MIB1_HUMAN - dbPTM
MIB1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MIB1_HUMAN
UniProt AC Q86YT6
Protein Name E3 ubiquitin-protein ligase MIB1
Gene Name MIB1
Organism Homo sapiens (Human).
Sequence Length 1006
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cell membrane. Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remai
Protein Description E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation..
Protein Sequence MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
25UbiquitinationVVRGPDWKWGKQDGG
EEECCCCCCCCCCCC
54.1523000965
28NeddylationGPDWKWGKQDGGEGH
CCCCCCCCCCCCCCC
44.0632015554
28UbiquitinationGPDWKWGKQDGGEGH
CCCCCCCCCCCCCCC
44.0621906983
44UbiquitinationGTVRSFESPEEVVVV
EEEEECCCCCCEEEE
35.2823503661
50UbiquitinationESPEEVVVVWDNGTA
CCCCCEEEEECCCCE
4.3221890473
76PhosphorylationRILDSAPTGIKHDGT
EEEECCCCCCCCCCC
51.7829396449
79UbiquitinationDSAPTGIKHDGTMCD
ECCCCCCCCCCCCCC
36.6722817900
106PhosphorylationKCAECTNYDLCTVCY
EECCCCCCEEEEEEE
7.67-
128UbiquitinationRHRFYRITTPGSERV
EECEEEECCCCHHHH
20.2421890473
132PhosphorylationYRITTPGSERVLLES
EEECCCCHHHHHCCH
24.3524719451
141UbiquitinationRVLLESRRKSKKITA
HHHCCHHHCCCCCCH
57.8021890473
194PhosphorylationSSPHSAAYVLWDNGA
CCCCCEEEEEECCCC
8.87-
196UbiquitinationPHSAAYVLWDNGAKN
CCCEEEEEECCCCCC
2.8721890473
201UbiquitinationYVLWDNGAKNLYRVG
EEEECCCCCCEEEEC
12.1022053931
202AcetylationVLWDNGAKNLYRVGF
EEECCCCCCEEEECC
49.2119822263
202UbiquitinationVLWDNGAKNLYRVGF
EEECCCCCCEEEECC
49.2123000965
216AcetylationFEGMSDLKCVQDAKG
CCCCCCCEEEEECCC
37.0319822271
216UbiquitinationFEGMSDLKCVQDAKG
CCCCCCCEEEEECCC
37.0323503661
222NeddylationLKCVQDAKGGSFYRD
CEEEEECCCCCCCCC
72.5832015554
222UbiquitinationLKCVQDAKGGSFYRD
CEEEEECCCCCCCCC
72.5822817900
227UbiquitinationDAKGGSFYRDHCPVL
ECCCCCCCCCCCCCC
19.4821890473
236UbiquitinationDHCPVLGEQNGNRNP
CCCCCCCCCCCCCCC
36.3921890473
245UbiquitinationNGNRNPGGLQIGDLV
CCCCCCCCCCHHHEE
18.7021890473
248UbiquitinationRNPGGLQIGDLVNID
CCCCCCCHHHEEEEE
5.8023000965
249UbiquitinationNPGGLQIGDLVNIDL
CCCCCCHHHEEEEEC
14.8323000965
259UbiquitinationVNIDLDLEIVQSLQH
EEEECCHHHHHHHHC
40.5621890473
260UbiquitinationNIDLDLEIVQSLQHG
EEECCHHHHHHHHCC
4.4322817900
265UbiquitinationLEIVQSLQHGHGGWT
HHHHHHHHCCCCCCC
45.8521890473
281UbiquitinationGMFETLTTTGTVCGI
CCEEEECCCCCEECC
26.7522505724
282UbiquitinationMFETLTTTGTVCGID
CEEEECCCCCEECCC
26.1422505724
297UbiquitinationEDHDIVVQYPSGNRW
CCCCEEEECCCCCCE
33.2621890473
301UbiquitinationIVVQYPSGNRWTFNP
EEEECCCCCCEEECC
24.1822817900
304UbiquitinationQYPSGNRWTFNPAVL
ECCCCCCEEECCHHH
14.8922817900
306UbiquitinationPSGNRWTFNPAVLTK
CCCCCEEECCHHHEC
9.0522053931
309UbiquitinationNRWTFNPAVLTKANI
CCEEECCHHHECCCE
15.2822817900
313UbiquitinationFNPAVLTKANIVRSG
ECCHHHECCCEEECC
34.9621963094
323UbiquitinationIVRSGDAAQGAEGGT
EEECCCCCCCCCCCC
17.0622817900
336UbiquitinationGTSQFQVGDLVQVCY
CCCCCCHHHHHHHHH
16.2622817900
349UbiquitinationCYDLERIKLLQRGHG
HHCHHHHHHHHCCCH
49.7432015554
358UbiquitinationLQRGHGEWAEAMLPT
HHCCCHHHHHHHHHH
12.1923503661
359UbiquitinationQRGHGEWAEAMLPTL
HCCCHHHHHHHHHHC
7.1423503661
364UbiquitinationEWAEAMLPTLGKVGR
HHHHHHHHHCCCCCC
16.7023503661
368UbiquitinationAMLPTLGKVGRVQQI
HHHHHCCCCCCEEEE
44.6321906983
376PhosphorylationVGRVQQIYSDSDLKV
CCCEEEEECCCCCEE
11.3325884760
377PhosphorylationGRVQQIYSDSDLKVE
CCEEEEECCCCCEEE
32.0621815630
382UbiquitinationIYSDSDLKVEVCGTS
EECCCCCEEEEECCC
41.1422817900
383UbiquitinationYSDSDLKVEVCGTSW
ECCCCCEEEEECCCC
9.6622817900
399UbiquitinationYNPAAVSKVASAGSA
CCHHHHHHHHHCCHH
34.9121906983
402PhosphorylationAAVSKVASAGSAISN
HHHHHHHHCCHHHHC
35.8323403867
405PhosphorylationSKVASAGSAISNASG
HHHHHCCHHHHCCCH
23.3430266825
405UbiquitinationSKVASAGSAISNASG
HHHHHCCHHHHCCCH
23.3421963094
406UbiquitinationKVASAGSAISNASGE
HHHHCCHHHHCCCHH
14.3322817900
408PhosphorylationASAGSAISNASGERL
HHCCHHHHCCCHHHH
26.5130266825
411PhosphorylationGSAISNASGERLSQL
CHHHHCCCHHHHHHH
45.5030266825
416PhosphorylationNASGERLSQLLKKLF
CCCHHHHHHHHHHHH
25.6330266825
420UbiquitinationERLSQLLKKLFETQE
HHHHHHHHHHHHCCC
56.9023000965
421UbiquitinationRLSQLLKKLFETQES
HHHHHHHHHHHCCCC
59.3823000965
427UbiquitinationKKLFETQESGDLNEE
HHHHHCCCCCCCCHH
65.2023503661
437UbiquitinationDLNEELVKAAANGDV
CCCHHHHHHHHCCCC
44.9521906983
446UbiquitinationAANGDVAKVEDLLKR
HHCCCCCCHHHHHHC
46.1127667366
448UbiquitinationNGDVAKVEDLLKRPD
CCCCCCHHHHHHCCC
42.0822817900
4522-HydroxyisobutyrylationAKVEDLLKRPDVDVN
CCHHHHHHCCCCCCC
70.00-
452UbiquitinationAKVEDLLKRPDVDVN
CCHHHHHHCCCCCCC
70.0032015554
459UbiquitinationKRPDVDVNGQCAGHT
HCCCCCCCCCCCCHH
30.2921890473
481UbiquitinationNGHVDILKLLLKQNV
CCCHHHHHHHHHCCC
37.1122817900
485NeddylationDILKLLLKQNVDVEA
HHHHHHHHCCCCCCE
39.5332015554
485UbiquitinationDILKLLLKQNVDVEA
HHHHHHHHCCCCCCE
39.5321906983
495UbiquitinationVDVEAEDKDGDRAVH
CCCCEECCCCCCEEE
55.9321906983
519UbiquitinationVIEVLHRGSADLNAR
EEEEEECCCCCCCCC
19.2122053931
540UbiquitinationPLHIAVNKGHLQVVK
CEEEEEECCHHHHHH
40.9021890473
547UbiquitinationKGHLQVVKTLLDFGC
CCHHHHHHHHHHCCC
34.3032015554
554UbiquitinationKTLLDFGCHPSLQDS
HHHHHCCCCCHHCCC
4.2721890473
563UbiquitinationPSLQDSEGDTPLHDA
CHHCCCCCCCCHHHH
48.3121890473
573UbiquitinationPLHDAISKKRDDILA
CHHHHHHCCHHHHHH
45.7932015554
577UbiquitinationAISKKRDDILAVLLE
HHHCCHHHHHHHHHH
41.6621890473
578UbiquitinationISKKRDDILAVLLEA
HHCCHHHHHHHHHHC
2.8922817900
599UbiquitinationTNNNGFNALHHAALR
ECCCCCHHHHHHHHC
13.1522505724
600UbiquitinationNNNGFNALHHAALRG
CCCCCHHHHHHHHCC
2.9722505724
615UbiquitinationNPSAMRVLLSKLPRP
CHHHHHHHHCCCCCC
2.9321890473
618UbiquitinationAMRVLLSKLPRPWIV
HHHHHHCCCCCCEEE
63.5822817900
619UbiquitinationMRVLLSKLPRPWIVD
HHHHHCCCCCCEEEC
3.8022817900
622UbiquitinationLLSKLPRPWIVDEKK
HHCCCCCCEEECCCC
24.1722817900
624UbiquitinationSKLPRPWIVDEKKDD
CCCCCCEEECCCCCC
2.8722053931
654UbiquitinationVAELLVHQGNANLDI
HHHHHHHCCCCCCEE
39.0822817900
676UbiquitinationALHLAVERQHTQIVR
HHHHHHHHHHHHHHH
27.2923503661
677UbiquitinationLHLAVERQHTQIVRL
HHHHHHHHHHHHHHH
30.4023503661
682UbiquitinationERQHTQIVRLLVRAG
HHHHHHHHHHHHHCC
2.2523503661
691UbiquitinationLLVRAGAKLDIQDKD
HHHHCCCCCCCCCCC
45.8621906983
697UbiquitinationAKLDIQDKDGDTPLH
CCCCCCCCCCCCCHH
47.4329967540
700UbiquitinationDIQDKDGDTPLHEAL
CCCCCCCCCCHHHHH
56.1122817900
701UbiquitinationIQDKDGDTPLHEALR
CCCCCCCCCHHHHHH
33.0222817900
723UbiquitinationRQLQDMQDVGKVDAA
HHHHHHHHHCCCCCC
44.4921963094
724UbiquitinationQLQDMQDVGKVDAAW
HHHHHHHHCCCCCCC
4.5022817900
726NeddylationQDMQDVGKVDAAWEP
HHHHHHCCCCCCCCC
36.4732015554
726UbiquitinationQDMQDVGKVDAAWEP
HHHHHHCCCCCCCCC
36.4727667366
735NeddylationDAAWEPSKNTLIMGL
CCCCCCCCCEEEEEC
65.7432015554
735UbiquitinationDAAWEPSKNTLIMGL
CCCCCCCCCEEEEEC
65.7427667366
744PhosphorylationTLIMGLGTQGAEKKS
EEEEECCCCCCCHHH
28.9528857561
745UbiquitinationLIMGLGTQGAEKKSA
EEEECCCCCCCHHHH
47.5023503661
749UbiquitinationLGTQGAEKKSAASIA
CCCCCCCHHHHHHHH
52.0421906983
750UbiquitinationGTQGAEKKSAASIAC
CCCCCCHHHHHHHHH
36.5122817900
764UbiquitinationCFLAANGADLSIRNK
HHHHHCCCCEEECCC
17.8727667366
766UbiquitinationLAANGADLSIRNKKG
HHHCCCCEEECCCCC
4.5522817900
767PhosphorylationAANGADLSIRNKKGQ
HHCCCCEEECCCCCC
21.7624719451
771UbiquitinationADLSIRNKKGQSPLD
CCEEECCCCCCCCHH
48.7222505724
772UbiquitinationDLSIRNKKGQSPLDL
CEEECCCCCCCCHHC
66.7733845483
777UbiquitinationNKKGQSPLDLCPDPN
CCCCCCCHHCCCCHH
10.7221890473
787NeddylationCPDPNLCKALAKCHK
CCCHHHHHHHHHHHH
49.9932015554
787UbiquitinationCPDPNLCKALAKCHK
CCCHHHHHHHHHHHH
49.9921906983
791UbiquitinationNLCKALAKCHKEKVS
HHHHHHHHHHHHHCC
37.4122817900
794UbiquitinationKALAKCHKEKVSGQV
HHHHHHHHHHCCCCC
69.5622817900
796UbiquitinationLAKCHKEKVSGQVGS
HHHHHHHHCCCCCCC
46.6421906983
798PhosphorylationKCHKEKVSGQVGSRS
HHHHHHCCCCCCCCC
34.2826074081
803PhosphorylationKVSGQVGSRSPSMIS
HCCCCCCCCCHHHCC
30.6330576142
805PhosphorylationSGQVGSRSPSMISND
CCCCCCCCHHHCCCC
24.0325159151
807PhosphorylationQVGSRSPSMISNDSE
CCCCCCHHHCCCCCC
29.9623663014
810PhosphorylationSRSPSMISNDSETLE
CCCHHHCCCCCCCHH
26.4123663014
813PhosphorylationPSMISNDSETLEECM
HHHCCCCCCCHHHHC
36.4123663014
815PhosphorylationMISNDSETLEECMVC
HCCCCCCCHHHHCCC
43.3423663014
826UbiquitinationCMVCSDMKRDTLFGP
HCCCCCCCCCCCCCC
52.7121906983
848UbiquitinationSLCSPRVKKCLICKE
HHCCCCCCEEEECHH
38.7623503661
849UbiquitinationLCSPRVKKCLICKEQ
HCCCCCCEEEECHHH
31.2723503661
854NeddylationVKKCLICKEQVQSRT
CCEEEECHHHHCCCC
44.1632015554
854UbiquitinationVKKCLICKEQVQSRT
CCEEEECHHHHCCCC
44.1632015554
859PhosphorylationICKEQVQSRTKIEEC
ECHHHHCCCCCCEEE
42.9629083192
861PhosphorylationKEQVQSRTKIEECVV
HHHHCCCCCCEEEEE
41.4429083192
862UbiquitinationEQVQSRTKIEECVVC
HHHCCCCCCEEEEEC
47.1932015554
872AcetylationECVVCSDKKAAVLFQ
EEEECCCCCEEEEEE
28.1927452117
872UbiquitinationECVVCSDKKAAVLFQ
EEEECCCCCEEEEEE
28.1921906983
873UbiquitinationCVVCSDKKAAVLFQP
EEECCCCCEEEEEEC
46.7122817900
895NeddylationENCANLMKKCVQCRA
HHHHHHHHHHHHCHH
46.3032015554
895UbiquitinationENCANLMKKCVQCRA
HHHHHHHHHHHHCHH
46.3021963094
896UbiquitinationNCANLMKKCVQCRAV
HHHHHHHHHHHCHHH
26.1822817900
917UbiquitinationFIMCCGGKSSEDATD
EEEECCCCCCCCCCC
35.7723503661
927PhosphorylationEDATDDISSGNIPVL
CCCCCCCCCCCCCEE
38.9128555341
928PhosphorylationDATDDISSGNIPVLQ
CCCCCCCCCCCCEEE
35.8727251275
936UbiquitinationGNIPVLQKDKDNTNV
CCCCEEEECCCCCCC
63.6921906983
938UbiquitinationIPVLQKDKDNTNVNA
CCEEEECCCCCCCCH
60.9721906983
949NeddylationNVNADVQKLQQQLQD
CCCHHHHHHHHHHHH
48.3832015554
949UbiquitinationNVNADVQKLQQQLQD
CCCHHHHHHHHHHHH
48.3822817900
958UbiquitinationQQQLQDIKEQTMCPV
HHHHHHHHHHHCCHH
52.6532015554
990PhosphorylationQLCGDRMSECPICRK
HHCCCHHHCCHHHHH
36.6223898821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseMIB1Q86YT6
PMID:12351649

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MIB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MIB1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RYK_HUMANRYKphysical
21875946
DLL1_HUMANDLL1physical
21985982
TBK1_HUMANTBK1physical
21903422
SNX5_HUMANSNX5physical
16857196
DAPK1_HUMANDAPK1physical
15048887
CMIP_HUMANCMIPphysical
20018188
UBE2N_HUMANUBE2Nphysical
21903422
SMN_HUMANSMN1physical
23615451
PCM1_HUMANPCM1physical
24121310
MIB1_HUMANMIB1physical
24239288
USP9X_HUMANUSP9Xphysical
24239288
ZC3H1_HUMANZFC3H1physical
24239288
RAGP1_HUMANRANGAP1physical
24239288
BLM_HUMANBLMphysical
24239288
ZBT10_HUMANZBTB10physical
24239288
GEMI4_HUMANGEMIN4physical
24239288
MCM3_HUMANMCM3physical
24239288
TOP3A_HUMANTOP3Aphysical
24239288
DDB1_HUMANDDB1physical
24239288
TOP3B_HUMANTOP3Bphysical
24239288
RBBP4_HUMANRBBP4physical
24239288
MCM7_HUMANMCM7physical
24239288
CDC27_HUMANCDC27physical
24239288
UB2D3_HUMANUBE2D3physical
24239288
PLK4_HUMANPLK4physical
25795303
JAG1_HUMANJAG1physical
25747658
DL_DROMEDlphysical
25747658
UB2D2_HUMANUBE2D2physical
25747658
E41LA_HUMANEPB41L4Aphysical
27510968

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615092Left ventricular non-compaction 7 (LVNC7)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MIB1_HUMAN

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Related Literatures of Post-Translational Modification

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