MAFK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAFK_HUMAN
• UniProt AC: O60675
• Protein Name: Transcription factor MafK
• Gene Name: MAFK
• Organism: Homo sapiens (Human).
• Sequence Length: 156
• Subcellular Localization: Nucleus.
• Protein Description: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. [PubMed: 9150357 However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites]
• Protein Sequence: MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTTNPKPNK ------CCCCCCCCC	34.97	26699800
3	Phosphorylation	-----MTTNPKPNKA -----CCCCCCCCCC	48.50	26699800
9	Ubiquitination	TTNPKPNKALKVKKE CCCCCCCCCCCCCCC	64.72	-
25	Phosphorylation	GENAPVLSDDELVSM CCCCCCCCHHHHHHH	43.16	29255136
31	Phosphorylation	LSDDELVSMSVRELN CCHHHHHHHHHHHHH	20.26	29255136
33	Phosphorylation	DDELVSMSVRELNQH HHHHHHHHHHHHHHH	15.54	29396449
46	Sumoylation	QHLRGLTKEEVTRLK HHHCCCCHHHHHHHH	57.85	-
46	Ubiquitination	QHLRGLTKEEVTRLK HHHCCCCHHHHHHHH	57.85	-
46	Sumoylation	QHLRGLTKEEVTRLK HHHCCCCHHHHHHHH	57.85	-
71	Acetylation	YAASCRIKRVTQKEE HHHHHHEEECCCHHH	22.82	20167786
74	Phosphorylation	SCRIKRVTQKEELER HHHEEECCCHHHHHH	37.65	-
76	Ubiquitination	RIKRVTQKEELERQR HEEECCCHHHHHHHH	43.73	-
76	Sumoylation	RIKRVTQKEELERQR HEEECCCHHHHHHHH	43.73	-
76	Sumoylation	RIKRVTQKEELERQR HEEECCCHHHHHHHH	43.73	-
92	Ubiquitination	ELQQEVEKLARENSS HHHHHHHHHHHHCCC	53.26	-
98	Phosphorylation	EKLARENSSMRLELD HHHHHHCCCHHHHHH	22.28	28555341
99	Phosphorylation	KLARENSSMRLELDA HHHHHCCCHHHHHHH	21.36	25954137
109	Phosphorylation	LELDALRSKYEALQT HHHHHHHHHHHHHHH	40.20	25954137
110	Ubiquitination	ELDALRSKYEALQTF HHHHHHHHHHHHHHH	40.45	21890473
110	Ubiquitination	ELDALRSKYEALQTF HHHHHHHHHHHHHHH	40.45	21890473
110	Sumoylation	ELDALRSKYEALQTF HHHHHHHHHHHHHHH	40.45	-
110	Sumoylation	ELDALRSKYEALQTF HHHHHHHHHHHHHHH	40.45	-
111	Phosphorylation	LDALRSKYEALQTFA HHHHHHHHHHHHHHH	14.00	-
120	O-linked_Glycosylation	ALQTFARTVARGPVA HHHHHHHHHHCCCCC	18.32	20068230
130	Sumoylation	RGPVAPSKVATTSVI CCCCCCCCCEECEEE	34.53	28112733
130	Ubiquitination	RGPVAPSKVATTSVI CCCCCCCCCEECEEE	34.53	-
133	Phosphorylation	VAPSKVATTSVITIV CCCCCCEECEEEEEE	23.69	-
133	O-linked_Glycosylation	VAPSKVATTSVITIV CCCCCCEECEEEEEE	23.69	20068230
134	Phosphorylation	APSKVATTSVITIVK CCCCCEECEEEEEEE	15.97	20068230
134	O-linked_Glycosylation	APSKVATTSVITIVK CCCCCEECEEEEEEE	15.97	20068230
134	O-linked_Glycosylation	APSKVATTSVITIVK CCCCCEECEEEEEEE	15.97	30059200
135	O-linked_Glycosylation	PSKVATTSVITIVKS CCCCEECEEEEEEEC	13.73	20068230
138	O-linked_Glycosylation	VATTSVITIVKSTEL CEECEEEEEEECCCC	19.98	20068230
142	O-linked_Glycosylation	SVITIVKSTELSSTS EEEEEEECCCCCCCC	19.07	20068230
146	O-linked_Glycosylation	IVKSTELSSTSVPFS EEECCCCCCCCCCCC	25.90	20068230
147	O-linked_Glycosylation	VKSTELSSTSVPFSA EECCCCCCCCCCCCC	37.01	20068230
153	O-linked_Glycosylation	SSTSVPFSAAS---- CCCCCCCCCCC----	19.49	30059200
153	O-linked_Glycosylation	SSTSVPFSAAS---- CCCCCCCCCCC----	19.49	20068230
156	O-linked_Glycosylation	SVPFSAAS------- CCCCCCCC-------	40.23	20068230

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAFK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAFK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAFK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NF2L2_HUMAN	NFE2L2	physical	10747902
KAT6A_HUMAN	KAT6A	physical	17083329
BACH1_HUMAN	BACH1	physical	19011633
HDAC1_HUMAN	HDAC1	physical	18241676
HDAC2_HUMAN	HDAC2	physical	18241676
HDAC3_HUMAN	HDAC3	physical	18241676
TF65_HUMAN	RELA	physical	18241676
NF2L2_HUMAN	NFE2L2	physical	21988832
NF2L2_HUMAN	NFE2L2	physical	23737527

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND MASSSPECTROMETRY.
PubMed: 18691976