PAX7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAX7_HUMAN
• UniProt AC: P23759
• Protein Name: Paired box protein Pax-7
• Gene Name: PAX7
• Organism: Homo sapiens (Human).
• Sequence Length: 505
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation..
• Protein Sequence: MAALPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRSTVPSGLVSSISRVLRIKFGKKEEEDEADKKEDDGEKKAKHSIDGILGDKGNRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPPTGMPTLPPYQLPDSTYPTTTISQDGGSTVHRPQPLPPSTMHQGGLAAAAAAADTSSAYGARHSFSSYSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQPQADFSISPLHGGLDSATSISASCSQRADSIKPGDSLPTSQAYCPPTYSTTGYSVDPVAGYQYGQYGQTAVDYLAKNVSLSTQRRMKLGEHSAVLGLLPVETGQAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAALPGTVPRMMRP -CCCCCCCCCCCCCC	25.95	22985185
20	Phosphorylation	RPAPGQNYPRTGFPL CCCCCCCCCCCCCCE	6.04	24043423
30	Phosphorylation	TGFPLEVSTPLGQGR CCCCEEEECCCCCCC	18.22	27251275
31	Phosphorylation	GFPLEVSTPLGQGRV CCCEEEECCCCCCCC	27.92	27251275
90	Phosphorylation	VSKILCRYQETGSIR HHHHHHHHHCCCCCC	15.09	28258704
95	Phosphorylation	CRYQETGSIRPGAIG HHHHCCCCCCCCCCC	23.89	28258704
121	Phosphorylation	VEKKIEEYKRENPGM HHHHHHHHHHHCCCC	11.53	-
147	Phosphorylation	DGHCDRSTVPSGLVS CCCCCCCCCCHHHHH	37.01	-
176	Acetylation	EEDEADKKEDDGEKK HCCHHHHCCCCCHHH	67.91	30591141
203	Phosphorylation	GNRLDEGSDVESEPD CCCCCCCCCCCCCCC	36.11	29083192
207	Phosphorylation	DEGSDVESEPDLPLK CCCCCCCCCCCCCCC	55.03	29083192
480 (in isoform 2)	Phosphorylation	-	5.55	-
482 (in isoform 1)	Phosphorylation	-	41.97	-
493 (in isoform 2)	Phosphorylation	-	43.51	22461510
495 (in isoform 1)	Phosphorylation	-	8.42	22461510
497 (in isoform 2)	Phosphorylation	-	2.92	22461510
499 (in isoform 1)	Phosphorylation	-	31.64	22461510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:26304770

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAX7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAX7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR5_HUMAN	WDR5	physical	18066051
ASH2L_HUMAN	ASH2L	physical	18066051
TRI27_HUMAN	TRIM27	physical	25025573
NEDD4_HUMAN	NEDD4	physical	26304770

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.