TCHL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCHL1_HUMAN
• UniProt AC: Q5QJ38
• Protein Name: Trichohyalin-like protein 1
• Gene Name: TCHHL1
• Organism: Homo sapiens (Human).
• Sequence Length: 904
• Protein Sequence: MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQPCVLHAVEKNSNLLNIDSNGIISFDEFVLAIFNLLNLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQIAQASGPELCSVSLTSEISDCSVFFNYSQASQPYTRGLPLDESPAGAQETPAPQALEDKQGHPQRERLVLQREASTTKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
94	Phosphorylation	DIKSLLSSELRQVTK HHHHHHCHHHHHCCC	40.39	24719451
100	O-linked_Glycosylation	SSELRQVTKPEKEKL CHHHHHCCCCCHHCC	32.32	30379171
115	Phosphorylation	DDVDVQATTGDGQWT CCCCEEEECCCCCEE	17.77	22210691
116	Phosphorylation	DVDVQATTGDGQWTV CCCEEEECCCCCEEC	35.97	22210691
128	Phosphorylation	WTVGTSPTQEKRMLP EECCCCCCCCCCCCC	49.48	22210691
142	Phosphorylation	PSGMASSSQLIPEES CCCCCCHHHCCCCCC	26.89	19664995
215	Phosphorylation	TNKPMAGSKKTSSPT CCCCCCCCCCCCCCC	22.80	26552605
218	Phosphorylation	PMAGSKKTSSPTERK CCCCCCCCCCCCCCC	37.87	26552605
219	Phosphorylation	MAGSKKTSSPTERKG CCCCCCCCCCCCCCC	43.11	26552605
220	Phosphorylation	AGSKKTSSPTERKGQ CCCCCCCCCCCCCCC	40.86	26552605
222	Phosphorylation	SKKTSSPTERKGQDK CCCCCCCCCCCCCCC	50.82	26552605
225	Acetylation	TSSPTERKGQDKEIS CCCCCCCCCCCCCHH	55.48	30592895
314	Phosphorylation	PEQAAARSPSQTQKS HHHHHHHCCCCCCCC	24.95	24719451
324	Phosphorylation	QTQKSTDSKDVCRMF CCCCCCCCHHHHHHH	30.74	-
333	Phosphorylation	DVCRMFDTQEPGKDA HHHHHHCCCCCCCCC	24.46	28348404
359	Phosphorylation	EPEDYGRTSETQEKE CHHHCCCCCHHCCHH	26.93	23836654
359	O-linked_Glycosylation	EPEDYGRTSETQEKE CHHHCCCCCHHCCHH	26.93	30379171
360	Phosphorylation	PEDYGRTSETQEKEC HHHCCCCCHHCCHHH	36.97	23836654
362	Phosphorylation	DYGRTSETQEKECET HCCCCCHHCCHHHHC	41.62	23836654
376	Phosphorylation	TKDLPVQYGSRNGSE CCCCCCCCCCCCCCC	19.80	25002506
378	Phosphorylation	DLPVQYGSRNGSETS CCCCCCCCCCCCCCC	20.03	25002506
412	Phosphorylation	QKERDRKTRPLVLET HHHCCCCCCCEEEEE	38.11	30631047
421	Phosphorylation	PLVLETQTQDGKYQE CEEEEEECCCCCCHH	35.73	30631047
900	Phosphorylation	LVLQREASTTKQ--- HHHHHHHHCCCC---	31.68	21949786
901	Phosphorylation	VLQREASTTKQ---- HHHHHHHCCCC----	45.09	21949786
902	Phosphorylation	LQREASTTKQ----- HHHHHHCCCC-----	25.59	21949786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCHL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCHL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCHL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TCHL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.