dbPTM

CHD7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CHD7_HUMAN
UniProt AC	Q9P2D1
Protein Name	Chromodomain-helicase-DNA-binding protein 7
Gene Name	CHD7
Organism	Homo sapiens (Human).
Sequence Length	2997
Subcellular Localization	Isoform 1: Nucleus . Isoform 3: Nucleus, nucleolus .
Protein Description	Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production..
Protein Sequence	MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTNQNQTKLTHFDHYNQYEQQKMHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGGGQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQGHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQQSPSMAPSLRHSVQQFHHHPSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVPSPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQGLMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGIPMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGCPGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQLHPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQQESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNKVLLRVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKNFAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEGKEEEEETDGSGKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKNFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRKIEIEAERAAKRRNLMEMVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSSLSSKFILPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIETPPTRNIPSPGQLDPDTRIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKNADVLFSSFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAAAAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKGNENEDENKDSEKSTDAVSAADSANGSVGAATAPAGLPSNPLAFNPFLLSTMAPGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEEKAADKAEGGPFKDGETLEGSDAEESLDKTAESSLLEDEIAQGEELDSLDGGDEIENNENDE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	HFDHYNQYEQQKMHL CCCCCHHHHHHHHHH	16.44	-
148	Methylation	SSSMWGPRAVQVPDQ CCCCCCCCCCCCCHH	43.37	24129315
195	Methylation	QMGSYMARGDFSMQQ HHHHHHHHCCCCHHH	28.78	-
199	Phosphorylation	YMARGDFSMQQHGQP HHHHCCCCHHHCCCC	22.03	-
209	Methylation	QHGQPQQRMSQFSQG HCCCCCHHHHHHHHH	22.82	-
286	Asymmetric dimethylarginine	PPQQGAVRPQTLNFS CCCCCCCCCCCCCCC	19.64	-
286	Methylation	PPQQGAVRPQTLNFS CCCCCCCCCCCCCCC	19.64	-
301	Phosphorylation	SRSQTVPSPTINNSG CCCCCCCCCCCCCCC	30.27	21815630
303	Phosphorylation	SQTVPSPTINNSGQY CCCCCCCCCCCCCCC	40.45	25627689
307	Phosphorylation	PSPTINNSGQYSRYP CCCCCCCCCCCCCCC	23.84	25002506
310	Phosphorylation	TINNSGQYSRYPYSN CCCCCCCCCCCCCCC	9.91	26852163
311	Phosphorylation	INNSGQYSRYPYSNL CCCCCCCCCCCCCCC	19.90	25002506
408	Phosphorylation	AMSNPAGTPPPQVRP CCCCCCCCCCCCCCC	34.43	27732954
414	Methylation	GTPPPQVRPGSAGIP CCCCCCCCCCCCCCC	25.31	-
417	Phosphorylation	PPQVRPGSAGIPMEV CCCCCCCCCCCCCCC	26.46	28348404
448	Methylation	GAMGIGQRNMGPRNM CCCCCCCCCCCCCCC	29.86	-
543	Phosphorylation	PWAQLHPSPQNTPQK CHHHCCCCCCCCCCC	28.50	23663014
547	Phosphorylation	LHPSPQNTPQKVPVH CCCCCCCCCCCCCCC	23.11	23663014
557	Phosphorylation	KVPVHQHSPSEPFLE CCCCCCCCCCCCCCC	24.45	29255136
559	Phosphorylation	PVHQHSPSEPFLEKP CCCCCCCCCCCCCCC	62.00	29255136
565	Acetylation	PSEPFLEKPVPDMTQ CCCCCCCCCCCCCCC	54.16	26051181
571	Phosphorylation	EKPVPDMTQVSGPNA CCCCCCCCCCCCCCC	32.95	23663014
574	Phosphorylation	VPDMTQVSGPNAQLV CCCCCCCCCCCCEEE	38.42	21406692
612	Phosphorylation	HIVAEDPSKGFGKDD CCCCCCCCCCCCCCC	58.70	-
617	Acetylation	DPSKGFGKDDFPGGV CCCCCCCCCCCCCCC	52.44	23236377
633	Phosphorylation	NQELNRNSLDGSQEE HHHHCCCCCCCCHHH	25.30	25159151
637	Phosphorylation	NRNSLDGSQEEKKKK CCCCCCCCHHHHHHH	33.80	25159151
689	Phosphorylation	EKKAKTATPKPKSSK HHCCCCCCCCCCCCC	36.76	-
708	Phosphorylation	KKPDSEASALKKKVN CCCCHHHHHHHHHHH	30.04	20068231
719	Phosphorylation	KKVNKGKTEGSENSD HHHHCCCCCCCCCCC	55.00	30576142
722	Phosphorylation	NKGKTEGSENSDLDK HCCCCCCCCCCCCCC	27.63	30576142
725	Phosphorylation	KTEGSENSDLDKTPP CCCCCCCCCCCCCCC	35.18	21815630
730	Phosphorylation	ENSDLDKTPPPSPPP CCCCCCCCCCCCCCC	40.47	30576142
734	Phosphorylation	LDKTPPPSPPPEEDE CCCCCCCCCCCCCCC	56.67	30576142
768	Phosphorylation	EDLEFKISDEEADDA CCCCEECCHHHCCCC	39.29	30266825
782	Phosphorylation	ADAAGRDSPSNTSQS CCCCCCCCCCCCCHH	28.94	28985074
784	Phosphorylation	AAGRDSPSNTSQSEQ CCCCCCCCCCCHHHH	57.61	25262027
786	Phosphorylation	GRDSPSNTSQSEQQE CCCCCCCCCHHHHHH	32.26	30377224
787	Phosphorylation	RDSPSNTSQSEQQES CCCCCCCCHHHHHHH	35.64	25262027
789	Phosphorylation	SPSNTSQSEQQESVD CCCCCCHHHHHHHCC	36.82	25262027
794	Phosphorylation	SQSEQQESVDAEGPV CHHHHHHHCCCCCHH	22.43	25262027
834	Phosphorylation	YVKYKNFSYLHCQWA EEEECCCCEEEEEEE	35.86	20860994
928	Ubiquitination	RQDIDQAKIEEFEKL HHCHHHHHHHHHHHH	45.04	-
934	Acetylation	AKIEEFEKLMSREPE HHHHHHHHHHCCCCC	55.61	26822725
934	Ubiquitination	AKIEEFEKLMSREPE HHHHHHHHHHCCCCC	55.61	21890473
934 (in isoform 1)	Ubiquitination	-	55.61	21890473
934 (in isoform 2)	Ubiquitination	-	55.61	21890473
1000	Phosphorylation	DEMGLGKTIQSITFL HCCCCCHHHHHHHHH	23.58	26552605
1003	Phosphorylation	GLGKTIQSITFLYEI CCCHHHHHHHHHHHH	21.53	26552605
1005	Phosphorylation	GKTIQSITFLYEIYL CHHHHHHHHHHHHHH	16.91	26552605
1008	Phosphorylation	IQSITFLYEIYLKGI HHHHHHHHHHHHCCC	8.97	26552605
1011	Phosphorylation	ITFLYEIYLKGIHGP HHHHHHHHHCCCCCC	7.16	26552605
1116	Ubiquitination	RLKNRNCKLLEGLKM HHHCCCCCHHCCCCC	60.71	-
1177	Ubiquitination	KTEEQVQKLQAILKP CCHHHHHHHHHHHHH	43.65	-
1183	Ubiquitination	QKLQAILKPMMLRRL HHHHHHHHHHHHHHH	25.42	-
1196	Sumoylation	RLKEDVEKNLAPKEE HHHHHHHHHCCCCCC	58.05	-
1196	Sumoylation	RLKEDVEKNLAPKEE HHHHHHHHHCCCCCC	58.05	-
1204	Phosphorylation	NLAPKEETIIEVELT HCCCCCCEEEEEEEH	28.48	-
1217	Phosphorylation	LTNIQKKYYRAILEK EHHHHHHHHHHHHHH	12.76	-
1218	Phosphorylation	TNIQKKYYRAILEKN HHHHHHHHHHHHHHC	11.49	-
1227	Phosphorylation	AILEKNFTFLSKGGG HHHHHCCEEEECCCC	32.81	-
1250	Ubiquitination	NTMMELRKCCNHPYL HHHHHHHHHCCCCHH	56.62	-
1256	Phosphorylation	RKCCNHPYLINGAEE HHHCCCCHHHCCHHH	16.80	20860994
1297	Ubiquitination	GKLVLIDKLLPKLKA HHHHHHHHHHHHHCC	44.95	-
1308	Methylation	KLKAGGHRVLIFSQM HHCCCCEEEEEEHHH	28.36	-
1315	Sulfoxidation	RVLIFSQMVRCLDIL EEEEEHHHHHHHHHH	1.67	31801345
1317	Methylation	LIFSQMVRCLDILED EEEHHHHHHHHHHHH	15.22	-
1359	Methylation	FSKPDSDRFVFLLCT HCCCCHHCEEEEEEC	33.31	-
1427	Ubiquitination	YEREMFDKASLKLGL HHHHCCCHHHHHHCC	28.72	-
1431	Ubiquitination	MFDKASLKLGLDKAV CCCHHHHHHCCCHHH	37.70	-
1436	Ubiquitination	SLKLGLDKAVLQSMS HHHHCCCHHHHHHHC	45.50	-
1441	Phosphorylation	LDKAVLQSMSGRENA CCHHHHHHHCCCCCC	15.68	21406692
1443	Phosphorylation	KAVLQSMSGRENATN HHHHHHHCCCCCCCC	39.69	21406692
1449	Phosphorylation	MSGRENATNGVQQLS HCCCCCCCCHHHHHC	44.05	21406692
1456	Phosphorylation	TNGVQQLSKKEIEDL CCHHHHHCHHHHHHH	37.03	21406692
1457	Acetylation	NGVQQLSKKEIEDLL CHHHHHCHHHHHHHH	64.12	26051181
1458	Ubiquitination	GVQQLSKKEIEDLLR HHHHHCHHHHHHHHH	61.62	-
1466	Ubiquitination	EIEDLLRKGAYGALM HHHHHHHCCCHHHCC	48.11	-
1511	Ubiquitination	GKGSTFAKASFVASG CCCCEEEEEEEEECC	40.13	-
1513	Phosphorylation	GSTFAKASFVASGNR CCEEEEEEEEECCCC	21.39	-
1533	Ubiquitination	DDPNFWQKWAKKAEL CCCCHHHHHHHHHCC	39.45	-
1555	Phosphorylation	RNNLVIDTPRVRKQT CCCEEECCHHHHHHH	11.23	25159151
1566	Phosphorylation	RKQTRLYSAVKEDEL HHHHHHHHHHCHHHH	31.04	-
1577	Phosphorylation	EDELMEFSDLESDSE HHHHCHHHCCCCCCC	28.16	25159151
1581	Phosphorylation	MEFSDLESDSEEKPC CHHHCCCCCCCCCCC	54.45	25159151
1583	Phosphorylation	FSDLESDSEEKPCAK HHCCCCCCCCCCCCC	57.86	25159151
1635	Phosphorylation	GRYKRQLTEQDVETI CCHHCCCCHHHHHHH	24.22	20068231
1641	Phosphorylation	LTEQDVETICRTILV CCHHHHHHHHHHHHH	25.81	26074081
1645	Phosphorylation	DVETICRTILVYCLN HHHHHHHHHHHHHHH	17.79	26074081
1649	Phosphorylation	ICRTILVYCLNHYKG HHHHHHHHHHHHCCC	6.43	26074081
1654	Phosphorylation	LVYCLNHYKGDENIK HHHHHHHCCCCCCHH	18.65	26074081
1683	Phosphorylation	TRALVNHSGLSAPVP EEEEECCCCCCCCCC	35.90	28555341
1793	Phosphorylation	WDKEADKSLLIGVFK CCHHCCHHHEEEHHH	29.02	20068231
1827	Acetylation	RVGMPDAKAIAAEQR HHCCCCHHHHHHHHH	47.94	26051181
1857	Phosphorylation	REDEDPEYKPTRTPF CCCCCCCCCCCCCCC	27.88	29449344
1860	Phosphorylation	EDPEYKPTRTPFKDE CCCCCCCCCCCCHHH	42.92	29449344
1862	Phosphorylation	PEYKPTRTPFKDEID CCCCCCCCCCHHHHH	35.24	28450419
1874	Phosphorylation	EIDEFANSPSEDKEE HHHHHCCCCCCCHHH	26.77	28355574
1876	Phosphorylation	DEFANSPSEDKEESM HHHCCCCCCCHHHHH	59.24	23927012
1882	Phosphorylation	PSEDKEESMEIHATG CCCCHHHHHEEEECC	23.86	30576142
1888	Phosphorylation	ESMEIHATGKHSESN HHHEEEECCCCCCCC	32.38	23927012
1960	Phosphorylation	AEREAIISEKRQKWT HHHHHHHHHHHHHHH	30.84	24719451
2010	O-linked_Glycosylation	LDKKSDESLEKYFSC CCCCCHHHHHHHHHH	46.98	30379171
2123	Phosphorylation	ILNDPELSFLDAHKN CCCCCCCCHHHHHHH	23.31	28555341
2140	Phosphorylation	QNRGAGNTSSLNPLA HHCCCCCCCCCCCCC	20.83	25850435
2141	Phosphorylation	NRGAGNTSSLNPLAV HCCCCCCCCCCCCCC	36.51	25850435
2142	Phosphorylation	RGAGNTSSLNPLAVG CCCCCCCCCCCCCCE	30.08	25850435
2153	Phosphorylation	LAVGFVQTPPVISSA CCCEECCCCCCEEEC	25.02	18669648
2158	Phosphorylation	VQTPPVISSAHIQDE CCCCCCEEECCCCCH	23.00	29978859
2159	Phosphorylation	QTPPVISSAHIQDER CCCCCEEECCCCCHH	16.85	29978859
2174	Acetylation	VLEQAEGKVEEPENP HHHHHCCCCCCCCCH	37.67	26051181
2184	Acetylation	EPENPAAKEKCEGKE CCCCHHHHHHHCCCC	60.87	26051181
2196	Phosphorylation	GKEEEEETDGSGKES CCCCCCCCCCCCHHH	49.27	29449344
2199	Phosphorylation	EEEETDGSGKESKQE CCCCCCCCCHHHHHH	49.88	28985074
2203	Phosphorylation	TDGSGKESKQECEAE CCCCCHHHHHHHHHH	43.03	30576142
2212	Phosphorylation	QECEAEASSVKNELK HHHHHHHHHHHHHHC	27.46	29978859
2213	Phosphorylation	ECEAEASSVKNELKG HHHHHHHHHHHHHCC	44.13	25159151
2227	Phosphorylation	GVEVGADTGSKSISE CCEECCCCCCCCHHH	42.70	25850435
2229	Phosphorylation	EVGADTGSKSISEKG EECCCCCCCCHHHCC	25.89	21815630
2230	Acetylation	VGADTGSKSISEKGS ECCCCCCCCHHHCCC	53.83	23236377
2231	Phosphorylation	GADTGSKSISEKGSE CCCCCCCCHHHCCCH	32.80	21406692
2233	Phosphorylation	DTGSKSISEKGSEED CCCCCCHHHCCCHHH	40.11	21815630
2237	Phosphorylation	KSISEKGSEEDEEEK CCHHHCCCHHHHHHC	49.21	21815630
2251	Phosphorylation	KLEDDDKSEESSQPE CCCCCCCCCCCCCCC	54.30	25159151
2254	Phosphorylation	DDDKSEESSQPEAGA CCCCCCCCCCCCCCC	30.16	17525332
2255	Phosphorylation	DDKSEESSQPEAGAV CCCCCCCCCCCCCCH	53.70	17525332
2266	Acetylation	AGAVSRGKNFDEESN CCCHHCCCCCCHHHC	54.02	26051181
2266	Ubiquitination	AGAVSRGKNFDEESN CCCHHCCCCCCHHHC	54.02	-
2272	Phosphorylation	GKNFDEESNASMSTA CCCCCHHHCCCCCCC	35.33	29255136
2275	Phosphorylation	FDEESNASMSTARDE CCHHHCCCCCCCCHH	19.95	29255136
2277	Phosphorylation	EESNASMSTARDETR HHHCCCCCCCCHHHC	19.20	29255136
2278	Phosphorylation	ESNASMSTARDETRD HHCCCCCCCCHHHCC	19.64	29255136
2283	Phosphorylation	MSTARDETRDGFYME CCCCCHHHCCCCCCC	38.05	25849741
2288	Phosphorylation	DETRDGFYMEDGDPS HHHCCCCCCCCCCHH	12.72	20068231
2349	Phosphorylation	FQGLIPGYTPTTVDS CCCCCCCCCCCCCCC	12.28	20068231
2350	Phosphorylation	QGLIPGYTPTTVDSP CCCCCCCCCCCCCCH	21.77	18669648
2352	Phosphorylation	LIPGYTPTTVDSPLQ CCCCCCCCCCCCHHH	31.48	22199227
2353	Phosphorylation	IPGYTPTTVDSPLQK CCCCCCCCCCCHHHH	24.42	29116813
2356	Phosphorylation	YTPTTVDSPLQKRSF CCCCCCCCHHHHCCC	24.15	21712546
2373	Phosphorylation	LSMVGQASISGSEDI EEEEEECCCCCCCCC	14.92	23532336
2395	Phosphorylation	KEDALNLSVPRQRRR HHHHHCCCCCHHHHH	29.06	28555341
2446	Acetylation	EKVVDLSKASREATS EEEEEHHHHHHHHCC	58.65	26051181
2446	Ubiquitination	EKVVDLSKASREATS EEEEEHHHHHHHHCC	58.65	-
2454	Phosphorylation	ASREATSSTSNFSSL HHHHHCCCCCCCHHH	31.34	25627689
2459	Phosphorylation	TSSTSNFSSLSSKFI CCCCCCCHHHCCCCC	34.32	26437602
2460	Phosphorylation	SSTSNFSSLSSKFIL CCCCCCHHHCCCCCC	28.29	26437602
2464	Acetylation	NFSSLSSKFILPNVS CCHHHCCCCCCCCCC	32.80	26051181
2471	Phosphorylation	KFILPNVSTPVSDAF CCCCCCCCCCCHHHH	33.36	29255136
2472	Phosphorylation	FILPNVSTPVSDAFK CCCCCCCCCCHHHHH	24.35	29255136
2475	Phosphorylation	PNVSTPVSDAFKTQM CCCCCCCHHHHHHHH	25.15	29255136
2480	Phosphorylation	PVSDAFKTQMELLQA CCHHHHHHHHHHHHH	27.05	23312004
2490	Phosphorylation	ELLQAGLSRTPTRHL HHHHHHHCCCCCCHH	32.94	29978859
2492	Phosphorylation	LQAGLSRTPTRHLLN HHHHHCCCCCCHHHC	26.15	29978859
2494	Phosphorylation	AGLSRTPTRHLLNGS HHHCCCCCCHHHCCC	30.06	29978859
2501	Phosphorylation	TRHLLNGSLVDGEPP CCHHHCCCCCCCCCC	24.93	25159151
2532	Phosphorylation	LFMSHKRTSLSAEDA EEECCCCCCCCHHHH	38.53	29255136
2533	Phosphorylation	FMSHKRTSLSAEDAE EECCCCCCCCHHHHH	25.10	29255136
2535	Phosphorylation	SHKRTSLSAEDAEVT CCCCCCCCHHHHHHH	29.40	29255136
2542	Phosphorylation	SAEDAEVTKAFEEDI CHHHHHHHHHHHHCC	14.25	29255136
2551	Phosphorylation	AFEEDIETPPTRNIP HHHHCCCCCCCCCCC	34.60	23401153
2554	Phosphorylation	EDIETPPTRNIPSPG HCCCCCCCCCCCCCC	37.24	30266825
2559	Phosphorylation	PPTRNIPSPGQLDPD CCCCCCCCCCCCCCC	37.55	19664994
2567	Phosphorylation	PGQLDPDTRIPVINL CCCCCCCCCCEEEEC	35.57	22167270
2578	Phosphorylation	VINLEDGTRLVGEDA EEECCCCCEECCCCC	32.90	24732914
2601	Phosphorylation	WLKLHPTYTVDMPSY HHHHCCEEEECCCCC	14.82	-
2608	Phosphorylation	YTVDMPSYVPKNADV EEECCCCCCCCCCCC	18.20	-
2618	Phosphorylation	KNADVLFSSFQKPKQ CCCCCHHCCCCCHHH	26.53	21712546
2619	Phosphorylation	NADVLFSSFQKPKQK CCCCHHCCCCCHHHH	25.10	20068231
2640	Phosphorylation	PNKLDINTLTGEERV CCCCCCCCCCCCCCC	26.48	21060948
2657	Ubiquitination	VNKRNGKKMGGAMAP EECCCCCCCCCCCCC	44.14	-
2667	Ubiquitination	GAMAPPMKDLPRWLE CCCCCCHHHHHHHHH	62.98	-
2698	Phosphorylation	QSGFVPESMFDRLLT HHCCCCHHHHHHHHH	20.76	24667141
2705	Phosphorylation	SMFDRLLTGPVVRGE HHHHHHHHCCEECCC	43.99	20860994
2715	Phosphorylation	VVRGEGASRRGRRPK EECCCCCCCCCCCCH	33.11	20860994
2952	Phosphorylation	GPFKDGETLEGSDAE CCCCCCCCCCCCCHH	35.32	22167270
2956	Phosphorylation	DGETLEGSDAEESLD CCCCCCCCCHHHHHH	25.03	29255136
2961	Phosphorylation	EGSDAEESLDKTAES CCCCHHHHHHHHHHH	33.11	22167270
2965	Phosphorylation	AEESLDKTAESSLLE HHHHHHHHHHHHHHH	35.01	18669648
2969	Phosphorylation	LDKTAESSLLEDEIA HHHHHHHHHHHHHHH	28.60	18452278
2983	Phosphorylation	AQGEELDSLDGGDEI HCCCCCCCCCCCCCC	40.77	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1227	T	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CHD7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CHD7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTCF_HUMAN	CTCF	physical	17603073
SMCA4_HUMAN	SMARCA4	physical	20130577
SMRC2_HUMAN	SMARCC2	physical	20130577
SMRC1_HUMAN	SMARCC1	physical	20130577
SMCE1_HUMAN	SMARCE1	physical	20130577
PB1_HUMAN	PBRM1	physical	20130577
BRD7_HUMAN	BRD7	physical	20130577
ARID2_HUMAN	ARID2	physical	20130577
MTA2_HUMAN	MTA2	physical	21532573
MTA1_HUMAN	MTA1	physical	21532573
P66A_HUMAN	GATAD2A	physical	21532573
SALL3_HUMAN	SALL3	physical	21532573
SMRC2_HUMAN	SMARCC2	physical	21532573
SMCA4_HUMAN	SMARCA4	physical	21532573
ARI1A_HUMAN	ARID1A	physical	21532573
SMCE1_HUMAN	SMARCE1	physical	21532573
ZBT20_HUMAN	ZBTB20	physical	21532573
SOX2_HUMAN	SOX2	physical	21532573
OLIG1_HUMAN	OLIG1	physical	21532573
SYVC_HUMAN	VARS	physical	21532573
CHD8_HUMAN	CHD8	physical	20453063
WDR5_HUMAN	WDR5	physical	24705355
ASH2L_HUMAN	ASH2L	physical	24705355
RBBP5_HUMAN	RBBP5	physical	24705355
CHD8_HUMAN	CHD8	physical	24705355

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
214800	CHARGE syndrome (CHARGES)
608765	Idiopathic scoliosis 3 (IS3)
612370	Hypogonadotropic hypogonadism 5 with or without anosmia (HH5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CHD7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2559, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1874 AND SER-2559, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2350; SER-2356; SER-2533AND SER-2559, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2559, AND MASSSPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2254 AND SER-2255, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2559, AND MASSSPECTROMETRY.	15302935 [Abstract]