHHH
66.5729967540
1302PhosphorylationIVPQKEPSPLLEKKI
CCCCCCCCCHHHHHH
29.3128555341
1304NeddylationPQKEPSPLLEKKIQL
CCCCCCCHHHHHHHH
13.0032015554
1307UbiquitinationEPSPLLEKKIQLLEA
CCCCHHHHHHHHHHH
55.9629967540
1308SumoylationPSPLLEKKIQLLEAK
CCCHHHHHHHHHHHH
26.7228112733
1308UbiquitinationPSPLLEKKIQLLEAK
CCCHHHHHHHHHHHH
26.7229967540
1310NeddylationPLLEKKIQLLEAKFA
CHHHHHHHHHHHHHH
49.2032015554
1311NeddylationLLEKKIQLLEAKFAE
HHHHHHHHHHHHHHH
5.4832015554
1314NeddylationKKIQLLEAKFAELEG
HHHHHHHHHHHHHCC
16.5532015554
1326NeddylationLEGGDDDIEEMGEED
HCCCCCCHHHCCCCC
6.5932015554
1328NeddylationGGDDDIEEMGEEDSE
CCCCCHHHCCCCCCC
53.4732015554
1329NeddylationGDDDIEEMGEEDSEV
CCCCHHHCCCCCCCC
5.4832015554
1346UbiquitinationPPSLPQLQTPLASEL
CCCCCCCCCCCCCCC
35.5121890473
1346 (in isoform 4)Ubiquitination-35.5121890473
1353 (in isoform 4)Phosphorylation-5.9327251275
1359PhosphorylationELDLMPYTPPQSTPK
CCCCCCCCCCCCCCC
23.7124275569
1363PhosphorylationMPYTPPQSTPKSAKG
CCCCCCCCCCCCCCC
53.0724275569
1366 (in isoform 3)Ubiquitination-64.2321890473
1367PhosphorylationPPQSTPKSAKGSAKK
CCCCCCCCCCCCCCC
36.09-
1371PhosphorylationTPKSAKGSAKKEGSK
CCCCCCCCCCCCCCC
35.89-
1373 (in isoform 3)Phosphorylation-53.72-
1373 (in isoform 9)Ubiquitination-53.7221890473
1384PhosphorylationSKRKINMSGYILFSS
CCCCCCCCEEEEEEH
24.7728555341
1386PhosphorylationRKINMSGYILFSSEM
CCCCCCEEEEEEHHH
6.2729449344
1390PhosphorylationMSGYILFSSEMRAVI
CCEEEEEEHHHHHHH
23.1929116813
1391PhosphorylationSGYILFSSEMRAVIK
CEEEEEEHHHHHHHH
28.2529116813
1394UbiquitinationILFSSEMRAVIKAQH
EEEEHHHHHHHHHHC
22.9621890473
1398SumoylationSEMRAVIKAQHPDYS
HHHHHHHHHHCCCCC
35.08-
1398SumoylationSEMRAVIKAQHPDYS
HHHHHHHHHHCCCCC
35.0828112733
1398UbiquitinationSEMRAVIKAQHPDYS
HHHHHHHHHHCCCCC
35.0823000965
1398 (in isoform 1)Ubiquitination-35.0821890473
1398 (in isoform 2)Ubiquitination-35.0821890473
1398 (in isoform 5)Ubiquitination-35.0821890473
1404PhosphorylationIKAQHPDYSFGELSR
HHHHCCCCCHHHHHH
15.4521712546
1405PhosphorylationKAQHPDYSFGELSRL
HHHCCCCCHHHHHHH
33.8723401153
1405 (in isoform 5)Phosphorylation-33.8724719451
1410PhosphorylationDYSFGELSRLVGTEW
CCCHHHHHHHHCCCC
21.1825159151
1411UbiquitinationYSFGELSRLVGTEWR
CCHHHHHHHHCCCCC
46.1221890473
1413UbiquitinationFGELSRLVGTEWRNL
HHHHHHHHCCCCCCH
9.6621890473
1413 (in isoform 7)Ubiquitination-9.6621890473
1413 (in isoform 8)Ubiquitination-9.6621890473
1416UbiquitinationLSRLVGTEWRNLETA
HHHHHCCCCCCHHHH
38.2121890473
1418UbiquitinationRLVGTEWRNLETAKK
HHHCCCCCCHHHHHH
31.4621890473
1419UbiquitinationLVGTEWRNLETAKKA
HHCCCCCCHHHHHHH
43.2121890473
1422PhosphorylationTEWRNLETAKKAEYE
CCCCCHHHHHHHHHH
47.1221712546
1422UbiquitinationTEWRNLETAKKAEYE
CCCCCHHHHHHHHHH
47.1221890473
1427UbiquitinationLETAKKAEYEERAAK
HHHHHHHHHHHHHHH
63.4621890473
1428UbiquitinationETAKKAEYEERAAKV
HHHHHHHHHHHHHHH
28.1321890473
1430UbiquitinationAKKAEYEERAAKVAE
HHHHHHHHHHHHHHH
46.8721890473
1431UbiquitinationKKAEYEERAAKVAEQ
HHHHHHHHHHHHHHH
28.0921890473
1433UbiquitinationAEYEERAAKVAEQQE
HHHHHHHHHHHHHHH
17.0521890473
1434UbiquitinationEYEERAAKVAEQQER
HHHHHHHHHHHHHHH
40.7821890473
1440UbiquitinationAKVAEQQERERAAQQ
HHHHHHHHHHHHHHH
57.0921890473
1442UbiquitinationVAEQQERERAAQQQQ
HHHHHHHHHHHHHHC
46.0121890473
1443UbiquitinationAEQQERERAAQQQQP
HHHHHHHHHHHHHCC
41.2521890473
1451PhosphorylationAAQQQQPSASPRAGT
HHHHHCCCCCCCCCC
36.7229255136
1453PhosphorylationQQQQPSASPRAGTPV
HHHCCCCCCCCCCCC
21.1829255136
1505UbiquitinationQGPVDGLVSMGSMQP
CCCCCCCEECCCCCC
4.5329967540
1519UbiquitinationPLHPGGPPPHHLPPG
CCCCCCCCCCCCCCC
44.1029967540
1531UbiquitinationPPGVPGLPGIPPPGV
CCCCCCCCCCCCCCC
44.5833845483
1535UbiquitinationPGLPGIPPPGVMNQG
CCCCCCCCCCCCCCC
36.0333845483
1535 (in isoform 4)Ubiquitination-36.0321890473
1535 (in isoform 5)Ubiquitination-36.0321890473
1536UbiquitinationGLPGIPPPGVMNQGV
CCCCCCCCCCCCCCC
42.5333845483
1546UbiquitinationMNQGVAPMVGTPAPG
CCCCCCCCCCCCCCC
2.9033845483
1547UbiquitinationNQGVAPMVGTPAPGG
CCCCCCCCCCCCCCC
8.2229967540
1550 (in isoform 7)Ubiquitination-30.4521890473
1552UbiquitinationPMVGTPAPGGSPYGQ
CCCCCCCCCCCCCCC
49.2133845483
1553UbiquitinationMVGTPAPGGSPYGQQ
CCCCCCCCCCCCCCC
51.8533845483
1555 (in isoform 3)Ubiquitination-22.3621890473
1556UbiquitinationTPAPGGSPYGQQVGV
CCCCCCCCCCCCCCC
40.3133845483
1562 (in isoform 9)Ubiquitination-12.4721890473
1568UbiquitinationVGVLGPPGQQAPPPY
CCCCCCCCCCCCCCC
35.0533845483
1570UbiquitinationVLGPPGQQAPPPYPG
CCCCCCCCCCCCCCC
62.8533845483
1571UbiquitinationLGPPGQQAPPPYPGP
CCCCCCCCCCCCCCC
15.6433845483
1587UbiquitinationPAGPPVIQQPTTPMF
CCCCCCCCCCCCCCC
43.3533845483
1587 (in isoform 2)Ubiquitination-43.3521890473
1605 (in isoform 8)Ubiquitination-4.5621890473
1611UbiquitinationLLHSEAYLKYIEGLS
HHCCHHHHHHHHHCC
4.3533845483
1612UbiquitinationLHSEAYLKYIEGLSA
HCCHHHHHHHHHCCC
31.35-
1618PhosphorylationLKYIEGLSAESNSIS
HHHHHHCCCCCCCCC
40.6326074081
1621PhosphorylationIEGLSAESNSISKWD
HHHCCCCCCCCCHHH
35.2826074081
1623PhosphorylationGLSAESNSISKWDQT
HCCCCCCCCCHHHHH
37.2026074081
1625PhosphorylationSAESNSISKWDQTLA
CCCCCCCCHHHHHHH
27.7526074081
1626AcetylationAESNSISKWDQTLAA
CCCCCCCHHHHHHHH
53.7926051181
1626UbiquitinationAESNSISKWDQTLAA
CCCCCCCHHHHHHHH
53.79-
1630PhosphorylationSISKWDQTLAARRRD
CCCHHHHHHHHHHHH
18.8526074081
1641PhosphorylationRRRDVHLSKEQESRL
HHHHHCCCHHHHHCC
21.1926074081
1642SumoylationRRDVHLSKEQESRLP
HHHHCCCHHHHHCCC
70.5428112733
1642UbiquitinationRRDVHLSKEQESRLP
HHHHCCCHHHHHCCC
70.542190698
1642 (in isoform 1)Ubiquitination-70.5421890473
1654MethylationRLPSHWLKSKGAHTT
CCCHHHHHHCCCCCH
44.95115975379
1654SumoylationRLPSHWLKSKGAHTT
CCCHHHHHHCCCCCH
44.9528112733
1654UbiquitinationRLPSHWLKSKGAHTT
CCCHHHHHHCCCCCH
44.95-
1656SumoylationPSHWLKSKGAHTTMA
CHHHHHHCCCCCHHH
59.5428112733
1656UbiquitinationPSHWLKSKGAHTTMA
CHHHHHHCCCCCHHH
59.54-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
948SPhosphorylationKinaseATMQ13315
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PB1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H31_HUMANHIST1H3Aphysical
20368734
H2B2E_HUMANHIST2H2BEphysical
20368734
H2A2C_HUMANHIST2H2ACphysical
20368734
TAT_HV1H2tatphysical
20368734
CHD7_HUMANCHD7physical
20130577
ARID2_HUMANARID2physical
15985610
SMRC2_HUMANSMARCC2physical
15985610
SMRC1_HUMANSMARCC1physical
15985610
SMRD1_HUMANSMARCD1physical
15985610
SMCE1_HUMANSMARCE1physical
15985610
ACL6A_HUMANACTL6Aphysical
15985610
SNF5_HUMANSMARCB1physical
15985610
SMCA4_HUMANSMARCA4physical
15985610
H31T_HUMANHIST3H3physical
17320048
CALL5_HUMANCALML5physical
16934469
A4_HUMANAPPphysical
21832049
TF3C5_HUMANGTF3C5physical
22939629
TCHL1_HUMANTCHHL1physical
22939629
ARID2_HUMANARID2physical
26344197
CSN3_HUMANCOPS3physical
26344197
TOP1_HUMANTOP1genetic
28319113
VHL_HUMANVHLgenetic
28319113

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
144700Renal cell carcinoma (RCC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PB1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-948, AND MASSSPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-636 AND SER-1453, ANDMASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-39; SER-353;SER-355; SER-371; SER-375; SER-498 AND SER-636, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-636 ANDSER-1453, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-131; SER-314;SER-316; SER-319; SER-353; SER-355; SER-636 AND SER-1405, AND MASSSPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-636, AND MASSSPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-301, AND MASSSPECTROMETRY.
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-54, AND MASSSPECTROMETRY.

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