SALL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SALL3_HUMAN
• UniProt AC: Q9BXA9
• Protein Name: Sal-like protein 3
• Gene Name: SALL3
• Organism: Homo sapiens (Human).
• Sequence Length: 1300
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcription factor..
• Protein Sequence: MSRRKQAKPQHLKSDEELLPPDGAPEHAAPGEGAEDADSGPESRSGGEETSVCEKCCAEFFKWADFLEHQRSCTKLPPVLIVHEDAPAPPPEDFPEPSPASSPSERAESEAAEEAGAEGAEGEARPVEKEAEPMDAEPAGDTRAPRPPPAAPAPPTPAYGAPSTNVTLEALLSTKVAVAQFSQGARAAGGSGAGGGVAAAAVPLILEQLMALQQQQIHQLQLIEQIRSQVALMQRPPPRPSLSPAAAPSAPGPAPSQLPGLAALPLSAGAPAAAIAGSGPAAPAAFEGAQPLSRPESGASTPGGPAEPSAPAAPSAAPAPAAPAPAPAPQSAASSQPQSASTPPALAPGSLLGAAPGLPSPLLPQTSASGVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTCSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTSVGLQLPPTVPGAHGYADSPSATPASRSPQRPSPASSECASLSPGLNHVESGVSATAESPQSLLGGPPLTKAEPVSLPCTNARAGDAPVGAQASAAPTSVDGAPTSLGSPGLPAVSEQFKAQFPFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGFQDAMDSELAYDDKNAETLSSYDDDMDENSMEDDAELKDAATDPAKPLLSYAGSCPPSPPSVISSIAALENQMKMIDSVMSCQQLTGLKSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAPSNGESFRSKSPGLGAPEEPQEIPLKTERPDSPAAAPGSGGAPGRAGIKEEAPFSLLFLSRERGKCPSTVCGVCGKPFACKSALEIHYRSHTKERPFVCALCRRGCSTMGNLKQHLLTHRLKELPSQLFDPNFALGPSQSTPSLISSAAPTMIKMEVNGHGKAMALGEGPPLPAGVQVPAGPQTVMGPGLAPMLAPPPRRTPKQHNCQSCGKTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPMALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGIPQLPVSLGGSALPPLGSMASGMDKARTGSSPPIVSLDKASSETAASRPFTRFIEDNKEIGIN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	AKPQHLKSDEELLPP CCCCCCCCCHHHCCC	57.52	21406692
39	Phosphorylation	EGAEDADSGPESRSG CCCCCCCCCCCCCCC	58.95	20363803
43	Phosphorylation	DADSGPESRSGGEET CCCCCCCCCCCCCCC	34.57	20363803
45	Phosphorylation	DSGPESRSGGEETSV CCCCCCCCCCCCCHH	61.50	21406692
50	Phosphorylation	SRSGGEETSVCEKCC CCCCCCCCHHHHHHH	23.35	21406692
51	Phosphorylation	RSGGEETSVCEKCCA CCCCCCCHHHHHHHH	28.22	21406692
109	Phosphorylation	SPSERAESEAAEEAG CHHHHHHHHHHHHHH	31.39	21406692
173	Phosphorylation	VTLEALLSTKVAVAQ CCHHHHHCCHHHHHH	27.34	24719451
431	Phosphorylation	FCAKVFGSDSALQIH HHHHHHCCCCEEEEE	19.54	23186163
433	Phosphorylation	AKVFGSDSALQIHLR HHHHCCCCEEEEEEE	32.35	23186163
443	Phosphorylation	QIHLRSHTGERPFKC EEEEECCCCCCCEEC	41.82	21857030
449	Methylation	HTGERPFKCNICGNR CCCCCCEECEECCCC	29.11	-
464	Acetylation	FSTKGNLKVHFQRHK CCCCCCEEEEECHHH	37.35	11794991
700	Phosphorylation	ALKMHYRTHTGERPF HHHHHHCCCCCCCCE	19.34	28555341
702	Phosphorylation	KMHYRTHTGERPFKC HHHHCCCCCCCCEEC	39.87	25159151
804	Phosphorylation	DDDMDENSMEDDAEL CCCCCCCCCCCHHHH	22.85	21406692
832	Phosphorylation	YAGSCPPSPPSVISS HCCCCCCCCHHHHHH	34.29	28348404
835	Phosphorylation	SCPPSPPSVISSIAA CCCCCCHHHHHHHHH	35.15	28348404
855	Phosphorylation	KMIDSVMSCQQLTGL HHHHHHHHHHHHHCC	13.45	22210691
860	Phosphorylation	VMSCQQLTGLKSVEN HHHHHHHHCCCCCCC	35.81	22210691
864	Phosphorylation	QQLTGLKSVENGSGE HHHHCCCCCCCCCCC	39.44	21406692
869	Phosphorylation	LKSVENGSGESDRLS CCCCCCCCCCCHHCC	51.47	21406692
872	Phosphorylation	VENGSGESDRLSNDS CCCCCCCCHHCCCCC	31.40	22210691
876	Phosphorylation	SGESDRLSNDSSSAV CCCCHHCCCCCCCHH	39.21	21406692
879	Phosphorylation	SDRLSNDSSSAVGDL CHHCCCCCCCHHHCH	30.37	21406692
880	Phosphorylation	DRLSNDSSSAVGDLE HHCCCCCCCHHHCHH	25.77	21406692
881	Phosphorylation	RLSNDSSSAVGDLES HCCCCCCCHHHCHHH	30.81	21406692
888	Phosphorylation	SAVGDLESRSAGSPA CHHHCHHHHCCCCCC	38.54	21406692
917	Phosphorylation	SNGESFRSKSPGLGA CCCCCHHCCCCCCCC	35.16	22617229
919	Phosphorylation	GESFRSKSPGLGAPE CCCHHCCCCCCCCCC	26.00	20363803
935	Phosphorylation	PQEIPLKTERPDSPA CCCCCCCCCCCCCCC	44.93	21406692
940	Phosphorylation	LKTERPDSPAAAPGS CCCCCCCCCCCCCCC	21.08	25954137
947	Phosphorylation	SPAAAPGSGGAPGRA CCCCCCCCCCCCCCC	32.75	17929957
990	Phosphorylation	GKPFACKSALEIHYR CCCCCCCHHHHHHHC	37.66	22210691
993 (in isoform 3)	Ubiquitination	-	27.69	21890473
998	Phosphorylation	ALEIHYRSHTKERPF HHHHHHCCCCCCCCC	28.48	22210691
1000	Phosphorylation	EIHYRSHTKERPFVC HHHHCCCCCCCCCCH	35.53	22210691
1054	Phosphorylation	QSTPSLISSAAPTMI CCCHHHHHHCCCCEE	21.15	-
1065 (in isoform 4)	Ubiquitination	-	10.46	21890473
1126 (in isoform 2)	Ubiquitination	-	31.31	21890473
1134	Phosphorylation	ALQIHERTHTGEKPF HHHHHCCCCCCCCCC	22.32	-
1136	Phosphorylation	QIHERTHTGEKPFGC HHHCCCCCCCCCCCE	46.56	-
1177	Phosphorylation	ARRGRRLSVENPMAL CCCCCCCCCCCHHHH	26.10	29978859
1198	Ubiquitination	KFSEMFQKDLAARAM HHHHHHHHHHHHHHC	43.36	21890473
1198 (in isoform 1)	Ubiquitination	-	43.36	21890473
1265	Phosphorylation	SGMDKARTGSSPPIV CCCCHHCCCCCCCEE	46.40	21406692
1267	Phosphorylation	MDKARTGSSPPIVSL CCHHCCCCCCCEEEC	38.77	21406692
1268	Phosphorylation	DKARTGSSPPIVSLD CHHCCCCCCCEEECC	35.72	19664994
1273	Phosphorylation	GSSPPIVSLDKASSE CCCCCEEECCCCCCH	31.41	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SALL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SALL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SALL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM3A_HUMAN	DNMT3A	physical	19139273

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.