dbPTM

SET1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SET1A_HUMAN
UniProt AC	O15047
Protein Name	Histone-lysine N-methyltransferase SETD1A
Gene Name	SETD1A
Organism	Homo sapiens (Human).
Sequence Length	1707
Subcellular Localization	Nucleus speckle . Chromosome . Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.
Protein Description	Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression..
Protein Sequence	MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDLQDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDMSYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Ubiquitination	SFQWRNYKLIVDPAL CCCCCCEEEEECCCC	34.97	29967540
97	Phosphorylation	QIPLKEVTFARLNDN CCCCCEEEEEECCHH	16.81	-
111	Ubiquitination	NVRETFLKDMCRKYG HHHHHHHHHHHHHHC	38.94	29967540
179	Phosphorylation	KGQQRMKYYELIVNG CCCCCCEEEEEEECC	7.88	22817900
180	Phosphorylation	GQQRMKYYELIVNGS CCCCCEEEEEEECCC	9.95	22817900
187	Phosphorylation	YELIVNGSYTPQTVP EEEEECCCCCCCCCC	22.19	29507054
188	Phosphorylation	ELIVNGSYTPQTVPT EEEECCCCCCCCCCC	24.68	22817900
203	Acetylation	GGKALSEKFQGSGAA CCHHHHHHHCCCCCC	39.34	26051181
207	Phosphorylation	LSEKFQGSGAATETA HHHHHCCCCCCCHHH	17.93	21712546
211	Phosphorylation	FQGSGAATETAESRR HCCCCCCCHHHHHHH	33.08	22210691
213	Phosphorylation	GSGAATETAESRRRS CCCCCCHHHHHHHHC	31.22	22210691
220	Phosphorylation	TAESRRRSSSDTAAY HHHHHHHCCCCCCCC	32.17	23401153
221	Phosphorylation	AESRRRSSSDTAAYP HHHHHHCCCCCCCCC	30.35	28387310
222	Phosphorylation	ESRRRSSSDTAAYPA HHHHHCCCCCCCCCC	39.98	26657352
224	Phosphorylation	RRRSSSDTAAYPAGT HHHCCCCCCCCCCCC	18.35	30108239
227	Phosphorylation	SSSDTAAYPAGTTAV CCCCCCCCCCCCCCC	7.37	30108239
231	Phosphorylation	TAAYPAGTTAVGTPG CCCCCCCCCCCCCCC	17.43	30108239
232	Phosphorylation	AAYPAGTTAVGTPGN CCCCCCCCCCCCCCC	20.59	30108239
236	Phosphorylation	AGTTAVGTPGNGTPC CCCCCCCCCCCCCCC	22.79	30108239
241	Phosphorylation	VGTPGNGTPCSQDTS CCCCCCCCCCCCCCC	25.73	22210691
244	Phosphorylation	PGNGTPCSQDTSFSS CCCCCCCCCCCCCCC	32.09	22210691
252	Phosphorylation	QDTSFSSSRQDTPSS CCCCCCCCCCCCCCC	32.53	22210691
268	Phosphorylation	GQFTPQSSQGTPYTS CCCCCCCCCCCCCCC	27.64	28985074
271	Phosphorylation	TPQSSQGTPYTSRGS CCCCCCCCCCCCCCC	12.89	-
273	Phosphorylation	QSSQGTPYTSRGSTP CCCCCCCCCCCCCCC	19.72	-
274	Phosphorylation	SSQGTPYTSRGSTPY CCCCCCCCCCCCCCC	17.10	-
275	O-linked_Glycosylation	SQGTPYTSRGSTPYS CCCCCCCCCCCCCCC	28.88	30059200
276	Methylation	QGTPYTSRGSTPYSQ CCCCCCCCCCCCCCC	34.97	115916505
278	Phosphorylation	TPYTSRGSTPYSQDS CCCCCCCCCCCCCCC	25.71	28348404
279	O-linked_Glycosylation	PYTSRGSTPYSQDSA CCCCCCCCCCCCCCC	29.12	30059200
279	Phosphorylation	PYTSRGSTPYSQDSA CCCCCCCCCCCCCCC	29.12	28450419
281	Phosphorylation	TSRGSTPYSQDSAYS CCCCCCCCCCCCCCC	21.03	28450419
282	O-linked_Glycosylation	SRGSTPYSQDSAYSS CCCCCCCCCCCCCCC	28.81	30059200
282	Phosphorylation	SRGSTPYSQDSAYSS CCCCCCCCCCCCCCC	28.81	28450419
285	Phosphorylation	STPYSQDSAYSSSTT CCCCCCCCCCCCCCC	22.82	27794612
287	Phosphorylation	PYSQDSAYSSSTTST CCCCCCCCCCCCCCC	17.03	23312004
288	O-linked_Glycosylation	YSQDSAYSSSTTSTS CCCCCCCCCCCCCCC	19.96	30059200
288	Phosphorylation	YSQDSAYSSSTTSTS CCCCCCCCCCCCCCC	19.96	23312004
289	Phosphorylation	SQDSAYSSSTTSTSF CCCCCCCCCCCCCCC	21.01	23312004
290	O-linked_Glycosylation	QDSAYSSSTTSTSFK CCCCCCCCCCCCCCC	29.75	30059200
290	Phosphorylation	QDSAYSSSTTSTSFK CCCCCCCCCCCCCCC	29.75	23312004
291	O-linked_Glycosylation	DSAYSSSTTSTSFKP CCCCCCCCCCCCCCC	27.06	30059200
291	Phosphorylation	DSAYSSSTTSTSFKP CCCCCCCCCCCCCCC	27.06	23312004
292	Phosphorylation	SAYSSSTTSTSFKPR CCCCCCCCCCCCCCC	31.77	23312004
293	Phosphorylation	AYSSSTTSTSFKPRR CCCCCCCCCCCCCCC	23.34	23312004
294	Phosphorylation	YSSSTTSTSFKPRRS CCCCCCCCCCCCCCC	35.77	23312004
295	Phosphorylation	SSSTTSTSFKPRRSE CCCCCCCCCCCCCCC	30.92	23312004
297	Acetylation	STTSTSFKPRRSENS CCCCCCCCCCCCCCC	37.06	23236377
301	Phosphorylation	TSFKPRRSENSYQDA CCCCCCCCCCCHHHH	42.27	21815630
315	Phosphorylation	AFSRRHFSASSASTT HHHHHCCCCCCCCCC	22.55	-
330	Phosphorylation	ASTAIAATTAATASS HHHHHHHHHHHHCCC	14.14	-
343	Phosphorylation	SSSASSSSLSSSSSS CCCCCCCCCCCCCCC	33.93	-
345	Phosphorylation	SASSSSLSSSSSSSS CCCCCCCCCCCCCCC	30.07	24905233
347	Phosphorylation	SSSSLSSSSSSSSSS CCCCCCCCCCCCCCC	30.75	24905233
348	Phosphorylation	SSSLSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	24905233
349	Phosphorylation	SSLSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
350	Phosphorylation	SLSSSSSSSSSSSSS CCCCCCCCCCCCCCH	35.87	-
351	Phosphorylation	LSSSSSSSSSSSSSQ CCCCCCCCCCCCCHH	35.87	-
352	Phosphorylation	SSSSSSSSSSSSSQF CCCCCCCCCCCCHHH	35.87	-
361	Phosphorylation	SSSSQFRSSDANYPA CCCHHHCCCCCCCCH	33.58	23663014
362	Phosphorylation	SSSQFRSSDANYPAY CCHHHCCCCCCCCHH	36.16	23663014
366	Phosphorylation	FRSSDANYPAYYESW HCCCCCCCCHHHHHH	7.31	23663014
369	Phosphorylation	SDANYPAYYESWNRY CCCCCCHHHHHHHHH	11.85	23663014
370	Phosphorylation	DANYPAYYESWNRYQ CCCCCHHHHHHHHHH	12.95	23663014
372	Phosphorylation	NYPAYYESWNRYQRH CCCHHHHHHHHHHHH	17.33	23663014
388	Phosphorylation	SYPPRRATREEPPGA CCCCCCCCCCCCCCC	36.48	28985074
408	Phosphorylation	TAERFPPSYTSYLPP CHHHCCCCHHCCCCC	41.08	25072903
409	Phosphorylation	AERFPPSYTSYLPPE HHHCCCCHHCCCCCC	12.89	22817900
410	Phosphorylation	ERFPPSYTSYLPPEP HHCCCCHHCCCCCCC	18.42	25072903
411	Phosphorylation	RFPPSYTSYLPPEPS HCCCCHHCCCCCCCC	19.21	25072903
412	Phosphorylation	FPPSYTSYLPPEPSR CCCCHHCCCCCCCCC	18.54	25072903
418	Phosphorylation	SYLPPEPSRPTDQDY CCCCCCCCCCCCCCC	49.59	25072903
421	Phosphorylation	PPEPSRPTDQDYRPP CCCCCCCCCCCCCCC	45.22	20873877
425	Phosphorylation	SRPTDQDYRPPASEA CCCCCCCCCCCCHHC	21.27	20873877
430	Phosphorylation	QDYRPPASEAPPPEP CCCCCCCHHCCCCCC	39.81	20873877
450	Phosphorylation	GGGGGGPSPEREEVR CCCCCCCCCHHHHHC	42.54	29255136
458	Phosphorylation	PEREEVRTSPRPASP CHHHHHCCCCCCCCC	48.54	27794612
459	Phosphorylation	EREEVRTSPRPASPA HHHHHCCCCCCCCCC	14.35	27794612
464	Phosphorylation	RTSPRPASPARSGSP CCCCCCCCCCCCCCC	23.06	27794612
468	Phosphorylation	RPASPARSGSPAPET CCCCCCCCCCCCCCC	45.81	29255136
470	Phosphorylation	ASPARSGSPAPETTN CCCCCCCCCCCCCCC	21.09	29255136
475	Phosphorylation	SGSPAPETTNESVPF CCCCCCCCCCCCCCC	33.58	30266825
476	Phosphorylation	GSPAPETTNESVPFA CCCCCCCCCCCCCCC	35.01	30266825
479	Phosphorylation	APETTNESVPFAQHS CCCCCCCCCCCCCCC	36.84	22167270
486	Phosphorylation	SVPFAQHSSLDSRIE CCCCCCCCCHHHHHH	22.10	22167270
487	Phosphorylation	VPFAQHSSLDSRIEM CCCCCCCCHHHHHHH	33.79	22167270
490	Phosphorylation	AQHSSLDSRIEMLLK CCCCCHHHHHHHHHH	40.21	22167270
501	Phosphorylation	MLLKEQRSKFSFLAS HHHHHHHHHCCCCCC	37.43	28450419
504	Phosphorylation	KEQRSKFSFLASDTE HHHHHHCCCCCCCCC	24.08	30278072
508	Phosphorylation	SKFSFLASDTEEEEE HHCCCCCCCCCCHHH	47.41	23401153
510	Phosphorylation	FSFLASDTEEEEENS CCCCCCCCCCHHHHH	42.68	30278072
517	Phosphorylation	TEEEEENSSMVLGAR CCCHHHHHCEEEEEC	24.08	28450419
518	Phosphorylation	EEEEENSSMVLGARD CCHHHHHCEEEEECC	25.21	26074081
526	Phosphorylation	MVLGARDTGSEVPSG EEEEECCCCCCCCCC	36.73	30278072
528	Phosphorylation	LGARDTGSEVPSGSG EEECCCCCCCCCCCC	37.20	25022875
532	Phosphorylation	DTGSEVPSGSGHGPC CCCCCCCCCCCCCCC	51.25	25159151
534	Phosphorylation	GSEVPSGSGHGPCTP CCCCCCCCCCCCCCC	31.77	30278072
540	Phosphorylation	GSGHGPCTPPPAPAN CCCCCCCCCCCCCCC	41.80	27273156
554	Phosphorylation	NFEDVAPTGSGEPGA CCCCCCCCCCCCCCC	33.95	30278072
556	Phosphorylation	EDVAPTGSGEPGATR CCCCCCCCCCCCCCC	42.32	30278072
562	Phosphorylation	GSGEPGATRESPKAN CCCCCCCCCCCCCCC	40.67	30278072
565	Phosphorylation	EPGATRESPKANGQN CCCCCCCCCCCCCCC	28.54	30278072
579	Phosphorylation	NQASPCSSGDDMEIS CCCCCCCCCCCCCCC	53.62	28985074
586	Phosphorylation	SGDDMEISDDDRGGS CCCCCCCCCCCCCCC	22.98	-
748	Phosphorylation	GAYSREAYHLPMPMA CCCCCEECCCCCCCC	10.11	27642862
761	Phosphorylation	MAAEPLPSSSVSGEE CCCCCCCCCCCCCCC	42.82	28450419
762	Phosphorylation	AAEPLPSSSVSGEEA CCCCCCCCCCCCCCC	32.59	28450419
763	Phosphorylation	AEPLPSSSVSGEEAR CCCCCCCCCCCCCCC	25.33	28450419
765	Phosphorylation	PLPSSSVSGEEARLP CCCCCCCCCCCCCCC	42.29	28450419
803	Acetylation	AMLVQEMKSIMQRDL HHHHHHHHHHHHHHH	35.76	18585059
862	Phosphorylation	LKEPGLLSLVDWAKS CCCCCHHHHHHHHHC	31.24	22210691
882	Phosphorylation	IEAFAFGSGLRGALR EEEEEECCCCCCHHC	28.35	21712546
892	Phosphorylation	RGALRLPSFKVKRKE CCHHCCCCCCEECCC	42.14	26434776
898	Acetylation	PSFKVKRKEPSEISE CCCCEECCCHHHHCH	69.16	7824949
901	Phosphorylation	KVKRKEPSEISEASE CEECCCHHHHCHHCC	48.96	23401153
904	Phosphorylation	RKEPSEISEASEEKR CCCHHHHCHHCCCCC	24.06	23401153
907	Phosphorylation	PSEISEASEEKRPRP HHHHCHHCCCCCCCC	42.09	20068231
910	Acetylation	ISEASEEKRPRPSTP HCHHCCCCCCCCCCC	64.75	7824959
915	Phosphorylation	EEKRPRPSTPAEEDE CCCCCCCCCCCCCCC	48.58	29255136
916	Phosphorylation	EKRPRPSTPAEEDED CCCCCCCCCCCCCCC	29.24	29255136
958	Phosphorylation	TQGKHRKSFALDSEG CCCCCHHHCEECCCC	18.73	18452278
963	Phosphorylation	RKSFALDSEGEEASQ HHHCEECCCCHHHHH	48.64	19651622
969	Phosphorylation	DSEGEEASQESSSEK CCCCHHHHHHCCCCC	37.45	19651622
972	Phosphorylation	GEEASQESSSEKDEE CHHHHHHCCCCCCCC	31.37	19651622
973	Phosphorylation	EEASQESSSEKDEED HHHHHHCCCCCCCCC	41.59	19651622
1004	Phosphorylation	TKKETEVSDGEDEES CHHHEECCCCCCCCC	33.40	28985074
1035	Phosphorylation	DSTSDSESSSSSSSS CCCCCCCCCCCCCCC	39.20	-
1036	Phosphorylation	STSDSESSSSSSSSS CCCCCCCCCCCCCCC	30.13	-
1037	Phosphorylation	TSDSESSSSSSSSSS CCCCCCCCCCCCCCC	43.44	-
1038	Phosphorylation	SDSESSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1039	Phosphorylation	DSESSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1040	Phosphorylation	SESSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1041	Phosphorylation	ESSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1042	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1043	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1044	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1045	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
1046	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
1047	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
1048	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
1049	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1050	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1051	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
1052	Phosphorylation	SSSSSSSSSSSSSSE CCCCCCCCCCCCCCC	35.87	-
1053	Phosphorylation	SSSSSSSSSSSSSES CCCCCCCCCCCCCCC	35.87	-
1055	Phosphorylation	SSSSSSSSSSSESSS CCCCCCCCCCCCCCC	35.87	-
1056	Phosphorylation	SSSSSSSSSSESSSE CCCCCCCCCCCCCCC	39.57	-
1058	Phosphorylation	SSSSSSSSESSSEDE CCCCCCCCCCCCCCH	43.37	-
1076	Phosphorylation	ERPAALPSASPPPRE HCCCCCCCCCCCCCC	42.08	28188228
1078	Phosphorylation	PAALPSASPPPREVP CCCCCCCCCCCCCCC	42.13	29978859
1088	Phosphorylation	PREVPVPTPAPVEVP CCCCCCCCCCCCCCC	32.11	25850435
1103	Phosphorylation	VPERVAGSPVTPLPE CCCCCCCCCCCCCCH	13.37	19664994
1106	Phosphorylation	RVAGSPVTPLPEQEA CCCCCCCCCCCHHHC	23.61	29255136
1114	Phosphorylation	PLPEQEASPARPAGP CCCHHHCCCCCCCCC	20.52	29255136
1122	Phosphorylation	PARPAGPTEESPPSA CCCCCCCCCCCCCCC	52.01	25850435
1125	Phosphorylation	PAGPTEESPPSAPLR CCCCCCCCCCCCCCC	35.56	29255136
1128	Phosphorylation	PTEESPPSAPLRPPE CCCCCCCCCCCCCCC	46.00	29255136
1152	Phosphorylation	PRPDERPSSPIPLLP CCCCCCCCCCCCCCC	55.77	29255136
1153	Phosphorylation	RPDERPSSPIPLLPP CCCCCCCCCCCCCCC	29.54	29255136
1167	Phosphorylation	PPKKRRKTVSFSAIE CCCCCCCEEEEEEEE	21.41	25159151
1169	Phosphorylation	KKRRKTVSFSAIEVV CCCCCEEEEEEEEEE	20.79	25159151
1171	Phosphorylation	RRKTVSFSAIEVVPA CCCEEEEEEEEEECC	22.34	30631047
1185	Phosphorylation	APEPPPATPPQAKFP CCCCCCCCCCCCCCC	41.07	22199227
1196	Phosphorylation	AKFPGPASRKAPRGV CCCCCCCCCCCCCCH	37.13	26074081
1206	Phosphorylation	APRGVERTIRNLPLD CCCCHHHHHHCCCCC	15.69	23312004
1216	Phosphorylation	NLPLDHASLVKSWPE CCCCCHHHHHHHCCH	30.21	20068231
1227	Methylation	SWPEEVSRGGRSRAG HCCHHHHCCCCCCCC	57.68	30760981
1262	Phosphorylation	VLADLALTPARRGLP HHHHHHCCCHHHCCC	14.86	27732954
1469	Phosphorylation	DTHWVHHTITNLTTP CCCCHHHHHHCCCCC	18.02	28348404
1471	Phosphorylation	HWVHHTITNLTTPKR CCHHHHHHCCCCCCC	25.90	28348404
1474	Phosphorylation	HHTITNLTTPKRKRR HHHHHCCCCCCCCCC	43.02	28348404
1475	Phosphorylation	HTITNLTTPKRKRRP HHHHCCCCCCCCCCC	29.94	24719451
1517	Phosphorylation	YLDVCPVSARQLEGV CEEECCCCHHHHCCC	11.68	29978859
1545	Phosphorylation	SEQRRLLSAIGTSAI HHHHHHHHHHHHHHH	23.56	24247654
1549	Phosphorylation	RLLSAIGTSAIMDSD HHHHHHHHHHHHCHH	14.63	27251275
1550	Phosphorylation	LLSAIGTSAIMDSDL HHHHHHHHHHHCHHH	15.58	27251275
1637	Ubiquitination	DTIIDATKCGNLARF CEEEECHHCCHHHHH	41.69	29967540
1656	Acetylation	CTPNCYAKVITIESQ CCCCCEEEEEEEECC	14.01	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SET1A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SET1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SET1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CXXC1_HUMAN	CXXC1	physical	18082152
ASH2L_HUMAN	ASH2L	physical	16253997
RBBP5_HUMAN	RBBP5	physical	16253997
CXXC1_HUMAN	CXXC1	physical	16253997
CXXC1_HUMAN	CXXC1	physical	17355966
RBBP5_HUMAN	RBBP5	physical	17355966
WDR5_HUMAN	WDR5	physical	17355966
WDR82_HUMAN	WDR82	physical	17355966
CXXC1_HUMAN	CXXC1	physical	19951360
CBP_HUMAN	CREBBP	physical	16061203
CXXC1_HUMAN	CXXC1	physical	17998332
ASH2L_HUMAN	ASH2L	physical	17998332
RBBP5_HUMAN	RBBP5	physical	17998332
WDR82_HUMAN	WDR82	physical	17998332
HCFC1_HUMAN	HCFC1	physical	17998332
RPB1_HUMAN	POLR2A	physical	17998332
WDR82_HUMAN	WDR82	physical	20516061
RBBP5_HUMAN	RBBP5	physical	20516061
RBBP5_HUMAN	RBBP5	physical	22147691
WDR5_HUMAN	WDR5	physical	22665483
H32_HUMAN	HIST2H3C	physical	22266653
RBBP5_HUMAN	RBBP5	physical	21653943
ASH2L_HUMAN	ASH2L	physical	21653943
SMCA1_HUMAN	SMARCA1	physical	21653943
H31_HUMAN	HIST1H3A	physical	19410543
H31_HUMAN	HIST1H3A	physical	23453808
RBBP5_HUMAN	RBBP5	physical	23453808
CXXC1_HUMAN	CXXC1	physical	23453808
ASH2L_HUMAN	ASH2L	physical	23453808
WDR5_HUMAN	WDR5	physical	23453808
DPY30_HUMAN	DPY30	physical	23453808
CXXC1_HUMAN	CXXC1	physical	23870121
ASH2L_HUMAN	ASH2L	physical	23870121
RBBP5_HUMAN	RBBP5	physical	23870121
WDR5_HUMAN	WDR5	physical	23870121
WDR82_HUMAN	WDR82	physical	23870121
DPY30_HUMAN	DPY30	physical	23870121
H31_HUMAN	HIST1H3A	physical	23870121
P53_HUMAN	TP53	physical	23870121
PNISR_HUMAN	PNISR	physical	26344197
SET1B_HUMAN	SETD1B	physical	17355966
WDR5_HUMAN	WDR5	physical	27563068
RBBP5_HUMAN	RBBP5	physical	27563068
ASH2L_HUMAN	ASH2L	physical	27563068
CXXC1_HUMAN	CXXC1	physical	27563068
WDR82_HUMAN	WDR82	physical	27563068
HCFC1_HUMAN	HCFC1	physical	27563068

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SET1A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-508, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468 AND SER-470, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-916, AND MASSSPECTROMETRY.	19413330 [Abstract]