| UniProt ID | DEUP1_HUMAN | |
|---|---|---|
| UniProt AC | Q05D60 | |
| Protein Name | Deuterosome assembly protein 1 {ECO:0000312|HGNC:HGNC:26344} | |
| Gene Name | DEUP1 {ECO:0000312|HGNC:HGNC:26344} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 604 | |
| Subcellular Localization | Cytoplasm. Localizes to the deuterosome.. | |
| Protein Description | Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).. | |
| Protein Sequence | MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTCLDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKVPRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQFQKQAQSYQTQLNGKKQCLEDSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHLKGMMGDLDPGEYMSMDFTNREQSRHTSINKLQYENERLRNDLAKLHVNGKSTWTNQNTYEETGRYAYQSQIKVEQNEERLSHDCEPNRSTMPPLPPSTFQAKEMTSPLVSDDDVFPLSPPDMSFPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLKQNRHI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 150 | Phosphorylation | LEEFRAKSREWDKQE HHHHHHHCCCCHHHH | - | ||
| 175 | Phosphorylation | DAQQKLLSEKCNQFQ HHHHHHHHHHHHHHH | 24719451 | ||
| 187 | Phosphorylation | QFQKQAQSYQTQLNG HHHHHHHHHHHHHHC | 30619164 | ||
| 188 | Phosphorylation | FQKQAQSYQTQLNGK HHHHHHHHHHHHHCC | 30619164 | ||
| 190 | Phosphorylation | KQAQSYQTQLNGKKQ HHHHHHHHHHHCCHH | 30619164 | ||
| 240 | Phosphorylation | AVNEIALSRNKLQDE HHHHHHHHHHHCHHH | 24719451 | ||
| 270 | Phosphorylation | QAMEAGLSEVKSELQ HHHHHCHHHHHHHHH | 29083192 | ||
| 315 | Phosphorylation | GNKTRLESSYLPSIK CCCCCCCHHCCCCCC | 23403867 | ||
| 316 | Phosphorylation | NKTRLESSYLPSIKE CCCCCCHHCCCCCCC | 23403867 | ||
| 317 | Phosphorylation | KTRLESSYLPSIKEP CCCCCHHCCCCCCCH | 23403867 | ||
| 320 | Phosphorylation | LESSYLPSIKEPERK CCHHCCCCCCCHHHH | 23403867 | ||
| 333 | Phosphorylation | RKIKELFSVMQDQPN HHHHHHHHHHCCCCC | 25159151 | ||
| 419 | Phosphorylation | QKVSDMKYKAVRTEN HCCCCCCHHHHHCCC | - | ||
| 547 | Phosphorylation | DDDVFPLSPPDMSFP CCCCCCCCCCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DEUP1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DEUP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DEUP1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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