UniProt ID | BRM1L_HUMAN | |
---|---|---|
UniProt AC | Q5PSV4 | |
Protein Name | Breast cancer metastasis-suppressor 1-like protein | |
Gene Name | BRMS1L | |
Organism | Homo sapiens (Human). | |
Sequence Length | 323 | |
Subcellular Localization | Nucleus . | |
Protein Description | Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.. | |
Protein Sequence | MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICIDKKDECPTSAVITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
28 | Ubiquitination | DYAENEGSSSEDEDT ECCCCCCCCCCCCCC | 25.22 | - | |
28 | Ubiquitination | DYAENEGSSSEDEDT ECCCCCCCCCCCCCC | 25.22 | 21890473 | |
30 | Phosphorylation | AENEGSSSEDEDTES CCCCCCCCCCCCCCC | 51.25 | 22210691 | |
46 | Phosphorylation | SVSEDGDSSEMDDED CCCCCCCCCCCCHHH | 33.45 | 22210691 | |
66 | Phosphorylation | MECLDEMSNLEKQFT HHHHHHHHHHHHHHH | 35.89 | 25849741 | |
76 | Ubiquitination | EKQFTDLKDQLYKER HHHHHHHHHHHHHHH | 46.36 | 29967540 | |
81 | Acetylation | DLKDQLYKERLSQVD HHHHHHHHHHHHHHH | 44.97 | 19811739 | |
102 | Phosphorylation | IAGKAPEYLEPLATL HCCCCCHHHHHHHHH | 18.46 | 30576142 | |
118 | Ubiquitination | ENMQIRTKVAGIYRE HHHHHHHHHHHHHHH | 21.90 | 29967540 | |
134 | Acetylation | CLESVKNKYECEIQA HHHHHHHHHHHHHHH | 36.39 | 26051181 | |
156 | Phosphorylation | EKLLLYDTVQSELEE HEEEHHHHHHHHHHH | 13.59 | 24719451 | |
164 | Ubiquitination | VQSELEEKIRRLEED HHHHHHHHHHHHHHH | 31.94 | 29967540 | |
174 | Phosphorylation | RLEEDRHSIDITSEL HHHHHHHHCCCCHHH | 23.89 | 30266825 | |
178 | Phosphorylation | DRHSIDITSELWNDE HHHHCCCCHHHHHHH | 16.64 | 27251275 | |
179 | Phosphorylation | RHSIDITSELWNDEL HHHCCCCHHHHHHHH | 30.90 | 30266825 | |
186 | Ubiquitination | SELWNDELQSRKKRK HHHHHHHHHHHHHCC | 6.63 | 21890473 | |
186 | Ubiquitination | SELWNDELQSRKKRK HHHHHHHHHHHHHCC | 6.63 | 21890473 | |
197 | Phosphorylation | KKRKDPFSPDKKKPV HHCCCCCCCCCCCCE | 37.26 | 23401153 | |
225 | Phosphorylation | LDILEDWTTIRKAMA HHHHCCHHHHHHHHH | 25.35 | 26074081 | |
226 | Phosphorylation | DILEDWTTIRKAMAT HHHCCHHHHHHHHHH | 17.96 | 26074081 | |
233 | Phosphorylation | TIRKAMATLGPHRVK HHHHHHHHHCCCCCC | 21.11 | 26074081 | |
240 | Sumoylation | TLGPHRVKTEPPVKL HHCCCCCCCCCCCCH | 47.31 | 28112733 | |
240 | Sumoylation | TLGPHRVKTEPPVKL HHCCCCCCCCCCCCH | 47.31 | - | |
241 | Phosphorylation | LGPHRVKTEPPVKLE HCCCCCCCCCCCCHH | 51.36 | 26074081 | |
246 | Sumoylation | VKTEPPVKLEKHLHS CCCCCCCCHHHHHHC | 57.62 | 28112733 | |
311 | Phosphorylation | SKSKLYISQLQKGKY CCEEEEEHHHHCCCC | 15.98 | - | |
318 | Phosphorylation | SQLQKGKYSIKHS-- HHHHCCCCCCCCC-- | 25.05 | - | |
319 | Phosphorylation | QLQKGKYSIKHS--- HHHCCCCCCCCC--- | 28.75 | 24719451 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BRM1L_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BRM1L_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BRM1L_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
RET1_HUMAN | RBP1 | physical | 15451426 | |
SIN3A_HUMAN | SIN3A | physical | 15451426 | |
HDAC1_HUMAN | HDAC1 | physical | 15451426 | |
HDAC2_HUMAN | HDAC2 | physical | 15451426 | |
RBBP7_HUMAN | RBBP7 | physical | 15451426 | |
RBBP4_HUMAN | RBBP4 | physical | 15451426 | |
ING1_HUMAN | ING1 | physical | 15451426 | |
BRMS1_HUMAN | BRMS1 | physical | 15451426 | |
SAP30_HUMAN | SAP30 | physical | 15451426 | |
DEUP1_HUMAN | CCDC67 | physical | 25416956 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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