ZXDC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZXDC_HUMAN
• UniProt AC: Q2QGD7
• Protein Name: Zinc finger protein ZXDC
• Gene Name: ZXDC
• Organism: Homo sapiens (Human).
• Sequence Length: 858
• Subcellular Localization: Nucleus .
• Protein Description: Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes..
• Protein Sequence: MDLPALLPAPTARGGQHGGGPGPLRRAPAPLGASPARRRLLLVRGPEDGGPGARPGEASGPSPPPAEDDSDGDSFLVLLEVPHGGAAAEAAGSQEAEPGSRVNLASRPEQGPSGPAAPPGPGVAPAGAVTISSQDLLVRLDRGVLALSAPPGPATAGAAAPRRAPQASGPSTPGYRCPEPQCALAFAKKHQLKVHLLTHGGGQGRRPFKCPLEGCGWAFTTSYKLKRHLQSHDKLRPFGCPVGGCGKKFTTVYNLKAHMKGHEQESLFKCEVCAERFPTHAKLSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHRRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSKKHVQDVGAPKSRCPVSTCNRLFTSKHSMKAHMVRQHSRRQDLLPQLEAPSSLTPSSELSSPGQSELTNMDLAALFSDTPANASGSAGGSDEALNSGILTIDVTSVSSSLGGNLPANNSSLGPMEPLVLVAHSDIPPSLDSPLVLGTAATVLQQGSFSVDDVQTVSAGALGCLVALPMKNLSDDPLALTSNSNLAAHITTPTSSSTPRENASVPELLAPIKVEPDSPSRPGAVGQQEGSHGLPQSTLPSPAEQHGAQDTELSAGTGNFYLESGGSARTDYRAIQLAKEKKQRGAGSNAGASQSTQRKIKEGKMSPPHFHASQNSWLCGSLVVPSGGRPGPAPAAGVQCGAQGVQVQLVQDDPSGEGVLPSARGPATFLPFLTVDLPVYVLQEVLPSSGGPAGPEATQFPGSTINLQDLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Methylation	LLPAPTARGGQHGGG CCCCCCCCCCCCCCC	52.86	115386749
25	Methylation	GGGPGPLRRAPAPLG CCCCCCCCCCCCCCC	35.53	115386755
34	Phosphorylation	APAPLGASPARRRLL CCCCCCCCHHHCEEE	19.79	30266825
62	Phosphorylation	PGEASGPSPPPAEDD CCCCCCCCCCCCCCC	54.27	28348404
70	Phosphorylation	PPPAEDDSDGDSFLV CCCCCCCCCCCEEEE	56.68	28348404
74	Phosphorylation	EDDSDGDSFLVLLEV CCCCCCCEEEEEEEC	26.47	28348404
113	Phosphorylation	SRPEQGPSGPAAPPG CCCCCCCCCCCCCCC	65.32	24719451
132	Phosphorylation	PAGAVTISSQDLLVR CCCCEEECCHHHEEE	16.75	24719451
168	Phosphorylation	PRRAPQASGPSTPGY CCCCCCCCCCCCCCC	46.09	28450419
171	Phosphorylation	APQASGPSTPGYRCP CCCCCCCCCCCCCCC	51.24	27273156
172	Phosphorylation	PQASGPSTPGYRCPE CCCCCCCCCCCCCCC	24.70	27273156
175	Phosphorylation	SGPSTPGYRCPEPQC CCCCCCCCCCCCHHH	15.39	28450419
247	Ubiquitination	CPVGGCGKKFTTVYN CCCCCCCCCEEEEEE	49.11	29967540
250	Phosphorylation	GGCGKKFTTVYNLKA CCCCCCEEEEEEHHH	25.00	23911959
251	Phosphorylation	GCGKKFTTVYNLKAH CCCCCEEEEEEHHHH	24.91	23911959
256	Ubiquitination	FTTVYNLKAHMKGHE EEEEEEHHHHHCCCH	32.38	29967540
260	Ubiquitination	YNLKAHMKGHEQESL EEHHHHHCCCHHCCC	47.45	29967540
266	Phosphorylation	MKGHEQESLFKCEVC HCCCHHCCCCCCCHH	38.51	24719451
269	Sumoylation	HEQESLFKCEVCAER CHHCCCCCCCHHHHH	34.48	-
269	Ubiquitination	HEQESLFKCEVCAER CHHCCCCCCCHHHHH	34.48	29967540
269	Sumoylation	HEQESLFKCEVCAER CHHCCCCCCCHHHHH	34.48	-
282	Ubiquitination	ERFPTHAKLSSHQRS HHCCCHHHCCHHCCC	41.10	29967540
331	Phosphorylation	EQELFSCSFPGCSKQ HHHHHCCCCCCCHHH	33.02	21815630
337	Ubiquitination	CSFPGCSKQYDKACR CCCCCCHHHHCCCCC	57.88	-
397	Ubiquitination	CPVEGCGKSFTRAEH CCCCCCCCCCCCHHH	46.61	-
406	Ubiquitination	FTRAEHLKGHSITHL CCCHHHHCCCCCEEC	57.39	29967540
433	Phosphorylation	CARFSARSSLYIHSK HHHCHHCCCEEEEEC	25.14	27251275
434	Phosphorylation	ARFSARSSLYIHSKK HHCHHCCCEEEEECC	21.46	27251275
436	Phosphorylation	FSARSSLYIHSKKHV CHHCCCEEEEECCCC	9.87	27642862
440	Ubiquitination	SSLYIHSKKHVQDVG CCEEEEECCCCCCCC	32.51	-
441	Ubiquitination	SLYIHSKKHVQDVGA CEEEEECCCCCCCCC	52.61	29967540
450	Ubiquitination	VQDVGAPKSRCPVST CCCCCCCCCCCCHHH	50.42	29967540
465	Sumoylation	CNRLFTSKHSMKAHM HHHHHCCCHHHHHHH	36.32	-
465	Sumoylation	CNRLFTSKHSMKAHM HHHHHCCCHHHHHHH	36.32	-
465	Ubiquitination	CNRLFTSKHSMKAHM HHHHHCCCHHHHHHH	36.32	-
523	Phosphorylation	SDTPANASGSAGGSD CCCCCCCCCCCCCCH	32.84	-
628	Phosphorylation	SDDPLALTSNSNLAA CCCCCEECCCCCEEE	21.91	28450419
629	Phosphorylation	DDPLALTSNSNLAAH CCCCEECCCCCEEEE	38.83	28450419
631	Phosphorylation	PLALTSNSNLAAHIT CCEECCCCCEEEEEE	32.75	28450419
638	Phosphorylation	SNLAAHITTPTSSST CCEEEEEECCCCCCC	19.49	28450419
639	Phosphorylation	NLAAHITTPTSSSTP CEEEEEECCCCCCCC	24.78	28450419
641	Phosphorylation	AAHITTPTSSSTPRE EEEEECCCCCCCCCC	38.87	28450419
642	Phosphorylation	AHITTPTSSSTPREN EEEECCCCCCCCCCC	24.40	28450419
643	Phosphorylation	HITTPTSSSTPRENA EEECCCCCCCCCCCC	40.48	28450419
644	Phosphorylation	ITTPTSSSTPRENAS EECCCCCCCCCCCCC	42.04	28450419
645	Phosphorylation	TTPTSSSTPRENASV ECCCCCCCCCCCCCC	28.45	28450419
651	Phosphorylation	STPRENASVPELLAP CCCCCCCCCCHHHCC	50.19	27499020
660	Sumoylation	PELLAPIKVEPDSPS CHHHCCEEECCCCCC	39.21	17696781
660	Sumoylation	PELLAPIKVEPDSPS CHHHCCEEECCCCCC	39.21	-
665	Phosphorylation	PIKVEPDSPSRPGAV CEEECCCCCCCCCCC	35.18	17696781
667	Phosphorylation	KVEPDSPSRPGAVGQ EECCCCCCCCCCCCC	55.87	26074081
688	Phosphorylation	LPQSTLPSPAEQHGA CCCCCCCCHHHHCCC	39.59	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZXDC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
660	K	Sumoylation	Sumoylated at Lys-660 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.	17696781

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZXDC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NR1H3_HUMAN	NR1H3	physical	15604093
NR1H2_HUMAN	NR1H2	physical	15604093
RORA_HUMAN	RORA	physical	15604093
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.