CBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBP_HUMAN
• UniProt AC: Q92793
• Protein Name: CREB-binding protein
• Gene Name: CREBBP
• Organism: Homo sapiens (Human).
• Sequence Length: 2442
• Subcellular Localization: Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
• Protein Description: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). [PubMed: 24939902]
• Protein Sequence: MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAENLLDGP ------CCCCCCCCC	26.20	22814378
13	Acetylation	LDGPPNPKRAKLSSP CCCCCCCCCCCCCCC	72.18	23954790
13	Ubiquitination	LDGPPNPKRAKLSSP CCCCCCCCCCCCCCC	72.18	24816145
18	Phosphorylation	NPKRAKLSSPGFSAN CCCCCCCCCCCCCCC	33.51	26074081
19	Phosphorylation	PKRAKLSSPGFSAND CCCCCCCCCCCCCCC	39.21	26074081
23	Phosphorylation	KLSSPGFSANDSTDF CCCCCCCCCCCCCCC	31.88	26074081
27	Phosphorylation	PGFSANDSTDFGSLF CCCCCCCCCCCHHHH	29.68	26074081
28	Phosphorylation	GFSANDSTDFGSLFD CCCCCCCCCCHHHHC	37.91	26074081
78	Phosphorylation	SELLRGGSGSSINPG HHHHHCCCCCCCCCC	38.02	30377224
80	Phosphorylation	LLRGGSGSSINPGIG HHHCCCCCCCCCCCC	29.73	30377224
81	Phosphorylation	LRGGSGSSINPGIGN HHCCCCCCCCCCCCC	29.88	30377224
90	Phosphorylation	NPGIGNVSASSPVQQ CCCCCCCCCCCCCCC	26.83	28348404
92	Phosphorylation	GIGNVSASSPVQQGL CCCCCCCCCCCCCCC	27.89	25159151
93	Phosphorylation	IGNVSASSPVQQGLG CCCCCCCCCCCCCCC	28.89	25627689
120	Acetylation	ASLSAMGKSPLSQGD HHHHHCCCCCCCCCC	35.50	26051181
121	Phosphorylation	SLSAMGKSPLSQGDS HHHHCCCCCCCCCCC	25.91	19664994
124	Phosphorylation	AMGKSPLSQGDSSAP HCCCCCCCCCCCCCC	35.19	17525332
128	Phosphorylation	SPLSQGDSSAPSLPK CCCCCCCCCCCCCCH	34.91	30266825
129	Phosphorylation	PLSQGDSSAPSLPKQ CCCCCCCCCCCCCHH	49.27	30266825
139	O-linked_Glycosylation	SLPKQAASTSGPTPA CCCHHHHCCCCCCHH	26.56	32574038
141	O-linked_Glycosylation	PKQAASTSGPTPAAS CHHHHCCCCCCHHHH	40.04	32574038
148	O-linked_Glycosylation	SGPTPAASQALNPQA CCCCHHHHHHHCHHH	20.35	32574038
202	O-linked_Glycosylation	HSLINQASQGQAQVM CHHHHHHHHCCHHHH	25.69	32574038
212	O-linked_Glycosylation	QAQVMNGSLGAAGRG CHHHHCCCCCCCCCC	20.73	32574038
220	Methylation	LGAAGRGRGAGMPYP CCCCCCCCCCCCCCC	30.35	24129315
270	Phosphorylation	GMAKMGITGNTSPFG CCCCCCCCCCCCCCC	20.74	26074081
273	Phosphorylation	KMGITGNTSPFGQPF CCCCCCCCCCCCCCC	38.84	25159151
274	Phosphorylation	MGITGNTSPFGQPFS CCCCCCCCCCCCCCH	23.41	25159151
281	O-linked_Glycosylation	SPFGQPFSQAGGQPM CCCCCCCHHCCCCCC	26.29	32574038
281	Phosphorylation	SPFGQPFSQAGGQPM CCCCCCCHHCCCCCC	26.29	26074081
302	Phosphorylation	PQLASKQSMVNSLPT HHHHCCHHHHHCCCC	28.56	11970865
306	Phosphorylation	SKQSMVNSLPTFPTD CCHHHHHCCCCCCCC	25.06	27080861
309	Phosphorylation	SMVNSLPTFPTDIKN HHHHCCCCCCCCCCC	47.76	27080861
320	Phosphorylation	DIKNTSVTNVPNMSQ CCCCCCCCCCCCHHH	30.20	-
326	O-linked_Glycosylation	VTNVPNMSQMQTSVG CCCCCCHHHCCCEEE	29.19	32574038
330	O-linked_Glycosylation	PNMSQMQTSVGIVPT CCHHHCCCEEEEEEC	21.75	32574038
366	Acetylation	VLLLHAHKCQRREQA HHHHHHHHHHHHHHH	32.61	30583157
381	Phosphorylation	NGEVRACSLPHCRTM CCCCCCCCCCHHHHH	43.90	20068231
389	Acetylation	LPHCRTMKNVLNHMT CCHHHHHHHHHHHHH	43.20	66727641
402	Acetylation	MTHCQAGKACQVAHC HHHHCCCCHHHHHHH	49.34	26051181
437	Phosphorylation	CLPLKNASDKRNQQT EEECCCCCCCCCCCH	53.73	15146178
448	Phosphorylation	NQQTILGSPASGIQN CCCHHCCCCCCCCCC	17.53	28555341
451	Phosphorylation	TILGSPASGIQNTIG HHCCCCCCCCCCCCC	39.55	27251275
456	Phosphorylation	PASGIQNTIGSVGTG CCCCCCCCCCCCCCC	15.44	28555341
584	Ubiquitination	IPTAAPPSSTGVRKG CCCCCCCCCCCCCCC	39.20	32015554
601	Methylation	EHVTQDLRSHLVHKL HHHHHHHHHHHHHHH	30.25	-
607	Acetylation	LRSHLVHKLVQAIFP HHHHHHHHHHHHHCC	42.76	26051181
622	Acetylation	TPDPAALKDRRMENL CCCHHHHHHHHHHHH	44.45	69361
622	Ubiquitination	TPDPAALKDRRMENL CCCHHHHHHHHHHHH	44.45	32015554
625	Methylation	PAALKDRRMENLVAY HHHHHHHHHHHHHHH	47.07	-
635	Acetylation	NLVAYAKKVEGDMYE HHHHHHHHHCCCHHH	37.03	17267393
635	Butyrylation	NLVAYAKKVEGDMYE HHHHHHHHHCCCHHH	37.03	-
635	Propionylation	NLVAYAKKVEGDMYE HHHHHHHHHCCCHHH	37.03	-
657	Acetylation	YYHLLAEKIYKIQKE HHHHHHHHHHHHHHH	45.81	25953088
659	Phosphorylation	HLLAEKIYKIQKELE HHHHHHHHHHHHHHH	17.07	12196545
663	Butyrylation	EKIYKIQKELEEKRR HHHHHHHHHHHHHHH	68.67	-
663	Propionylation	EKIYKIQKELEEKRR HHHHHHHHHHHHHHH	68.67	-
664	Methylation	KIYKIQKELEEKRRS HHHHHHHHHHHHHHH	45.07	12374746
676	Methylation	RRSRLHKQGILGNQP HHHHHHHCCCCCCCC	33.15	12374746
702	Methylation	IPQAQPVRPPNGPLS CCCCCCCCCCCCCCC	47.87	12374746
704	Methylation	QAQPVRPPNGPLSLP CCCCCCCCCCCCCCC	48.09	12374746
714	Methylation	PLSLPVNRMQVSQGM CCCCCCCCCHHCCCC	19.69	12374746
730	Methylation	SFNPMSLGNVQLPQA CCCCCCCCCCCCCCC	25.59	12374746
742	Methylation	PQAPMGPRAASPMNH CCCCCCCCCCCCCCC	36.74	12374746
745	Phosphorylation	PMGPRAASPMNHSVQ CCCCCCCCCCCCCCC	24.56	24275569
750	Phosphorylation	AASPMNHSVQMNSMG CCCCCCCCCCCCCCC	14.72	24275569
768	Methylation	GMAISPSRMPQPPNM CCEECCCCCCCCCCC	44.15	12374746
832	Ubiquitination	PGAALPNPLNMLGPQ CCCCCCCCHHHCCCC	24.15	24816145
944	Ubiquitination	PSVATPQSSQQQPTP CCCCCCCCCCCCCCC	31.17	24816145
974	Phosphorylation	SIDNRVPTPSSVASA HCCCCCCCHHHHHCC	32.71	29255136
976	Acetylation	DNRVPTPSSVASAET CCCCCCHHHHHCCCC	39.66	19608861
976	Phosphorylation	DNRVPTPSSVASAET CCCCCCHHHHHCCCC	39.66	30206219
977	Phosphorylation	NRVPTPSSVASAETN CCCCCHHHHHCCCCC	23.94	30206219
980	Phosphorylation	PTPSSVASAETNSQQ CCHHHHHCCCCCCCC	25.20	30206219
983	Phosphorylation	SSVASAETNSQQPGP HHHHCCCCCCCCCCC	39.63	30206219
985	Phosphorylation	VASAETNSQQPGPDV HHCCCCCCCCCCCCC	37.30	23663014
998	Acetylation	DVPVLEMKTETQAED CCCEEEEEECCCCCC	46.64	26051181
998	Sumoylation	DVPVLEMKTETQAED CCCEEEEEECCCCCC	46.64	-
999	Phosphorylation	VPVLEMKTETQAEDT CCEEEEEECCCCCCC	42.84	26074081
1001	Phosphorylation	VLEMKTETQAEDTEP EEEEEECCCCCCCCC	38.01	17525332
1014	Acetylation	EPDPGESKGEPRSEM CCCCCCCCCCCCHHH	64.09	19608861
1019	Phosphorylation	ESKGEPRSEMMEEDL CCCCCCCHHHHHHHH	40.33	27690223
1030	Phosphorylation	EEDLQGASQVKEETD HHHHHHHHHHHHHHC	42.18	17525332
1033	Acetylation	LQGASQVKEETDIAE HHHHHHHHHHHCHHH	42.04	26051181
1033	Sumoylation	LQGASQVKEETDIAE HHHHHHHHHHHCHHH	42.04	-
1036	Phosphorylation	ASQVKEETDIAEQKS HHHHHHHHCHHHHHC	33.52	23927012
1042	Acetylation	ETDIAEQKSEPMEVD HHCHHHHHCCCCCCC	48.57	23236377
1043	Phosphorylation	TDIAEQKSEPMEVDE HCHHHHHCCCCCCCC	46.77	23927012
1045	Ubiquitination	IAEQKSEPMEVDEKK HHHHHCCCCCCCCCC	31.18	24816145
1051	Acetylation	EPMEVDEKKPEVKVE CCCCCCCCCCCCEEE	69.99	25953088
1052	Acetylation	PMEVDEKKPEVKVEV CCCCCCCCCCCEEEE	44.34	25953088
1056	Sumoylation	DEKKPEVKVEVKEEE CCCCCCCEEEEECCC	30.89	-
1056	Sumoylation	DEKKPEVKVEVKEEE CCCCCCCEEEEECCC	30.89	-
1060	Acetylation	PEVKVEVKEEEESSS CCCEEEEECCCCCCC	45.99	26051181
1065	Phosphorylation	EVKEEEESSSNGTAS EEECCCCCCCCCCCC	42.20	23927012
1066	Phosphorylation	VKEEEESSSNGTASQ EECCCCCCCCCCCCC	30.97	23927012
1067	Phosphorylation	KEEEESSSNGTASQS ECCCCCCCCCCCCCC	48.86	23927012
1068	Ubiquitination	EEEESSSNGTASQST CCCCCCCCCCCCCCC	54.50	24816145
1070	Phosphorylation	EESSSNGTASQSTSP CCCCCCCCCCCCCCC	27.64	28450419
1072	Phosphorylation	SSSNGTASQSTSPSQ CCCCCCCCCCCCCCC	25.22	17525332
1074	Phosphorylation	SNGTASQSTSPSQPR CCCCCCCCCCCCCCC	28.49	23927012
1075	Phosphorylation	NGTASQSTSPSQPRK CCCCCCCCCCCCCCC	36.70	23927012
1076	Phosphorylation	GTASQSTSPSQPRKK CCCCCCCCCCCCCCC	28.00	19664994
1078	Phosphorylation	ASQSTSPSQPRKKIF CCCCCCCCCCCCCCC	53.21	28450419
1081	Ubiquitination	STSPSQPRKKIFKPE CCCCCCCCCCCCCHH	45.31	24816145
1082	Acetylation	TSPSQPRKKIFKPEE CCCCCCCCCCCCHHH	57.83	26051181
1083	Acetylation	SPSQPRKKIFKPEEL CCCCCCCCCCCHHHH	55.44	26051181
1083	Ubiquitination	SPSQPRKKIFKPEEL CCCCCCCCCCCHHHH	55.44	24816145
1108	Phosphorylation	LYRQDPESLPFRQPV HHHCCCCCCCCCCCC	46.89	28509920
1125	Phosphorylation	QLLGIPDYFDIVKNP HHCCCCCHHHHHCCC	9.59	-
1165	Acetylation	WLMFNNAWLYNRKTS EEEECCEECCCCCHH	11.08	19608861
1171	Phosphorylation	AWLYNRKTSRVYKFC EECCCCCHHHHHHHH	20.66	-
1178	Acetylation	TSRVYKFCSKLAEVF HHHHHHHHHHHHHHH	2.83	19608861
1203	Acetylation	LGYCCGRKYEFSPQT HCCCCCCCCCCCCCE	34.12	19608861
1216	Acetylation	QTLCCYGKQLCTIPR CEEEECCCEEECCCC	17.39	19608861
1239	Acetylation	NRYHFCEKCFTEIQG CHHHHHHHHCCEECC	35.51	26822725
1264	Acetylation	QPQTTISKDQFEKKK CCCCCCCHHHHHHHC	52.26	26051181
1274	Phosphorylation	FEKKKNDTLDPEPFV HHHHCCCCCCCCCCC	42.32	26074081
1320	Propionylation	KKTGRPRKENKFSAK HHHCCCCCCCCCCHH	69.21	-
1323	Propionylation	GRPRKENKFSAKRLQ CCCCCCCCCCHHHHH	41.61	-
1327	Propionylation	KENKFSAKRLQTTRL CCCCCCHHHHHHHHC	53.06	-
1341	Methylation	LGNHLEDRVNKFLRR CHHHHHHHHHHHHHH	25.24	-
1344	Acetylation	HLEDRVNKFLRRQNH HHHHHHHHHHHHCCC	42.81	26051181
1367	Acetylation	RVVASSDKTVEVKPG EEEECCCCEEEECCC	57.32	18584585
1372	Acetylation	SDKTVEVKPGMKSRF CCCEEEECCCCCCCC	23.50	23236377
1376	Acetylation	VEVKPGMKSRFVDSG EEECCCCCCCCCCCC	44.38	23236377
1382	Phosphorylation	MKSRFVDSGEMSESF CCCCCCCCCCCCCCC	31.20	19060867
1386	Phosphorylation	FVDSGEMSESFPYRT CCCCCCCCCCCCCCH	26.28	19060867
1391	Phosphorylation	EMSESFPYRTKALFA CCCCCCCCCHHHHEE	28.98	25884760
1447	Phosphorylation	FRPRCLRTAVYHEIL CCHHHHHHHHHHHHH	13.92	20049867
1450	Phosphorylation	RCLRTAVYHEILIGY HHHHHHHHHHHHHHH	7.41	18083107
1457	Phosphorylation	YHEILIGYLEYVKKL HHHHHHHHHHHHHHH	6.86	18083107
1460	Phosphorylation	ILIGYLEYVKKLGYV HHHHHHHHHHHHCCC	18.25	18083107
1482	Phosphorylation	PPSEGDDYIFHCHPP CCCCCCCCEEECCCC	15.38	-
1497	Ubiquitination	DQKIPKPKRLQEWYK CCCCCCCHHHHHHHH	72.38	29967540
1509	Acetylation	WYKKMLDKAFAERII HHHHHHHHHHHHHHH	41.25	17267393
1509	Butyrylation	WYKKMLDKAFAERII HHHHHHHHHHHHHHH	41.25	-
1509	Propionylation	WYKKMLDKAFAERII HHHHHHHHHHHHHHH	41.25	-
1524	Ubiquitination	HDYKDIFKQATEDRL HHHHHHHHHHHHHHC	39.08	-
1535	Acetylation	EDRLTSAKELPYFEG HHHCCCCHHCCCCCC	60.60	132807
1535	Ubiquitination	EDRLTSAKELPYFEG HHHCCCCHHCCCCCC	60.60	29967540
1545	Acetylation	PYFEGDFWPNVLEES CCCCCCCHHHHHHHH	6.57	19608861
1548	Acetylation	EGDFWPNVLEESIKE CCCCHHHHHHHHHHH	6.62	19608861
1549	Acetylation	GDFWPNVLEESIKEL CCCHHHHHHHHHHHH	8.42	19608861
1553	Acetylation	PNVLEESIKELEQEE HHHHHHHHHHHHHHH	4.55	19608861
1554	Acetylation	NVLEESIKELEQEEE HHHHHHHHHHHHHHH	66.58	19608861
1557	Acetylation	EESIKELEQEEEERK HHHHHHHHHHHHHHH	57.97	19608861
1559	Acetylation	SIKELEQEEEERKKE HHHHHHHHHHHHHHH	58.98	19608861
1564	Acetylation	EQEEEERKKEESTAA HHHHHHHHHHHHHHH	68.75	69365
1565	Methylation	QEEEERKKEESTAAS HHHHHHHHHHHHHHH	73.30	-
1568	Phosphorylation	EERKKEESTAASETT HHHHHHHHHHHHHCC	25.16	29449344
1569	Phosphorylation	ERKKEESTAASETTE HHHHHHHHHHHHCCC	29.53	29449344
1572	Phosphorylation	KEESTAASETTEGSQ HHHHHHHHHCCCCCC	32.77	23403867
1574	Phosphorylation	ESTAASETTEGSQGD HHHHHHHCCCCCCCC	27.87	23403867
1575	Phosphorylation	STAASETTEGSQGDS HHHHHHCCCCCCCCH	34.01	23403867
1578	Phosphorylation	ASETTEGSQGDSKNA HHHCCCCCCCCHHHH	25.43	23403867
1582	Phosphorylation	TEGSQGDSKNAKKKN CCCCCCCHHHHHHHC	34.33	23403867
1583	Acetylation	EGSQGDSKNAKKKNN CCCCCCHHHHHHHCC	66.71	19608861
1586	Acetylation	QGDSKNAKKKNNKKT CCCHHHHHHHCCCCC	73.92	23954790
1587	Acetylation	GDSKNAKKKNNKKTN CCHHHHHHHCCCCCC	59.32	19608861
1588	Acetylation	DSKNAKKKNNKKTNK CHHHHHHHCCCCCCC	66.11	16916647
1591	Acetylation	NAKKKNNKKTNKNKS HHHHHCCCCCCCCHH	71.07	19608861
1591	Butyrylation	NAKKKNNKKTNKNKS HHHHHCCCCCCCCHH	71.07	-
1591	Propionylation	NAKKKNNKKTNKNKS HHHHHCCCCCCCCHH	71.07	-
1592	Acetylation	AKKKNNKKTNKNKSS HHHHCCCCCCCCHHH	60.50	19608861
1595	Acetylation	KNNKKTNKNKSSISR HCCCCCCCCHHHHHH	71.61	19608861
1595	Butyrylation	KNNKKTNKNKSSISR HCCCCCCCCHHHHHH	71.61	-
1597	Acetylation	NKKTNKNKSSISRAN CCCCCCCHHHHHHHH	47.38	19608861
1597	Butyrylation	NKKTNKNKSSISRAN CCCCCCCHHHHHHHH	47.38	-
1597	Propionylation	NKKTNKNKSSISRAN CCCCCCCHHHHHHHH	47.38	-
1605	Acetylation	SSISRANKKKPSMPN HHHHHHHCCCCCCCC	62.28	26051181
1605	Propionylation	SSISRANKKKPSMPN HHHHHHHCCCCCCCC	62.28	-
1606	Acetylation	SISRANKKKPSMPNV HHHHHHCCCCCCCCC	70.49	26051181
1606	Propionylation	SISRANKKKPSMPNV HHHHHHCCCCCCCCC	70.49	-
1607	Acetylation	ISRANKKKPSMPNVS HHHHHCCCCCCCCCC	43.89	26051181
1609	Phosphorylation	RANKKKPSMPNVSND HHHCCCCCCCCCCHH	56.61	28555341
1614	Phosphorylation	KPSMPNVSNDLSQKL CCCCCCCCHHHHHHH	31.13	29083192
1618	Phosphorylation	PNVSNDLSQKLYATM CCCCHHHHHHHHHHH	28.29	-
1620	Acetylation	VSNDLSQKLYATMEK CCHHHHHHHHHHHHH	39.84	25953088
1622	Phosphorylation	NDLSQKLYATMEKHK HHHHHHHHHHHHHHC	13.68	-
1627	Acetylation	KLYATMEKHKEVFFV HHHHHHHHHCCEEEE	49.51	22647723
1669	Phosphorylation	DGRDAFLTLARDKHW CCHHHHHHHHHHCCC	16.36	24719451
1680	Phosphorylation	DKHWEFSSLRRSKWS HCCCCHHHHHHHHHH	31.08	24719451
1697	Phosphorylation	CMLVELHTQGQDRFV HHEEHHHHCCCCEEE	47.20	-
1703	Acetylation	HTQGQDRFVYTCNEC HHCCCCEEEEECCCC	7.10	19608861
1706	Acetylation	GQDRFVYTCNECKHH CCCEEEEECCCCCCC	11.98	19608861
1711	Acetylation	VYTCNECKHHVETRW EEECCCCCCCCCCCE	30.48	69401
1736	Acetylation	CINCYNTKSHAHKMV EEECCCCHHHHHHHH	36.28	23749302
1741	Acetylation	NTKSHAHKMVKWGLG CCHHHHHHHHHCCCC	46.29	19608861
1744	Acetylation	SHAHKMVKWGLGLDD HHHHHHHHCCCCCCC	31.85	19608861
1754	Phosphorylation	LGLDDEGSSQGEPQS CCCCCCCCCCCCCCC	19.90	30108239
1755	Phosphorylation	GLDDEGSSQGEPQSK CCCCCCCCCCCCCCC	53.73	17525332
1761	Phosphorylation	SSQGEPQSKSPQESR CCCCCCCCCCHHHHH	45.90	30576142
1762	Acetylation	SQGEPQSKSPQESRR CCCCCCCCCHHHHHH	61.99	23749302
1762	Ubiquitination	SQGEPQSKSPQESRR CCCCCCCCCHHHHHH	61.99	-
1763	Phosphorylation	QGEPQSKSPQESRRL CCCCCCCCHHHHHHH	36.74	23927012
1767	Phosphorylation	QSKSPQESRRLSIQR CCCCHHHHHHHHHHH	19.90	28450419
1771	Phosphorylation	PQESRRLSIQRCIQS HHHHHHHHHHHHHHH	18.18	20068231
1791	Phosphorylation	QCRNANCSLPSCQKM HHCCCCCCCCHHHHH	43.02	21712546
1797	Acetylation	CSLPSCQKMKRVVQH CCCCHHHHHHHHHHH	51.20	69417
1799	Acetylation	LPSCQKMKRVVQHTK CCHHHHHHHHHHHCC	49.42	69421
1799	Ubiquitination	LPSCQKMKRVVQHTK CCHHHHHHHHHHHCC	49.42	32015554
1806	Acetylation	KRVVQHTKGCKRKTN HHHHHHCCCCCCCCC	61.25	7395865
1806	Butyrylation	KRVVQHTKGCKRKTN HHHHHHCCCCCCCCC	61.25	-
1806	Propionylation	KRVVQHTKGCKRKTN HHHHHHCCCCCCCCC	61.25	-
1809	Acetylation	VQHTKGCKRKTNGGC HHHCCCCCCCCCCCC	66.65	7395877
1809	Butyrylation	VQHTKGCKRKTNGGC HHHCCCCCCCCCCCC	66.65	-
1809	Propionylation	VQHTKGCKRKTNGGC HHHCCCCCCCCCCCC	66.65	-
1820	Acetylation	NGGCPVCKQLIALCC CCCCHHHHHHHHHHH	48.66	25953088
1824	Ubiquitination	PVCKQLIALCCYHAK HHHHHHHHHHHHHHH	11.79	23000965
1831	Acetylation	ALCCYHAKHCQENKC HHHHHHHHHHHHCCC	31.44	-
1837	Acetylation	AKHCQENKCPVPFCL HHHHHHCCCCCCCHH	38.88	30583151
1837	Ubiquitination	AKHCQENKCPVPFCL HHHHHHCCCCCCCHH	38.88	32015554
1847	Acetylation	VPFCLNIKHKLRQQQ CCCHHHHHHHHHHHH	33.35	25953088
1849	Acetylation	FCLNIKHKLRQQQIQ CHHHHHHHHHHHHHH	40.12	25953088
1851	Ubiquitination	LNIKHKLRQQQIQHR HHHHHHHHHHHHHHH	36.74	21890473
1871	Phosphorylation	LMRRRMATMNTRNVP HHHHHHHHHCCCCCC	11.12	-
1874	Phosphorylation	RRMATMNTRNVPQQS HHHHHHCCCCCCHHH	16.88	-
1884	Phosphorylation	VPQQSLPSPTSAPPG CCHHHCCCCCCCCCC	46.21	28348404
1886	Phosphorylation	QQSLPSPTSAPPGTP HHHCCCCCCCCCCCC	41.69	28348404
1887	Phosphorylation	QSLPSPTSAPPGTPT HHCCCCCCCCCCCCC	42.01	25921289
1892	Phosphorylation	PTSAPPGTPTQQPST CCCCCCCCCCCCCCC	29.01	27251275
1894	Phosphorylation	SAPPGTPTQQPSTPQ CCCCCCCCCCCCCCC	39.41	27251275
1898	Phosphorylation	GTPTQQPSTPQTPQP CCCCCCCCCCCCCCC	48.67	27251275
1899	Phosphorylation	TPTQQPSTPQTPQPP CCCCCCCCCCCCCCC	26.54	27251275
1912	Phosphorylation	PPAQPQPSPVSMSPA CCCCCCCCCCCCCCC	32.46	25921289
1927	Phosphorylation	GFPSVARTQPPTTVS CCCCCCCCCCCCEEE	35.37	25072903
1931	Phosphorylation	VARTQPPTTVSTGKP CCCCCCCCEEECCCC	46.65	25072903
1932	Phosphorylation	ARTQPPTTVSTGKPT CCCCCCCEEECCCCC	20.45	25072903
1936	Ubiquitination	PPTTVSTGKPTSQVP CCCEEECCCCCCCCC	26.83	23000965
1937	Acetylation	PTTVSTGKPTSQVPA CCEEECCCCCCCCCC	45.25	23236377
1963	Ubiquitination	VEAARQIEREAQQQQ HHHHHHHHHHHHHHH	35.81	21890473
1973	Phosphorylation	AQQQQHLYRVNINNS HHHHHCEEEEECCCC	15.47	-
1986	Phosphorylation	NSMPPGRTGMGTPGS CCCCCCCCCCCCCCC	37.12	29507054
1988	Ubiquitination	MPPGRTGMGTPGSQM CCCCCCCCCCCCCCC	5.52	23000965
1990	Phosphorylation	PGRTGMGTPGSQMAP CCCCCCCCCCCCCCC	18.65	29507054
1993	Phosphorylation	TGMGTPGSQMAPVSL CCCCCCCCCCCCEEC	20.27	29507054
2015	Ubiquitination	VSGPVMPSMPPGQWQ CCCCCCCCCCCCCCC	26.31	21890473
2037	Ubiquitination	QPMPGLPRPVISMQA CCCCCCCCCEEEEEH	43.06	23000965
2041	Phosphorylation	GLPRPVISMQAQAAV CCCCCEEEEEHHHHH	12.70	18669648
2060	Ubiquitination	MPSVQPPRSISPSAL CCCCCCCCCCCHHHH	53.99	23000965
2061	Phosphorylation	PSVQPPRSISPSALQ CCCCCCCCCCHHHHH	32.94	22167270
2063	Phosphorylation	VQPPRSISPSALQDL CCCCCCCCHHHHHHH	17.66	29255136
2064	Ubiquitination	QPPRSISPSALQDLL CCCCCCCHHHHHHHH	23.19	21890473
2064	Ubiquitination	QPPRSISPSALQDLL CCCCCCCHHHHHHHH	23.19	21890473
2065	Phosphorylation	PPRSISPSALQDLLR CCCCCCHHHHHHHHH	34.52	22167270
2073	Phosphorylation	ALQDLLRTLKSPSSP HHHHHHHHCCCCCCH	38.21	21712546
2073	Ubiquitination	ALQDLLRTLKSPSSP HHHHHHHHCCCCCCH	38.21	23000965
2075	Acetylation	QDLLRTLKSPSSPQQ HHHHHHCCCCCCHHH	60.76	25953088
2075	Ubiquitination	QDLLRTLKSPSSPQQ HHHHHHCCCCCCHHH	60.76	23000965
2076	Phosphorylation	DLLRTLKSPSSPQQQ HHHHHCCCCCCHHHH	32.88	25159151
2078	Phosphorylation	LRTLKSPSSPQQQQQ HHHCCCCCCHHHHHH	62.84	25159151
2079	Phosphorylation	RTLKSPSSPQQQQQV HHCCCCCCHHHHHHH	30.06	25159151
2087	Ubiquitination	PQQQQQVLNILKSNP HHHHHHHHHHHHHCH	2.61	21890473
2091	Acetylation	QQVLNILKSNPQLMA HHHHHHHHHCHHHHH	44.37	23236377
2100	Ubiquitination	NPQLMAAFIKQRTAK CHHHHHHHHHHHHHH	5.35	21890473
2102	Ubiquitination	QLMAAFIKQRTAKYV HHHHHHHHHHHHHHH	27.55	32015554
2307	Phosphorylation	QMKQQIGSPGQPNPM HHHHHHCCCCCCCCC	27.73	20068231
2313	Phosphorylation	GSPGQPNPMSPQQHM CCCCCCCCCCHHHHH	31.17	33259812
2315	Phosphorylation	PGQPNPMSPQQHMLS CCCCCCCCHHHHHHC	22.33	28348404
2322	O-linked_Glycosylation	SPQQHMLSGQPQASH CHHHHHHCCCCCHHH	28.01	32574038
2322	Phosphorylation	SPQQHMLSGQPQASH CHHHHHHCCCCCHHH	28.01	20068231
2323	Phosphorylation	PQQHMLSGQPQASHL HHHHHHCCCCCHHHC	38.95	32142685
2328	O-linked_Glycosylation	LSGQPQASHLPGQQI HCCCCCHHHCCHHHH	21.95	32574038
2328	Phosphorylation	LSGQPQASHLPGQQI HCCCCCHHHCCHHHH	21.95	20068231
2337	O-linked_Glycosylation	LPGQQIATSLSNQVR CCHHHHHHHHHCCCC	31.65	32574038
2337	Phosphorylation	LPGQQIATSLSNQVR CCHHHHHHHHHCCCC	31.65	20068231
2338	O-linked_Glycosylation	PGQQIATSLSNQVRS CHHHHHHHHHCCCCC	22.30	32574038
2338	Phosphorylation	PGQQIATSLSNQVRS CHHHHHHHHHCCCCC	22.30	20068231
2340	Phosphorylation	QQIATSLSNQVRSPA HHHHHHHHCCCCCCC	25.61	20068231
2345	Phosphorylation	SLSNQVRSPAPVQSP HHHCCCCCCCCCCCC	26.93	23927012
2351	Phosphorylation	RSPAPVQSPRPQSQP CCCCCCCCCCCCCCC	24.10	23927012
2353	Methylation	PAPVQSPRPQSQPPH CCCCCCCCCCCCCCC	47.33	-
2356	O-linked_Glycosylation	VQSPRPQSQPPHSSP CCCCCCCCCCCCCCC	47.54	32574038
2356	Phosphorylation	VQSPRPQSQPPHSSP CCCCCCCCCCCCCCC	47.54	20068231
2361	O-linked_Glycosylation	PQSQPPHSSPSPRIQ CCCCCCCCCCCCCCC	50.12	32574038
2361	Phosphorylation	PQSQPPHSSPSPRIQ CCCCCCCCCCCCCCC	50.12	29255136
2362	Phosphorylation	QSQPPHSSPSPRIQP CCCCCCCCCCCCCCC	26.77	29255136
2364	O-linked_Glycosylation	QPPHSSPSPRIQPQP CCCCCCCCCCCCCCC	28.85	32574038
2364	Phosphorylation	QPPHSSPSPRIQPQP CCCCCCCCCCCCCCC	28.85	29255136
2372	Phosphorylation	PRIQPQPSPHHVSPQ CCCCCCCCCCCCCCC	31.45	20068231
2377	Phosphorylation	QPSPHHVSPQTGSPH CCCCCCCCCCCCCCC	13.61	20068231
2380	Phosphorylation	PHHVSPQTGSPHPGL CCCCCCCCCCCCCCE	42.90	20068231
2382	Phosphorylation	HVSPQTGSPHPGLAV CCCCCCCCCCCCEEE	24.35	20068231
2390	Phosphorylation	PHPGLAVTMASSIDQ CCCCEEEEECCCCCC	11.04	20068231
2393	Phosphorylation	GLAVTMASSIDQGHL CEEEEECCCCCCCCC	19.60	20068231
2394	Phosphorylation	LAVTMASSIDQGHLG EEEEECCCCCCCCCC	22.20	20068231
2406	Phosphorylation	HLGNPEQSAMLPQLN CCCCHHHHCCCCCCC	17.62	20068231
2414	Phosphorylation	AMLPQLNTPSRSALS CCCCCCCCCCHHHHH	31.10	20068231
2416	Phosphorylation	LPQLNTPSRSALSSE CCCCCCCCHHHHHHH	36.51	20068231
2418	Phosphorylation	QLNTPSRSALSSELS CCCCCCHHHHHHHHH	37.59	20068231
2421	Phosphorylation	TPSRSALSSELSLVG CCCHHHHHHHHHHCC	22.83	27251275
2422	Phosphorylation	PSRSALSSELSLVGD CCHHHHHHHHHHCCC	43.33	20068231
2425	Phosphorylation	SALSSELSLVGDTTG HHHHHHHHHCCCCCH	19.56	20068231
2430	Phosphorylation	ELSLVGDTTGDTLEK HHHHCCCCCHHHHHH	27.10	20068231
2431	Phosphorylation	LSLVGDTTGDTLEKF HHHCCCCCHHHHHHH	37.49	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
93	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
93	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
302	S	Phosphorylation	Kinase	CAMK4	Q16566	GPS
302	S	Phosphorylation	Kinase	KKCC1	Q8N5S9	PhosphoELM
437	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
437	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
1382	S	Phosphorylation	Kinase	CHUK	O15111	GPS
1382	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
1386	S	Phosphorylation	Kinase	CHUK	O15111	GPS
1386	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
1871	T	Phosphorylation	Kinase	AKT1	P31749	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:10207051

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1382	S	Phosphorylation	Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386; these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B.	17434128
1386	S	Phosphorylation	Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386; these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B.	17434128

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGR1_HUMAN	EGR1	physical	9806899
HNF4A_HUMAN	HNF4A	physical	9434765
NF2L2_HUMAN	NFE2L2	physical	11683914
TDG_HUMAN	TDG	physical	11864601
AIRE_HUMAN	AIRE	physical	10748110
BRCA1_HUMAN	BRCA1	physical	10655477
CREB1_HUMAN	CREB1	physical	15073328
ANDR_HUMAN	AR	physical	15691881
CREB1_HUMAN	CREB1	physical	15691881
TF65_HUMAN	RELA	physical	15140884
PIAS3_HUMAN	PIAS3	physical	14691252
PML_HUMAN	PML	physical	12622724
SRF_HUMAN	SRF	physical	12622724
TF65_HUMAN	RELA	physical	11931769
P53_HUMAN	TP53	physical	12426395
KLF1_HUMAN	KLF1	physical	11259590
ING1_HUMAN	ING1	physical	12015309
SMAD1_HUMAN	SMAD1	physical	10673036
PML_HUMAN	PML	physical	10077561
PML_HUMAN	PML	physical	10610177
CSK21_HUMAN	CSNK2A1	physical	9685505
CUX1_HUMAN	CUX1	physical	10852958
CASP_HUMAN	CUX1	physical	10852958
CREB1_HUMAN	CREB1	physical	8663317
ATF1_HUMAN	ATF1	physical	8663317
CREB1_HUMAN	CREB1	physical	9413984
GCR_HUMAN	NR3C1	physical	9649342
HNF1A_HUMAN	HNF1A	physical	10777539
HXB7_HUMAN	HOXB7	physical	10435624
MSX1_HUMAN	MSX1	physical	10215616
TFE2_HUMAN	TCF3	physical	12435739
MGMT_HUMAN	MGMT	physical	11564893
KMT2A_HUMAN	KMT2A	physical	12205094
MYOD1_HUMAN	MYOD1	physical	11463815
TF65_HUMAN	RELA	physical	9548485
ATF2_HUMAN	ATF2	physical	9786917
CREB1_HUMAN	CREB1	physical	9786917
JUN_HUMAN	JUN	physical	9786917
EVI1_HUMAN	MECOM	physical	11568182
GLI3_HUMAN	GLI3	physical	10075717
PTMA_HUMAN	PTMA	physical	11897665
MYB_HUMAN	MYB	physical	12196545
P53_HUMAN	TP53	physical	11782467
P53_HUMAN	TP53	physical	10848610
CREB1_HUMAN	CREB1	physical	10848610
FOXO1_HUMAN	FOXO1	physical	10973497
FOXO4_HUMAN	FOXO4	physical	10973497
KS6A3_HUMAN	RPS6KA3	physical	11564891
CITE1_HUMAN	CITED1	physical	10722728
STAT1_HUMAN	STAT1	physical	8986769
MAF_HUMAN	MAF	physical	11943779
PELP1_HUMAN	PELP1	physical	11481323
KS6A2_HUMAN	RPS6KA2	physical	8756728
RBBP4_HUMAN	RBBP4	physical	10866654
RBBP7_HUMAN	RBBP7	physical	10866654
CREB1_HUMAN	CREB1	physical	10866654
HNF6_HUMAN	ONECUT1	physical	10811635
SRTD1_HUMAN	SERTAD1	physical	12736710
HNF4A_HUMAN	HNF4A	genetic	9434765
HNF4A_HUMAN	HNF4A	physical	10085149
SRBP1_HUMAN	SREBF1	physical	8918891
SRBP2_HUMAN	SREBF2	physical	8918891
NFAC2_HUMAN	NFATC2	physical	9625762
NFE2_HUMAN	NFE2	physical	11154691
STAT2_HUMAN	STAT2	physical	8848048
NCOA1_HUMAN	NCOA1	physical	11113179
MYBB_HUMAN	MYBL2	physical	11423988
KMT2A_HUMAN	KMT2A	physical	11259575
CREB1_HUMAN	CREB1	physical	11259575
KAT2B_HUMAN	KAT2B	physical	11864601
TF2B_HUMAN	GTF2B	physical	11864601
CITE2_HUMAN	CITED2	physical	9887100
HIF1A_HUMAN	HIF1A	physical	9887100
NUP98_HUMAN	NUP98	physical	9858599
TREF1_HUMAN	TRERF1	physical	11349124
TGS1_HUMAN	TGS1	physical	11912212
KLF4_HUMAN	KLF4	physical	10666450
STAT3_HUMAN	STAT3	physical	11239394
NGN1_HUMAN	NEUROG1	physical	11239394
SMAD1_HUMAN	SMAD1	physical	11239394
HIPK2_HUMAN	HIPK2	physical	11740489
KHDR1_HUMAN	KHDRBS1	physical	12496368
GATA1_HUMAN	GATA1	physical	12496368
PHX2A_HUMAN	PHOX2A	physical	10644760
NFAC4_HUMAN	NFATC4	physical	11514544
KLF13_HUMAN	KLF13	physical	11748222
XRCC6_HUMAN	XRCC6	physical	9488450
ESR1_HUMAN	ESR1	physical	11782371
FOS_HUMAN	FOS	physical	11782371
TF2B_HUMAN	GTF2B	physical	11782371
TF65_HUMAN	RELA	physical	9096323
KAT2B_HUMAN	KAT2B	physical	9710619
RPB1_HUMAN	POLR2A	physical	9710619
SNF5_HUMAN	SMARCB1	physical	9710619
CCNC_HUMAN	CCNC	physical	9710619
CDK8_HUMAN	CDK8	physical	9710619
HNF6_HUMAN	ONECUT1	physical	12509444
AIRE_HUMAN	AIRE	physical	12929931
RFA2_HUMAN	RPA2	physical	17525332
PRGC1_HUMAN	PPARGC1A	physical	10558993
CREB1_HUMAN	CREB1	physical	12198160
BRCA1_HUMAN	BRCA1	physical	9443979
H31T_HUMAN	HIST3H3	physical	11163245
HIF1A_HUMAN	HIF1A	physical	18426857
P53_HUMAN	TP53	physical	18485870
EP300_HUMAN	EP300	physical	17970752
STAT1_HUMAN	STAT1	physical	9037008
NCOA3_HUMAN	NCOA3	physical	8616895
HIF1A_HUMAN	HIF1A	physical	16579968
CTNB1_HUMAN	CTNNB1	physical	16476742
APC5_HUMAN	ANAPC5	physical	16319895
APC7_HUMAN	ANAPC7	physical	16319895
CADH1_HUMAN	CDH1	physical	16319895
CDC20_HUMAN	CDC20	physical	16319895
DDX17_HUMAN	DDX17	physical	17226766
GCM1_HUMAN	GCM1	physical	16166624
MYB_HUMAN	MYB	physical	16055500
PAPOA_HUMAN	PAPOLA	physical	17172643
CPSF6_HUMAN	CPSF6	physical	17172643
P53_HUMAN	TP53	physical	19805293
TBX21_HUMAN	TBX21	physical	17075044
NCOR1_HUMAN	NCOR1	physical	17073437
TYY1_HUMAN	YY1	physical	16878156
MYC_HUMAN	MYC	physical	16878156
BRCA1_HUMAN	BRCA1	physical	16860316
SP1_HUMAN	SP1	physical	16734381
SP3_HUMAN	SP3	physical	16734381
NUP98_HUMAN	NUP98	physical	16651408
P53_HUMAN	TP53	physical	16537920
HDAC1_HUMAN	HDAC1	physical	16528103
HDAC3_HUMAN	HDAC3	physical	16528103
CREB1_HUMAN	CREB1	physical	18599546
ATF2_HUMAN	ATF2	physical	16303757
DAXX_HUMAN	DAXX	physical	16287980
PARP1_HUMAN	PARP1	physical	16204234
TAT_HV1H2	tat	physical	12549909
PTMS_HUMAN	PTMS	physical	16150697
H31_HUMAN	HIST1H3A	physical	16122695
SET1A_HUMAN	SETD1A	physical	16061203
MYBA_HUMAN	MYBL1	physical	16055500
NLK_HUMAN	NLK	physical	16055500
MYBB_HUMAN	MYBL2	physical	16055500
SMAD3_HUMAN	SMAD3	physical	15990875
DEK_HUMAN	DEK	physical	15987677
FGFR1_HUMAN	FGFR1	physical	15929978
KS6A1_HUMAN	RPS6KA1	physical	15929978
STAT1_HUMAN	STAT1	physical	15894584
CDN1A_HUMAN	CDKN1A	physical	15743834
SND1_HUMAN	SND1	physical	15695802
STAT6_HUMAN	STAT6	physical	15695802
NCOA2_HUMAN	NCOA2	physical	15657427
STAT3_HUMAN	STAT3	physical	15653507
TAF6L_HUMAN	TAF6L	physical	18400184
HNF1A_HUMAN	HNF1A	physical	15598887
EP300_HUMAN	EP300	physical	15598887
CREB1_HUMAN	CREB1	physical	15585582
TF65_HUMAN	RELA	physical	18241676
NF2L2_HUMAN	NFE2L2	physical	18241676
MAFK_HUMAN	MAFK	physical	18241676
MYB_HUMAN	MYB	physical	11073948
HDAC2_HUMAN	HDAC2	physical	10958685
MYOD1_HUMAN	MYOD1	physical	10944526
HXB6_HUMAN	HOXB6	physical	15269212
FOXO1_HUMAN	FOXO1	physical	15220471
HNF4A_HUMAN	HNF4A	physical	10882110
IMA1_HUMAN	KPNA2	physical	10801418
IMA7_HUMAN	KPNA6	physical	10801418
HMGA1_HUMAN	HMGA1	physical	10428834
FOXO4_HUMAN	FOXO4	physical	15126506
SRCAP_HUMAN	SRCAP	physical	10347196
VDR_HUMAN	VDR	physical	10224118
H31_HUMAN	HIST1H3A	physical	10097092
HES6_HUMAN	HES6	physical	18160400
FOSL1_HUMAN	FOSL1	physical	15025563
FOSB_HUMAN	FOSB	physical	15025563
JUNB_HUMAN	JUNB	physical	15025563
FOXM1_HUMAN	FOXM1	physical	15024056
XRCC6_HUMAN	XRCC6	physical	15023334
KHDR1_HUMAN	KHDRBS1	physical	15021911
TAT_HV1H2	tat	physical	9811832
HMGA1_HUMAN	HMGA1	physical	9809067
H31_HUMAN	HIST1H3A	physical	15005629
HMGB1_HUMAN	HMGB1	physical	15005629
HMGB2_HUMAN	HMGB2	physical	15005629
PIT1_HUMAN	POU1F1	physical	9751061
IRF1_HUMAN	IRF1	physical	9659924
TF65_HUMAN	RELA	physical	9659924
JUN_HUMAN	JUN	physical	9659924
ATF2_HUMAN	ATF2	physical	9659924
ESR1_HUMAN	ESR1	physical	14766010
MYB_HUMAN	MYB	physical	14761981
ETS1_HUMAN	ETS1	physical	9528793
TAT_HV1H2	tat	physical	14744133
KAT2B_HUMAN	KAT2B	physical	9445475
P53_HUMAN	TP53	physical	9288775
P53_HUMAN	TP53	physical	9194564
ESR1_HUMAN	ESR1	physical	9192902
NCOA3_HUMAN	NCOA3	physical	9192892
NCOA1_HUMAN	NCOA1	physical	9192892
RARA_HUMAN	RARA	physical	17475621
ETS2_HUMAN	ETS2	physical	14722092
NCOA1_HUMAN	NCOA1	physical	14722092
P53_HUMAN	TP53	physical	14722092
KLF4_HUMAN	KLF4	physical	17908689
KHDR1_HUMAN	KHDRBS1	physical	17891136
SH3G1_HUMAN	SH3GL1	physical	17891136
KAT6A_HUMAN	KAT6A	physical	17697320
P53_HUMAN	TP53	physical	21390126
BCL6_HUMAN	BCL6	physical	21390126
CREB1_HUMAN	CREB1	physical	20403362
SMAD2_HUMAN	SMAD2	physical	20403362
KLF8_HUMAN	KLF8	physical	20107328
SP1_HUMAN	SP1	physical	20072153
NFYB_HUMAN	NFYB	physical	20072153
WDR5_HUMAN	WDR5	physical	19660582
GCR_HUMAN	NR3C1	physical	20018896
IRF5_HUMAN	IRF5	physical	20935208
CDC27_HUMAN	CDC27	physical	21454660
ATG3_HUMAN	ATG3	physical	19932681
MDM2_HUMAN	MDM2	physical	21149449
HXB2_HUMAN	HOXB2	physical	11585930
HXB3_HUMAN	HOXB3	physical	11585930
HXB6_HUMAN	HOXB6	physical	11585930
HXB7_HUMAN	HOXB7	physical	11585930
HXB9_HUMAN	HOXB9	physical	11585930
HXD12_HUMAN	HOXD12	physical	11585930
HXD13_HUMAN	HOXD13	physical	11585930
HXD10_HUMAN	HOXD10	physical	11585930
HXD4_HUMAN	HOXD4	physical	11585930
HXB4_HUMAN	HOXB4	physical	11585930
HXA10_HUMAN	HOXA10	physical	11585930
HXA9_HUMAN	HOXA9	physical	11585930
PBX1_HUMAN	PBX1	physical	11585930
H31_HUMAN	HIST1H3A	physical	11585930
NF2L2_HUMAN	NFE2L2	physical	19273602
MYH9_HUMAN	MYH9	physical	16051665
CSK21_HUMAN	CSNK2A1	physical	16051665
MSH6_HUMAN	MSH6	physical	16051665
MSH2_HUMAN	MSH2	physical	16051665
ZBTB2_HUMAN	ZBTB2	physical	16051665
ZN639_HUMAN	ZNF639	physical	16051665
ACTA_HUMAN	ACTA2	physical	16051665
CSK22_HUMAN	CSNK2A2	physical	16051665
SRBP1_HUMAN	SREBF1	physical	16799563
CREB1_HUMAN	CREB1	physical	16799563
MYB_HUMAN	MYB	physical	16799563
KMT2A_HUMAN	KMT2A	physical	16799563
P73_HUMAN	TP73	physical	10648616
PRLR_HUMAN	PRLR	physical	20962278
MED25_HUMAN	MED25	physical	17641689
PTOV1_HUMAN	PTOV1	physical	17641689
IRF9_HUMAN	IRF9	physical	17923090
H31_HUMAN	HIST1H3A	physical	15616580
NCOA3_HUMAN	NCOA3	physical	15383283
KAT5_HUMAN	KAT5	physical	16001085
STAT1_HUMAN	STAT1	physical	19915063
PYGO2_HUMAN	PYGO2	physical	19555349
MDM2_HUMAN	MDM2	physical	15013777
HBP1_HUMAN	HBP1	physical	21967847
TACC2_HUMAN	TACC2	physical	14767476
NPAT_HUMAN	NPAT	physical	15555599
CCNE1_HUMAN	CCNE1	physical	15555599
CREB1_HUMAN	CREB1	physical	11313407
P73_HUMAN	TP73	physical	11279015
IRF3_HUMAN	IRF3	physical	9566918
PRS8_HUMAN	PSMC5	physical	18662994
FOS_HUMAN	FOS	physical	16055710
P53_HUMAN	TP53	physical	20962272
MDM2_HUMAN	MDM2	physical	22349818
IRF3_HUMAN	IRF3	physical	17015689
MDC1_HUMAN	MDC1	physical	19826003
CDC20_HUMAN	CDC20	physical	19826003
APC7_HUMAN	ANAPC7	physical	19826003
CDC27_HUMAN	CDC27	physical	19826003
ZCH12_HUMAN	ZCCHC12	physical	19416967
ESR1_HUMAN	ESR1	physical	16417649
BRCA1_HUMAN	BRCA1	physical	16417649
BRCA1_HUMAN	BRCA1	physical	9926942
IKKA_HUMAN	CHUK	physical	14597638
IKKB_HUMAN	IKBKB	physical	14597638
NEMO_HUMAN	IKBKG	physical	14597638
TF65_HUMAN	RELA	physical	14597638
H2B2E_HUMAN	HIST2H2BE	physical	21739721
IRF3_HUMAN	IRF3	physical	10082512
IRF3_HUMAN	IRF3	physical	17296604
TF65_HUMAN	RELA	physical	17296604
ATF2_HUMAN	ATF2	physical	17296604
JUN_HUMAN	JUN	physical	17296604
NFAC2_HUMAN	NFATC2	physical	19060202
NCOA2_HUMAN	NCOA2	physical	9430642
IRF3_HUMAN	IRF3	physical	17138826
TF65_HUMAN	RELA	physical	17138826
IRF3_HUMAN	IRF3	physical	17761676
MYBA_HUMAN	MYBL1	physical	9210395
TLR2_HUMAN	TLR2	physical	17126870
IRF3_HUMAN	IRF3	physical	17126870
SMAD3_HUMAN	SMAD3	physical	10497242
SMAD3_HUMAN	SMAD3	physical	15467747
KBZIP_HHV8P	K8	physical	15467747
LYRIC_HUMAN	MTDH	physical	18316612
CREB1_HUMAN	CREB1	physical	9829964
LDLR_HUMAN	LDLR	physical	18660751
STAT1_HUMAN	STAT1	physical	16481475
IRF3_HUMAN	IRF3	physical	16154084
TF65_HUMAN	RELA	physical	15806143
IRF3_HUMAN	IRF3	physical	11314014
VIRF1_HHV8P	vIRF-1	physical	11314014
ANDR_HUMAN	AR	physical	20541699
VIRF3_HHV8P	vIRF-3	physical	14668346
IRF3_HUMAN	IRF3	physical	14668346
HNF4A_HUMAN	HNF4A	physical	9792714
IRF3_HUMAN	IRF3	physical	15502848
IRF3_HUMAN	IRF3	physical	20581830
CREB1_HUMAN	CREB1	physical	11564156
ATF2_HUMAN	ATF2	physical	11564156
ATF4_HUMAN	ATF4	physical	11564156
CSN2_HUMAN	COPS2	physical	23441852
PSME3_HUMAN	PSME3	physical	23612972
KLF2_HUMAN	KLF2	physical	21482710
KLF4_HUMAN	KLF4	physical	21482710
UB2D1_HUMAN	UBE2D1	physical	19805293
CBP_HUMAN	CREBBP	physical	19805293
UBC9_HUMAN	UBE2I	physical	23395904
KAT2B_HUMAN	KAT2B	physical	8684459
JUN_HUMAN	JUN	physical	18443043
ETS1_HUMAN	ETS1	physical	18443043
H2B1B_HUMAN	HIST1H2BB	physical	14720327
H31_HUMAN	HIST1H3A	physical	14720327
HIF1A_HUMAN	HIF1A	physical	19880525
P53_HUMAN	TP53	physical	19880525
CTNB1_MOUSE	Ctnnb1	physical	11973335
CEBPB_RAT	Cebpb	physical	20452968
EID1_HUMAN	EID1	physical	15987788
EID3_HUMAN	EID3	physical	15987788
NCOA2_HUMAN	NCOA2	physical	15987788
PO2F3_HUMAN	POU2F3	physical	11429405
FOXO1_HUMAN	FOXO1	physical	24419059
H31_HUMAN	HIST1H3A	physical	23415232
H31_HUMAN	HIST1H3A	physical	19270680
TF65_HUMAN	RELA	physical	17434128
P53_HUMAN	TP53	physical	17434128
IKKA_HUMAN	CHUK	physical	17434128
NFIC_MOUSE	Nfic	physical	10085123
P53_HUMAN	TP53	physical	14759370
CREB1_HUMAN	CREB1	physical	7870179
TFE2_HUMAN	TCF3	physical	15507449
CREB1_HUMAN	CREB1	physical	8028671
JUN_HUMAN	JUN	physical	8028671
SRBP1_HUMAN	SREBF1	physical	9651391
ELK1_HUMAN	ELK1	physical	8941362
TFE2_HUMAN	TCF3	physical	22207202
IMA1_HUMAN	KPNA2	physical	16969114
HIF1A_HUMAN	HIF1A	physical	15615775
CREM_HUMAN	CREM	physical	9006899
MYOD1_HUMAN	MYOD1	physical	12154097
P53_HUMAN	TP53	physical	12154097
ZEB1_HUMAN	ZEB1	physical	12743039
CRTC1_HUMAN	CRTC1	physical	15961999
MAML2_HUMAN	MAML2	physical	15961999
IRF3_HUMAN	IRF3	physical	12473110
SRF_HUMAN	SRF	physical	9388250
SRBP2_HUMAN	SREBF2	physical	25368385
TFDP1_HUMAN	TFDP1	physical	25368385
MYB_HUMAN	MYB	physical	23980173
FHL2_HUMAN	FHL2	physical	15572674
PPARG_HUMAN	PPARG	physical	17704298
IRF3_HUMAN	IRF3	physical	23824799
ANDR_HUMAN	AR	physical	9822653
KS6A1_HUMAN	RPS6KA1	physical	12540838
CADH2_HUMAN	CDH2	physical	13678586
SMAD3_HUMAN	SMAD3	physical	19589780
PHX2B_HUMAN	PHOX2B	physical	19191321
XAF1_HUMAN	XAF1	physical	18362468
CREB1_HUMAN	CREB1	physical	17707401
KMT2A_HUMAN	KMT2A	physical	17707401
PPARG_HUMAN	PPARG	physical	17312272
TDG_HUMAN	TDG	physical	17060459
MYC_HUMAN	MYC	physical	12776737
IASPP_HUMAN	PPP1R13L	physical	25675294
BRMS1_HUMAN	BRMS1	physical	25675294
PCNA_HUMAN	PCNA	physical	24939902
TLE3_HUMAN	TLE3	physical	26344197
TF65_HUMAN	RELA	physical	10454579
TRIP4_HUMAN	TRIP4	physical	10454579
NCOA1_HUMAN	NCOA1	physical	16860316
TDG_HUMAN	TDG	physical	24748645
P53_HUMAN	TP53	physical	25451029
SNAI1_HUMAN	SNAI1	physical	25314079
TF65_HUMAN	RELA	physical	25314079
LYRIC_HUMAN	MTDH	physical	26141861
TF65_HUMAN	RELA	physical	25733689
STAT1_HUMAN	STAT1	physical	25733689
BMAL1_HUMAN	ARNTL	physical	26164627
CLOCK_HUMAN	CLOCK	physical	26164627
VE6_HPV16	E6	physical	10487758
CREB1_HUMAN	CREB1	physical	12933667
SUMO1_HUMAN	SUMO1	physical	27129204
TF65_HUMAN	RELA	physical	12163591
NCOA1_HUMAN	NCOA1	physical	12163591
NKX21_HUMAN	NKX2-1	physical	15449938
CPSF4_HUMAN	CPSF4	physical	26628108
P53_HUMAN	TP53	physical	18753379
P53_HUMAN	TP53	physical	23908595
NFYA_HUMAN	NFYA	physical	23908595
MARF1_HUMAN	KIAA0430	physical	27173435
NISCH_HUMAN	NISCH	physical	27173435
PCGF3_HUMAN	PCGF3	physical	27173435
PAN2_HUMAN	PAN2	physical	27173435
P53_HUMAN	TP53	physical	27618436
PLAK_HUMAN	JUP	physical	26657156
CTNB1_HUMAN	CTNNB1	physical	26657156
KHDR1_HUMAN	KHDRBS1	physical	28648376
CTNB1_HUMAN	CTNNB1	physical	28648376
UBC9_HUMAN	UBE2I	physical	22227369

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• : Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8
• : 16)(p11
• : p13) with KAT6A
• : translocation t(11
• : 16)(q23
• : p13.3) with KMT2A/MLL1
• : translocation t(10
• : 16)(q22
• : p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
• 180849:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-274; SER-2063 AND SER-2079, AND MASSSPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1014; LYS-1216; LYS-1583;LYS-1591; LYS-1592; LYS-1595; LYS-1597; LYS-1741 AND LYS-1744, ANDMASS SPECTROMETRY.
PubMed: 19608861

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1588; LYS-1591; LYS-1592;LYS-1595 AND LYS-1597, AND MASS SPECTROMETRY.
PubMed: 16916647

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2063, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-274; SER-2063 AND SER-2079, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-2063; SER-2076AND SER-2079, AND MASS SPECTROMETRY.
PubMed: 18669648

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; THR-1001; SER-1030;SER-1072 AND SER-1755, AND MASS SPECTROMETRY.
PubMed: 17525332

"Phosphorylation of CBP by IKKalpha promotes cell growth by switchingthe binding preference of CBP from p53 to NF-kappaB.";
Huang W.C., Ju T.K., Hung M.C., Chen C.C.;
Mol. Cell 26:75-87(2007).
Cited for: PHOSPHORYLATION AT SER-1382 AND SER-1386 BY CHUK/IKKA.
PubMed: 17434128