dbPTM

PNISR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PNISR_HUMAN
UniProt AC	Q8TF01
Protein Name	Arginine/serine-rich protein PNISR
Gene Name	PNISR
Organism	Homo sapiens (Human).
Sequence Length	805
Subcellular Localization	Nucleus speckle .
Protein Description
Protein Sequence	MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQREASGQQSMVEQPPGMMPNGQDMSTMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPHPPPDQPWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Phosphorylation	DQPWMPPTPGPMDIV CCCCCCCCCCCCCCC	34.70	26074081
123	Phosphorylation	PMDIVPPSEDSNSQD CCCCCCCCCCCCCCC	48.22	26074081
126	Phosphorylation	IVPPSEDSNSQDSGE CCCCCCCCCCCCCCC	34.04	26074081
128	Phosphorylation	PPSEDSNSQDSGEFA CCCCCCCCCCCCCCC	39.04	26074081
131	Phosphorylation	EDSNSQDSGEFAPDN CCCCCCCCCCCCCCC	32.36	26074081
203	Phosphorylation	QNRRERPSSFRDRQR CCCCCCCCCHHCCCC	48.61	23401153
204	Phosphorylation	NRRERPSSFRDRQRS CCCCCCCCHHCCCCC	27.30	23401153
211	Phosphorylation	SFRDRQRSPIALPVK CHHCCCCCCCCCCCC	16.60	29255136
218	Sumoylation	SPIALPVKQEPPQID CCCCCCCCCCCCCCC	47.18	-
218	Sumoylation	SPIALPVKQEPPQID CCCCCCCCCCCCCCC	47.18	28112733
228	Ubiquitination	PPQIDAVKRRTLPAW CCCCCHHHHCCHHHH	37.57	-
231	Phosphorylation	IDAVKRRTLPAWIRE CCHHHHCCHHHHHHH	40.92	28555341
266	Acetylation	QRSQLSKKEKKATED HHHHHHHHHHHHHHC	71.97	7959861
271	Phosphorylation	SKKEKKATEDAEGGD HHHHHHHHHCCCCCC	43.19	-
286	Phosphorylation	GPRLPQRSKFDSDEE CCCCCCCCCCCCCCC	32.21	29255136
290	Phosphorylation	PQRSKFDSDEEEEDT CCCCCCCCCCCHHHH	50.48	29255136
297	Phosphorylation	SDEEEEDTENVEAAS CCCCHHHHCCCHHHH	32.51	29255136
304	Phosphorylation	TENVEAASSGKVTRS HCCCHHHHCCCCCCC	46.82	23927012
305	Phosphorylation	ENVEAASSGKVTRSP CCCHHHHCCCCCCCC	37.60	23927012
309	Phosphorylation	AASSGKVTRSPSPVP HHHCCCCCCCCCCCC	28.99	25159151
311	Phosphorylation	SSGKVTRSPSPVPQE HCCCCCCCCCCCCCC	21.99	26503892
313	Phosphorylation	GKVTRSPSPVPQEEH CCCCCCCCCCCCCCC	39.51	26503892
321	Phosphorylation	PVPQEEHSDPEMTEE CCCCCCCCCHHCCHH	59.13	26503892
326	Phosphorylation	EHSDPEMTEEEKEYQ CCCCHHCCHHHHHHH	38.29	22115753
332	Phosphorylation	MTEEEKEYQMMLLTK CCHHHHHHHHHHHHH	16.87	28111955
338	Phosphorylation	EYQMMLLTKMLLTEI HHHHHHHHHHHHHHH	15.50	28111955
343	Phosphorylation	LLTKMLLTEILLDVT HHHHHHHHHHHHCCC	19.61	29083192
355	Phosphorylation	DVTDEEIYYVAKDAH CCCCHHHHHHHHHHH	8.65	29083192
356	Phosphorylation	VTDEEIYYVAKDAHR CCCHHHHHHHHHHHH	10.29	20068231
376	Phosphorylation	PAKQLAQSSALASLT CHHHHHHHHHHHHHH	16.39	27732954
377	Phosphorylation	AKQLAQSSALASLTG HHHHHHHHHHHHHHC	18.41	27732954
381	Phosphorylation	AQSSALASLTGLGGL HHHHHHHHHHCCCCC	27.58	27732954
383	Phosphorylation	SSALASLTGLGGLGG HHHHHHHHCCCCCCC	28.06	27732954
391	Phosphorylation	GLGGLGGYGSGDSED CCCCCCCCCCCCCCC	13.30	27732954
393	Phosphorylation	GGLGGYGSGDSEDER CCCCCCCCCCCCCCC	30.83	20873877
396	Phosphorylation	GGYGSGDSEDERSDR CCCCCCCCCCCCCCC	50.93	20873877
401	Phosphorylation	GDSEDERSDRGSESS CCCCCCCCCCCCCCC	29.61	28290473
405	Phosphorylation	DERSDRGSESSDTDD CCCCCCCCCCCCCCH	34.89	23927012
407	Phosphorylation	RSDRGSESSDTDDEE CCCCCCCCCCCCHHH	34.90	20873877
408	Phosphorylation	SDRGSESSDTDDEEL CCCCCCCCCCCHHHH	40.24	20873877
410	Phosphorylation	RGSESSDTDDEELRH CCCCCCCCCHHHHHH	47.50	23927012
448	Phosphorylation	MEEEKQQTERVTKEM HHHHHHHHHHHHHHH	24.22	22210691
453	Acetylation	QQTERVTKEMNEFIH HHHHHHHHHHHHHHH	52.70	26051181
461	Acetylation	EMNEFIHKEQNSLSL HHHHHHHHHHHCHHH	57.06	26051181
465	Phosphorylation	FIHKEQNSLSLLEAR HHHHHHHCHHHHHHH	21.01	20164059
467	Phosphorylation	HKEQNSLSLLEAREA HHHHHCHHHHHHHHH	30.63	23401153
485	Phosphorylation	VVNEKKRTPNETTSV CCCCCCCCCCCCCCC	39.07	30266825
489	Phosphorylation	KKRTPNETTSVLEPK CCCCCCCCCCCCCCC	30.89	30266825
490	Phosphorylation	KRTPNETTSVLEPKK CCCCCCCCCCCCCCH	15.62	30266825
491	Phosphorylation	RTPNETTSVLEPKKE CCCCCCCCCCCCCHH	31.93	30266825
496	Sumoylation	TTSVLEPKKEHKEKE CCCCCCCCHHHHHHH	62.51	28112733
515	Phosphorylation	SRSGSSSSGSSSSNS CCCCCCCCCCCCCCC	44.64	30576142
517	Phosphorylation	SGSSSSGSSSSNSRT CCCCCCCCCCCCCCC	29.06	-
518	Phosphorylation	GSSSSGSSSSNSRTS CCCCCCCCCCCCCCC	41.11	-
522	Phosphorylation	SGSSSSNSRTSSTSS CCCCCCCCCCCCCCC	38.59	-
524	Phosphorylation	SSSSNSRTSSTSSTV CCCCCCCCCCCCCEE	27.18	22468782
526	Phosphorylation	SSNSRTSSTSSTVSS CCCCCCCCCCCEECC	31.53	30576142
527	Phosphorylation	SNSRTSSTSSTVSSS CCCCCCCCCCEECCC	26.85	-
528	Phosphorylation	NSRTSSTSSTVSSSS CCCCCCCCCEECCCC	26.42	30576142
529	Phosphorylation	SRTSSTSSTVSSSSY CCCCCCCCEECCCCC	32.68	-
530	Phosphorylation	RTSSTSSTVSSSSYS CCCCCCCEECCCCCC	24.95	-
532	Phosphorylation	SSTSSTVSSSSYSSS CCCCCEECCCCCCCC	25.29	-
533	Phosphorylation	STSSTVSSSSYSSSS CCCCEECCCCCCCCC	20.97	-
535	Phosphorylation	SSTVSSSSYSSSSGS CCEECCCCCCCCCCC	30.86	30576142
537	Phosphorylation	TVSSSSYSSSSGSSR EECCCCCCCCCCCCC	26.20	30576142
539	Phosphorylation	SSSSYSSSSGSSRTS CCCCCCCCCCCCCCC	32.55	-
540	Phosphorylation	SSSYSSSSGSSRTSS CCCCCCCCCCCCCCC	44.64	30576142
550	Phosphorylation	SRTSSRSSSPKRKKR CCCCCCCCCCHHHHC	49.93	30576142
551	Phosphorylation	RTSSRSSSPKRKKRH CCCCCCCCCHHHHCC	35.37	30576142
559	Phosphorylation	PKRKKRHSRSRSPTI CHHHHCCCCCCCCCH	35.66	17081983
561	Phosphorylation	RKKRHSRSRSPTIKA HHHCCCCCCCCCHHH	39.87	28176443
563	Phosphorylation	KRHSRSRSPTIKARR HCCCCCCCCCHHHHH	27.86	28176443
565	Phosphorylation	HSRSRSPTIKARRSR CCCCCCCCHHHHHHH	36.03	23663014
571	Phosphorylation	PTIKARRSRSRSYSR CCHHHHHHHCCCHHC	29.11	19651622
573	Phosphorylation	IKARRSRSRSYSRRI HHHHHHHCCCHHCCE	27.16	20068231
575	Phosphorylation	ARRSRSRSYSRRIKI HHHHHCCCHHCCEEE	28.80	20068231
576	Phosphorylation	RRSRSRSYSRRIKIE HHHHCCCHHCCEEEE	12.70	20068231
577	Phosphorylation	RSRSRSYSRRIKIES HHHCCCHHCCEEEEC	19.14	20068231
584	Phosphorylation	SRRIKIESNRARVKI HCCEEEECCCHHHHH	34.78	29514088
597	Phosphorylation	KIRDRRRSNRNSIER HHHHHHHHCCHHHHH	38.03	28176443
601	Phosphorylation	RRRSNRNSIERERRR HHHHCCHHHHHHHHH	23.69	20164059
611	Phosphorylation	RERRRNRSPSRERRR HHHHHCCCHHHHHHH	30.67	30576142
613	Phosphorylation	RRRNRSPSRERRRSR HHHCCCHHHHHHHHH	48.28	30576142
621	Phosphorylation	RERRRSRSRSRDRRT HHHHHHHHHHHHHHH	35.54	20068231
623	Phosphorylation	RRRSRSRSRDRRTNR HHHHHHHHHHHHHHH	39.52	20068231
634	Phosphorylation	RTNRASRSRSRDRRK HHHHHHHHHHHHHHH	31.92	20068231
636	Phosphorylation	NRASRSRSRDRRKID HHHHHHHHHHHHHCC	39.52	20068231
650	Phosphorylation	DDQRGNLSGNSHKHK CCCCCCCCCCCHHCC	39.67	25159151
670	Phosphorylation	QERKKERSRSIDKDR HHHHHHHHHHHHHHH	31.32	25849741
672	Phosphorylation	RKKERSRSIDKDRKK HHHHHHHHHHHHHHH	36.06	25849741
703	Sumoylation	KREEKDFKFSSQDDR HHHHHCCCCCCHHHH	55.24	28112733
705	Phosphorylation	EEKDFKFSSQDDRLK HHHCCCCCCHHHHHH	27.90	29523821
706	Phosphorylation	EKDFKFSSQDDRLKR HHCCCCCCHHHHHHH	40.54	17525332
720	Phosphorylation	RKRESERTFSRSGSI HHHHHHCCCCCCCCE	23.16	22617229
722	Phosphorylation	RESERTFSRSGSISV HHHHCCCCCCCCEEE	25.56	25159151
724	Phosphorylation	SERTFSRSGSISVKI HHCCCCCCCCEEEEE	35.38	25159151
726	Phosphorylation	RTFSRSGSISVKIIR CCCCCCCCEEEEEEE	16.97	25159151
728	Phosphorylation	FSRSGSISVKIIRHD CCCCCCEEEEEEECC	21.03	26552605
730	Acetylation	RSGSISVKIIRHDSR CCCCEEEEEEECCCC	26.14	23954790
752	Phosphorylation	TKDSKKHSGSDSSGR CCCCCCCCCCCCCCC	49.20	-
760	Phosphorylation	GSDSSGRSSSESPGS CCCCCCCCCCCCCCC	41.56	28985074
761	Phosphorylation	SDSSGRSSSESPGSS CCCCCCCCCCCCCCH	36.44	29038488
762	Phosphorylation	DSSGRSSSESPGSSK CCCCCCCCCCCCCHH	43.25	29038488
767	Phosphorylation	SSSESPGSSKEKKAK CCCCCCCCHHHHHCC	41.44	22468782
768	Phosphorylation	SSESPGSSKEKKAKK CCCCCCCHHHHHCCC	51.23	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PNISR_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PNISR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PNISR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PNISR_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PNISR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311; SER-313 ANDSER-321, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211 AND SER-290, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211; SER-311; SER-313;SER-321 AND THR-410, AND MASS SPECTROMETRY.	15302935 [Abstract]