dbPTM

F199X_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	F199X_HUMAN
UniProt AC	Q6PEV8
Protein Name	Protein FAM199X
Gene Name	FAM199X
Organism	Homo sapiens (Human).
Sequence Length	388
Subcellular Localization
Protein Description
Protein Sequence	MSDEASAITSYEKFLTPEEPFPLLGPPRGVGTCPSEEPGCLDISDFGCQLSSCHRTDPLHRFHTNRWNLTSCGTSVASSEGSEELFSSVSVGDQDDCYSLLDDQDFTSFDLFPEGSVCSDVSSSISTYWDWSDSEFEWQLPGSDIASGSDVLSDVIPSIPSSPCLLPKKKNKHRNLDELPWSAMTNDEQVEYIEYLSRKVSTEMGLREQLDIIKIIDPSAQISPTDSEFIIELNCLTDEKLKQVRNYIKEHSPRQRPAREAWKRSNFSCASTSGVSGASASASSSSASMVSSASSSGSSVGNSASNSSANMSRAHSDSNLSASAAERIRDSKKRSKQRKLQQKAFRKRQLKEQRQARKERLSGLFLNEEVLSLKVTEEDHEADVDVLM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDEASAIT ------CCHHHHHHH	44.13	25849741
13 (in isoform 2)	Ubiquitination	-	37.12	21890473
13 (in isoform 1)	Ubiquitination	-	37.12	21890473
13	Ubiquitination	SAITSYEKFLTPEEP HHHHCHHHCCCCCCC	37.12	21890473
16	Phosphorylation	TSYEKFLTPEEPFPL HCHHHCCCCCCCCCC	31.61	27050516
35	Phosphorylation	RGVGTCPSEEPGCLD CCCCCCCCCCCCEEE	57.65	27050516
56	Phosphorylation	QLSSCHRTDPLHRFH CCCCCCCCCCCHHCC	20.50	23532336
199	Ubiquitination	YIEYLSRKVSTEMGL HHHHHHHHHHHHHCH	36.84	-
201	Phosphorylation	EYLSRKVSTEMGLRE HHHHHHHHHHHCHHH	22.99	24719451
240	Ubiquitination	LNCLTDEKLKQVRNY EECCCHHHHHHHHHH	64.89	-
242	Ubiquitination	CLTDEKLKQVRNYIK CCCHHHHHHHHHHHH	58.79	-
249	Ubiquitination	KQVRNYIKEHSPRQR HHHHHHHHHHCCCCC	38.73	-
265	Phosphorylation	AREAWKRSNFSCAST HHHHHHHCCCCCCCC	38.20	22210691
298	Phosphorylation	SSASSSGSSVGNSAS HCCCCCCCCCCCCCC	24.65	-
299	Phosphorylation	SASSSGSSVGNSASN CCCCCCCCCCCCCCC	37.25	-
305	Phosphorylation	SSVGNSASNSSANMS CCCCCCCCCCCCCHH	36.75	-
312	Phosphorylation	SNSSANMSRAHSDSN CCCCCCHHHHCCCCC	26.56	-
316	Phosphorylation	ANMSRAHSDSNLSAS CCHHHHCCCCCCCHH	41.57	29255136
318	Phosphorylation	MSRAHSDSNLSASAA HHHHCCCCCCCHHHH	42.56	25159151
321	Phosphorylation	AHSDSNLSASAAERI HCCCCCCCHHHHHHH	25.16	29255136
323	Phosphorylation	SDSNLSASAAERIRD CCCCCCHHHHHHHHH	25.33	29255136
343	Ubiquitination	KQRKLQQKAFRKRQL HHHHHHHHHHHHHHH	36.21	-
372	Phosphorylation	FLNEEVLSLKVTEED HCCHHHHEEECCCCH	31.18	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of F199X_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of F199X_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of F199X_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of F199X_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of F199X_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316 AND SER-321, ANDMASS SPECTROMETRY.	18669648 [Abstract]