PCNT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCNT_HUMAN
• UniProt AC: O95613
• Protein Name: Pericentrin
• Gene Name: PCNT
• Organism: Homo sapiens (Human).
• Sequence Length: 3336
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
• Protein Description: Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome..
• Protein Sequence: MEVEQEQRRRKVEAGRTKLAHFRQRKTKGDSSHSEKKTAKRKGSAVDASVQEESPVTKEDSALCGGGDICKSTSCDDTPDGAGGAFAAQPEDCDGEKREDLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMFTVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKLNRLLYSMTFQNVDAADTKSLWPMASAHLLESSWSDDSCDGEEPDISPHIDTCDANTATGGVTDVIKNQAIDACDANTTPGGVTDVIKNWDSLIPDEMPDSPIQEKSECQDMSLSSPTSVLGGSRHQSHTAEAGPRKSPVGMLDLSSWSSPEVLRKDWTLEPWPSLPVTPHSGALSLCSADTSLGDRADTSLPQTQGPGLLCSPGVSAAALALQWAESPPADDHHVQRTAVEKDVEDFITTSFDSQETLSSPPPGLEGKADRSEKSDGSGFGARLSPGSGGPEAQTAGPVTPASISGRFQPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKAERKITSRPFTRFRTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPGPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLAAAASPHSGGRATPSPNSRLERSLTASQDPEHSLTEYIHHLEVIQQRLGGVLPDSTSKKSCHPMIKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	KTAKRKGSAVDASVQ HHHHHCCCCCCHHHC	28.31	29255136
49	Phosphorylation	KGSAVDASVQEESPV CCCCCCHHHCCCCCC	21.62	23927012
54	Phosphorylation	DASVQEESPVTKEDS CHHHCCCCCCCHHHH	24.74	23927012
57	O-linked_Glycosylation	VQEESPVTKEDSALC HCCCCCCCHHHHCCC	31.91	30379171
57	Phosphorylation	VQEESPVTKEDSALC HCCCCCCCHHHHCCC	31.91	23927012
61	Phosphorylation	SPVTKEDSALCGGGD CCCCHHHHCCCCCCC	25.00	21815630
72	Phosphorylation	GGGDICKSTSCDDTP CCCCCCCCCCCCCCC	22.57	26471730
73	Phosphorylation	GGDICKSTSCDDTPD CCCCCCCCCCCCCCC	20.90	26471730
74	Phosphorylation	GDICKSTSCDDTPDG CCCCCCCCCCCCCCC	23.73	26471730
78	Phosphorylation	KSTSCDDTPDGAGGA CCCCCCCCCCCCCCC	15.27	21815630
153	Ubiquitination	FTVSDHPPEQHGMFT EECCCCCHHHCCCEE	50.92	29967540
155	Ubiquitination	VSDHPPEQHGMFTVS CCCCCHHHCCCEECC	44.18	29967540
173	Phosphorylation	PEQRGMFTISDHQPE HHHCCCEEECCCCCH	15.64	28348404
175	Phosphorylation	QRGMFTISDHQPEQR HCCCEEECCCCCHHC	26.44	20860994
186	Phosphorylation	PEQRGMFTVSDHTPE CHHCCCEECCCCCCC	15.37	22199227
188	Phosphorylation	QRGMFTVSDHTPEQR HCCCEECCCCCCCCC	22.18	28555341
191	Phosphorylation	MFTVSDHTPEQRGIF CEECCCCCCCCCCEE	33.25	25159151
201	Phosphorylation	QRGIFTISDHPAEQR CCCEEEECCCCHHHC	27.15	20860994
212	Phosphorylation	AEQRGMFTKECEQEC HHHCCCCCHHHHHHC	19.62	22210691
236	Ubiquitination	GREDEAGLHQSQAVH CCCCCCCCCHHHHCC	4.24	29967540
253	Phosphorylation	ELEALRLSLSNMHTA HHHHHHHHHHHHHHH	24.26	20068231
255	Phosphorylation	EALRLSLSNMHTAQL HHHHHHHHHHHHHHH	28.82	20068231
259	Phosphorylation	LSLSNMHTAQLELTQ HHHHHHHHHHHHHHH	12.82	20068231
265	Phosphorylation	HTAQLELTQANLQKE HHHHHHHHHHHHHHH	19.09	27080861
271	Ubiquitination	LTQANLQKEKETALT HHHHHHHHHHHHHHH	74.13	29967540
273	Ubiquitination	QANLQKEKETALTEL HHHHHHHHHHHHHHH	68.36	29967540
275	Ubiquitination	NLQKEKETALTELRE HHHHHHHHHHHHHHH	37.73	24816145
300	Ubiquitination	ALLQSRQQHELELLR HHHHHHHHHHHHHHH	30.80	29967540
319	Ubiquitination	REKEEVVLRCGQEAA HHHHHHHHHHHHHHH	4.53	29967540
338	Acetylation	KLQSEMEKNAQIVKT HHHHHHHHHHHHHHH	57.16	19819019
345	O-linked_Glycosylation	KNAQIVKTLKEDWES HHHHHHHHHHHHHHC	31.97	30379171
354	Ubiquitination	KEDWESEKDLCLENL HHHHHCHHHHHHHHH	66.34	29967540
387	Ubiquitination	FQKELAEQRAELEKI HHHHHHHHHHHHHHH	44.25	21890473
391	Ubiquitination	LAEQRAELEKIFQDK HHHHHHHHHHHHCCH	8.73	22817900
393	Ubiquitination	EQRAELEKIFQDKNQ HHHHHHHHHHCCHHH	62.54	24816145
414	Ubiquitination	NLESHHQAAIEKLRE HHHHHHHHHHHHHHH	13.17	29967540
418	Ubiquitination	HHQAAIEKLREDLQS HHHHHHHHHHHHHHH	46.89	29967540
420	Ubiquitination	QAAIEKLREDLQSEH HHHHHHHHHHHHHHC	46.59	24816145
437	Ubiquitination	CLEDLEFKFKESEKE HHHHHCHHCCCCHHH	46.26	29967540
451	Ubiquitination	EKQLELENLQASYED HHHHHHHHHHHHHHH	50.51	29967540
454	Ubiquitination	LELENLQASYEDLKA HHHHHHHHHHHHHHH	19.76	29967540
455	Phosphorylation	ELENLQASYEDLKAQ HHHHHHHHHHHHHHH	18.98	26471730
456	Phosphorylation	LENLQASYEDLKAQS HHHHHHHHHHHHHHC	19.24	27251275
479	Phosphorylation	SQLDSARTSRQELSE HHHHHHHHHHHHHHH	28.16	-
485	Phosphorylation	RTSRQELSELHEQLL HHHHHHHHHHHHHHH	37.04	20068231
495	Phosphorylation	HEQLLARTSRVEDLE HHHHHHHHCCHHHHH	18.44	20068231
496	Phosphorylation	EQLLARTSRVEDLEQ HHHHHHHCCHHHHHH	28.86	20068231
505	Ubiquitination	VEDLEQLKQREKTQH HHHHHHHHHHHHHHC	47.18	22817900
509	Ubiquitination	EQLKQREKTQHESEL HHHHHHHHHHCHHHH	56.53	22817900
514	Phosphorylation	REKTQHESELEQLRI HHHHHCHHHHHHHHH	45.41	30108239
532	Ubiquitination	KKLRDAEKTYQEDLT HHHHHHHHHHHHHHH	55.01	21890473
533	Phosphorylation	KLRDAEKTYQEDLTL HHHHHHHHHHHHHHH	23.18	29978859
534	Phosphorylation	LRDAEKTYQEDLTLL HHHHHHHHHHHHHHH	22.45	29978859
536	Ubiquitination	DAEKTYQEDLTLLQQ HHHHHHHHHHHHHHH	44.57	22817900
539	Phosphorylation	KTYQEDLTLLQQRLQ HHHHHHHHHHHHHHH	37.43	29978859
556	Phosphorylation	REDALLDSVEVGLSC HHHHHHHHHHHCCCC	21.83	21712546
562	Phosphorylation	DSVEVGLSCVGLEEK HHHHHCCCCCCCCCC	10.79	21712546
569	Ubiquitination	SCVGLEEKPEKGRKD CCCCCCCCCCCCCCC	49.45	29967540
572	Ubiquitination	GLEEKPEKGRKDHVD CCCCCCCCCCCCCHH	72.97	29967540
578	Ubiquitination	EKGRKDHVDELEPER CCCCCCCHHHCCHHH	9.79	29967540
589	Phosphorylation	EPERHKESLPRFQAE CHHHHHHHCHHHHHH	48.77	29214152
610	Phosphorylation	HQLEALESPLCIQHE HHHHHHHCCEEEECC	24.83	25159151
629	Phosphorylation	DRCCVETSALGHEWR CCEEEEHHCCCCEEE	14.16	24961811
640	Phosphorylation	HEWRLEPSEGHSQEL CEEEECCCCCCCCCC	47.00	27251275
644	Phosphorylation	LEPSEGHSQELPWVH ECCCCCCCCCCCEEE	35.89	26471730
670	Ubiquitination	DTERAARVLGLETEH HHHHHHHHHCCCCHH	4.22	21890473
682	Phosphorylation	TEHKVQLSLLQTELK CHHHHHHHHHHHHHH	15.22	25159151
696	Ubiquitination	KEEIELLKIENRNLY HHHHHHHEECCCCCH	61.67	29967540
763	Ubiquitination	KEELQREAEEKLTLM HHHHHHHHHHHHHHH	32.22	29967540
788	Ubiquitination	EKQTIINKFELREAE HHHHHHHHHHHHHHH	29.79	22817900
813	Phosphorylation	QILDLERSLTEQQGR HHHHHHHHHHHHHHH	30.21	22199227
815	Phosphorylation	LDLERSLTEQQGRLQ HHHHHHHHHHHHHHH	32.75	22199227
815	Ubiquitination	LDLERSLTEQQGRLQ HHHHHHHHHHHHHHH	32.75	21890473
829	Phosphorylation	QQLEQDLTSDDALHC HHHHHCCCCCCCCCH	38.10	26471730
830	Phosphorylation	QLEQDLTSDDALHCS HHHHCCCCCCCCCHH	40.57	24275569
837	Phosphorylation	SDDALHCSQCGREPP CCCCCCHHHCCCCCC	20.12	26471730
881	Ubiquitination	ERKEITEKFSAEQDA HHHHHHHHHCHHHHH	35.65	29967540
886	Ubiquitination	TEKFSAEQDAFLQEA HHHHCHHHHHHHHHH	47.23	29967540
900	Ubiquitination	AQEQHARELQLLQER HHHHHHHHHHHHHHH	41.47	29967540
904	Ubiquitination	HARELQLLQERHQQQ HHHHHHHHHHHHHHH	2.99	29967540
931	Phosphorylation	QAALGELTASLESKQ HHHHHHHHHCHHHHH	15.19	20873877
933	Phosphorylation	ALGELTASLESKQGA HHHHHHHCHHHHHHH	27.68	20873877
936	Phosphorylation	ELTASLESKQGALLA HHHHCHHHHHHHHHH	35.26	20873877
951	Ubiquitination	ARVAELQTKHAADLG HHHHHHHHHHHHHHC	37.10	29967540
952	Ubiquitination	RVAELQTKHAADLGA HHHHHHHHHHHHHCH	20.48	-
962	Phosphorylation	ADLGALETRHLSSLD HHHCHHCHHCCCCHH	25.00	20058876
970	Ubiquitination	RHLSSLDSLESCYLS HCCCCHHHHHHHHHH	39.05	29967540
1004	Ubiquitination	FEEQLWKKDSLHQTI HHHHHCCCCCHHHHH	40.75	29967540
1006	Phosphorylation	EQLWKKDSLHQTILT HHHCCCCCHHHHHHH	36.31	21712546
1018	Ubiquitination	ILTQELEKLKRKHEG HHHHHHHHHHHHCCC	72.44	29967540
1022	Ubiquitination	ELEKLKRKHEGELQS HHHHHHHHCCCCHHH	44.41	29967540
1069	Ubiquitination	KKTALHEKEETLRLQ HHHHHHHHHHHHHHH	50.53	29967540
1088	Ubiquitination	QPFHQEEKESLSLQL CCCCHHHHHHHHHHH	52.42	29967540
1090	Phosphorylation	FHQEEKESLSLQLQK CCHHHHHHHHHHHHH	34.03	26471730
1092	Phosphorylation	QEEKESLSLQLQKKN HHHHHHHHHHHHHHH	24.29	26471730
1142	Phosphorylation	REGANLLSMLKADVN HHHHHHHHHHHHCCC	25.82	28555341
1145	Ubiquitination	ANLLSMLKADVNLSH HHHHHHHHHCCCCCH	33.62	-
1178	Phosphorylation	ETLRAAVTLRSRIGE HHHHHHHHHHHHHHH	16.24	-
1180	Ubiquitination	LRAAVTLRSRIGERV HHHHHHHHHHHHHHH	17.96	29967540
1190	Ubiquitination	IGERVGLCLDDAGAG HHHHHEEECCCCCCC	3.01	29967540
1199	Ubiquitination	DDAGAGLALSTAPAL CCCCCCCCHHCCHHH	9.88	29967540
1209	Phosphorylation	TAPALEETWSDVALP CCHHHHHHHCCCCHH	22.39	22184200
1221	Phosphorylation	ALPELDRTLSECAEM CHHHHHHHHHHHHHH	34.01	22184200
1223	Ubiquitination	PELDRTLSECAEMSS HHHHHHHHHHHHHHH	29.98	29967540
1230	Ubiquitination	SECAEMSSVAEISSH HHHHHHHHHHHHHHH	24.84	29967540
1235	Phosphorylation	MSSVAEISSHMRESF HHHHHHHHHHHHHHH	13.00	22184200
1241	Phosphorylation	ISSHMRESFLMSPES HHHHHHHHHCCCHHH	17.20	22184200
1245	Phosphorylation	MRESFLMSPESVREC HHHHHCCCHHHHHHC	27.88	21815630
1248	Phosphorylation	SFLMSPESVRECEQP HHCCCHHHHHHCCHH	29.83	23186163
1289	Phosphorylation	EEARQIHSRFEKEFS HHHHHHHHHHHHHHC	40.05	20068231
1293	Ubiquitination	QIHSRFEKEFSFKNE HHHHHHHHHHCCCCH	62.44	-
1296	Phosphorylation	SRFEKEFSFKNEETA HHHHHHHCCCCHHHH	36.08	24719451
1298	Ubiquitination	FEKEFSFKNEETAQV HHHHHCCCCHHHHHH	63.35	29967540
1308	Ubiquitination	ETAQVVRKHQELLEC HHHHHHHHHHHHHHH	37.72	29967540
1317	Ubiquitination	QELLECLKEESAAKA HHHHHHHCCCHHHHH	71.71	29967540
1319	Ubiquitination	LLECLKEESAAKAEL HHHHHCCCHHHHHHH	44.05	29967540
1341	Ubiquitination	QGTLEGFKVETADLK CCCCCCCEEEECCHH	50.44	29967540
1348	Ubiquitination	KVETADLKEVLAGKE EEEECCHHHHHCCCC	46.45	29967540
1354	Ubiquitination	LKEVLAGKEDSEHRL HHHHHCCCCCCCHHH	53.38	29967540
1367	Phosphorylation	RLVLELESLRRQLQQ HHHHHHHHHHHHHHH	39.54	-
1387	Phosphorylation	AALREECTRLWSRGE HHHHHHHHHHHHCCC	31.88	28302921
1417	Ubiquitination	EVEDLTKEQSETRKQ HHHHHHHHHHHHHHH	54.85	29967540
1430	Phosphorylation	KQAEKDRSALLSQMK HHHHHHHHHHHHHHH	33.14	20860994
1432	Ubiquitination	AEKDRSALLSQMKIL HHHHHHHHHHHHHHH	5.08	29967540
1437	Ubiquitination	SALLSQMKILESELE HHHHHHHHHHHHHHH	36.18	29967540
1461	Phosphorylation	AKQAEAVTALEQQVA HHHHHHHHHHHHHHH	32.35	20068231
1469	Phosphorylation	ALEQQVASLDKHLRN HHHHHHHHHHHHHHH	37.94	20068231
1472	Ubiquitination	QQVASLDKHLRNQRQ HHHHHHHHHHHHHHH	50.24	29967540
1535	Ubiquitination	EVELLQQKLREKLDE HHHHHHHHHHHHHHH	36.23	29967540
1550	Ubiquitination	FNELAIQKESADRQV HHHHHHHHHHHHHHH	47.74	29967540
1600	Ubiquitination	KGLEQDKEVLKKQQM HHHHHHHHHHHHHHH	62.46	29967540
1630	Phosphorylation	GRCPEPPSGSPPEGP CCCCCCCCCCCCCCC	63.72	26657352
1632	Phosphorylation	CPEPPSGSPPEGPEI CCCCCCCCCCCCCCC	41.44	26657352
1653	Phosphorylation	RALLRRESEVLDLKE HHHHHHHHHHHCHHH	31.06	29255136
1671	Phosphorylation	KMKGDLESKNEEILH HHCCCHHHCCHHHHH	48.34	-
1685	Sulfoxidation	HLNLKLDMQNSQTAV HEEEEECCCCCCCEE	6.19	21406390
1688	Phosphorylation	LKLDMQNSQTAVSLR EEECCCCCCCEEHHH	16.41	21815630
1693	Phosphorylation	QNSQTAVSLRELEEE CCCCCEEHHHHHHHH	21.17	28555341
1702	Phosphorylation	RELEEENTSLKVIYT HHHHHHCCCCEEEEE	38.42	28857561
1703	Phosphorylation	ELEEENTSLKVIYTR HHHHHCCCCEEEEEC	37.46	25159151
1705	Ubiquitination	EEENTSLKVIYTRSS HHHCCCCEEEEECHH	26.76	-
1710	Methylation	SLKVIYTRSSEIEEL CCEEEEECHHHHHHH	22.63	115383937
1711	Phosphorylation	LKVIYTRSSEIEELK CEEEEECHHHHHHHH	25.23	20068231
1712	Phosphorylation	KVIYTRSSEIEELKA EEEEECHHHHHHHHH	39.02	21815630
1718	Ubiquitination	SSEIEELKATIENLQ HHHHHHHHHHHHHHH	46.92	29967540
1746	Ubiquitination	IEQLHEVIEKLQHEL HHHHHHHHHHHHHHH	3.35	29967540
1764	Phosphorylation	GPVVHEVSDSQAGSL HCEEEECCCCCCCCH	28.67	28348404
1766	Phosphorylation	VVHEVSDSQAGSLQS EEEECCCCCCCCHHH	17.90	28348404
1770	Phosphorylation	VSDSQAGSLQSELLC CCCCCCCCHHHHHHH	26.67	27251275
1799	Ubiquitination	LEAALEAKEALSRLL HHHHHHHHHHHHHHH	33.86	-
1814	Phosphorylation	ADQERRHSQALEALQ HHHHHHHHHHHHHHH	18.48	25159151
1864	Ubiquitination	QEFEAALKAKEATIA HHHHHHHHHHHHHHH	53.32	29967540
1884	Ubiquitination	IDALNQRKAAHSAEL HHHHHHHHHHCHHHH	39.91	-
1920	Ubiquitination	GAAPPELQWLRAQCA CCCCHHHHHHHHHHH	35.18	29967540
1936	Ubiquitination	LSRQLQVLHQRFLRC HHHHHHHHHHHHHHH	1.51	29967540
1953	Ubiquitination	ELDRRQARRATAHTR HHHHHHHHHHHCCCC	22.04	29967540
1958	Ubiquitination	QARRATAHTRVPGAH HHHHHHCCCCCCCCC	15.17	29967540
2015	Ubiquitination	LKDAPLCKQEGVMSV ECCCCCCCCCCCHHH	60.10	-
2021	Phosphorylation	CKQEGVMSVLTVCQR CCCCCCHHHHHHHHH	16.15	26546556
2038	Ubiquitination	QSELLLVKNEMRLSL HCHHHHHHCCHHCCC	47.35	29967540
2044	Phosphorylation	VKNEMRLSLEDGGKG HHCCHHCCCCCCCCC	21.24	25159151
2050	Ubiquitination	LSLEDGGKGKEKVLE CCCCCCCCCCHHHHH	72.79	-
2052	Ubiquitination	LEDGGKGKEKVLEDC CCCCCCCCHHHHHHC	58.82	-
2054	Ubiquitination	DGGKGKEKVLEDCQL CCCCCCHHHHHHCCC	56.45	29967540
2059	Phosphorylation	KEKVLEDCQLPKVDL CHHHHHHCCCCCCCH	3.06	32142685
2071	Ubiquitination	VDLVAQVKQLQEKLN CCHHHHHHHHHHHHH	32.96	29967540
2076	Ubiquitination	QVKQLQEKLNRLLYS HHHHHHHHHHHHHHH	37.79	29967540
2082	Phosphorylation	EKLNRLLYSMTFQNV HHHHHHHHHHHCCCC	10.86	20860994
2085	Phosphorylation	NRLLYSMTFQNVDAA HHHHHHHHCCCCCHH	19.01	20860994
2094	Phosphorylation	QNVDAADTKSLWPMA CCCCHHCCCCHHHHH	20.15	20860994
2108	Phosphorylation	ASAHLLESSWSDDSC HHHHHHHCCCCCCCC	36.76	24275569
2114	Phosphorylation	ESSWSDDSCDGEEPD HCCCCCCCCCCCCCC	21.06	24275569
2154	Phosphorylation	IDACDANTTPGGVTD CCCCCCCCCCCCHHH	35.77	25159151
2155	Phosphorylation	DACDANTTPGGVTDV CCCCCCCCCCCHHHH	21.53	25159151
2160	Phosphorylation	NTTPGGVTDVIKNWD CCCCCCHHHHHHCHH	28.02	20068231
2168	Phosphorylation	DVIKNWDSLIPDEMP HHHHCHHHCCCCCCC	21.58	23403867
2177	Phosphorylation	IPDEMPDSPIQEKSE CCCCCCCCCCCCCCC	20.31	28355574
2183	Phosphorylation	DSPIQEKSECQDMSL CCCCCCCCCCCCCCC	42.74	29978859
2189	Phosphorylation	KSECQDMSLSSPTSV CCCCCCCCCCCCCCC	33.13	29632367
2191	Phosphorylation	ECQDMSLSSPTSVLG CCCCCCCCCCCCCCC	27.28	28102081
2192	Phosphorylation	CQDMSLSSPTSVLGG CCCCCCCCCCCCCCC	37.17	25159151
2194	Phosphorylation	DMSLSSPTSVLGGSR CCCCCCCCCCCCCCC	33.15	28102081
2195	Phosphorylation	MSLSSPTSVLGGSRH CCCCCCCCCCCCCCC	20.80	30108239
2200	Phosphorylation	PTSVLGGSRHQSHTA CCCCCCCCCCCCCCC	25.45	26074081
2204	Phosphorylation	LGGSRHQSHTAEAGP CCCCCCCCCCCCCCC	19.38	-
2213	Acetylation	TAEAGPRKSPVGMLD CCCCCCCCCCCCCCC	63.34	30591171
2214	Phosphorylation	AEAGPRKSPVGMLDL CCCCCCCCCCCCCCC	26.54	30266825
2222	Phosphorylation	PVGMLDLSSWSSPEV CCCCCCCCCCCCHHH	29.45	30266825
2223	Phosphorylation	VGMLDLSSWSSPEVL CCCCCCCCCCCHHHH	37.97	27080861
2223	Ubiquitination	VGMLDLSSWSSPEVL CCCCCCCCCCCHHHH	37.97	24816145
2225	Phosphorylation	MLDLSSWSSPEVLRK CCCCCCCCCHHHHCC	37.65	30266825
2226	Phosphorylation	LDLSSWSSPEVLRKD CCCCCCCCHHHHCCC	20.87	21815630
2234	Ubiquitination	PEVLRKDWTLEPWPS HHHHCCCCCCCCCCC	13.11	24816145
2237	Phosphorylation	LRKDWTLEPWPSLPV HCCCCCCCCCCCCCC	37.63	32142685
2279	Phosphorylation	QGPGLLCSPGVSAAA CCCCCCCCCCHHHHH	25.34	28348404
2316	Phosphorylation	KDVEDFITTSFDSQE HCHHHHHHCCCCCCC	19.17	27251275
2317	Phosphorylation	DVEDFITTSFDSQET CHHHHHHCCCCCCCC	23.68	28348404
2318	Phosphorylation	VEDFITTSFDSQETL HHHHHHCCCCCCCCC	20.57	27251275
2320	Ubiquitination	DFITTSFDSQETLSS HHHHCCCCCCCCCCC	49.53	29967540
2321	Phosphorylation	FITTSFDSQETLSSP HHHCCCCCCCCCCCC	28.10	20873877
2324	Phosphorylation	TSFDSQETLSSPPPG CCCCCCCCCCCCCCC	25.05	20873877
2326	Phosphorylation	FDSQETLSSPPPGLE CCCCCCCCCCCCCCC	48.49	30278072
2327	Phosphorylation	DSQETLSSPPPGLEG CCCCCCCCCCCCCCC	44.53	30278072
2339	Phosphorylation	LEGKADRSEKSDGSG CCCCCCCCCCCCCCC	50.34	21712546
2341	Ubiquitination	GKADRSEKSDGSGFG CCCCCCCCCCCCCCC	55.91	24816145
2342	Phosphorylation	KADRSEKSDGSGFGA CCCCCCCCCCCCCCC	43.05	30576142
2345	Phosphorylation	RSEKSDGSGFGARLS CCCCCCCCCCCCCCC	35.62	21815630
2345	Ubiquitination	RSEKSDGSGFGARLS CCCCCCCCCCCCCCC	35.62	29967540
2352	Phosphorylation	SGFGARLSPGSGGPE CCCCCCCCCCCCCCC	22.97	29255136
2352	Ubiquitination	SGFGARLSPGSGGPE CCCCCCCCCCCCCCC	22.97	24816145
2355	Phosphorylation	GARLSPGSGGPEAQT CCCCCCCCCCCCCCC	43.91	29255136
2362	Phosphorylation	SGGPEAQTAGPVTPA CCCCCCCCCCCCCCC	40.40	29255136
2367	Phosphorylation	AQTAGPVTPASISGR CCCCCCCCCCCCCCC	19.10	28985074
2368	Ubiquitination	QTAGPVTPASISGRF CCCCCCCCCCCCCCC	25.01	24816145
2370	Phosphorylation	AGPVTPASISGRFQP CCCCCCCCCCCCCCC	20.63	23312004
2372	Phosphorylation	PVTPASISGRFQPLP CCCCCCCCCCCCCCC	22.78	23312004
2386	Ubiquitination	PEAMKEKEVRPKHVK CHHHHCCCCCHHHHH	44.87	29967540
2433	Phosphorylation	EDEIQDISLHGGKTQ HHHCCEEECCCCCCC	23.70	29255136
2438	Ubiquitination	DISLHGGKTQEVPTA EEECCCCCCCCCCCC	52.18	29967540
2439	O-linked_Glycosylation	ISLHGGKTQEVPTAC EECCCCCCCCCCCCC	32.98	30379171
2452	Ubiquitination	ACPDWRGDLLQVVQE CCCCCCCHHHHHHHH	35.32	29967540
2463	Ubiquitination	VVQEAFEKEQEMQGV HHHHHHHHHHHHCCC	59.24	29967540
2465	Ubiquitination	QEAFEKEQEMQGVEL HHHHHHHHHHCCCCC	63.63	29967540
2477	Phosphorylation	VELQPRLSGSDLGGH CCCCCCCCCCCCCCC	37.21	29255136
2479	Phosphorylation	LQPRLSGSDLGGHSS CCCCCCCCCCCCCHH	26.70	29255136
2479	Ubiquitination	LQPRLSGSDLGGHSS CCCCCCCCCCCCCHH	26.70	29967540
2485	Phosphorylation	GSDLGGHSSLLERLE CCCCCCCHHHHHHHH	26.42	23401153
2486	Phosphorylation	SDLGGHSSLLERLEK CCCCCCHHHHHHHHH	31.16	25159151
2492	Ubiquitination	SSLLERLEKIIREQG HHHHHHHHHHHHHHC	48.72	29967540
2504	Ubiquitination	EQGDLQEKSLEHLRL HHCCCCHHHHHHCCC	47.59	29967540
2505	Phosphorylation	QGDLQEKSLEHLRLP HCCCCHHHHHHCCCC	37.93	28857561
2515	Phosphorylation	HLRLPDRSSLLSEIQ HCCCCCHHHHHHHHH	32.49	28555341
2519	Phosphorylation	PDRSSLLSEIQALRA CCHHHHHHHHHHHHH	37.64	-
2531	Ubiquitination	LRAQLRMTHLQNQEK HHHHHHHHHHCCHHH	17.01	29967540
2538	Ubiquitination	THLQNQEKLQHLRTA HHHCCHHHHHHHHHH	43.62	-
2543	Ubiquitination	QEKLQHLRTALTSAE HHHHHHHHHHHHHHH	18.81	29967540
2554	Phosphorylation	TSAEARGSQQEHQLR HHHHHHCHHHHHHHH	24.12	28555341
2567	Ubiquitination	LRRQVELLAYKVEQE HHHHHHHHHHHHHHH	2.87	29967540
2570	Ubiquitination	QVELLAYKVEQEKCI HHHHHHHHHHHHHHH	33.42	29967540
2575	Ubiquitination	AYKVEQEKCIAGDLQ HHHHHHHHHHHHHHH	30.54	-
2583	Ubiquitination	CIAGDLQKTLSEEQE HHHHHHHHHCCHHHH	59.75	29967540
2584	Phosphorylation	IAGDLQKTLSEEQEK HHHHHHHHCCHHHHH	23.66	20068231
2586	Phosphorylation	GDLQKTLSEEQEKAN HHHHHHCCHHHHHHH	44.30	-
2591	Ubiquitination	TLSEEQEKANSVQKL HCCHHHHHHHHHHHH	53.19	29967540
2594	Phosphorylation	EEQEKANSVQKLLAA HHHHHHHHHHHHHHH	30.68	20068231
2597	Ubiquitination	EKANSVQKLLAAEQT HHHHHHHHHHHHHHH	43.22	29967540
2602	Ubiquitination	VQKLLAAEQTVVRDL HHHHHHHHHHHHHHH	40.97	29967540
2604	Phosphorylation	KLLAAEQTVVRDLKS HHHHHHHHHHHHHHH	16.69	24719451
2610	Ubiquitination	QTVVRDLKSDLCESR HHHHHHHHHHHHHHH	46.33	29967540
2627	Ubiquitination	SEQLSRSLCEVQQEV HHHHHHHHHHHHHHH	2.54	29967540
2649	Ubiquitination	SSKENELKAALQELE HCCHHHHHHHHHHHH	25.99	29967540
2661	Ubiquitination	ELESEQGKGRALQSQ HHHHHCCCCHHHHHH	44.94	29967540
2685	Ubiquitination	QRESQSAKALEELRA HHHHHHHHHHHHHHH	59.77	29967540
2692	Ubiquitination	KALEELRASLETQRA HHHHHHHHHHHHHHH	30.96	29967540
2709	Acetylation	SRLCVALKHEQTAKD HHHHHHHCCHHHHHH	35.04	23749302
2709	Ubiquitination	SRLCVALKHEQTAKD HHHHHHHCCHHHHHH	35.04	29967540
2720	Ubiquitination	TAKDNLQKELRIEHS HHHHHHHHHHHHHHH	62.98	29967540
2727	Phosphorylation	KELRIEHSRCEALLA HHHHHHHHHHHHHHH	26.32	24532841
2735	Ubiquitination	RCEALLAQERSQLSE HHHHHHHHHHHHHHH	46.75	22505724
2745	Ubiquitination	SQLSELQKDLAAEKS HHHHHHHHHHHHHHH	68.30	29967540
2747	Ubiquitination	LSELQKDLAAEKSRT HHHHHHHHHHHHHHH	6.66	29967540
2810	Ubiquitination	DLQAMLEKVQQQALH HHHHHHHHHHHHHHH	41.19	29967540
2825	Ubiquitination	SQQQLEAEAQKHCEA CHHHHHHHHHHHHHH	42.11	22505724
2826	Ubiquitination	QQQLEAEAQKHCEAL HHHHHHHHHHHHHHH	30.67	29967540
2828	Ubiquitination	QLEAEAQKHCEALRR HHHHHHHHHHHHHHH	58.22	29967540
2837	Ubiquitination	CEALRREKEVSATLK HHHHHHHHHHHHHHH	62.70	29967540
2840	Phosphorylation	LRREKEVSATLKSTV HHHHHHHHHHHHHHH	19.34	29759185
2842	Phosphorylation	REKEVSATLKSTVEA HHHHHHHHHHHHHHH	27.49	29759185
2845	Phosphorylation	EVSATLKSTVEALHT HHHHHHHHHHHHHHH	40.58	29759185
2846	Phosphorylation	VSATLKSTVEALHTQ HHHHHHHHHHHHHHH	22.30	29759185
2852	Phosphorylation	STVEALHTQKRELRC HHHHHHHHHHHHHHH	36.31	29759185
2853	Ubiquitination	TVEALHTQKRELRCS HHHHHHHHHHHHHHC	31.87	22505724
2854	Ubiquitination	VEALHTQKRELRCSL HHHHHHHHHHHHHCC	49.33	29967540
2860	Phosphorylation	QKRELRCSLEREREK HHHHHHHCCHHHHCC	27.16	20860994
2860	Ubiquitination	QKRELRCSLEREREK HHHHHHHCCHHHHCC	27.16	21890473
2860 (in isoform 2)	Ubiquitination	-	27.16	-
2867	Ubiquitination	SLEREREKPAWLQAE CCHHHHCCCHHHHHH	46.38	29967540
2878	Phosphorylation	LQAELEQSHPRLKEQ HHHHHHHHCHHHHHH	26.53	25159151
2878	Ubiquitination	LQAELEQSHPRLKEQ HHHHHHHHCHHHHHH	26.53	29967540
2884	Ubiquitination	QSHPRLKEQEGRKAA HHCHHHHHHHHHHHH	59.46	29967540
2889	Ubiquitination	LKEQEGRKAARRSAE HHHHHHHHHHHHHHH	58.20	29967540
2894	Phosphorylation	GRKAARRSAEARQSP HHHHHHHHHHHHCCH	25.55	23403867
2900	Phosphorylation	RSAEARQSPAAAEQW HHHHHHCCHHHHHHH	15.79	25159151
2902	Ubiquitination	AEARQSPAAAEQWRK HHHHCCHHHHHHHHH	25.26	29967540
2932	Ubiquitination	QRDLHKIKQLQQTVR HHHHHHHHHHHHHHH	50.16	22505724
2934	Ubiquitination	DLHKIKQLQQTVRDL HHHHHHHHHHHHHHH	3.28	29967540
2943	Ubiquitination	QTVRDLESKDEVPGS HHHHHHHCCCCCCCC	53.34	22505724
2944	Ubiquitination	TVRDLESKDEVPGSR HHHHHHCCCCCCCCC	48.83	29967540
2950	Ubiquitination	SKDEVPGSRLHLGSA CCCCCCCCCCCCCHH	26.12	21890473
2956	Phosphorylation	GSRLHLGSARRAAGS CCCCCCCHHHHHCCC	25.59	23401153
2959	Ubiquitination	LHLGSARRAAGSDAD CCCCHHHHHCCCCHH	28.62	22505724
2963	Phosphorylation	SARRAAGSDADHLRE HHHHHCCCCHHHHHH	25.54	28348404
2978	Ubiquitination	QQRELEAMRQRLLSA HHHHHHHHHHHHHHH	2.47	21890473
2990	Phosphorylation	LSAARLLTSFTSQAV HHHHHHHHHHHHHHH	26.79	30576142
2999	Methylation	FTSQAVDRTVNDWTS HHHHHHHHHHCCCCC	33.69	115486699
3000	Phosphorylation	TSQAVDRTVNDWTSS HHHHHHHHHCCCCCC	21.14	29083192
3005	Phosphorylation	DRTVNDWTSSNEKAV HHHHCCCCCCHHHHH	25.74	29083192
3006	Phosphorylation	RTVNDWTSSNEKAVM HHHCCCCCCHHHHHH	27.23	29083192
3007	Phosphorylation	TVNDWTSSNEKAVMS HHCCCCCCHHHHHHH	41.45	29083192
3010	Ubiquitination	DWTSSNEKAVMSLLH CCCCCHHHHHHHHHH	51.00	-
3014	Phosphorylation	SNEKAVMSLLHTLEE CHHHHHHHHHHHHHH	22.60	24247654
3023	Ubiquitination	LHTLEELKSDLSRPT HHHHHHHHHHHCCCC	45.24	29967540
3032	Ubiquitination	DLSRPTSSQKKMAAE HHCCCCHHHHHHHHH	48.80	29967540
3034	Ubiquitination	SRPTSSQKKMAAELQ CCCCHHHHHHHHHHH	46.60	29967540
3035	Ubiquitination	RPTSSQKKMAAELQF CCCHHHHHHHHHHHH	26.57	-
3057	Ubiquitination	KDNVSLTKALSTVTQ HCCCCHHHHHHHHCH	53.26	23000965
3060	Phosphorylation	VSLTKALSTVTQEKL CCHHHHHHHHCHHHH	26.20	20068231
3061	Phosphorylation	SLTKALSTVTQEKLE CHHHHHHHHCHHHHH	28.55	20068231
3063	Phosphorylation	TKALSTVTQEKLELS HHHHHHHCHHHHHHH	30.97	20068231
3066	Ubiquitination	LSTVTQEKLELSRAV HHHHCHHHHHHHHHH	37.13	-
3068	Ubiquitination	TVTQEKLELSRAVSK HHCHHHHHHHHHHHH	56.62	21890473
3070	Phosphorylation	TQEKLELSRAVSKLE CHHHHHHHHHHHHHH	14.60	20068231
3074	Phosphorylation	LELSRAVSKLEKLLK HHHHHHHHHHHHHHH	30.45	23186163
3075	Acetylation	ELSRAVSKLEKLLKH HHHHHHHHHHHHHHH	54.81	23749302
3075	Ubiquitination	ELSRAVSKLEKLLKH HHHHHHHHHHHHHHH	54.81	29967540
3077	Phosphorylation	SRAVSKLEKLLKHHL HHHHHHHHHHHHHHH	45.45	33259812
3081	Ubiquitination	SKLEKLLKHHLQKGC HHHHHHHHHHHHCCC	39.14	29967540
3084	Ubiquitination	EKLLKHHLQKGCSPS HHHHHHHHHCCCCCC	5.87	21890473
3086	Ubiquitination	LLKHHLQKGCSPSRS HHHHHHHCCCCCCHH	69.14	29967540
3089	Phosphorylation	HHLQKGCSPSRSERS HHHHCCCCCCHHHCC	34.28	30576142
3099	Ubiquitination	RSERSAWKPDETAPQ HHHCCCCCCCCCCCC	42.16	29967540
3107	Phosphorylation	PDETAPQSSLRRPDP CCCCCCCHHCCCCCC	30.22	20860994
3108	Phosphorylation	DETAPQSSLRRPDPG CCCCCCHHCCCCCCC	22.20	28857561
3130	Ubiquitination	EEAHTSNVKMEKLYL CCCHHCCCCHHHHHH	6.64	29967540
3131	Ubiquitination	EAHTSNVKMEKLYLH CCHHCCCCHHHHHHH	45.66	29967540
3136	Phosphorylation	NVKMEKLYLHYLRAE CCCHHHHHHHHHHHH	11.51	23663014
3139	Phosphorylation	MEKLYLHYLRAESFR HHHHHHHHHHHHHHH	8.69	23663014
3151	Phosphorylation	SFRKALIYQKKYLLL HHHHHHHHCHHHHHH	18.35	30622161
3166	Phosphorylation	LIGGFQDSEQETLSM HHCCCCCCHHHHHHH	30.32	-
3189	Phosphorylation	SKAERKITSRPFTRF CHHHHCCCCCCCCHH	23.01	23312004
3190	Phosphorylation	KAERKITSRPFTRFR HHHHCCCCCCCCHHH	41.24	23312004
3194	Phosphorylation	KITSRPFTRFRTAVR CCCCCCCCHHHHHHH	31.42	23312004
3229	Ubiquitination	KGALAQGKAPRPGPR CCHHHCCCCCCCCCC	43.04	29967540
3242	Phosphorylation	PRARQPQSPPRTRES CCCCCCCCCCCCCCC	43.48	30266825
3246	Phosphorylation	QPQSPPRTRESPPTR CCCCCCCCCCCCCCC	44.56	23403867
3249	Phosphorylation	SPPRTRESPPTRDVP CCCCCCCCCCCCCCC	32.65	20860994
3252	Phosphorylation	RTRESPPTRDVPSGH CCCCCCCCCCCCCCC	42.77	27794612
3257	Phosphorylation	PPTRDVPSGHTRDPA CCCCCCCCCCCCCCH	42.95	20860994
3274	Phosphorylation	RRLAAAASPHSGGRA CHHHHHCCCCCCCCC	20.58	30266825
3277	Phosphorylation	AAAASPHSGGRATPS HHHCCCCCCCCCCCC	46.45	30266825
3282	Phosphorylation	PHSGGRATPSPNSRL CCCCCCCCCCCCCHH	23.96	23401153
3284	Phosphorylation	SGGRATPSPNSRLER CCCCCCCCCCCHHHH	32.15	23401153
3287	Phosphorylation	RATPSPNSRLERSLT CCCCCCCCHHHHHCC	41.44	23403867
3292	Phosphorylation	PNSRLERSLTASQDP CCCHHHHHCCCCCCC	22.24	26055452
3294	Phosphorylation	SRLERSLTASQDPEH CHHHHHCCCCCCCCC	26.05	20068231
3296	Phosphorylation	LERSLTASQDPEHSL HHHHCCCCCCCCCCH	29.85	30108239
3302	Phosphorylation	ASQDPEHSLTEYIHH CCCCCCCCHHHHHHH	35.01	21712546
3304	Phosphorylation	QDPEHSLTEYIHHLE CCCCCCHHHHHHHHH	29.74	30108239
3306	Phosphorylation	PEHSLTEYIHHLEVI CCCCHHHHHHHHHHH	10.58	30108239
3324	Phosphorylation	LGGVLPDSTSKKSCH HCCCCCCCCCCCCCC	32.42	20860994
3325	Phosphorylation	GGVLPDSTSKKSCHP CCCCCCCCCCCCCCC	52.53	20860994
3326	Phosphorylation	GVLPDSTSKKSCHPM CCCCCCCCCCCCCCC	41.88	21815630
3327	Ubiquitination	VLPDSTSKKSCHPMI CCCCCCCCCCCCCCC	49.12	29967540
3328	Ubiquitination	LPDSTSKKSCHPMIK CCCCCCCCCCCCCCC	59.07	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1209	T	Phosphorylation	Kinase	PLK1	P53350	PSP
1221	T	Phosphorylation	Kinase	PLK1	P53350	PSP
1235	S	Phosphorylation	Kinase	PLK1	P53350	PSP
1241	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCNT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCNT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCM1_HUMAN	PCM1	physical	11171385
GCP3_HUMAN	TUBGCP3	physical	12221128
GCP2_HUMAN	TUBGCP2	physical	12221128
DC1L1_HUMAN	DYNC1LI1	physical	10893222
CHD4_HUMAN	CHD4	physical	17626165
CHD3_HUMAN	CHD3	physical	17626165
MBD3_HUMAN	MBD3	physical	17626165
MTA2_HUMAN	MTA2	physical	17626165
RBBP7_HUMAN	RBBP7	physical	17626165
ADT1_HUMAN	SLC25A4	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
PON2_HUMAN	PON2	physical	26496610
KAP2_HUMAN	PRKAR2A	physical	26496610
OFD1_HUMAN	OFD1	physical	26496610
MTA2_HUMAN	MTA2	physical	26496610
PIBF1_HUMAN	PIBF1	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
CK5P2_HUMAN	CDK5RAP2	physical	26496610
MIB1_HUMAN	MIB1	physical	26496610
WDR35_HUMAN	WDR35	physical	26496610
CG050_HUMAN	C7orf50	physical	26496610
M17L2_HUMAN	MPV17L2	physical	26496610
IMP4_HUMAN	IMP4	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 210720: Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2177 AND SER-2327, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54; SER-1688; SER-2044;SER-2900; SER-2963 AND SER-3274, AND MASS SPECTROMETRY.
PubMed: 19007248

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1703, AND MASSSPECTROMETRY.
PubMed: 16565220