dbPTM

CHD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CHD8_HUMAN
UniProt AC	Q9HCK8
Protein Name	Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255\|HAMAP-Rule:MF_03071}
Gene Name	CHD8 {ECO:0000255\|HAMAP-Rule:MF_03071}
Organism	Homo sapiens (Human).
Sequence Length	2581
Subcellular Localization	Nucleus . Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites.
Protein Description	DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription..
Protein Sequence	MADPIMDLFDDPNLFGLDSLTDDSFNQVTQDPIEEALGLPSSLDSLDQMNQDGGGGDVGNSSASELVPPPEETAPTELSKESTAPAPESITLHDYTTQPASQEQPAQPVLQTSTPTSGLLQVSKSQEILSQGNPFMGVSATAVSSSSAGGQPPQSAPKIVILKAPPSSSVTGAHVAQIQAQGITSTAQPLVAGTANGGKVTFTKVLTGTPLRPGVSIVSGNTVLAAKVPGNQAAVQRIVQPSRPVKQLVLQPVKGSAPAGNPGATGPPLKPAVTLTSTPTQGESKRITLVLQQPQSGGPQGHRHVVLGSLPGKIVLQGNQLAALTQAKNAQGQPAKVVTIQLQVQQPQQKIQIVPQPPSSQPQPQQPPSTQPVTLSSVQQAQIMGPGQSPGQRLSVPVKVVLQPQAGSSQGASSGLSVVKVLSASEVAALSSPASSAPHSGGKTGMEENRRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVRPEEEGEKKRRKKSAGERLKEEKPKKSKTSGASKTKGKSKLNTITPVVGKKRKRNTSSDNSDVEVMPAQSPREDEESSIQKRRSNRQVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPEPILPEPVQEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRIVKKELPSGQYTEAEEFFVKYKNYSYLHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSIDKDNGEPVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELKRVNRPQASAWKKLELSHEYKNRNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTEMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLSKGAGHTNMPNLLNTMMELRKCCNHPYLINGAEEKILTEFREACHIIPHDFHLQAMVRSAGKLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAYAAIMEEDDEGSKFCEEDIDQILLRRTTTITIESEGKGSTFAKASFVASENRTDISLDDPNFWQKWAKKADLDMDLLNSKNNLVIDTPRVRKQTRHFSTLKDDDLVEFSDLESEDDERPRSRRHDRHHAYGRTDCFRVEKHLLVYGWGRWRDILSHGRFKRRMTERDVETICRAILVYCLLHYRGDENIKGFIWDLISPAENGKTKELQNHSGLSIPVPRGRKGKKVKSQSTFDIHKADWIRKYNPDTLFQDESYKKHLKHQCNKVLLRVRMLYYLRQEVIGDQAEKVLGGAIASEIDIWFPVVDQLEVPTTWWDSEADKSLLIGVFKHGYEKYNTMRADPALCFLEKAGRPDDKAIAAEHRVLDNFSDIVEGVDFDKDCEDPEYKPLQGPPKDQDDEGDPLMMMDEEISVIDGDEAQVTQQPGHLFWPPGSALTARLRRLVTAYQRSYKREQMKIEAAERGDRRRRRCEAAFKLKEIARREKQQRWTRREQTDFYRVVSTFGVEYDPDTMQFHWDRFRTFARLDKKTDESLTKYFHGFVAMCRQVCRLPPAAGDEPPDPNLFIEPITEERASRTLYRIELLRRLREQVLCHPLLEDRLALCQPPGPELPKWWEPVRHDGELLRGAARHGVSQTDCNIMQDPDFSFLAARMNYMQNHQAGAPAPSLSRCSTPLLHQQYTSRTASPLPLRPDAPVEKSPEETATQVPSLESLTLKLEHEVVARSRPTPQDYEMRVSPSDTTPLVSRSVPPVKLEDEDDSDSELDLSKLSPSSSSSSSSSSSSSSTDESEDEKEEKLTDQSRSKLYDEESLLSLTMSQDGFPNEDGEQMTPELLLLQERQRASEWPKDRVLINRIDLVCQAVLSGKWPSSRRSQEMVTGGILGPGNHLLDSPSLTPGEYGDSPVPTPRSSSAASMAEEEASAVSTAAAQFTKLRRGMDEKEFTVQIKDEEGLKLTFQKHKLMANGVMGDGHPLFHKKKGNRKKLVELEVECMEEPNHLDVDLETRIPVINKVDGTLLVGEDAPRRAELEMWLQGHPEFAVDPRFLAYMEDRRKQKWQRCKKNNKAELNCLGMEPVQTANSRNGKKGHHTETVFNRVLPGPIAPESSKKRARRMRPDLSKMMALMQGGSTGSLSLHNTFQHSSSGLQSVSSLGHSSATSASLPFMPFVMGGAPSSPHVDSSTMLHHHHHHPHPHHHHHHHPGLRAPGYPSSPVTTASGTTLRLPPLQPEEDDDEDEEDDDDLSQGYDSSERDFSLIDDPMMPANSDSSEDADD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Ubiquitination	SLDSLDQMNQDGGGG CHHHHHHHCCCCCCC	4.93	32015554
82	Phosphorylation	PTELSKESTAPAPES CCCCCCCCCCCCCCC	33.34	30377224
83	Phosphorylation	TELSKESTAPAPESI CCCCCCCCCCCCCCE	37.44	30377224
101	Phosphorylation	DYTTQPASQEQPAQP CCCCCCCCCCCCCCC	40.72	28348404
112	Phosphorylation	PAQPVLQTSTPTSGL CCCCCCCCCCCCCCC	30.33	28348404
113	O-linked_Glycosylation	AQPVLQTSTPTSGLL CCCCCCCCCCCCCCE	21.30	30379171
113	Phosphorylation	AQPVLQTSTPTSGLL CCCCCCCCCCCCCCE	21.30	28348404
114	Phosphorylation	QPVLQTSTPTSGLLQ CCCCCCCCCCCCCEE	33.69	28348404
117	O-linked_Glycosylation	LQTSTPTSGLLQVSK CCCCCCCCCCEEECC	28.75	30379171
123	O-linked_Glycosylation	TSGLLQVSKSQEILS CCCCEEECCHHHHHH	17.39	30379171
125	Phosphorylation	GLLQVSKSQEILSQG CCEEECCHHHHHHCC	26.07	-
199	Acetylation	AGTANGGKVTFTKVL EEECCCCEEEEEEEE	39.23	26051181
207	Phosphorylation	VTFTKVLTGTPLRPG EEEEEEEECCCCCCC	41.83	25850435
209	Phosphorylation	FTKVLTGTPLRPGVS EEEEEECCCCCCCEE	17.57	22199227
216	Phosphorylation	TPLRPGVSIVSGNTV CCCCCCEEEECCCEE	24.16	29978859
219	Phosphorylation	RPGVSIVSGNTVLAA CCCEEEECCCEEEEE	25.34	28122231
222	Phosphorylation	VSIVSGNTVLAAKVP EEEECCCEEEEEECC	22.03	28122231
222	Ubiquitination	VSIVSGNTVLAAKVP EEEECCCEEEEEECC	22.03	24816145
246	Acetylation	VQPSRPVKQLVLQPV CCCCCCHHEEEEEEC	40.37	25953088
254	Acetylation	QLVLQPVKGSAPAGN EEEEEECCCCCCCCC	54.56	26051181
256	Phosphorylation	VLQPVKGSAPAGNPG EEEECCCCCCCCCCC	25.92	20860994
258	Phosphorylation	QPVKGSAPAGNPGAT EECCCCCCCCCCCCC	42.26	16964243
265	Phosphorylation	PAGNPGATGPPLKPA CCCCCCCCCCCCCCC	57.02	29978859
270	Acetylation	GATGPPLKPAVTLTS CCCCCCCCCCEEEEE	36.38	25953088
270	Ubiquitination	GATGPPLKPAVTLTS CCCCCCCCCCEEEEE	36.38	32015554
270 (in isoform 1)	Ubiquitination	-	36.38	21906983
274	Phosphorylation	PPLKPAVTLTSTPTQ CCCCCCEEEEECCCC	26.82	29978859
276	Phosphorylation	LKPAVTLTSTPTQGE CCCCEEEEECCCCCC	22.61	29978859
277	Phosphorylation	KPAVTLTSTPTQGES CCCEEEEECCCCCCC	35.19	29978859
278	Phosphorylation	PAVTLTSTPTQGESK CCEEEEECCCCCCCC	25.72	29496963
280	Phosphorylation	VTLTSTPTQGESKRI EEEEECCCCCCCCEE	49.66	29978859
284	Phosphorylation	STPTQGESKRITLVL ECCCCCCCCEEEEEE	33.77	29978859
285	Ubiquitination	TPTQGESKRITLVLQ CCCCCCCCEEEEEEE	43.44	29967540
288	Phosphorylation	QGESKRITLVLQQPQ CCCCCEEEEEEECCC	18.17	28555341
296	Phosphorylation	LVLQQPQSGGPQGHR EEEECCCCCCCCCCC	53.02	25159151
313	Ubiquitination	VLGSLPGKIVLQGNQ EECCCCCEEEEECCH	27.92	-
328	Ubiquitination	LAALTQAKNAQGQPA HHHHHHHHHCCCCCC	42.89	32015554
336	Acetylation	NAQGQPAKVVTIQLQ HCCCCCCEEEEEEEE	43.87	26051181
376	Ubiquitination	STQPVTLSSVQQAQI CCCCCCCCCEEEEEE	21.06	29967540
389	Phosphorylation	QIMGPGQSPGQRLSV EECCCCCCCCCCCCC	36.59	28555341
392	Ubiquitination	GPGQSPGQRLSVPVK CCCCCCCCCCCCEEE	46.67	29967540
399	Acetylation	QRLSVPVKVVLQPQA CCCCCEEEEEECCCC	22.13	25953088
399	Ubiquitination	QRLSVPVKVVLQPQA CCCCCEEEEEECCCC	22.13	-
409	Phosphorylation	LQPQAGSSQGASSGL ECCCCCCCCCCCCCC	31.54	-
420	Acetylation	SSGLSVVKVLSASEV CCCCEEEEEEEHHHH	34.99	26051181
423	Phosphorylation	LSVVKVLSASEVAAL CEEEEEEEHHHHHHH	32.51	24732914
425	Phosphorylation	VVKVLSASEVAALSS EEEEEEHHHHHHHCC	29.27	24732914
425	Ubiquitination	VVKVLSASEVAALSS EEEEEEHHHHHHHCC	29.27	29967540
431	Phosphorylation	ASEVAALSSPASSAP HHHHHHHCCCCCCCC	29.55	24732914
432	Phosphorylation	SEVAALSSPASSAPH HHHHHHCCCCCCCCC	25.90	25159151
435	Phosphorylation	AALSSPASSAPHSGG HHHCCCCCCCCCCCC	30.34	24732914
436	Phosphorylation	ALSSPASSAPHSGGK HHCCCCCCCCCCCCC	48.18	24732914
440	Phosphorylation	PASSAPHSGGKTGME CCCCCCCCCCCCCHH	48.45	25159151
443	Acetylation	SAPHSGGKTGMEENR CCCCCCCCCCHHHHH	45.49	26051181
459	Ubiquitination	LEHQKKQEKANRIVA HHHHHHHHHHHHHHH	64.12	29967540
501	Ubiquitination	PEEEGEKKRRKKSAG CHHHHHHHHHHCHHH	53.81	24816145
519	Ubiquitination	KEEKPKKSKTSGASK HHHCCCCCCCCCCCC	47.49	29967540
527	Phosphorylation	KTSGASKTKGKSKLN CCCCCCCCCCCCCCC	42.40	20068231
531	Phosphorylation	ASKTKGKSKLNTITP CCCCCCCCCCCCCCC	51.55	20068231
532	Acetylation	SKTKGKSKLNTITPV CCCCCCCCCCCCCCC	49.60	25953088
535	Phosphorylation	KGKSKLNTITPVVGK CCCCCCCCCCCCCCC	36.34	20068231
537	Phosphorylation	KSKLNTITPVVGKKR CCCCCCCCCCCCCCC	14.16	25159151
542	Acetylation	TITPVVGKKRKRNTS CCCCCCCCCCCCCCC	37.48	25953088
548	Phosphorylation	GKKRKRNTSSDNSDV CCCCCCCCCCCCCCC	33.37	22167270
549	Phosphorylation	KKRKRNTSSDNSDVE CCCCCCCCCCCCCCE	38.96	22167270
550	Phosphorylation	KRKRNTSSDNSDVEV CCCCCCCCCCCCCEE	38.48	22167270
553	Phosphorylation	RNTSSDNSDVEVMPA CCCCCCCCCCEECCC	48.28	22167270
562	Phosphorylation	VEVMPAQSPREDEES CEECCCCCCCCCHHH	28.20	30278072
569	Phosphorylation	SPREDEESSIQKRRS CCCCCHHHHHHHHHH	30.60	28450419
570	Phosphorylation	PREDEESSIQKRRSN CCCCHHHHHHHHHHH	32.11	21815630
592	Sumoylation	YTEDLDIKITDDEEE CCCCCCCCCCCCCCC	38.94	-
592	Sumoylation	YTEDLDIKITDDEEE CCCCCCCCCCCCCCC	38.94	-
609	Sumoylation	VDVTGPIKPEPILPE CCCCCCCCCCCCCCC	46.60	-
655	Ubiquitination	LSMRIVKKELPSGQY HHHEEEECCCCCCCC	54.30	29967540
663	Phosphorylation	ELPSGQYTEAEEFFV CCCCCCCCEEHHHHH	22.34	-
671	Ubiquitination	EAEEFFVKYKNYSYL EEHHHHHEECCCEEE	45.40	29967540
675	Phosphorylation	FFVKYKNYSYLHCEW HHHEECCCEEEECEE	8.44	29083192
676	Phosphorylation	FVKYKNYSYLHCEWA HHEECCCEEEECEEE	30.52	29083192
677	Phosphorylation	VKYKNYSYLHCEWAT HEECCCEEEECEEEE	7.07	29083192
704	Ubiquitination	KLKRFKTKMAQMRHF HHHHHHHHHHHHHHH	32.59	29967540
733	Phosphorylation	VDRILDESHSIDKDN HHHHHHCCCCCCCCC	23.38	25627689
734	Ubiquitination	DRILDESHSIDKDNG HHHHHCCCCCCCCCC	27.07	32015554
738	Acetylation	DESHSIDKDNGEPVI HCCCCCCCCCCCEEE	51.96	26051181
738	Ubiquitination	DESHSIDKDNGEPVI HCCCCCCCCCCCEEE	51.96	29967540
741	Ubiquitination	HSIDKDNGEPVIYYL CCCCCCCCCEEEEEE	51.20	29967540
788	Ubiquitination	RHPELKRVNRPQASA CCHHHHCCCCCCHHH	7.33	29967540
798	Ubiquitination	PQASAWKKLELSHEY CCHHHHHHHHHCHHC	36.17	29967540
814	Ubiquitination	NRNQLREYQLEGVNW CHHHHHHHHHHCCCH	16.38	29967540
959	Acetylation	RLKNRNCKLLDSLKH HHHCCCCCHHHHHHC	56.48	25953088
965	Acetylation	CKLLDSLKHMDLEHK CCHHHHHHCCCCCCC	40.61	25953088
1000	Ubiquitination	FLEPSQFPSESEFLK HHCHHHCCCHHHHHH	29.56	29967540
1013	Ubiquitination	LKDFGDLKTEEQVQK HHHHCCCCCHHHHHH	59.64	32015554
1020	Ubiquitination	KTEEQVQKLQAILKP CCHHHHHHHHHHHHH	43.65	29967540
1021	Ubiquitination	TEEQVQKLQAILKPM CHHHHHHHHHHHHHH	2.02	29967540
1022	Ubiquitination	EEQVQKLQAILKPMM HHHHHHHHHHHHHHH	33.13	29967540
1026	Ubiquitination	QKLQAILKPMMLRRL HHHHHHHHHHHHHHH	25.42	-
1030	Ubiquitination	AILKPMMLRRLKEDV HHHHHHHHHHHHHHH	2.04	29967540
1058	Ubiquitination	VELTNIQKKYYRAIL EEEHHHHHHHHHHHH	38.66	-
1060	Phosphorylation	LTNIQKKYYRAILEK EHHHHHHHHHHHHHH	12.76	-
1061	Phosphorylation	TNIQKKYYRAILEKN HHHHHHHHHHHHHHC	11.49	-
1067	Ubiquitination	YYRAILEKNFSFLSK HHHHHHHHCCCHHHC	60.90	29967540
1070	Phosphorylation	AILEKNFSFLSKGAG HHHHHCCCHHHCCCC	34.37	20873877
1075	Ubiquitination	NFSFLSKGAGHTNMP CCCHHHCCCCCCCCH	33.15	32142685
1093	Ubiquitination	NTMMELRKCCNHPYL HHHHHHHHHCCCCCC	56.62	29967540
1097	Ubiquitination	ELRKCCNHPYLINGA HHHHHCCCCCCCCCH	9.85	29967540
1099	Phosphorylation	RKCCNHPYLINGAEE HHHCCCCCCCCCHHH	16.80	20860994
1101	Ubiquitination	CCNHPYLINGAEEKI HCCCCCCCCCHHHHH	3.54	29967540
1112	Ubiquitination	EEKILTEFREACHII HHHHHHHHHHHHCCC	7.83	29967540
1119	Phosphorylation	FREACHIIPHDFHLQ HHHHHCCCCCCHHHH	0.81	16964243
1140	Acetylation	GKLVLIDKLLPKLKA CEEEEHHHHHHHHCC	44.95	26051181
1140	Ubiquitination	GKLVLIDKLLPKLKA CEEEEHHHHHHHHCC	44.95	-
1141	Phosphorylation	KLVLIDKLLPKLKAG EEEEHHHHHHHHCCC	9.81	17081983
1145	Phosphorylation	IDKLLPKLKAGGHKV HHHHHHHHCCCCEEE	4.31	17081983
1156	Phosphorylation	GHKVLIFSQMVRCLD CEEEEEEHHHHHHHH	15.46	24719451
1158	Sulfoxidation	KVLIFSQMVRCLDIL EEEEEHHHHHHHHHH	1.67	31801345
1168	Phosphorylation	CLDILEDYLIQRRYL HHHHHHHHHHHHHHH	9.06	24719451
1202	Methylation	FSKPDSDRFVFLLCT HCCCCHHCEEEEEEC	33.31	-
1238	Ubiquitination	WNPQNDLQAQARCHR CCCCCHHHHHHHHHH	34.00	29967540
1250	Acetylation	CHRIGQSKAVKVYRL HHHHCCCHHHHHEEE	49.68	-
1260	Ubiquitination	KVYRLITRNSYEREM HHEEEHHCCHHHHHC	24.09	29967540
1269	Ubiquitination	SYEREMFDKASLKLG HHHHHCCCHHHHHHC	44.28	29967540
1270	Ubiquitination	YEREMFDKASLKLGL HHHHCCCHHHHHHCC	28.72	-
1274	Ubiquitination	MFDKASLKLGLDKAV CCCHHHHHHCCCHHH	37.70	-
1275	Ubiquitination	FDKASLKLGLDKAVL CCHHHHHHCCCHHHH	11.33	29967540
1279	Ubiquitination	SLKLGLDKAVLQSMS HHHHCCCHHHHHHHC	45.50	29967540
1288	Ubiquitination	VLQSMSGRDGNITGI HHHHHCCCCCCCCHH	41.16	29967540
1300	Ubiquitination	TGIQQFSKKEIEDLL CHHHHCCHHHHHHHH	56.57	29967540
1301	Acetylation	GIQQFSKKEIEDLLR HHHHCCHHHHHHHHH	63.83	20167786
1301	Ubiquitination	GIQQFSKKEIEDLLR HHHHCCHHHHHHHHH	63.83	29967540
1309	Ubiquitination	EIEDLLRKGAYAAIM HHHHHHHCCCCEEEE	48.11	29967540
1323	Phosphorylation	MEEDDEGSKFCEEDI EECCCCCCCCCHHHH	22.10	18767875
1338	Phosphorylation	DQILLRRTTTITIES HHHHHHCCEEEEEEE	23.12	29496963
1339	Phosphorylation	QILLRRTTTITIESE HHHHHCCEEEEEEEC	17.87	20873877
1340	Phosphorylation	ILLRRTTTITIESEG HHHHCCEEEEEEECC	18.60	29496963
1342	Phosphorylation	LRRTTTITIESEGKG HHCCEEEEEEECCCC	19.32	27794612
1348	Acetylation	ITIESEGKGSTFAKA EEEEECCCCCCEEEE	45.71	26051181
1354	Ubiquitination	GKGSTFAKASFVASE CCCCCEEEEEEEEEC	40.13	32142685
1363	Methylation	SFVASENRTDISLDD EEEEECCCCCCCCCC	29.71	-
1365	Ubiquitination	VASENRTDISLDDPN EEECCCCCCCCCCCC	25.83	29967540
1376	Ubiquitination	DDPNFWQKWAKKADL CCCCHHHHHHHHCCC	39.45	29967540
1380	Ubiquitination	FWQKWAKKADLDMDL HHHHHHHHCCCCHHH	39.11	29967540
1387	Ubiquitination	KADLDMDLLNSKNNL HCCCCHHHHHCCCCE	3.81	29967540
1390	Phosphorylation	LDMDLLNSKNNLVID CCHHHHHCCCCEEEC	36.41	28555341
1391	Ubiquitination	DMDLLNSKNNLVIDT CHHHHHCCCCEEECC	49.10	29967540
1398	Phosphorylation	KNNLVIDTPRVRKQT CCCEEECCHHHHHHC	11.23	25159151
1400	Phosphorylation	NLVIDTPRVRKQTRH CEEECCHHHHHHCCC	42.86	32142685
1409	Phosphorylation	RKQTRHFSTLKDDDL HHHCCCCCCCCCCCC	27.06	29978859
1410	Phosphorylation	KQTRHFSTLKDDDLV HHCCCCCCCCCCCCE	36.56	29978859
1410	Ubiquitination	KQTRHFSTLKDDDLV HHCCCCCCCCCCCCE	36.56	29967540
1418	Ubiquitination	LKDDDLVEFSDLESE CCCCCCEEHHHCCCC	46.89	29967540
1420	Phosphorylation	DDDLVEFSDLESEDD CCCCEEHHHCCCCCC	27.99	29255136
1424	Phosphorylation	VEFSDLESEDDERPR EEHHHCCCCCCCCCC	54.33	29255136
1432	Phosphorylation	EDDERPRSRRHDRHH CCCCCCCHHCHHHHH	36.03	28111955
1466	Phosphorylation	GRWRDILSHGRFKRR CHHHHHHHCCCHHHC	24.99	-
1475	Phosphorylation	GRFKRRMTERDVETI CCHHHCCCHHHHHHH	26.51	-
1487	Ubiquitination	ETICRAILVYCLLHY HHHHHHHHHHHHHHH	1.88	24816145
1517	Ubiquitination	PAENGKTKELQNHSG HHHCCCCCCCCCCCC	60.97	29967540
1523	Phosphorylation	TKELQNHSGLSIPVP CCCCCCCCCCCCCCC	49.32	25159151
1526	Phosphorylation	LQNHSGLSIPVPRGR CCCCCCCCCCCCCCC	28.50	21712546
1539	Ubiquitination	GRKGKKVKSQSTFDI CCCCCCCCCCCCEEH	52.21	29967540
1540	Phosphorylation	RKGKKVKSQSTFDIH CCCCCCCCCCCEEHH	32.14	25159151
1542	Phosphorylation	GKKVKSQSTFDIHKA CCCCCCCCCEEHHHH	37.83	25627689
1548	Ubiquitination	QSTFDIHKADWIRKY CCCEEHHHHHHHHHH	48.66	29967540
1554	Ubiquitination	HKADWIRKYNPDTLF HHHHHHHHHCCCCCC	40.00	29967540
1559	Phosphorylation	IRKYNPDTLFQDESY HHHHCCCCCCCCHHH	30.63	30387612
1565	Phosphorylation	DTLFQDESYKKHLKH CCCCCCHHHHHHHHH	51.01	30387612
1567	Ubiquitination	LFQDESYKKHLKHQC CCCCHHHHHHHHHHH	42.89	29967540
1632	Phosphorylation	WDSEADKSLLIGVFK CCCHHCHHHEEEHHH	29.02	20068231
1644	Ubiquitination	VFKHGYEKYNTMRAD HHHCCHHHHHHCCCC	35.00	29967540
1659	Ubiquitination	PALCFLEKAGRPDDK HHHHHHHHCCCCCHH	59.28	29967540
1666	Acetylation	KAGRPDDKAIAAEHR HCCCCCHHHHHHHHH	49.42	7364345
1666	Ubiquitination	KAGRPDDKAIAAEHR HCCCCCHHHHHHHHH	49.42	29967540
1679	Phosphorylation	HRVLDNFSDIVEGVD HHHHHCHHHHHCCCC	32.45	22617229
1689	Ubiquitination	VEGVDFDKDCEDPEY HCCCCCCCCCCCCCC	65.36	29967540
1696	Phosphorylation	KDCEDPEYKPLQGPP CCCCCCCCCCCCCCC	24.24	26657352
1697	Sumoylation	DCEDPEYKPLQGPPK CCCCCCCCCCCCCCC	37.27	-
1697	Phosphorylation	DCEDPEYKPLQGPPK CCCCCCCCCCCCCCC	37.27	32142685
1697	Sumoylation	DCEDPEYKPLQGPPK CCCCCCCCCCCCCCC	37.27	-
1697	Ubiquitination	DCEDPEYKPLQGPPK CCCCCCCCCCCCCCC	37.27	29967540
1716	Phosphorylation	EGDPLMMMDEEISVI CCCCCEEECCEEEEE	3.50	32142685
1729	Phosphorylation	VIDGDEAQVTQQPGH EECCCCCCCCCCCCC	36.42	32142685
1746	Ubiquitination	WPPGSALTARLRRLV CCCCHHHHHHHHHHH	14.95	29967540
1766	Ubiquitination	SYKREQMKIEAAERG HHHHHHHHHHHHHHH	36.77	24816145
1767	Phosphorylation	YKREQMKIEAAERGD HHHHHHHHHHHHHHH	3.50	32142685
1785	Acetylation	RRCEAAFKLKEIARR HHHHHHHHHHHHHHH	54.65	25953088
1792	Phosphorylation	KLKEIARREKQQRWT HHHHHHHHHHHHHHH	46.58	33259812
1842	Phosphorylation	LDKKTDESLTKYFHG CCCCCCHHHHHHHHH	44.12	21659604
1947	Glutathionylation	HGVSQTDCNIMQDPD CCCCHHCCCCCCCCC	4.17	22555962
1962	Ubiquitination	FSFLAARMNYMQNHQ HHHHHHHHHHHHHCC	3.46	32015554
1964	Phosphorylation	FLAARMNYMQNHQAG HHHHHHHHHHHCCCC	7.25	23403867
1976	Phosphorylation	QAGAPAPSLSRCSTP CCCCCCCCHHHCCCC	40.87	23401153
1978	Phosphorylation	GAPAPSLSRCSTPLL CCCCCCHHHCCCCCC	35.26	22167270
1981	Phosphorylation	APSLSRCSTPLLHQQ CCCHHHCCCCCCCCC	31.76	23401153
1982	Phosphorylation	PSLSRCSTPLLHQQY CCHHHCCCCCCCCCC	22.91	23401153
1983	Ubiquitination	SLSRCSTPLLHQQYT CHHHCCCCCCCCCCC	19.34	29967540
1988	Ubiquitination	STPLLHQQYTSRTAS CCCCCCCCCCCCCCC	32.49	29967540
1989	Phosphorylation	TPLLHQQYTSRTASP CCCCCCCCCCCCCCC	10.50	23312004
1990	Phosphorylation	PLLHQQYTSRTASPL CCCCCCCCCCCCCCC	13.85	26074081
1990	Ubiquitination	PLLHQQYTSRTASPL CCCCCCCCCCCCCCC	13.85	29967540
1991	Phosphorylation	LLHQQYTSRTASPLP CCCCCCCCCCCCCCC	23.77	26074081
1993	Phosphorylation	HQQYTSRTASPLPLR CCCCCCCCCCCCCCC	31.11	29255136
1995	Phosphorylation	QYTSRTASPLPLRPD CCCCCCCCCCCCCCC	26.76	29255136
2008	Phosphorylation	PDAPVEKSPEETATQ CCCCCCCCHHHCCCC	24.84	19664994
2012	Phosphorylation	VEKSPEETATQVPSL CCCCHHHCCCCCCCH	33.09	29255136
2014	Phosphorylation	KSPEETATQVPSLES CCHHHCCCCCCCHHH	37.20	29255136
2018	Phosphorylation	ETATQVPSLESLTLK HCCCCCCCHHHHEEE	46.01	25159151
2021	Phosphorylation	TQVPSLESLTLKLEH CCCCCHHHHEEEEEE	31.76	23927012
2023	Phosphorylation	VPSLESLTLKLEHEV CCCHHHHEEEEEEEH	31.00	23927012
2025	Sumoylation	SLESLTLKLEHEVVA CHHHHEEEEEEEHHH	46.74	28112733
2025	Ubiquitination	SLESLTLKLEHEVVA CHHHHEEEEEEEHHH	46.74	29967540
2034	Phosphorylation	EHEVVARSRPTPQDY EEEHHHCCCCCCCCC	32.64	23927012
2037	Phosphorylation	VVARSRPTPQDYEMR HHHCCCCCCCCCEEC	32.26	23927012
2041	Phosphorylation	SRPTPQDYEMRVSPS CCCCCCCCEECCCCC	13.33	30576142
2041	Ubiquitination	SRPTPQDYEMRVSPS CCCCCCCCEECCCCC	13.33	29967540
2044	Methylation	TPQDYEMRVSPSDTT CCCCCEECCCCCCCC	17.52	-
2046	Phosphorylation	QDYEMRVSPSDTTPL CCCEECCCCCCCCCC	14.34	19664994
2048	Phosphorylation	YEMRVSPSDTTPLVS CEECCCCCCCCCCCC	39.83	30266825
2050	Phosphorylation	MRVSPSDTTPLVSRS ECCCCCCCCCCCCCC	34.35	23927012
2051	Phosphorylation	RVSPSDTTPLVSRSV CCCCCCCCCCCCCCC	21.44	23927012
2055	Phosphorylation	SDTTPLVSRSVPPVK CCCCCCCCCCCCCCC	26.90	23927012
2057	Phosphorylation	TTPLVSRSVPPVKLE CCCCCCCCCCCCCCC	31.31	25278378
2069	Phosphorylation	KLEDEDDSDSELDLS CCCCCCCCCCCCCHH	56.19	29255136
2071	Phosphorylation	EDEDDSDSELDLSKL CCCCCCCCCCCHHHC	43.97	29255136
2076	Phosphorylation	SDSELDLSKLSPSSS CCCCCCHHHCCCCCC	31.08	30108239
2083	Phosphorylation	SKLSPSSSSSSSSSS HHCCCCCCCCCCCCC	38.28	-
2084	Phosphorylation	KLSPSSSSSSSSSSS HCCCCCCCCCCCCCC	35.87	-
2085	Phosphorylation	LSPSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	30576142
2086	Phosphorylation	SPSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
2087	Phosphorylation	PSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	24275569
2088	Phosphorylation	SSSSSSSSSSSSSST CCCCCCCCCCCCCCC	35.87	-
2090	Phosphorylation	SSSSSSSSSSSSTDE CCCCCCCCCCCCCCC	35.87	30576142
2093	Phosphorylation	SSSSSSSSSTDESED CCCCCCCCCCCCCHH	38.92	30576142
2107	Phosphorylation	DEKEEKLTDQSRSKL HHHHHHHCHHHHHHH	42.96	27135362
2110	Phosphorylation	EEKLTDQSRSKLYDE HHHHCHHHHHHHCCH	41.13	27135362
2112	Phosphorylation	KLTDQSRSKLYDEES HHCHHHHHHHCCHHH	32.06	25921289
2115	Phosphorylation	DQSRSKLYDEESLLS HHHHHHHCCHHHHHH	25.66	30177828
2115	Ubiquitination	DQSRSKLYDEESLLS HHHHHHHCCHHHHHH	25.66	29967540
2119	Phosphorylation	SKLYDEESLLSLTMS HHHCCHHHHHHHHHC	32.34	28102081
2122	Phosphorylation	YDEESLLSLTMSQDG CCHHHHHHHHHCCCC	27.38	28102081
2124	Phosphorylation	EESLLSLTMSQDGFP HHHHHHHHHCCCCCC	16.05	28102081
2126	Phosphorylation	SLLSLTMSQDGFPNE HHHHHHHCCCCCCCC	21.64	28102081
2137	Ubiquitination	FPNEDGEQMTPELLL CCCCCCCCCCHHHHH	46.72	24816145
2139	Phosphorylation	NEDGEQMTPELLLLQ CCCCCCCCHHHHHHH	17.19	28102081
2175	Acetylation	CQAVLSGKWPSSRRS HHHHHCCCCCCCCCC	53.18	26051181
2182	Phosphorylation	KWPSSRRSQEMVTGG CCCCCCCCCCCHHCC	29.40	22115753
2187	Phosphorylation	RRSQEMVTGGILGPG CCCCCCHHCCCCCCC	28.51	20873877
2200	Phosphorylation	PGNHLLDSPSLTPGE CCCCCCCCCCCCCCC	19.16	22115753
2202	Phosphorylation	NHLLDSPSLTPGEYG CCCCCCCCCCCCCCC	49.15	22115753
2204	Phosphorylation	LLDSPSLTPGEYGDS CCCCCCCCCCCCCCC	33.32	28450419
2208	Phosphorylation	PSLTPGEYGDSPVPT CCCCCCCCCCCCCCC	31.95	26657352
2211	Phosphorylation	TPGEYGDSPVPTPRS CCCCCCCCCCCCCCC	24.35	22115753
2215	Phosphorylation	YGDSPVPTPRSSSAA CCCCCCCCCCCCCHH	31.41	28450419
2218	Phosphorylation	SPVPTPRSSSAASMA CCCCCCCCCCHHHHH	29.83	22617229
2219	Phosphorylation	PVPTPRSSSAASMAE CCCCCCCCCHHHHHH	25.85	21712546
2220	Phosphorylation	VPTPRSSSAASMAEE CCCCCCCCHHHHHHH	29.15	21712546
2223	Phosphorylation	PRSSSAASMAEEEAS CCCCCHHHHHHHHHH	20.45	22617229
2230	Phosphorylation	SMAEEEASAVSTAAA HHHHHHHHHHHHHHH	32.27	28450419
2233	Phosphorylation	EEEASAVSTAAAQFT HHHHHHHHHHHHHHH	16.43	27732954
2234	Phosphorylation	EEASAVSTAAAQFTK HHHHHHHHHHHHHHH	17.45	27732954
2240	Phosphorylation	STAAAQFTKLRRGMD HHHHHHHHHHHCCCC	19.65	30576142
2241	Ubiquitination	TAAAQFTKLRRGMDE HHHHHHHHHHCCCCC	41.08	32015554
2256	Sumoylation	KEFTVQIKDEEGLKL CCEEEEEECCCCCEE	41.83	-
2256	Sumoylation	KEFTVQIKDEEGLKL CCEEEEEECCCCCEE	41.83	25218447
2262	Ubiquitination	IKDEEGLKLTFQKHK EECCCCCEEEEEECC	57.23	29967540
2267	Ubiquitination	GLKLTFQKHKLMANG CCEEEEEECCHHHCC	38.22	29967540
2269	Ubiquitination	KLTFQKHKLMANGVM EEEEEECCHHHCCCC	47.17	29967540
2286	Acetylation	GHPLFHKKKGNRKKL CCCCCCCCCCCCCEE	58.29	7975725
2320	Ubiquitination	TRIPVINKVDGTLLV HCCEEEEEECCEEEE	30.49	29967540
2386	Phosphorylation	LGMEPVQTANSRNGK CCCCCCCCCCCCCCC	28.21	27732954
2389	Phosphorylation	EPVQTANSRNGKKGH CCCCCCCCCCCCCCC	25.34	27732954
2394	Ubiquitination	ANSRNGKKGHHTETV CCCCCCCCCCCCHHC	65.95	29967540
2398	Phosphorylation	NGKKGHHTETVFNRV CCCCCCCCHHCHHHC	27.90	28555341
2404	Methylation	HTETVFNRVLPGPIA CCHHCHHHCCCCCCC	21.64	-
2414	Phosphorylation	PGPIAPESSKKRARR CCCCCCHHHHHHHHH	46.53	25159151
2415	Phosphorylation	GPIAPESSKKRARRM CCCCCHHHHHHHHHH	40.30	21815630
2416	Ubiquitination	PIAPESSKKRARRMR CCCCHHHHHHHHHHC	56.40	24816145
2417	Ubiquitination	IAPESSKKRARRMRP CCCHHHHHHHHHHCC	53.92	-
2516	Phosphorylation	PGLRAPGYPSSPVTT CCCCCCCCCCCCCCC	10.01	23927012
2518	Phosphorylation	LRAPGYPSSPVTTAS CCCCCCCCCCCCCCC	38.50	25159151
2519	Phosphorylation	RAPGYPSSPVTTASG CCCCCCCCCCCCCCC	20.91	25159151
2522	Phosphorylation	GYPSSPVTTASGTTL CCCCCCCCCCCCCEE	21.74	30266825
2523	Phosphorylation	YPSSPVTTASGTTLR CCCCCCCCCCCCEEE	21.04	23927012
2525	Phosphorylation	SSPVTTASGTTLRLP CCCCCCCCCCEEECC	34.28	23927012
2527	Phosphorylation	PVTTASGTTLRLPPL CCCCCCCCEEECCCC	21.84	23927012
2528	Phosphorylation	VTTASGTTLRLPPLQ CCCCCCCEEECCCCC	17.26	23927012
2551	Phosphorylation	EEDDDDLSQGYDSSE CCCCCCCCCCCCCCC	28.67	28985074
2554	Phosphorylation	DDDLSQGYDSSERDF CCCCCCCCCCCCCCC	12.67	28985074
2556	Phosphorylation	DLSQGYDSSERDFSL CCCCCCCCCCCCCCC	26.14	23322592

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CHD8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CHD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CHD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTCF_HUMAN	CTCF	physical	16949368
ZN143_HUMAN	ZNF143	physical	17938208
CTDP1_HUMAN	CTDP1	physical	19255092
P53_HUMAN	TP53	physical	19151705
WDR5_HUMAN	WDR5	physical	20085832
ASH2L_HUMAN	ASH2L	physical	20085832
RBBP5_HUMAN	RBBP5	physical	20085832
CTNB1_HUMAN	CTNNB1	physical	22083958
ANDR_HUMAN	AR	physical	20308527
CHD7_HUMAN	CHD7	physical	20453063
ZN363_HUMAN	RCHY1	physical	21988832
CDC27_HUMAN	CDC27	physical	26496610
IMA5_HUMAN	KPNA1	physical	26496610
UH1BL_HUMAN	UHRF1BP1L	physical	26496610
IMA7_HUMAN	KPNA6	physical	26496610
AL1L2_HUMAN	ALDH1L2	physical	26496610
ZN707_HUMAN	ZNF707	physical	26496610
ASH2L_HUMAN	ASH2L	physical	24705355
RBBP5_HUMAN	RBBP5	physical	24705355
CHD7_HUMAN	CHD7	physical	24705355
WDR5_HUMAN	WDR5	physical	24705355
BRD4_HUMAN	BRD4	physical	26626481
NSD3_HUMAN	WHSC1L1	physical	26626481

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615032	Autism 18 (AUTS18)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CHD8_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553; SER-1420; SER-1424;THR-1993; SER-2008; SER-2046; SER-2200 AND SER-2519, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2008; SER-2518 ANDSER-2519, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-550; SER-553; SER-562;SER-1420; SER-1424; SER-1976; SER-1995; SER-2008; SER-2046 ANDSER-2518, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2182; SER-2200;SER-2202; SER-2211; SER-2518 AND SER-2519, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2046 AND SER-2519, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1420; SER-1424; SER-2069AND SER-2071, AND MASS SPECTROMETRY.	17081983 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-537 AND THR-1398, ANDMASS SPECTROMETRY.	16964243 [Abstract]