BRM1L_HUMAN - dbPTM
BRM1L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BRM1L_HUMAN
UniProt AC Q5PSV4
Protein Name Breast cancer metastasis-suppressor 1-like protein
Gene Name BRMS1L
Organism Homo sapiens (Human).
Sequence Length 323
Subcellular Localization Nucleus .
Protein Description Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth..
Protein Sequence MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICIDKKDECPTSAVITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28UbiquitinationDYAENEGSSSEDEDT
ECCCCCCCCCCCCCC		25.22-
28UbiquitinationDYAENEGSSSEDEDT
ECCCCCCCCCCCCCC		25.2221890473
30PhosphorylationAENEGSSSEDEDTES
CCCCCCCCCCCCCCC		51.2522210691
46PhosphorylationSVSEDGDSSEMDDED
CCCCCCCCCCCCHHH		33.4522210691
66PhosphorylationMECLDEMSNLEKQFT
HHHHHHHHHHHHHHH		35.8925849741
76UbiquitinationEKQFTDLKDQLYKER
HHHHHHHHHHHHHHH		46.3629967540
81AcetylationDLKDQLYKERLSQVD
HHHHHHHHHHHHHHH		44.9719811739
102PhosphorylationIAGKAPEYLEPLATL
HCCCCCHHHHHHHHH		18.4630576142
118UbiquitinationENMQIRTKVAGIYRE
HHHHHHHHHHHHHHH		21.9029967540
134AcetylationCLESVKNKYECEIQA
HHHHHHHHHHHHHHH		36.3926051181
156PhosphorylationEKLLLYDTVQSELEE
HEEEHHHHHHHHHHH		13.5924719451
164UbiquitinationVQSELEEKIRRLEED
HHHHHHHHHHHHHHH		31.9429967540
174PhosphorylationRLEEDRHSIDITSEL
HHHHHHHHCCCCHHH		23.8930266825
178PhosphorylationDRHSIDITSELWNDE
HHHHCCCCHHHHHHH		16.6427251275
179PhosphorylationRHSIDITSELWNDEL
HHHCCCCHHHHHHHH		30.9030266825
186UbiquitinationSELWNDELQSRKKRK
HHHHHHHHHHHHHCC		6.6321890473
186UbiquitinationSELWNDELQSRKKRK
HHHHHHHHHHHHHCC		6.6321890473
197PhosphorylationKKRKDPFSPDKKKPV
HHCCCCCCCCCCCCE		37.2623401153
225PhosphorylationLDILEDWTTIRKAMA
HHHHCCHHHHHHHHH		25.3526074081
226PhosphorylationDILEDWTTIRKAMAT
HHHCCHHHHHHHHHH		17.9626074081
233PhosphorylationTIRKAMATLGPHRVK
HHHHHHHHHCCCCCC		21.1126074081
240SumoylationTLGPHRVKTEPPVKL
HHCCCCCCCCCCCCH		47.3128112733
240SumoylationTLGPHRVKTEPPVKL
HHCCCCCCCCCCCCH		47.31-
241PhosphorylationLGPHRVKTEPPVKLE
HCCCCCCCCCCCCHH		51.3626074081
246SumoylationVKTEPPVKLEKHLHS
CCCCCCCCHHHHHHC		57.6228112733
311PhosphorylationSKSKLYISQLQKGKY
CCEEEEEHHHHCCCC		15.98-
318PhosphorylationSQLQKGKYSIKHS--
HHHHCCCCCCCCC--		25.05-
319PhosphorylationQLQKGKYSIKHS---
HHHCCCCCCCCC---		28.7524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BRM1L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BRM1L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BRM1L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RET1_HUMANRBP1physical
15451426
SIN3A_HUMANSIN3Aphysical
15451426
HDAC1_HUMANHDAC1physical
15451426
HDAC2_HUMANHDAC2physical
15451426
RBBP7_HUMANRBBP7physical
15451426
RBBP4_HUMANRBBP4physical
15451426
ING1_HUMANING1physical
15451426
BRMS1_HUMANBRMS1physical
15451426
SAP30_HUMANSAP30physical
15451426
DEUP1_HUMANCCDC67physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BRM1L_HUMAN

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Related Literatures of Post-Translational Modification

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