| UniProt ID | ING1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UK53 | |
| Protein Name | Inhibitor of growth protein 1 | |
| Gene Name | ING1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 422 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.. | |
| Protein Sequence | MSFVECPYHSPAERLVAEADEGGPSAITGMGLCFRCLLFSFSGRSGVEGGRVDLNVFGSLGLQPWIGSSRCWGGPCSSALRCGWFSSWPPPSKSAIPIGGGSRGAGRVSRWPPPHWLEAWRVSPLPLSPLSPATFGRGFIAVAVIPGLWARGRGCSSDRLPRPAGPARRQFQAASLLTRGWGRAWPWKQILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 (in isoform 2) | Phosphorylation | - | 5.32 | 25849741 | |
| 28 (in isoform 5) | Phosphorylation | - | 22.34 | 29116813 | |
| 44 (in isoform 2) | Phosphorylation | - | 29.10 | 20068231 | |
| 102 | Phosphorylation | AIPIGGGSRGAGRVS CCCCCCCCCCCCCCC | 30.71 | - | |
| 175 | Phosphorylation | RRQFQAASLLTRGWG HHHHHHHHHHHCCCC | 27.25 | 24719451 | |
| 224 | Phosphorylation | VQRALIRSQELGDEK HHHHHHHHHHHCHHH | 22.48 | 22210691 | |
| 269 | Phosphorylation | LGDTAGNSGKAGADR HHHCCCCCCCCCCCC | 40.53 | 18388957 | |
| 271 | Ubiquitination | DTAGNSGKAGADRPK HCCCCCCCCCCCCCC | 43.39 | - | |
| 278 | Sumoylation | KAGADRPKGEAAAQA CCCCCCCCHHHHHHC | 70.99 | 28112733 | |
| 287 | Acetylation | EAAAQADKPNSKRSR HHHHHCCCCCCHHHH | 49.46 | 25953088 | |
| 291 | Acetylation | QADKPNSKRSRRQRN HCCCCCCHHHHHHHH | 62.12 | 12435679 | |
| 293 | Phosphorylation | DKPNSKRSRRQRNNE CCCCCHHHHHHHHHH | 35.24 | - | |
| 306 | Phosphorylation | NENRENASSNHDHDD HHCCCCHHCCCCCCC | 43.16 | 30576142 | |
| 307 | Phosphorylation | ENRENASSNHDHDDG HCCCCHHCCCCCCCC | 35.45 | 20068231 | |
| 316 | Phosphorylation | HDHDDGASGTPKEKK CCCCCCCCCCHHHHH | 49.05 | 30576142 | |
| 318 | Phosphorylation | HDDGASGTPKEKKAK CCCCCCCCHHHHHHH | 28.79 | 25849741 | |
| 328 | Acetylation | EKKAKTSKKKKRSKA HHHHHHCHHHHHHHH | 74.06 | 30586007 | |
| 342 | Phosphorylation | AKAEREASPADLPID HHHHHHCCCCCCCCC | 18.83 | 20068231 | |
| 398 | Ubiquitination | KGKWYCPKCRGENEK CCCCCCCCCCCCCHH | 32.76 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ING1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ING1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 275355 | Squamous cell carcinoma of the head and neck (HNSCC) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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