dbPTM

WDR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WDR5_HUMAN
UniProt AC	P61964
Protein Name	WD repeat-containing protein 5
Gene Name	WDR5
Organism	Homo sapiens (Human).
Sequence Length	334
Subcellular Localization	Nucleus .
Protein Description	Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation..
Protein Sequence	MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATEEKKPE ------CCCCCCCCH	24.58	22814378
6	Ubiquitination	--MATEEKKPETEAA --CCCCCCCCHHHHH	68.35	24816145
7	Sumoylation	-MATEEKKPETEAAR -CCCCCCCCHHHHHH	51.90	28112733
7	Ubiquitination	-MATEEKKPETEAAR -CCCCCCCCHHHHHH	51.90	-
18	Phosphorylation	EAARAQPTPSSSATQ HHHHCCCCCCCCCCC	24.59	25159151
20	Phosphorylation	ARAQPTPSSSATQSK HHCCCCCCCCCCCCC	39.13	25159151
21	Phosphorylation	RAQPTPSSSATQSKP HCCCCCCCCCCCCCC	25.79	21406692
22	Phosphorylation	AQPTPSSSATQSKPT CCCCCCCCCCCCCCC	39.41	25159151
24	Phosphorylation	PTPSSSATQSKPTPV CCCCCCCCCCCCCCC	35.01	21406692
26	Phosphorylation	PSSSATQSKPTPVKP CCCCCCCCCCCCCCC	35.93	21406692
27	Ubiquitination	SSSATQSKPTPVKPN CCCCCCCCCCCCCCC	42.99	23000965
27	Sumoylation	SSSATQSKPTPVKPN CCCCCCCCCCCCCCC	42.99	28112733
29	Phosphorylation	SATQSKPTPVKPNYA CCCCCCCCCCCCCEE	44.44	21406692
32	Ubiquitination	QSKPTPVKPNYALKF CCCCCCCCCCEEEEE	28.84	23000965
35	Phosphorylation	PTPVKPNYALKFTLA CCCCCCCEEEEEEEC	23.10	21406692
38	Methylation	VKPNYALKFTLAGHT CCCCEEEEEEECCCC	28.29	115978643
38	Ubiquitination	VKPNYALKFTLAGHT CCCCEEEEEEECCCC	28.29	23000965
45	Phosphorylation	KFTLAGHTKAVSSVK EEEECCCCEEEEEEE	21.56	22210691
46	Sumoylation	FTLAGHTKAVSSVKF EEECCCCEEEEEEEE	40.91	-
46	Sumoylation	FTLAGHTKAVSSVKF EEECCCCEEEEEEEE	40.91	28112733
46	Acetylation	FTLAGHTKAVSSVKF EEECCCCEEEEEEEE	40.91	26051181
49	Phosphorylation	AGHTKAVSSVKFSPN CCCCEEEEEEEECCC	33.98	-
54	Phosphorylation	AVSSVKFSPNGEWLA EEEEEEECCCCCEEC	16.25	20068231
62	Phosphorylation	PNGEWLASSSADKLI CCCCEECCCCHHHHH	23.74	20068231
63	Phosphorylation	NGEWLASSSADKLIK CCCEECCCCHHHHHH	24.76	20068231
64	Phosphorylation	GEWLASSSADKLIKI CCEECCCCHHHHHHH	37.68	20068231
67	Acetylation	LASSSADKLIKIWGA ECCCCHHHHHHHHEE	52.40	26051181
77	Ubiquitination	KIWGAYDGKFEKTIS HHHEECCCCEEEEEC	24.71	32015554
78	Ubiquitination	IWGAYDGKFEKTISG HHEECCCCEEEEECC	47.67	29967540
78	Acetylation	IWGAYDGKFEKTISG HHEECCCCEEEEECC	47.67	25953088
81	2-Hydroxyisobutyrylation	AYDGKFEKTISGHKL ECCCCEEEEECCCCC	55.05	-
81	Acetylation	AYDGKFEKTISGHKL ECCCCEEEEECCCCC	55.05	27452117
87	Ubiquitination	EKTISGHKLGISDVA EEEECCCCCEEEEEE	52.51	32015554
96	Phosphorylation	GISDVAWSSDSNLLV EEEEEEECCCCCEEE	17.96	28348404
97	Phosphorylation	ISDVAWSSDSNLLVS EEEEEECCCCCEEEE	34.06	28348404
99	Phosphorylation	DVAWSSDSNLLVSAS EEEECCCCCEEEECC	31.18	28348404
112	Acetylation	ASDDKTLKIWDVSSG CCCCCCEEEEECCCC	47.16	19608861
116	Ubiquitination	KTLKIWDVSSGKCLK CCEEEEECCCCCEEE	2.70	33845483
120	Acetylation	IWDVSSGKCLKTLKG EEECCCCCEEEEECC	38.04	25953088
120	Ubiquitination	IWDVSSGKCLKTLKG EEECCCCCEEEEECC	38.04	23000965
123	Ubiquitination	VSSGKCLKTLKGHSN CCCCCEEEEECCCCC	62.37	23000965
126	Ubiquitination	GKCLKTLKGHSNYVF CCEEEEECCCCCEEE	60.86	23000965
131	Phosphorylation	TLKGHSNYVFCCNFN EECCCCCEEEEEECC	9.64	-
156	Ubiquitination	FDESVRIWDVKTGKC CCCCEEEEECCCCCE	8.19	33845483
159	Ubiquitination	SVRIWDVKTGKCLKT CEEEEECCCCCEECC	49.43	21906983
162	Ubiquitination	IWDVKTGKCLKTLPA EEECCCCCEECCCCC	41.44	22817900
221	Ubiquitination	NPPVSFVKFSPNGKY CCCCEEEEECCCCCE	37.81	23000965
227	Ubiquitination	VKFSPNGKYILAATL EEECCCCCEEEEEEC	35.44	23000965
227	Acetylation	VKFSPNGKYILAATL EEECCCCCEEEEEEC	35.44	26051181
228	Phosphorylation	KFSPNGKYILAATLD EECCCCCEEEEEECC	11.54	28152594
245	Malonylation	LKLWDYSKGKCLKTY EEEEECCCCCEEEEE	57.04	26320211
245	Acetylation	LKLWDYSKGKCLKTY EEEEECCCCCEEEEE	57.04	27452117
250	Acetylation	YSKGKCLKTYTGHKN CCCCCEEEEECCCCC	49.29	26051181
267	Phosphorylation	YCIFANFSVTGGKWI EEEEEEEEEECCEEE	20.69	17924679
290	Phosphorylation	VYIWNLQTKEIVQKL EEEEECCHHHHHHHH	33.54	-
291	Ubiquitination	YIWNLQTKEIVQKLQ EEEECCHHHHHHHHC	32.27	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WDR5_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WDR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WDR5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MBIP1_HUMAN	MBIP	physical	16189514
KMT2A_HUMAN	KMT2A	physical	15199122
RBBP5_HUMAN	RBBP5	physical	16253997
SET1A_HUMAN	SETD1A	physical	16253997
ASH2L_HUMAN	ASH2L	physical	16253997
CXXC1_HUMAN	CXXC1	physical	16253997
CHD8_HUMAN	CHD8	physical	18378692
SET1A_HUMAN	SETD1A	physical	17355966
SET1B_HUMAN	SETD1B	physical	17355966
ENL_HUMAN	MLLT1	physical	18829459
ENL_HUMAN	MLLT1	physical	18829457
H31_HUMAN	HIST1H3A	physical	16946699
H31_HUMAN	HIST1H3A	physical	16829960
H31_HUMAN	HIST1H3A	physical	16829959
H31_HUMAN	HIST1H3A	physical	16600877
H31_HUMAN	HIST1H3A	physical	15960974
ASH2L_HUMAN	ASH2L	physical	15960974
RBBP5_HUMAN	RBBP5	physical	15960974
KMT2D_HUMAN	KMT2D	physical	15960974
PAX7_HUMAN	PAX7	physical	18066051
ASH2L_HUMAN	ASH2L	physical	18066051
PAXI1_HUMAN	PAXIP1	physical	17500065
RBBP5_HUMAN	RBBP5	physical	17500065
PO5F1_HUMAN	POU5F1	physical	21477851
RBBP5_HUMAN	RBBP5	physical	21220120
KMT2A_HUMAN	KMT2A	physical	21220120
PRS8_HUMAN	PSMC5	physical	19660582
H31T_HUMAN	HIST3H3	physical	21124902
H31T_HUMAN	HIST3H3	physical	21135039
MAVS_HUMAN	MAVS	physical	20080758
TRAF3_HUMAN	TRAF3	physical	20080758
TRAF6_HUMAN	TRAF6	physical	20080758
MBB1A_HUMAN	MYBBP1A	physical	21531708
CSR2B_HUMAN	CSRP2BP	physical	21531708
ASH2L_HUMAN	ASH2L	physical	21531708
PK3CA_HUMAN	PIK3CA	physical	21531708
RBBP5_HUMAN	RBBP5	physical	21531708
PITX2_HUMAN	PITX2	physical	21531708
KDM4B_HUMAN	KDM4B	physical	21502505
ESR1_HUMAN	ESR1	physical	21502505
ASH2L_HUMAN	ASH2L	physical	20305087
CXXC1_HUMAN	CXXC1	physical	20305087
DPY30_HUMAN	DPY30	physical	20305087
HCFC1_HUMAN	HCFC1	physical	20305087
KMT2A_HUMAN	KMT2A	physical	20305087
KMT2B_HUMAN	KMT2B	physical	20305087
RBBP5_HUMAN	RBBP5	physical	20305087
SET1A_HUMAN	SETD1A	physical	20305087
HDAC3_HUMAN	HDAC3	physical	21884981
ASH2L_HUMAN	ASH2L	physical	21884981
RBBP5_HUMAN	RBBP5	physical	21884981
KMT2D_HUMAN	KMT2D	physical	22266653
KMT2C_HUMAN	KMT2C	physical	22266653
KMT2B_HUMAN	KMT2B	physical	22266653
SET1A_HUMAN	SETD1A	physical	22266653
SET1B_HUMAN	SETD1B	physical	22266653
KMT2A_HUMAN	KMT2A	physical	22266653
KAT2B_HUMAN	KAT2B	physical	18838386
YETS2_HUMAN	YEATS2	physical	18838386
KAT2A_HUMAN	KAT2A	physical	18838386
TAD2A_HUMAN	TADA2A	physical	18838386
TADA3_HUMAN	TADA3	physical	18838386
MBIP1_HUMAN	MBIP	physical	18838386
SGF29_HUMAN	CCDC101	physical	18838386
NC2B_HUMAN	DR1	physical	18838386
A4_HUMAN	APP	physical	21832049
XPO2_HUMAN	CSE1L	physical	22939629
KMT2A_HUMAN	KMT2A	physical	22989411
NFE4_HUMAN	NFE4	physical	22689669
KMT2D_HUMAN	KMT2D	physical	22689669
HDAC1_HUMAN	HDAC1	physical	22689669
ING2_HUMAN	ING2	physical	22689669
MBIP1_HUMAN	MBIP	physical	25416956
ZXDC_HUMAN	ZXDC	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
RUAS1_HUMAN	RUSC1-AS1	physical	25416956
H31T_HUMAN	HIST3H3	physical	24793694
BMAL1_HUMAN	ARNTL	physical	23555304
HDAC1_HUMAN	HDAC1	physical	26186194
KANL1_HUMAN	KANSL1	physical	26186194
CSR2B_HUMAN	CSRP2BP	physical	26186194
YETS2_HUMAN	YEATS2	physical	26186194
BOD1_HUMAN	BOD1	physical	26186194
KMT2D_HUMAN	KMT2D	physical	26186194
RBBP5_HUMAN	RBBP5	physical	26186194
ZZZ3_HUMAN	ZZZ3	physical	26186194
PDPK1_HUMAN	PDPK1	physical	26186194
HCFC2_HUMAN	HCFC2	physical	26186194
MGAP_HUMAN	MGA	physical	26186194
KMT2B_HUMAN	KMT2B	physical	26186194
KMT2A_HUMAN	KMT2A	physical	26186194
SET1B_HUMAN	SETD1B	physical	26186194
SET1A_HUMAN	SETD1A	physical	26186194
KDM6A_HUMAN	KDM6A	physical	26186194
LMBL2_HUMAN	L3MBTL2	physical	26186194
BD1L1_HUMAN	BOD1L1	physical	26186194
ASH2L_HUMAN	ASH2L	physical	26186194
KAT2B_HUMAN	KAT2B	physical	26186194
KAT2A_HUMAN	KAT2A	physical	26186194
RYBP_HUMAN	RYBP	physical	26186194
TADA3_HUMAN	TADA3	physical	26186194
MBIP1_HUMAN	MBIP	physical	26186194
PPR3F_HUMAN	PPP1R3F	physical	26186194
NC2B_HUMAN	DR1	physical	26186194
TAD2A_HUMAN	TADA2A	physical	26186194
PAXI1_HUMAN	PAXIP1	physical	26186194
F199X_HUMAN	FAM199X	physical	26186194
RING2_HUMAN	RNF2	physical	26186194
CXXC1_HUMAN	CXXC1	physical	26186194
ZXDC_HUMAN	ZXDC	physical	26186194
RERE_HUMAN	RERE	physical	26186194
YAF2_HUMAN	YAF2	physical	26186194
ATN1_HUMAN	ATN1	physical	26186194
SESN2_HUMAN	SESN2	physical	26186194
NCOA6_HUMAN	NCOA6	physical	26186194
KANL1_HUMAN	KANSL1	physical	24788516
KANL2_HUMAN	KANSL2	physical	24788516
KMT2D_HUMAN	KMT2D	physical	24788516
H31T_HUMAN	HIST3H3	physical	24788516
SYHC_HUMAN	HARS	physical	26344197
ASH2L_HUMAN	ASH2L	physical	25666610
RBBP5_HUMAN	RBBP5	physical	25666610
DPY30_HUMAN	DPY30	physical	25666610
H31_HUMAN	HIST1H3A	physical	25666610
KIF23_HUMAN	KIF23	physical	25666610
RGAP1_HUMAN	RACGAP1	physical	25666610
CEP55_HUMAN	CEP55	physical	25666610
CHM1B_HUMAN	CHMP1B	physical	25666610
ECT2_HUMAN	ECT2	physical	25666610
PDC6I_HUMAN	PDCD6IP	physical	25666610
TS101_HUMAN	TSG101	physical	25666610
PRC1_HUMAN	PRC1	physical	25666610
MYCN_HUMAN	MYCN	physical	26471359
KMT2D_HUMAN	KMT2D	physical	28514442
ATN1_HUMAN	ATN1	physical	28514442
KANL1_HUMAN	KANSL1	physical	28514442
KDM6A_HUMAN	KDM6A	physical	28514442
KMT2B_HUMAN	KMT2B	physical	28514442
MBIP1_HUMAN	MBIP	physical	28514442
PAXI1_HUMAN	PAXIP1	physical	28514442
RERE_HUMAN	RERE	physical	28514442
CXXC1_HUMAN	CXXC1	physical	28514442
TAD2A_HUMAN	TADA2A	physical	28514442
SET1B_HUMAN	SETD1B	physical	28514442
PDPK1_HUMAN	PDPK1	physical	28514442
PPR3F_HUMAN	PPP1R3F	physical	28514442
CSR2B_HUMAN	CSRP2BP	physical	28514442
KAT2B_HUMAN	KAT2B	physical	28514442
SET1A_HUMAN	SETD1A	physical	28514442
ZZZ3_HUMAN	ZZZ3	physical	28514442
KMT2A_HUMAN	KMT2A	physical	28514442
BOD1_HUMAN	BOD1	physical	28514442
TADA3_HUMAN	TADA3	physical	28514442
YETS2_HUMAN	YEATS2	physical	28514442
SESN2_HUMAN	SESN2	physical	28514442
BD1L1_HUMAN	BOD1L1	physical	28514442
NCOA6_HUMAN	NCOA6	physical	28514442
LMBL2_HUMAN	L3MBTL2	physical	28514442
KAT2A_HUMAN	KAT2A	physical	28514442
F199X_HUMAN	FAM199X	physical	28514442
PCGF6_HUMAN	PCGF6	physical	28514442
MGAP_HUMAN	MGA	physical	28514442
ZXDC_HUMAN	ZXDC	physical	28514442
ASH2L_HUMAN	ASH2L	physical	28514442
RBBP5_HUMAN	RBBP5	physical	28514442
HCFC2_HUMAN	HCFC2	physical	28514442
HDAC1_HUMAN	HDAC1	physical	28514442
RING2_HUMAN	RNF2	physical	28514442
RYBP_HUMAN	RYBP	physical	28514442
NC2B_HUMAN	DR1	physical	28514442
HDAC2_HUMAN	HDAC2	physical	28514442
MYC_HUMAN	MYC	physical	27320920
RBBP5_HUMAN	RBBP5	physical	27320920

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WDR5_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-112, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.	17924679 [Abstract]